JP6684214B2 - 流体の高スループット分析のためのスマートフォンベースの多重化粘度計 - Google Patents
流体の高スループット分析のためのスマートフォンベースの多重化粘度計 Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
- G01N11/06—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture by timing the outflow of a known quantity
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/20—Analysis of motion
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N2011/006—Determining flow properties indirectly by measuring other parameters of the system
- G01N2011/008—Determining flow properties indirectly by measuring other parameters of the system optical properties
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10016—Video; Image sequence
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Description
Patm-P1+ρgh1=QRt (8)
ρgh1は、密度ρの流体からの静水圧の寄与である。Rtは8μLt/πR4によって与えられるチュービング内の流体の流体力学的抵抗である。ここで、μは流体の粘度であり、Rはチュービングの半径(0.635mm)であり、Ltはチュービングの長さ(≦1.5m)である。
P1-P2=QRch (9)
式(9)で、Rchはマイクロチャネル内の流体の流体力学的抵抗であり、これは1よりもはるかに小さいチャネルアスペクト比の12μLch/wh3によって与えられる(我々のデバイスではh/w=0.06である)。
P2-P3+ρgh2=QRgc1 (10)
上式で、Rgc1(=8μh2/πr4)は、ガラス毛細管の垂直部分における流体の流体力学的抵抗を示している。
P3-P4=QRgc2 (11)
ρg(h1-h2)+PL=Q(Rt+Rch+Rgc1+Rgc2) (13)
ρgΔh+PL=μQS (14)
上式で、Δh=h1-h2であり、Sは次式によって与えられる幾何学的な係数である。
P1-P2=ρgΔh+PL (21)
である。
References:
1. Rao, M.A., Rheology of Fluid and Semisolid Foods: Principles and Applications. Food Engineering Series. 2007, New York: Springer
2. Buchmann, S., Main cosmetic vehicles, in Handbook of Cosmetic Science and Technology, A.O. Barel, M. Paye, and H.I. Maibach, Editors. 2001, Marcel Dekker, Inc.: New York. p. 145-171
3. Lin, H.-W., et al., The Rheological Behaviors of Screening Pastes. Journal of Materials Processing Technology, 2008. 197: p. 136-144
4. Kontopoulou, M., Applied Polymer Rheology:Polymeric Fluids with Industrial Applications 2011, New York: Wiley
5. Santoyo, E., et al., Rheological property measurement of drilling fluids used in geothermal wells. Applied Thermal Engineering, 2001. 21: p. 283-302
6. Malimard, J., M. Querry, and P. Vergne, Lubricant rheology in real conditions: measurements and confrontation with a ball/disk contact. Revue de Metallurgie, 2002. 98(02): p. 141-148
7. C. J. Pipe , T. S. Majmudar , and G. H. McKinley High shear rate viscometry. Rheologica Acta, 2008. 47: p. 621-642
8. Lee, J. and A. Tripathi, Intrinsic viscosity of polymers and biopolymers measured by microchip. Analytical Chemistry, 2005. 77(22): p. 7137-7147
9. N. Srivastava, R. D. Davenport, and M. A. Burns Nanoliter viscometer for analyzing blood plasma and other liquid samples. Analytical Chemistry, 2005. 77: p. 383-392
10. Guillot, P., et al., Viscosimeter on a microfluidic chip. Langmuir, 2006. 22: p. 6438-6445
11. Galambos, P. and F. Forster, An Optical Microfluidic Viscosmeter. ASME Int. Mech.Eng.Cong.&Exp., 1998. 66: p. 187-191
12. Pan, L. and P.E. Arratia, A high-shear, low Reynolds number microfluidic rheometer. Microfluidics and Nanofluidics, 2012(1613-4982)
13. Livak-Dahl, E., J. Lee, and M.A. Burns, Nanoliter droplet viscometer with additive free operation. Lab on a Chip, 2013. 13(2): p. 297-301
14. Moon, D. and K.B. Migler, Measurement of dynamic capillary pressure and viscosity via the multi-sample micro-slit rheometer. Chemical Engineering Science, 2009. 64(22): p. 4537-4542
15. Mark, D., F.v. Stetten, and R. Zengerle, Microfluidic Apps for off-the-shelf instruments. Lab on a Chip, 2012. 12: p. 2464-2468
16. Gallegos, D., et al., Label-free biodetection using a smartphone. Lab on a Chip, 2013. 13: p. 2124-2132
17. Choi, S. and J.K. Park, Microfluidic Rheometer for Characterization of Protein Unfolding and Aggregation in Microflows. Small, 2010. 6(12): p. 1306-1310
18. Macosko, C.W., Rheology: Principles, Measurements and Applications. 1994, New York: Wiley-VCH
19. Xia, Y.N. and G.M. Whitesides, Soft lithography. Angewandte Chemie-International Edition, 1998. 37(5): p. 551-575
20. Vargaftik, N.B., B.N. Volkov, and L.D. Voljak, International Tables of the Surface-Tension of Water. Journal of Physical and Chemical Reference Data, 1983. 12(3): p. 817-820
21. Finlayson-Pitts, B.J., et al., The heterogeneous hydrolysis of NO2 in laboratory systems and in outdoor and indoor atmospheres: An integrated mechanism. Physical Chemistry Chemical Physics, 2003. 5(2): p. 223-242
22. Wilkes, J.O., Fluid Mechanics for Chemical Engineers. 2005, New Jersey: Prentice Hall International Series
23. Moon, et al.; Multi-sample micro-slit rheometry; Journal of Rheology, Vol. 52 (2008) pp. 1131-1142
24. Srivastava, et al.; Nanoliter Viscometer for Analyzing Blood Plasma and Other Liquid Samples; Analytical Chemistry (2005) Vol. 77 (2), pp. 383-392
25. Bail; Image Processing on a Mobile Platform; University of Manchester-School of Computer Science (2009) Academia.edu
26. US Patent Application Publication No. 20120096929
Claims (15)
- マイクロチャネルと流体連通するガラス毛細管に接続された前記マイクロチャネルと、
前記マイクロチャネルに一定の圧力を適用する、前記マイクロチャネルに接続された圧力源と、
流体が前記ガラス毛細管中を移動する時に流体スラグの2又は3以上のデジタル画像をキャプチャするために前記ガラス毛細管に対して配置されたデジタルカメラと、
前記2又は3以上のデジタル画像の各々について前記ガラス毛細管中の前記流体スラグのロケーションを決定し、前記ガラス毛細管中の前記流体スラグのロケーションに基づいて前記流体の流量を決定し、適用された圧力及び前記流体の流量に基づいて前記流体の粘度を決定する、前記デジタルカメラに通信可能に結合されたプロセッサと
を備える、装置。 - マイクロ流体チャネルがソフトリソグラフィ技法を用いてマイクロ流体チップ上に製造されるか、
マイクロ流体チャネルが、100〜1000μmの幅(w)と、50〜100μmの高さ(h)と、1〜2cmの長さ(Lch)とを有するか、
マイクロ流体チャネルが、ガラス毛細管、マイクロチャネル、及び前記マイクロチャネルに接続されたチュービング中の全抵抗の85%超を占める流体力学的抵抗を有するか、或いは
前記ガラス毛細管が、0.375〜1mmの内半径と、5〜10cmの長さとを有する、請求項1に記載の装置。 - プロセッサが、デジタルカメラに統合されるか、前記デジタルカメラにワイヤレスに接続される、請求項1に記載の装置。
- スマートフォン、タブレット、パーソナルデジタルデバイス、コンピュータパッド、ネットブック、又はデジタルカメラを統合したコンピュータをさらに備える、請求項1に記載の装置。
- デジタルカメラを使用して流体の粘度を決定する方法であって、
マイクロチャネルと流体連通するガラス毛細管に接続された前記マイクロチャネルと、
前記マイクロチャネルに接続された圧力源と、
前記ガラス毛細管中の前記流体の2又は3以上の画像をキャプチャするために前記ガラス毛細管に対して配置された前記デジタルカメラと
を備える装置を提供するステップと、
前記マイクロチャネルに前記流体を導入するステップと、
前記圧力源を用いて前記マイクロチャネルに一定の圧力を適用するステップと、
前記流体が前記ガラス毛細管中を移動する時に流体スラグの前記2又は3以上のデジタル画像を、前記デジタルカメラを用いてキャプチャするステップと、
前記2又は3以上のデジタル画像の各々について前記ガラス毛細管中の前記流体スラグのロケーションを決定するステップと、
前記ガラス毛細管中の前記流体スラグのロケーションに基づいて前記流体の流量を決定し、適用された圧力及び前記流体の流量に基づいて、前記流体の前記粘度を決定するステップと、
を備える、方法。 - マイクロ流体チャネルがソフトリソグラフィ技法を用いてマイクロ流体チップ上に製造されるか、
前記マイクロ流体チャネルが、100〜1000μmの幅(w)と、50〜100μmの高さ(h)と、1〜2cmの長さ(Lch)とを有するか、
マイクロ流体チャネルが、ガラス毛細管、マイクロチャネル、及び前記マイクロチャネルに接続されたチュービング中の全抵抗の85%超を占める流体力学的抵抗を有するか、或いは
前記ガラス毛細管が、0.375〜1mmの内半径と、5〜10cmの長さとを有する、請求項5に記載の方法。 - マイクロチャネルに接続された静水頭を備える圧力源を使用して前記マイクロチャネルに1又は2以上の異なる駆動圧を適用するステップをさらに備える、請求項5に記載の方法。
- デジタルカメラのビデオキャプチャを、流体スラグがガラス毛細管中の1cmの最小距離を移動するために要する時間に設定するステップをさらに備える、請求項5に記載の方法。
- デジタルカメラの解像度を100ピクセル/cmに設定するステップをさらに備える、請求項5に記載の方法。
- 2又は3以上のデジタル画像を、ワイヤレスエリアネットワークを使用して、画像処理ワークステーションに転送するステップをさらに備える、請求項5に記載の方法。
- 自動化アルゴリズムを使用して、微小毛細管中の流体スラグのロケーションを検出するステップをさらに備える、請求項5に記載の方法。
- 視野内に毛細管だけを有するように2又は3以上のデジタル画像をトリミングするステップと、
前記2又は3以上のデジタル画像にしきい値を適用するステップと、
流体スラグの輪郭を識別するために、前記2又は3以上のデジタル画像内のエッジを検出するステップと、
前記流体スラグの長さを決定するために、前記流体スラグの前記エッジにハフ変換を適用するステップと
をさらに備える、請求項5に記載の方法。 - 極性及び非極性溶媒の両方の粘度が測定され得る、請求項5に記載の方法。
- 複数のサンプルの粘度測定を同時に実行するために使用される、請求項5に記載の方法。
- 請求項7〜14のいずれかに記載の方法を実行するようにさらに構成される、請求項1に記載の装置。
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CN106370559B (zh) * | 2016-11-17 | 2018-05-08 | 中国石油大学(华东) | 应用微流控技术测量流体粘度的实验装置及实验方法 |
US10928289B2 (en) | 2017-05-04 | 2021-02-23 | University Of Connecticut | Assembly for measuring the viscosity of fluids using microchannels |
IT201700071008A1 (it) * | 2017-06-26 | 2018-12-26 | Consiglio Nazionale Ricerche | Viscosimetro capillare e metodo per analisi di fluidi, in particolare olii. |
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US10533984B2 (en) | 2017-12-05 | 2020-01-14 | International Business Machines Corporation | Distinguishing fluids based upon determination and analysis of digital image color space characteristics |
JP7134430B2 (ja) * | 2018-07-04 | 2022-09-12 | 学校法人産業医科大学 | 体液粘性測定装置 |
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DE3230246C2 (de) * | 1982-08-13 | 1985-06-27 | Kiesewetter, Holger, Dr., 5100 Aachen | Vorrichtung zur Bestimmung der Viskosität von Flüssigkeiten, insbesondere des Blutplasmas |
US4942189A (en) * | 1987-11-02 | 1990-07-17 | Exxon Research And Engineering Company | Interfacial viscosification of aqueous solutions utilizing interpolymer complex |
JP2946095B2 (ja) * | 1989-03-02 | 1999-09-06 | 株式会社エヌ・ティ・ティ・データ | 線分抽出装置 |
US5489480A (en) * | 1992-06-26 | 1996-02-06 | Fuji Photo Film Co., Ltd. | Magnetic recording medium and process for producing the same |
DE4320813C2 (de) * | 1992-07-06 | 1997-07-03 | Schott Geraete | Verfahren zur Bestimmung der Viskosität von Flüssigkeiten |
EP0620432B1 (en) * | 1993-04-15 | 2004-08-25 | Zeptosens AG | Method for controlling sample introduction in microcolumn separation techniques and sampling device |
US6402703B1 (en) * | 1997-08-28 | 2002-06-11 | Visco Technologies, Inc. | Dual riser/single capillary viscometer |
JP2001264229A (ja) * | 2000-03-17 | 2001-09-26 | Nikkiso Co Ltd | 流動体の流動性測定システム |
US7252928B1 (en) * | 2002-03-12 | 2007-08-07 | Caliper Life Sciences, Inc. | Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels |
US7019834B2 (en) * | 2002-06-04 | 2006-03-28 | Lockheed Martin Corporation | Tribological debris analysis system |
KR20020095145A (ko) * | 2002-11-26 | 2002-12-20 | 신세현 | 마이크로 점도계 및 측정방법 |
WO2004087283A1 (en) * | 2003-03-25 | 2004-10-14 | Massachusetts Institute Of Technology | Fluid separation |
JP2008546542A (ja) * | 2005-05-18 | 2008-12-25 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | マイクロ流体ネットワークにおける伝導通路、マイクロ回路、マイクロ構造の製造 |
WO2008109176A2 (en) * | 2007-03-07 | 2008-09-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
EP2219020A4 (en) | 2007-11-28 | 2014-02-05 | Konica Minolta Opto Inc | SYSTEM AND METHOD FOR MEASURING THE BLOOD-FLOWING CAPACITY |
SE533103C2 (sv) * | 2008-04-01 | 2010-06-29 | Tommy Forsell | Blodviskositetsanalys |
US8079250B2 (en) * | 2008-07-09 | 2011-12-20 | Lockheed Martin Corporation | Viscometer system utilizing an optical flow cell |
CN101750515B (zh) | 2008-12-03 | 2011-08-31 | 中国科学院理化技术研究所 | 一种非接触式测量液体参数的测量方法 |
KR20100109383A (ko) * | 2009-03-30 | 2010-10-08 | 삼성전자주식회사 | 바이오 분석 장치를 포함하는 인터넷 폰 장치 및 이를 이용한 원격 의료 서비스 방법 |
KR101103626B1 (ko) * | 2009-10-08 | 2012-01-09 | 광주과학기술원 | 유체 점도 측정 장치 |
JP2011200367A (ja) * | 2010-03-25 | 2011-10-13 | Fujifilm Corp | 画像撮像方法および装置 |
CN105784547B (zh) | 2010-04-26 | 2019-11-05 | 电流感应器公司 | 便携式粘度计 |
JP2012016545A (ja) * | 2010-07-09 | 2012-01-26 | Fujifilm Corp | 内視鏡装置 |
CA2859033A1 (en) * | 2011-12-15 | 2013-06-20 | Schlumberger Canada Limited | Method and apparatus for characterizing interfacial tension between two immiscible or partially miscible fluids |
US10301746B2 (en) * | 2012-10-16 | 2019-05-28 | Avintiv Specialty Materials, Inc. | Multi-zone spinneret, apparatus and method for making filaments and nonwoven fabrics therefrom |
US10209171B2 (en) | 2013-12-09 | 2019-02-19 | Texas Tech University System | Smart phone based multiplexed viscometer for high throughput analysis of fluids |
-
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