JP6538044B2 - 化学療法感受性および化学毒性を判定する方法 - Google Patents
化学療法感受性および化学毒性を判定する方法 Download PDFInfo
- Publication number
- JP6538044B2 JP6538044B2 JP2016527380A JP2016527380A JP6538044B2 JP 6538044 B2 JP6538044 B2 JP 6538044B2 JP 2016527380 A JP2016527380 A JP 2016527380A JP 2016527380 A JP2016527380 A JP 2016527380A JP 6538044 B2 JP6538044 B2 JP 6538044B2
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- JP
- Japan
- Prior art keywords
- cancer
- treatment
- cells
- patient
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361897547P | 2013-10-30 | 2013-10-30 | |
| US61/897,547 | 2013-10-30 | ||
| PCT/US2014/063121 WO2015066305A1 (en) | 2013-10-30 | 2014-10-30 | Methods for determining chemosensitivity and chemotoxicity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016538539A JP2016538539A (ja) | 2016-12-08 |
| JP2016538539A5 JP2016538539A5 (https=) | 2017-12-14 |
| JP6538044B2 true JP6538044B2 (ja) | 2019-07-03 |
Family
ID=53005110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527380A Expired - Fee Related JP6538044B2 (ja) | 2013-10-30 | 2014-10-30 | 化学療法感受性および化学毒性を判定する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10640803B2 (https=) |
| EP (1) | EP3063302B1 (https=) |
| JP (1) | JP6538044B2 (https=) |
| AU (1) | AU2014342269B2 (https=) |
| WO (1) | WO2015066305A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102062416B1 (ko) * | 2012-05-10 | 2020-01-03 | 유트로픽스 파마슈티컬스, 인크. | 실용 가능한 암 진단 대체 법 |
| US10793915B2 (en) | 2015-01-12 | 2020-10-06 | Eutropics Pharmaceuticals, Inc. | Context dependent diagnostics test for guiding cancer treatment |
| US9901574B2 (en) * | 2015-04-20 | 2018-02-27 | Tolero Pharmaceuticals, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| ES2739749T3 (es) | 2015-05-18 | 2020-02-03 | Tolero Pharmaceuticals Inc | Profármacos de alvocidib que tienen biodisponibilidad aumentada |
| MX2018001289A (es) | 2015-08-03 | 2018-04-30 | Tolero Pharmaceuticals Inc | Terapias de combinacion para el tratamiento del cancer. |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| KR20190099260A (ko) | 2016-12-19 | 2019-08-26 | 톨레로 파마수티컬스, 인크. | 프로파일링 펩티드 및 감도 프로파일링을 위한 방법 |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| US20210379042A1 (en) * | 2018-10-12 | 2021-12-09 | Sumitomo Dainippon Pharma Oncology, Inc. | Methods for monitoring tumor lysis syndrome |
| US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
| EP4100955A4 (en) * | 2020-02-06 | 2024-02-28 | Oncohost Ltd | MACHINE LEARNING PREDICTION OF THERAPEUTIC RESPONSE |
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| US5622852A (en) | 1994-10-31 | 1997-04-22 | Washington University | Bcl-x/Bcl-2 associated cell death regulator |
| GB9422836D0 (en) | 1994-11-11 | 1995-01-04 | Wainscoat James | Monitoring malignant disease |
| US5955593A (en) | 1996-09-09 | 1999-09-21 | Washington University | BH3 interacting domain death agonist |
| WO1998009643A1 (en) | 1996-09-09 | 1998-03-12 | Washington University | Modulation of apoptosis by serine phosphorylation of blc-xl/blc-2 associated cell death regulator |
| US5856445A (en) | 1996-10-18 | 1999-01-05 | Washington University | Serine substituted mutants of BCL-XL /BCL-2 associated cell death regulator |
| US5981201A (en) | 1997-01-08 | 1999-11-09 | Beth Israel Deaconess Medical Center | Methods of detection and treatment of breast cancer |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| WO1999014321A1 (en) | 1997-09-17 | 1999-03-25 | The Walter And Eliza Hall Institute Of Medical Research | Novel therapeutic molecules |
| AU9402898A (en) | 1997-09-26 | 1999-04-23 | Washington University | Cell death agonists |
| US6165732A (en) | 1997-10-14 | 2000-12-26 | Washington University | Method for identifying apoptosis modulating compounds |
| US7026456B1 (en) | 1998-01-23 | 2006-04-11 | Hoffman-La Roche, Inc. | Antibodies against human IL-12 |
| AU762756B2 (en) | 1998-05-18 | 2003-07-03 | Apoptosis Technology, Inc. | Compounds, screening methods, and uses involving anti-apoptotic genes and gene products |
| US6326354B1 (en) | 1998-08-19 | 2001-12-04 | Washington University | Modulation of apoptosis with bid |
| AU5233799A (en) | 1998-08-19 | 2000-03-14 | Washington University | Modulation of apoptosis with bid |
| WO2002005835A2 (en) | 2000-07-17 | 2002-01-24 | Washington University | Modulation of apoptosis |
| US7198895B2 (en) * | 2000-11-14 | 2007-04-03 | Mohanlal Ramon W | In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals |
| MXPA03005930A (es) | 2000-12-28 | 2003-09-10 | Thomson Licensing Sa | Presentacion en pantalla como ayuda de diagnostico. |
| US20020177692A1 (en) | 2001-04-16 | 2002-11-28 | Myriad Genetics, Incorporated | BCL-XL-interacting protein and use thereof |
| US7235702B2 (en) | 2001-01-16 | 2007-06-26 | Governors Of The University Of Alberta | Process for production of alcohols |
| US20030073661A1 (en) | 2001-09-24 | 2003-04-17 | Shigemi Matsuyama | Method of modulating or examining Ku70 levels in cells |
| AU2002364364A1 (en) | 2001-12-31 | 2003-07-24 | Dana-Farber Cancer Institute, Inc. | Method of treating apoptosis and compositions thereof |
| WO2004022580A2 (en) | 2002-09-09 | 2004-03-18 | Dana-Farber Cancer Institute, Inc. | Bh3 peptides and method of use thereof |
| RU2345137C2 (ru) | 2002-12-26 | 2009-01-27 | Закрытое акционерное общество "ЕВРОГЕН" | Флуоресцирующие белки из веслоногих ракообразных и способы их применения |
| WO2004066958A2 (en) | 2003-01-30 | 2004-08-12 | The Trustees Of Princeton University | Caspase-9:bir3 domain of xiap complexes and methods of use |
| TW200418829A (en) | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| MXPA05009722A (es) | 2003-03-10 | 2006-03-09 | Schering Corp | Inhibidores heterociclicos de cinasa: metodos de uso y sintesis. |
| US7755765B2 (en) | 2003-03-17 | 2010-07-13 | Massachusetts Institute Of Technology | Method and apparatus for inertial sensing via measurement of trapped orbit dynamics |
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| FR2855650B1 (fr) | 2003-05-30 | 2006-03-03 | Soitec Silicon On Insulator | Substrats pour systemes contraints et procede de croissance cristalline sur un tel substrat |
| CN1302004C (zh) | 2003-08-22 | 2007-02-28 | 浙江海正药业股份有限公司 | 一种阿糖胞苷的制备方法 |
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| WO2005079434A2 (en) | 2004-02-17 | 2005-09-01 | The University Of North Carolina At Chapel Hill | Modulation of epidermal growth factor heterodimer activity |
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| EP2008106A2 (en) | 2006-03-31 | 2008-12-31 | Dana-Farber Cancer Institute | Methods of determining cellular chemosensitivity |
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| WO2013138702A2 (en) | 2012-03-15 | 2013-09-19 | Bristol-Myers Squibb Company | Methods for predicting gastrointestinal immune-related adverse events (gi-irae) in patients treated with modulation of the co-stimulatory pathway |
| KR102062416B1 (ko) | 2012-05-10 | 2020-01-03 | 유트로픽스 파마슈티컬스, 인크. | 실용 가능한 암 진단 대체 법 |
| WO2016196358A1 (en) * | 2015-05-29 | 2016-12-08 | Epicentre Technologies Corporation | Methods of analyzing nucleic acids |
-
2014
- 2014-10-30 WO PCT/US2014/063121 patent/WO2015066305A1/en not_active Ceased
- 2014-10-30 JP JP2016527380A patent/JP6538044B2/ja not_active Expired - Fee Related
- 2014-10-30 EP EP14857789.3A patent/EP3063302B1/en active Active
- 2014-10-30 US US15/033,810 patent/US10640803B2/en active Active
- 2014-10-30 AU AU2014342269A patent/AU2014342269B2/en not_active Ceased
-
2020
- 2020-03-24 US US16/828,240 patent/US11519015B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015066305A1 (en) | 2015-05-07 |
| US20160273020A1 (en) | 2016-09-22 |
| US11519015B2 (en) | 2022-12-06 |
| AU2014342269B2 (en) | 2020-02-27 |
| EP3063302A4 (en) | 2017-04-05 |
| AU2014342269A1 (en) | 2016-05-05 |
| US20200283819A1 (en) | 2020-09-10 |
| JP2016538539A (ja) | 2016-12-08 |
| US10640803B2 (en) | 2020-05-05 |
| EP3063302A1 (en) | 2016-09-07 |
| EP3063302B1 (en) | 2019-12-04 |
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