JP6321118B1 - A solution for electronic cigarettes containing green tea extract - Google Patents

Abstract

The present invention provides a liquid for electronic cigarettes that improves safety by preventing the formation of carcinogenic substances such as formaldehyde. The present invention relates to a liquid for electronic cigarettes mainly comprising plant-derived glycerin and containing at least a fragrance and purified water, wherein the liquid contains a required amount of green tea extract. An electronic cigarette that is excellent for being able to suppress the formation of carbonyl compounds such as formaldehyde, acetaldehyde, and acrolein, which are liquids for use in the preparation of green tea extract and are of concern for carcinogenicity and irritation. Liquid can be provided. [Selection figure] None

Description

  The present invention relates to a solution for electronic cigarettes containing a green tea extract that can be discharged into a cigarette smoke by being put into a dedicated tool and evaporated by suction.

  In general, a plurality of inventions have been disclosed and publicly known as solutions of this type of electronic cigarette, that is, an electronic cigarette liquid. First, as a first known technique, a chemical solution used in an atomization apparatus that can atomize a chemical solution and release it into the air, the blending ratio of glycerin and water is 25: 1 to 0.5-1. It is a chemical used for an atomizer characterized by being blended, and at least one component of a hot spring-containing component, a Chinese herbal medicine component, a vitamin component, a mineral component, and an amino acid component is mixed with the chemical solution having the above-mentioned blending ratio. It is a chemical | medical solution used for the atomization apparatus formed (patent document 1).

  And in the 1st well-known technique, it is suitable for atomization by making the mixture ratio of glycerin and water in the above-mentioned range, and does not contain a component harmful to the human body. In addition to being difficult to convert, the amount of glycerin increases, the price as a chemical solution increases, and the health promoting action can be obtained by adding nutrients and health benefit agents.

  As a second known technique, a tobacco leaf of 5-20% electronic cigarette smoke amount w / v is measured, put into an extraction can, the prepared solvent is put into the extraction can, and the tobacco leaf After soaking for 30-100 minutes, warming to 40-60 ° C., performing heat retention / immersion extraction for 2-8 hours, filtering the extract, and adding 1-10% w / v e-cigarette to the filtrate. Add smoke liquid cocoa bean extract and mix / stir for 20-40 minutes, then supplement with 100% production cigarette smoke volume of propanediol or polyglycol, mix and stir uniformly This is a kind of electronic cigarette smoke production method characterized in that a product is obtained (Patent Document 2).

In the second known technique, the scent of tobacco leaves is first extracted by extracting tobacco leaves directly under relatively mild conditions using a propanediol or polyglycol solvent containing polysorbate 80 as an extract. By allowing the ingredients to go directly into the extract and then extracting tobacco leaves directly under mild conditions, some volatile or temperature sensitive components under complex processes and high temperature concentration conditions Features such as avoiding the loss and destruction of tobacco leaves, as well as higher viscosity of solvents such as propanediol or polyglycol, and a certain heat retention compared to other commonly used fragrance solvents Has a better holding action on the scented components.
A large number of customers know that after using the product of this invention, it is close to the taste of tobacco, reflecting this, they are more fond of this product, and this product is stored for two to three years However, the scent is still well held.

The third known technique is an abstract of a Chinese patent publication, which relates to an electronic cigarette liquid produced using a tea leaf extract of black tea, and includes the following parts by mass:
1-25 parts tea leaf extract, 2-25 parts tobacco extract, 0.5-15 parts tobacco fragrance essence, 50-80 parts propylene glycol, 5-30 parts glycerin, 2-5 parts edible alcohol (patent Reference 3).
This third prior art invention ameliorates to some extent the shortage of the aroma and taste of electronic cigarette liquids by mixing tea leaf extracts of specific black tea and specific tobacco extracts: Because it contains seed active ingredients, it has a certain degree of health maintenance.

JP2012-5412A JP 2013-13394 A Abstract of Chinese Patent Publication No. 10544543

  About the said 1st and 3rd well-known technique, since glycerin is used, formaldehyde of a carcinogenic substance is inevitably generated, and there exists a problem in safety. The third electronic cigarette liquid is intended to improve the aroma and taste by mixing tea leaf extract and tobacco extract of black tea, but tea leaf extract of black tea is a tea leaf extract of green tea, There is a clear difference in the components depending on whether it is fermented or heat-dried, and since there is no disclosure or suggestion of suppressing the generation of formaldehyde, there is still a problem in safety.

  The second known technique is an electronic cigarette liquid obtained by adding a cocoa bean extract to a tobacco leaf extract obtained by extracting tobacco leaves with a propanediol or polyglycol solvent containing polysorbate 80. Since it is an extract, it is said to be close to the taste of tobacco, but it also has a problem that it does not escape from the harmful effects of tobacco leaves.

  In any case, carbonyl compounds such as formaldehyde, acetaldehyde, and acrolein that are classified as carcinogenic are detected from smoke smoked by filling an electronic cigarette liquid into an electronic cigarette device and heating it in May 2015. It was announced by the Ministry of Health and Welfare Research Group, and it was reported that carbonyl compounds such as formaldehyde at higher concentrations than the mainstream smoke of general cigarettes were observed in the commercially available liquids for electronic cigarettes on the market. Has been.

  Accordingly, the conventional electronic cigarette liquid has a problem of improving safety by preventing generation of carcinogenic substances such as formaldehyde.

As a specific means for solving the above-mentioned problems, the present invention provides a liquid for electronic cigarettes mainly comprising plant-derived glycerin and containing at least a fragrance and purified water, and 0.1 to 4 w / w% of green tea is extracted from the liquid. As the green tea extract, the powder derived from camellia tea leaves is dissolved in purified water at a concentration of 50 w / w%, and the solution is added and mixed to 0.3 w / w% with respect to the fragrance. The present invention provides a liquid for electronic cigarettes.

In the invention, as the green tea extract, a camellia tea leaf-derived powder is dissolved in purified water at a concentration of 50% w / w, and the solution is added and mixed so as to be 0.3% w / w with respect to the fragrance. And the green tea extract is a powder derived from camellia tea leaves and the green tea extract is a green tea polyphenol as additional requirements.

The liquid for electronic cigarettes blended with the tea leaf extract according to the present invention has an excellent effect of suppressing the formation of carbonyl compounds such as formaldehyde, acetaldehyde and acrolein, which are concerned about carcinogenicity and irritation.
In particular, the effect of the green tea extract is less than 0.1 w / w%, and if it exceeds 5 w / w%, the liquid taste is affected, and the cost and physical properties are also affected. There is an excellent effect that inconvenience can be eliminated .

It is the perspective view which isolate | separated and shown the suction side and the battery side of the well-known suction apparatus (The pipe | tube made from Liberty Flyz) for sucking the liquid for electronic cigarettes.

  The present invention is obtained by blending a required amount of green tea extract in a solution for electronic cigarettes, and examples of Japanese green tea used in the present invention include, for example, kettle roasted tea, gyokuro, sencha, new tea, kabusecha , Powdered tea, stem tea, rough tea, bancha, etc., as long as it is a tea leaf containing green tea polyphenols that are drunk in Japan, it is meant to contain all regardless of the type, hereinafter collectively referred to as green tea In general, the type is not limited.

  In the present invention, basically, a solution for a known electronic cigarette mainly composed of plant-derived glycerin is used. For example, a liquid for an electronic cigarette manufactured by Liberty Flights (UK) is used. Including a required amount of green tea extract (also referred to as green tea extract) with respect to the basic composition (base) is included as one of them.

必要に応じてベース配合剤として食品用の油剤、乳化剤等を使用できる。 The basic composition (base) of this type of known electronic cigarette liquid is shown in Table 1 below.
Table 1

If necessary, food grade oils, emulsifiers and the like can be used as a base compounding agent.

  About the required amount of green tea extract, for example, 0.01 to 5 w / w% is within the range where it can be blended, preferably 0.05 to 1.0 w / w%. From the viewpoint of effectiveness, it is in the range of about 0.1 to 4 w / w%. If it is less than 0.01 w / w%, its effectiveness is low, and if it exceeds 5 w / w%, it begins to affect the taste of the liquid, and also starts to affect the cost and the physical properties of the liquid. However, depending on the user, the green tea extract may be remarkably preferred, so the blending range cannot be generally limited.

  Green tea polyphenols extracted from the leaves of camellia by the green tea extract are (+)-catechin, (−)-catechin gallate, (−)-shrimp catechin, (−)-shrimp catechin gallate, (−)-shrimp Examples include gallocatechin and (−)-shrimp catechin gallate.

  The blending amount of green tea polyphenol is preferably in the range of 0.001 to 2.0 w / w%, more preferably in the range of 0.01 to 1.0.

Moreover, the component used for the basic composition (base) of the liquid for electronic cigarettes can be used in the following ranges.
Various flavors (fragrances) for electronic cigarettes include food flavors, food flavors, food grade tobacco-like flavors, and the like, but are not limited thereto.
In addition, the compounding quantity of various flavors has the preferable range of 0.01-5.0 w / w%.

  Propylene glycol is used in medical grades and food grades, and the blending amount thereof is, for example, in the range of 0 to 95 w / w%, preferably in the range of 5 to 90 w / w%. The range of 50-80 w / w% is more preferable.

  Plant-derived glycerin is used for medical and food use clades, and the amount of the glycerin is, for example, in the range of 1 to 95 w / w%, preferably in the range of 5 to 90 w / w%, In particular, the range of 5.0-50 w / w% is more preferable.

  Purified water is purified using a clay, a reverse osmosis membrane, an ion exchange membrane, etc., and as a compounding quantity, it is the range of 0-10 w / w%, for example.

  As a base compounding agent, oil agents such as polyethylene glycol and propanol, food emulsifiers and the like can be appropriately blended, and alcohol can be blended if necessary. The alcohol used in this case is a grade for medical use or food addition, and the blending amount thereof is, for example, in the range of 0.1 to 10 w / w%, preferably 0.5 to 7 w / w%. In particular, the range of 2 to 5 w / w% is more preferable.

Furthermore, you may mix | blend food preservatives, saccharides, a flavoring agent, a sweetener, etc. as needed. Examples of food preservatives include sucrose fatty acid esters, polyglycerin fatty acid esters, diglycerin fatty acid monoesters, sorbitan fatty acid esters, methyl sodium paraoxybenzoate, propyl sodium paraoxybenzoate, and butyl paraoxybenzoate.
Examples of the saccharide include food additive or pharmaceutical grade mannitol. Examples of the flavoring agent include food, food additive or pharmaceutical grade paper mint, spearmint, ethyl maltol, and maltol. Examples of the sweetener include sucrose. , Stevia, aspartame, rahan fruit, sucralose, sorbitol and the like.

香料は、例えば、チェリーメンソール、ベリーナイス、ストロベリーなどである。
[Example]
A plurality of specific examples and comparative examples according to the present invention will be described. However, the present invention is not limited to these.
First, the basic composition of the known electronic cigarette liquid used is as shown in Table 2 below.
Table 2

A fragrance | flavor is a cherry menthol, a berry nice, a strawberry, etc., for example.

[Summary of effectiveness test]
Vapor smoke generated from the specimen is sucked through a cartridge (hereinafter simply referred to as cartridge) using 2,4-dinitrophenylhydrazine (DNPH), and the cartridge is washed with acetonitrile. Acetaldehyde was quantified to determine the formaldehyde concentration and acetaldehyde concentration in the steam.

[Test method]
1) Generation and suction of vapor (pretreatment)
The mouthpiece 1 in the known electronic cigarette device shown in FIG. 1 was removed, and 0.80 g (up to a 0.8 ml scale) liquid specimen was filled in the atomizer 2, and the mouthpiece 1 was tightened as it was. Reference numeral 3 is a switch, and 4 is a battery. The cartridge and syringe were connected in this order to the suction port of the electronic cigarette, and vapor smoke was sucked at a speed of 55 ml for 2 seconds. The syringe was removed from the cartridge, the vapor in the syringe was expelled, the same cartridge was connected and suctioned again, and suction was repeated 10 times at 28-second intervals. The cartridge was eluted with 4 ml of acetonitrile containing 1% phosphoric acid, allowed to stand for 10 minutes, 1 ml of ethanol was added, and acetonitrile containing 1% phosphoric acid was added to make 5 ml, which was used as a test solution. A series of operations was repeated three times, and test solutions were prepared three times.
2) Determination by high performance liquid chromatography The standard solution and the test solution were measured with a high performance liquid chromatograph analyzer under the following conditions, and the concentration in the vapor generated from the specimen was calculated.

<High-performance liquid chromatograph operating conditions>
Model: Alliance 2695 [Waters Corporation]
Detector: 2487 [Waters Corporation]
Column: TSK-GEL ODS-80Ts 4.6 mm × 150 mm [Tosoh Corporation]
Column temperature: 40 ° C
Mobile phase: Liquid A: Mixture of water and acetonitrile (6: 4)
Liquid B: 5 mmol / 1 mixed solution of ammonium acetate containing acetonitrile and water
(75:25)
Gradient: Liquid A 0 → 4min
Mixed liquid of A liquid and B liquid (6: 4) 4 → 22min
Flow rate: 0.7 ml / min
Measurement wavelength: 360 nm
Injection volume: 10 μl

表中の＊１は、定量下限０．１ｍｇ／ｍ³；＊２は、定量下限０．５ｍｇ／ｍ³
Example 1
For cherry menthol liquid, which is a fragrance having the basic composition shown in Table 2, camellia family tea leaf derived powder (Mitsubishi Chemical Foods Co., Ltd., Sunfood 100 (abbreviated as S-100), water-soluble powder, food additive) The effectiveness of the suppression of formaldehyde and acetaldehyde formation was investigated.
A sample of the camellia tea leaves is dissolved in purified water at a concentration of 50%, and the resulting solution is added to and mixed with cherry menthol liquid to a final concentration of 0.3% to prepare an electronic cigarette liquid. It was.
In Comparative Example 1, the cherry menthol liquid shown in Table 2 to which no camellia-derived tea leaf-derived powder was added was used as it was as a specimen.
The results of testing both samples by the test method are shown in Table 3 below.

Table 3

* 1 in the table is the lower limit of quantification 0.1 mg / m ³ ; * 2 is the lower limit of quantification 0.5 mg / m ³

なお、比較例２は、ツバキ科チャ葉由来粉末を添加しない表４に示したチェリーメンソールリキッドをそのままを検体として使用した。
そして、両検体を前記試験方法によって試験した結果を下記表５に示す。

表 ５

表中の＊１は、定量下限０．１ｍｇ／ｍ³；＊２は、定量下限０．５ｍｇ／ｍ³
Example 2
For the electronic cigarette liquid of the basic composition mainly composed of plant-derived glycerin shown in Table 4 below, formaldehyde-derived tea leaf-derived powder (Mitsubishi Chemical Foods Co., Ltd., Sunfood 100, water-soluble powder, food additive) And the effectiveness of acetaldehyde production suppression was investigated.
The camellia tea leaf-derived powder is dissolved in purified water at a concentration of 50%, and the resulting solution is added to and mixed with cherry menthol liquid so that the final concentrations are 0.1%, 0.2%, and 0.3%, respectively. The electronic cigarette liquid was prepared, and the respective sample numbers and identification numbers were assigned as Sample 1 (Ext. 100-01), Sample 2 (Ext. 100-02), and Sample 3 (Ext. 100-03).

Table 4

In Comparative Example 2, the cherry menthol liquid shown in Table 4 to which no camellia tea leaf-derived powder was added was used as a sample.
The results of testing both samples by the test method are shown in Table 5 below.

Table 5

* 1 in the table is the lower limit of quantification 0.1 mg / m ³ ; * 2 is the lower limit of quantification 0.5 mg / m ³

  As described above, as shown in Table 3 and Table 5, a known amount of green tea extract, that is, green tea extract, is added to and mixed with a known liquid for electronic cigarettes to mix formaldehyde, which is a carcinogenic substance. Generation | occurrence | production can be suppressed and the scent of green tea can be added.

  The liquid for electronic cigarettes according to the present invention is a liquid for electronic cigarettes mainly containing plant-derived glycerin and containing at least a fragrance and purified water, and is characterized in that the liquid contains a required amount of green tea extract. It is a liquid for electronic cigarettes, and it can suppress the formation of carbonyl compounds such as formaldehyde, acetaldehyde and acrolein that are concerned about carcinogenicity and irritation by adding green tea extract. The green tea extract can be widely applied to many liquids for electronic cigarettes that are commercially available.

Claims (2)

A liquid for electronic cigarettes mainly composed of plant-derived glycerin and containing at least a fragrance and purified water,
While blending 0.1-4 w / w% of green tea extract to the liquid,
As the green tea extract, a camellia tea leaf-derived powder is dissolved in purified water at a concentration of 50 w / w%, and the solution is added and mixed so as to be 0.3 w / w% with respect to the fragrance. Liquid for electronic cigarettes.   The liquid for electronic cigarettes according to claim 1, wherein the green tea extract is a green tea polyphenol.

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