JP6430933B2 - パリペリドンインプラント製剤 - Google Patents
パリペリドンインプラント製剤 Download PDFInfo
- Publication number
- JP6430933B2 JP6430933B2 JP2015514532A JP2015514532A JP6430933B2 JP 6430933 B2 JP6430933 B2 JP 6430933B2 JP 2015514532 A JP2015514532 A JP 2015514532A JP 2015514532 A JP2015514532 A JP 2015514532A JP 6430933 B2 JP6430933 B2 JP 6430933B2
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- composition
- drug
- paliperidone
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 135
- 229960001057 paliperidone Drugs 0.000 title claims description 115
- PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 title claims description 114
- 238000009472 formulation Methods 0.000 title claims description 47
- 239000007943 implant Substances 0.000 title claims description 21
- 229920000642 polymer Polymers 0.000 claims description 130
- 229940079593 drug Drugs 0.000 claims description 76
- 239000003814 drug Substances 0.000 claims description 76
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 57
- 239000002904 solvent Substances 0.000 claims description 37
- 238000011282 treatment Methods 0.000 claims description 27
- 238000007918 intramuscular administration Methods 0.000 claims description 25
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 24
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 22
- 229920001577 copolymer Polymers 0.000 claims description 20
- 239000002245 particle Substances 0.000 claims description 20
- 229920000249 biocompatible polymer Polymers 0.000 claims description 14
- 238000001727 in vivo Methods 0.000 claims description 13
- 239000000178 monomer Substances 0.000 claims description 11
- 238000009826 distribution Methods 0.000 claims description 10
- 235000014655 lactic acid Nutrition 0.000 claims description 10
- 239000004310 lactic acid Substances 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 238000011065 in-situ storage Methods 0.000 claims description 7
- 208000020016 psychiatric disease Diseases 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 201000000980 schizophrenia Diseases 0.000 claims description 5
- 208000020925 Bipolar disease Diseases 0.000 claims description 3
- 238000010952 in-situ formation Methods 0.000 claims description 3
- 230000036470 plasma concentration Effects 0.000 description 45
- 238000002347 injection Methods 0.000 description 32
- 239000007924 injection Substances 0.000 description 32
- 238000000034 method Methods 0.000 description 31
- 241000282472 Canis lupus familiaris Species 0.000 description 25
- 230000005855 radiation Effects 0.000 description 15
- 239000011159 matrix material Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 7
- VOMKSBFLAZZBOW-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC3=C(C)N=C4N(C3=O)CCCC4OC(=O)CCCCCCCCCCCCCCC)=NOC2=C1 VOMKSBFLAZZBOW-UHFFFAOYSA-N 0.000 description 6
- 238000013103 analytical ultracentrifugation Methods 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 229960000635 paliperidone palmitate Drugs 0.000 description 6
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 238000000149 argon plasma sintering Methods 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 4
- 230000001678 irradiating effect Effects 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- 210000003141 lower extremity Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000710 polymer precipitation Methods 0.000 description 4
- 229920002223 polystyrene Polymers 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003693 atypical antipsychotic agent Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 229940126534 drug product Drugs 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000007972 injectable composition Substances 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- -1 paliperidone compound Chemical class 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000004580 weight loss Effects 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000561 anti-psychotic effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 229940127236 atypical antipsychotics Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229920002988 biodegradable polymer Polymers 0.000 description 2
- 239000004621 biodegradable polymer Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 210000000852 deltoid muscle Anatomy 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000013178 mathematical model Methods 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 229960001534 risperidone Drugs 0.000 description 2
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 2
- 230000000698 schizophrenic effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 description 1
- 238000012371 Aseptic Filling Methods 0.000 description 1
- 208000036640 Asperger disease Diseases 0.000 description 1
- 201000006062 Asperger syndrome Diseases 0.000 description 1
- 206010003805 Autism Diseases 0.000 description 1
- 208000020706 Autistic disease Diseases 0.000 description 1
- 208000027534 Emotional disease Diseases 0.000 description 1
- OVGORFFCBUIFIA-UHFFFAOYSA-N Fenipentol Chemical compound CCCCC(O)C1=CC=CC=C1 OVGORFFCBUIFIA-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 208000000323 Tourette Syndrome Diseases 0.000 description 1
- 208000016620 Tourette disease Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 239000003420 antiserotonin agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000013267 controlled drug release Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100001223 noncarcinogenic Toxicity 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170366.4 | 2012-05-31 | ||
| EP12170366.4A EP2529757B1 (en) | 2011-05-31 | 2012-05-31 | Paliperidone implant formulation |
| PCT/EP2013/061319 WO2013178811A1 (en) | 2012-05-31 | 2013-05-31 | Paliperidone implant formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015518035A JP2015518035A (ja) | 2015-06-25 |
| JP6430933B2 true JP6430933B2 (ja) | 2018-11-28 |
Family
ID=47074463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514532A Active JP6430933B2 (ja) | 2012-05-31 | 2013-05-31 | パリペリドンインプラント製剤 |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP2529757B1 (ru) |
| JP (1) | JP6430933B2 (ru) |
| KR (1) | KR101892496B1 (ru) |
| CN (2) | CN109966239A (ru) |
| AU (1) | AU2013269546B2 (ru) |
| BR (1) | BR112014029208B1 (ru) |
| CA (1) | CA2874702C (ru) |
| CL (1) | CL2014003215A1 (ru) |
| CO (1) | CO7160109A2 (ru) |
| CY (1) | CY1114975T1 (ru) |
| DK (1) | DK2529757T3 (ru) |
| EA (1) | EA029921B1 (ru) |
| ES (1) | ES2456917T3 (ru) |
| HR (1) | HRP20140158T1 (ru) |
| IL (1) | IL235850A0 (ru) |
| IN (1) | IN2014DN10673A (ru) |
| MA (1) | MA37661B1 (ru) |
| MX (1) | MX365097B (ru) |
| MY (1) | MY181549A (ru) |
| NZ (1) | NZ703319A (ru) |
| PH (1) | PH12014502668A1 (ru) |
| PL (1) | PL2529757T3 (ru) |
| PT (1) | PT2529757E (ru) |
| SG (1) | SG11201407971QA (ru) |
| SI (1) | SI2529757T1 (ru) |
| SM (1) | SMT201400044B (ru) |
| UA (1) | UA115987C2 (ru) |
| WO (1) | WO2013178811A1 (ru) |
| ZA (1) | ZA201409297B (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2394663B1 (en) | 2010-05-31 | 2021-10-13 | Laboratorios Farmaceuticos Rovi, S.A. | Compositions for injectable in-situ biodegradable implants |
| US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
| US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
| US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
| DK2394664T3 (en) | 2010-05-31 | 2016-09-12 | Laboratorios Farmacéuticos Rovi S A | Antipsychotic injectable depot composition |
| US10881605B2 (en) | 2010-05-31 | 2021-01-05 | Laboratorios Farmaceuticos Rovi, S.A. | Methods for the preparation of injectable depot compositions |
| US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
| SI2529757T1 (sl) * | 2011-05-31 | 2014-05-30 | Laboratorios Farmaceuticos Rovi, S.A. | Formulacija paliperidon implantata |
| ES2878112T3 (es) * | 2011-05-31 | 2021-11-18 | Farm Rovi Lab Sa | Formulación de implante de risperidona y/o paliperidona |
| WO2016164218A1 (en) * | 2015-04-07 | 2016-10-13 | Janssen Pharmaceuticals, Inc. | Dosing regimen for missed doses for long-acting injectable paliperidone esters |
| CN106038569A (zh) * | 2016-05-26 | 2016-10-26 | 湖南赛沃药业有限公司 | 一种帕利哌酮植入剂及其制备方法 |
| EP4252849A3 (en) * | 2016-08-31 | 2023-11-01 | Mapi Pharma Ltd. | Depot systems comprising glatiramer acetate |
| JP7337080B2 (ja) * | 2017-10-27 | 2023-09-01 | 嘉奥制薬（石家庄）有限公司 | パリペリドンパルミチン酸エステル徐放性懸濁注射液の投薬レジメン |
| BR112020023982A2 (pt) | 2018-05-24 | 2021-02-23 | Celanese Eva Performance Polymers Llc | dispositivo implantável para liberação prolongada de um composto de fármaco macromolecular |
| WO2019226516A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| RS65178B1 (sr) | 2020-11-30 | 2024-03-29 | Janssen Pharmaceutica Nv | Režimi doziranja povezani sa injekcionim formulacijama paliperidona sa produženim oslobađanjem |
| KR20230116836A (ko) | 2020-11-30 | 2023-08-04 | 얀센 파마슈티카 엔.브이. | 서방형 팔리페리돈 주사용 제형과 관련된 투약 요법 |
| WO2022111858A1 (en) | 2020-11-30 | 2022-06-02 | Janssen Pharmaceutica Nv | Dosing regimens associated with extended release paliperidone injectable formulations |
| TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2915574C (en) * | 2003-07-18 | 2017-02-07 | Oakwood Laboratories, L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
| CN101035519A (zh) | 2004-08-04 | 2007-09-12 | 阿尔扎公司 | 以上升的零级释放模式释药的药物缓释组合物及其制备方法 |
| US8852638B2 (en) * | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| EP2154138B1 (en) | 2007-04-19 | 2015-08-19 | Youxin Li | Novel compounds for treatment of psychotic disorders, preparation methods and uses thereof |
| MX354603B (es) * | 2007-05-25 | 2018-03-13 | Indivior Uk Ltd | Formulaciones de transferencia sostenida de compuestos de risperidona. |
| EP2178872A1 (en) | 2007-07-27 | 2010-04-28 | Synthon B.V. | Paliperidone derivatives |
| SI2234617T1 (sl) | 2007-12-19 | 2021-07-30 | Janssen Pharmaceutica Nv | Režim odmerjanja v zvezi z dolgodelujočimi paliperidonijevimi estri za injiciranje |
| US8758780B2 (en) | 2009-10-06 | 2014-06-24 | Ascendis Pharma As | Subcutaneous paliperidone composition |
| EP2394663B1 (en) * | 2010-05-31 | 2021-10-13 | Laboratorios Farmaceuticos Rovi, S.A. | Compositions for injectable in-situ biodegradable implants |
| DK2394664T3 (en) * | 2010-05-31 | 2016-09-12 | Laboratorios Farmacéuticos Rovi S A | Antipsychotic injectable depot composition |
| SI2529757T1 (sl) * | 2011-05-31 | 2014-05-30 | Laboratorios Farmaceuticos Rovi, S.A. | Formulacija paliperidon implantata |
| ES2878112T3 (es) * | 2011-05-31 | 2021-11-18 | Farm Rovi Lab Sa | Formulación de implante de risperidona y/o paliperidona |
-
2012
- 2012-05-31 SI SI201230022T patent/SI2529757T1/sl unknown
- 2012-05-31 EP EP12170366.4A patent/EP2529757B1/en active Active
- 2012-05-31 PT PT121703664T patent/PT2529757E/pt unknown
- 2012-05-31 PL PL12170366T patent/PL2529757T3/pl unknown
- 2012-05-31 ES ES12170366.4T patent/ES2456917T3/es active Active
- 2012-05-31 DK DK12170366.4T patent/DK2529757T3/en active
-
2013
- 2013-05-31 JP JP2015514532A patent/JP6430933B2/ja active Active
- 2013-05-31 WO PCT/EP2013/061319 patent/WO2013178811A1/en active Application Filing
- 2013-05-31 UA UAA201414185A patent/UA115987C2/uk unknown
- 2013-05-31 NZ NZ703319A patent/NZ703319A/en unknown
- 2013-05-31 KR KR1020147036778A patent/KR101892496B1/ko active IP Right Grant
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