JP6314139B2 - 薬物送達デバイス - Google Patents
薬物送達デバイス Download PDFInfo
- Publication number
- JP6314139B2 JP6314139B2 JP2015529016A JP2015529016A JP6314139B2 JP 6314139 B2 JP6314139 B2 JP 6314139B2 JP 2015529016 A JP2015529016 A JP 2015529016A JP 2015529016 A JP2015529016 A JP 2015529016A JP 6314139 B2 JP6314139 B2 JP 6314139B2
- Authority
- JP
- Japan
- Prior art keywords
- driver
- button
- drug delivery
- dose
- housing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012377 drug delivery Methods 0.000 title claims description 64
- 239000003814 drug Substances 0.000 claims description 33
- 229940079593 drug Drugs 0.000 claims description 28
- 239000007788 liquid Substances 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 description 83
- 108010011459 Exenatide Proteins 0.000 description 49
- 229960001519 exenatide Drugs 0.000 description 49
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 22
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 21
- 230000007246 mechanism Effects 0.000 description 18
- 239000011295 pitch Substances 0.000 description 11
- 210000003811 finger Anatomy 0.000 description 10
- 239000012634 fragment Substances 0.000 description 10
- 235000001014 amino acid Nutrition 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 9
- 239000000427 antigen Substances 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 230000000994 depressogenic effect Effects 0.000 description 6
- 238000006073 displacement reaction Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
- 208000002249 Diabetes Complications Diseases 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- -1 carboxymethyl hepta decanoyl Chemical group 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 239000003055 low molecular weight heparin Substances 0.000 description 3
- 229940127215 low-molecular weight heparin Drugs 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 2
- 108010088406 Glucagon-Like Peptides Proteins 0.000 description 2
- 102000006771 Gonadotropins Human genes 0.000 description 2
- 108010086677 Gonadotropins Proteins 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 102000002265 Human Growth Hormone Human genes 0.000 description 2
- 108010000521 Human Growth Hormone Proteins 0.000 description 2
- 239000000854 Human Growth Hormone Substances 0.000 description 2
- 208000001435 Thromboembolism Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 108010015174 exendin 3 Proteins 0.000 description 2
- LMHMJYMCGJNXRS-IOPUOMRJSA-N exendin-3 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@H](C)O)[C@H](C)O)C(C)C)C1=CC=CC=C1 LMHMJYMCGJNXRS-IOPUOMRJSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000002622 gonadotropin Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 229960004532 somatropin Drugs 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010037003 Buserelin Proteins 0.000 description 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 description 1
- 108010041986 DNA Vaccines Proteins 0.000 description 1
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102400000932 Gonadoliberin-1 Human genes 0.000 description 1
- 108010069236 Goserelin Proteins 0.000 description 1
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 1
- 101500026183 Homo sapiens Gonadoliberin-1 Proteins 0.000 description 1
- 108010024118 Hypothalamic Hormones Proteins 0.000 description 1
- 102000015611 Hypothalamic Hormones Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108010000817 Leuprolide Proteins 0.000 description 1
- XVVOERDUTLJJHN-UHFFFAOYSA-N Lixisenatide Chemical compound C=1NC2=CC=CC=C2C=1CC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NCC(=O)NCC(=O)N1C(CCC1)C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)N1C(CCC1)C(=O)N1C(CCC1)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC=1C=CC=CC=1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(N)CC=1NC=NC=1)C(C)O)C(C)O)C(C)C)CC1=CC=CC=C1 XVVOERDUTLJJHN-UHFFFAOYSA-N 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 108010021717 Nafarelin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 108010047386 Pituitary Hormones Proteins 0.000 description 1
- 102000006877 Pituitary Hormones Human genes 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical group OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000010378 Pulmonary Embolism Diseases 0.000 description 1
- 108010050144 Triptorelin Pamoate Proteins 0.000 description 1
- 206010057362 Underdose Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229960002719 buserelin Drugs 0.000 description 1
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 229960004281 desmopressin Drugs 0.000 description 1
- NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960000610 enoxaparin Drugs 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229960001442 gonadorelin Drugs 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 229960002913 goserelin Drugs 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 239000000960 hypophysis hormone Substances 0.000 description 1
- 229940043650 hypothalamic hormone Drugs 0.000 description 1
- 239000000601 hypothalamic hormone Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000004026 insulin derivative Substances 0.000 description 1
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 1
- 229960004338 leuprorelin Drugs 0.000 description 1
- XVVOERDUTLJJHN-IAEQDCLQSA-N lixisenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 XVVOERDUTLJJHN-IAEQDCLQSA-N 0.000 description 1
- 108010004367 lixisenatide Proteins 0.000 description 1
- 229960001093 lixisenatide Drugs 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31515—Connection of piston with piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
- A61M2205/585—Means for facilitating use, e.g. by people with impaired vision by visual feedback having magnification means, e.g. magnifying glasses
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
Claims (15)
- 薬剤の多数のユーザ可変用量を選択し投薬するための、再使用可能な薬物送達デバイスであって、ハウジング(10、20)と、薬剤を収容したカートリッジ(81)を保持するためのカートリッジホルダ(80)と、カートリッジホルダ(80)に対して変位可能なピストンロッド(30)と、ピストンロッド(30)に連結されたドライバ(40)と、設定用量を示すための、ハウジング(10、20)およびドライバ(40)に連結された表示部材(60)と、ドライバ(40)をハウジング(10、20)または表示部材(60)に回転方向で連結するためのクラッチ(90)と、クラッチ(90)およびドライバ(40)に回転方向で連結されたボタン(70)とを含み:
次に示す少なくとも2つの機能、すなわち、
ドライバ(40)がピストンロッド(30)とねじ込み係合されており、ボタン(70)に恒久的に回転方向で係止され、ボタン(70)に対して軸線方向で変位可能であり、用量設定中および用量投薬中は回転方向で連結されるとともにデバイスの再設定中は回転方向でデカップリングされる少なくとも2つの別個の構成要素(41、42)を含むという機能、
表示部材(60)が、内側に突出するねじ山(64)を含む遠位端と、内側に突出するフランジ(66)を含む近位端とを有し、表示部材(60)が、ねじ山(64)を含む第1の構成要素(61)とフランジ(66)を含む他方の構成要素(62)との2つの別個の構成要素(61、62)を含むという機能、
ボタン(70)が、ボタン(70)をドライバ(40)に回転方向で連結するため、ドライバ(40)の対応するスロットを係合するとともに、ボタン(70)をクラッチ(90)に軸線方向で連結するため、クラッチ(90)の対応するスナップ機能(93)を係合するスナップ機能を含むフィンガ(73)を含むという機能、
ドライバ(40)が、ボタン(70)をドライバ(40)に回転方向で連結するため、ボタン(70)の対応するスロットを係合するとともに、ドライバ(40)を表示部材(60)に軸線方向で連結するため、表示部材(60)の対応する接触機能(66)を係合するフック機能(49)を含むフィンガ(48)を含むという機能、
ボタン(70)が、少なくとも用量投薬中は表示部材(60)の対応するクリッカ機能(68)を係合する、リング状のクリッカ歯(71)を含むという機能
を含む、前記薬物送達デバイス。 - ピストンロッド(30)は、デバイスの用量投薬中および再設定中はピストンロッド(30)が回転するように、ハウジング(10、20)とねじ込み係合されている、請求項1に記載の薬物送達デバイス。
- ピストンロッド(30)は、ハウジング(20)の雌ねじを係合する第1の外ねじ(32)と、ドライバ(40)の雌ねじを係合する第2の外ねじ(33)とを有する二条ねじのピストンロッドであり、第1および第2の外ねじ(32、33)は少なくとも部分的に互いに重なり合う、請求項1または2に記載の薬物送達デバイス。
- 第1および第2の外ねじ(32、33)は同じピッチを有する、請求項3に記載の薬物送達デバイス。
- ピストンロッド(30)は、少なくとも1つの事前定義された破断点によってピストンロッド(30)に取り付けられた軸受(31)を含み、軸受は、少なくとも1つの事前定義された破断点を破壊することによって、軸受(31)を取り外した後、軸線方向で拘束され、ただしピストンロッド(30)に対して回転可能である、請求項1〜4のいずれか1項に記載の薬物送達デバイス。
- ドライバ(40)は、ハウジング(10、20)とドライバ(40)との間に挟まれたナット(50)を係合する遠位部分(41)と、ボタン(70)の管状部分を少なくとも部分的に取り囲む近位部分(42)とを有する管状要素である、請求項1〜5のいずれか1項に記載の薬物送達デバイス。
- ドライバ(40)は、ナット(50)とねじ込み係合されている第1の構成要素(41)と、第2の構成要素(42)とを含み、第1および第2の構成要素はともに動作可能に連結され、それによって、ユーザがボタン(70)を回転させることによって用量を設定すると、ドライバの第1の構成要素(41)および第2の構成要素(42)の両方がともに回転し、またそれによって、ユーザがデバイスを再設定すると、ドライバ(40)の第1の構成要素(41)はドライバ(40)の第2の構成要素(42)からデカップリングされ、第1の構成要素(41)はハウジング(10、20)に対して、また第2の構成要素(42)に対して回転することが可能になる、請求項1〜6のいずれか1項に記載の薬物送達デバイス。
- ドライバ(40)はナット(50)とねじ込み係合されており、ねじ込み係合は、ドライバ(40)の第1の部分に沿って設けられた第1のピッチと、ドライバ(40)の第2の部分に沿って設けられた、第1のピッチよりも大きい第2のピッチと、場合により、ドライバ(40)の第3の部分に沿って設けられた、第2のピッチよりも小さい第3のピッチとを有する螺旋状の溝(44)を含む、請求項1〜7のいずれか1項に記載の薬物送達デバイス。
- ナット(50)は、薬物送達デバイスのカートリッジ(81)内に残っている液体の量を超える用量の設定を防ぐ用量リミッタの一部である、請求項7または8に記載の薬物送達デバイス。
- ハウジング(10、20)に対して回転方向で拘束された第1の歯付き要素(102)と、ドライバ(40)に対して回転方向で拘束された第2の歯付き要素(101)と、第1の歯付き要素(102)および第2の歯付き要素(101)を付勢して係合させるばね(103)とを有するクリッカ(100)をさらに含む、請求項1〜9のいずれか1項に記載の薬物送達デバイス。
- ハウジング(10、20)は、内側本体(20)と、外側本体(10)と、内側本体(20)の第1の保持手段(24)および外側本体(10)の第2の保持手段によってハウジング(10、20)に取り付けられた窓(130)とを含む、請求項1〜10のいずれか1項に記載の薬物送達デバイス。
- ハウジング(10、20)は内側本体(20)および外側本体(10)を含み、内側本体(20)は、螺旋状に捻れた少なくとも1つの内歯スプラインを含む、請求項1〜11のいずれか1項に記載の薬物送達デバイス。
- ハウジング(10、20)は内側本体(20)および外側本体(10)を含み、第1の回転止め具(25)は内側本体(20)と表示部材(60)との間に設けられ、第2の回転止め具(12)は外側本体(10)と表示部材(60)との間に設けられて、ハウジング(10、20)に対する表示部材(60)の回転方向の動きを、第1の回転止め具(25)によって定義される最小用量と第2の回転止め具(12)によって定義される最大用量との間で制限する、請求項1〜12のいずれか1項に記載の薬物送達デバイス。
- 用量設定中、ボタン(70)、ドライバ(40)、および表示部材(60)が、ハウジング(10、20)およびピストンロッド(30)に対して螺旋状経路上を動くように、ボタン(70)を回転させ、それにドライバ(40)および表示部材(60)を同調させ、用量投薬中、ボタン(70)、ドライバ(40)、および表示部材(60)が、ハウジング(10、20)およびピストンロッド(30)に対して軸線方向で動き、表示部材(60)およびピストンロッド(30)が、ハウジング(10、20)、ボタン(70)、およびドライバ(40)に対して回転するように、ボタン(70)を軸線方向で変位させ、それによってドライバ(40)および表示部材(60)を同調させる、請求項1〜13のいずれか1項に記載の薬物送達デバイス。
- 薬剤を収容したカートリッジ(81)をさらに含む、請求項1〜14のいずれか1項に記載の薬物送達デバイス。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12182564.0 | 2012-08-31 | ||
EP12182564 | 2012-08-31 | ||
US201261696496P | 2012-09-04 | 2012-09-04 | |
US61/696,496 | 2012-09-04 | ||
PCT/EP2013/067860 WO2014033195A1 (en) | 2012-08-31 | 2013-08-29 | Drug delivery device |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015526217A JP2015526217A (ja) | 2015-09-10 |
JP6314139B2 true JP6314139B2 (ja) | 2018-04-18 |
Family
ID=46785289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015529016A Active JP6314139B2 (ja) | 2012-08-31 | 2013-08-29 | 薬物送達デバイス |
Country Status (22)
Country | Link |
---|---|
US (2) | US9345841B2 (ja) |
EP (2) | EP2890435B1 (ja) |
JP (1) | JP6314139B2 (ja) |
KR (1) | KR102166890B1 (ja) |
CN (1) | CN104661696B (ja) |
AR (1) | AR092276A1 (ja) |
AU (1) | AU2013310947B2 (ja) |
BR (1) | BR112015004132B1 (ja) |
CL (1) | CL2015000455A1 (ja) |
DK (1) | DK3639872T3 (ja) |
ES (1) | ES2941078T3 (ja) |
HK (1) | HK1208387A1 (ja) |
HU (1) | HUE061532T2 (ja) |
IL (1) | IL236746B (ja) |
MX (1) | MX365296B (ja) |
MY (1) | MY179718A (ja) |
PL (2) | PL2890435T3 (ja) |
RU (1) | RU2648866C2 (ja) |
SG (1) | SG11201500322TA (ja) |
TW (1) | TWI595903B (ja) |
WO (1) | WO2014033195A1 (ja) |
ZA (1) | ZA201500299B (ja) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
AU2013310947B2 (en) * | 2012-08-31 | 2017-04-13 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
WO2014037946A1 (en) * | 2012-09-05 | 2014-03-13 | Elcam Medical Agricultural Cooperative Association Ltd. | Electronic auto-injection device |
EP2895218B1 (en) * | 2012-09-11 | 2017-12-27 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and drug delivery device |
GB2511806A (en) | 2013-03-14 | 2014-09-17 | Norton Healthcare Ltd | Dispensing mechanism for a medical device |
MX2015012900A (es) * | 2013-03-14 | 2016-04-04 | Norton Healthcare Ltd | Mecanismo de dispensacion para un dispositivo medico. |
JP6109352B2 (ja) | 2013-03-14 | 2017-04-05 | ノートン・ヘルスケア・リミテッド | 医療器具のための投薬機構 |
CN105102029B (zh) * | 2013-04-10 | 2019-07-26 | 赛诺菲 | 注射装置 |
CN105102036B (zh) * | 2013-04-10 | 2019-02-15 | 赛诺菲 | 注射装置 |
RU2015146766A (ru) * | 2013-04-10 | 2017-05-16 | Санофи | Инъекционное устройство |
CN105209095A (zh) * | 2013-05-21 | 2015-12-30 | 诺和诺德股份有限公司 | 具有活塞杆联轴器的药物输送装置 |
CN105307712A (zh) | 2013-05-21 | 2016-02-03 | 诺和诺德股份有限公司 | 具有动态轴向止动特征的前载型药物输送装置 |
USD790686S1 (en) | 2014-05-08 | 2017-06-27 | Glaxosmithkline Intellectual Property Management Limited | Housing for an autoinjector |
TW201603851A (zh) * | 2014-07-01 | 2016-02-01 | 賽諾菲公司 | 藥物輸送裝置 |
TW201603852A (zh) * | 2014-07-01 | 2016-02-01 | 賽諾菲公司 | 彈簧裝置及具有該彈簧裝置之藥物傳輸裝置 |
USD752210S1 (en) * | 2014-08-27 | 2016-03-22 | Merck Sharp & Dohme Corp. | Medical injector pen |
USD777907S1 (en) * | 2014-08-27 | 2017-01-31 | Merck Sharp & Dohme Corp. | Medical injector pen |
USD773646S1 (en) * | 2014-08-27 | 2016-12-06 | Merck Sharp & Dohme Corp | Medical injector pen |
US11000648B2 (en) | 2014-10-09 | 2021-05-11 | Sanofi | Resettable drug delivery device |
EP3204085B1 (en) | 2014-10-09 | 2019-03-13 | Sanofi | Housing and drug delivery device herewith |
TR201819651T4 (tr) | 2014-10-09 | 2019-01-21 | Sanofi Sa | İlaç tüpü değişimi sonrasında piston çubuğunu geri çekmeyi sağlayan yeniden ayarlanabilir mekanizmalı ilaç enjeksiyon cihazı. |
WO2016055631A1 (en) | 2014-10-09 | 2016-04-14 | Sanofi | Resettable drug delivery device |
TW201625324A (zh) | 2014-10-09 | 2016-07-16 | 賽諾菲公司 | 殼體及具有該殼體的藥物輸送裝置 |
AR102193A1 (es) * | 2014-10-09 | 2017-02-08 | Sanofi Sa | Manguito impulsor, dispositivo de administración de fármacos y método para ensamblar un dispositivo de administración de fármacos |
AU2016217923A1 (en) * | 2015-02-10 | 2017-09-28 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for an injection device |
PL414382A1 (pl) | 2015-10-15 | 2017-04-24 | Copernicus Spółka Z Ograniczoną Odpowiedzialnością | Mechanizm nastawczy, w szczególności do dozowania |
PL414383A1 (pl) | 2015-10-15 | 2017-04-24 | Copernicus Spółka Z Ograniczoną Odpowiedzialnością | Mechanizm nastawczy, w szczególności do dozowania substancji farmaceutycznych |
WO2017102745A1 (en) * | 2015-12-14 | 2017-06-22 | F. Hoffmann-La Roche Ag | Dosing device |
EP3181169A1 (en) | 2015-12-14 | 2017-06-21 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for an injection device |
EP3181171A1 (en) * | 2015-12-14 | 2017-06-21 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for an injection device |
EP3181170A1 (en) | 2015-12-14 | 2017-06-21 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for an injection device |
CN106039475B (zh) * | 2016-05-18 | 2019-08-02 | 苏州鹏烨医疗科技有限公司 | 一种注射笔 |
TWI729141B (zh) * | 2016-05-31 | 2021-06-01 | 德商賽諾菲阿凡提斯德意志有限公司 | 藥物輸送裝置之蓋組合件及其組裝方法 |
TW201803615A (zh) * | 2016-05-31 | 2018-02-01 | 賽諾菲阿凡提斯德意志有限公司 | 藥物輸送裝置的按鈕及組裝藥物輸送裝置的按鈕之方法 |
DK3478343T3 (da) | 2016-07-01 | 2021-03-29 | Sanofi Sa | Lægemiddeladministrationsanordning |
CN107875487B (zh) * | 2017-10-27 | 2024-01-26 | 江苏德尔福医疗器械有限公司 | 高精度笔式注射器 |
US20190151551A1 (en) * | 2017-11-10 | 2019-05-23 | Abbvie Inc. | Delivery device with a connector having displaceable portions |
AU2018372009B2 (en) | 2017-11-23 | 2024-08-22 | Sanofi | Medicament injection device with rotary encoder |
US11666709B2 (en) | 2017-12-21 | 2023-06-06 | Sanofi | Drive mechanism with noise reduction |
EP3727515A1 (en) | 2017-12-21 | 2020-10-28 | Sanofi | Transmission of data associated with an injection device usage using passive rf modulation |
CN111712278B (zh) * | 2017-12-21 | 2022-10-18 | 赛诺菲 | 用于注射装置的rfid剂量跟踪机构 |
US20200368445A1 (en) | 2018-01-19 | 2020-11-26 | Sanofi | Packaging Container |
WO2019189215A1 (ja) * | 2018-03-28 | 2019-10-03 | テルモ株式会社 | シリンジ用ガスケット押圧具または薬液吐出具、およびそれを備えた薬液投与具 |
EP3597233A1 (en) * | 2018-07-18 | 2020-01-22 | Sanofi | Drug delivery devices |
GB2577693B (en) | 2018-10-01 | 2022-06-22 | Janssen Pharmaceuticals Inc | Reset connector for an injection device and an injection device trainer |
GB2577696B (en) * | 2018-10-01 | 2022-09-14 | Janssen Pharmaceuticals Inc | Latch for an injection device and an injection device trainer |
EP3890806A1 (en) * | 2018-12-04 | 2021-10-13 | Sanofi | Assembly for a drug delivery device, drug delivery device, and method for producing a drug delivery device |
EP3736002A1 (de) | 2019-05-07 | 2020-11-11 | Ypsomed AG | Dosier- und ausschüttmechanismus für eine injektionsvorrichtung |
WO2021191325A1 (en) | 2020-03-27 | 2021-09-30 | Sanofi | Electronic system for a drug delivery device |
WO2021191329A1 (en) | 2020-03-27 | 2021-09-30 | Sanofi | Electronic system for a drug delivery device |
EP4126122A1 (en) | 2020-03-27 | 2023-02-08 | Sanofi | Switch assembly for an electronic system of a drug delivery device |
EP4000670A1 (en) | 2020-11-16 | 2022-05-25 | Sanofi | Electronic system and method for determining failure of a second switch in a drug delivery device |
EP4225406A1 (en) | 2020-03-27 | 2023-08-16 | Sanofi | Drug delivery device with electronic system |
JP2023522397A (ja) | 2020-04-23 | 2023-05-30 | サノフイ | 電子モジュールおよび薬物送達デバイス |
EP4138964A1 (en) | 2020-04-23 | 2023-03-01 | Sanofi | Injection device with an electronic detector |
CN115605243A (zh) | 2020-05-18 | 2023-01-13 | 赛诺菲(Fr) | 用于注射装置的刻度盘握把 |
JP2023530007A (ja) | 2020-06-19 | 2023-07-12 | サノフイ | 薬物送達デバイスのためのシステムおよび薬物送達デバイス |
WO2021260161A2 (en) | 2020-06-26 | 2021-12-30 | Sanofi | Improvements of an optical sensing system of a drug delivery device |
CN115803071A (zh) | 2020-07-15 | 2023-03-14 | 赛诺菲 | 对药物递送装置的可用性的改进 |
CN114129824A (zh) * | 2020-09-03 | 2022-03-04 | 甘甘医疗科技江苏有限公司 | 药物输送装置 |
US11052196B1 (en) | 2020-11-03 | 2021-07-06 | Sun Pharmaceutical Industries Limited | Method of injecting octreotide acetate into the body |
KR102271965B1 (ko) * | 2020-11-03 | 2021-07-02 | (주)풍림파마텍 | 피스톤 로드에 스크류 결합된 로드 락이 로드 홀더 내부에 회전 제한된 상태에서 직선 운동 가능한 구조를 갖는 약물 투입 조절 장치 |
JP2024505592A (ja) | 2021-02-09 | 2024-02-06 | サノフイ | 用量計数システム |
EP4291271A1 (en) | 2021-02-09 | 2023-12-20 | Sanofi | Dose counting system |
EP4070832A1 (en) * | 2021-04-07 | 2022-10-12 | medmix Switzerland AG | Keyed connectors |
WO2022214625A1 (en) * | 2021-04-07 | 2022-10-13 | Medmix Switzerland Ag | Drug delivery device |
WO2022223747A1 (en) | 2021-04-23 | 2022-10-27 | Sanofi | Electronic system for a drug delivery device |
EP4104881A1 (en) | 2021-06-17 | 2022-12-21 | Sanofi | Drug delivery device and method for operating a drug delivery device |
CN117940179A (zh) | 2021-09-07 | 2024-04-26 | 赛诺菲 | 注射装置和辅助装置 |
GB2611110A (en) * | 2021-09-22 | 2023-03-29 | Zf Steering Systems Poland Sp Zo O | Steering column assembly for a vehicle |
EP4405012A1 (en) | 2021-09-24 | 2024-07-31 | Sanofi | User interface member for a drug delivery device and drug delivery device |
EP4405002A1 (en) | 2021-09-24 | 2024-07-31 | Sanofi | Electronic component for a drug delivery device |
CN117999613A (zh) | 2021-09-24 | 2024-05-07 | 赛诺菲 | 药物递送装置或药物递送附加装置上的数据存储 |
EP4405001A1 (en) | 2021-09-24 | 2024-07-31 | Sanofi | Electronics device with battery life optimisation provided for a drug delivery device or a drug delivery add-on device |
CN117941386A (zh) | 2021-09-24 | 2024-04-26 | 赛诺菲 | 电子模块、药物递送装置和用于操作电子模块的方法 |
WO2023046799A1 (en) | 2021-09-24 | 2023-03-30 | Sanofi | Operating an electronic unit of a drug delivery device or a drug delivery add-on device |
WO2023046788A1 (en) | 2021-09-24 | 2023-03-30 | Sanofi | Dosing operation speed detection with electronic system for a drug delivery device |
EP4405011A1 (en) | 2021-09-24 | 2024-07-31 | Sanofi | Component for a drug delivery device and drug delivery device |
EP4405006A1 (en) | 2021-09-24 | 2024-07-31 | Sanofi | Information recording in a drug delivery device |
CN117980022A (zh) | 2021-09-24 | 2024-05-03 | 赛诺菲 | 控制药物递送装置的或药物递送附加装置的传感器 |
EP4405977A1 (en) | 2021-09-24 | 2024-07-31 | Sanofi | Determining data related to the approach of end of life of a drug delivery device |
WO2023046801A1 (en) | 2021-09-24 | 2023-03-30 | Sanofi | Electronic system, user interface member, drug delivery device and method for detecting whether a drug delivery device is, or was, exposed to fluid |
WO2023046791A1 (en) | 2021-09-24 | 2023-03-30 | Sanofi | Driving an optical sensor of a drug delivery device or of a drug delivery add-on device |
CN117980021A (zh) | 2021-09-24 | 2024-05-03 | 赛诺菲 | 对药物递送装置或药物递送附加装置的传感器的至少一个阈值的调节 |
CN117915974A (zh) | 2021-09-24 | 2024-04-19 | 赛诺菲 | 编码器环、剂量记录系统以及具有其的药物递送装置 |
EP4405010A1 (en) | 2021-09-24 | 2024-07-31 | Sanofi | Checking a sensor of a drug delivery device or of a drug delivery add-on device |
CN118201664A (zh) | 2021-11-03 | 2024-06-14 | 赛诺菲 | 用于药物递送装置的电子单元的供电装置 |
WO2023078853A1 (en) | 2021-11-03 | 2023-05-11 | Sanofi | Injection device and method of unlocking operation of the injection device |
WO2023078958A1 (en) | 2021-11-03 | 2023-05-11 | Sanofi | User authentication for a drug delivery device |
CN118176037A (zh) | 2021-11-03 | 2024-06-11 | 赛诺菲 | 注射装置和解锁注射装置的操作的方法 |
CN118201661A (zh) | 2021-11-03 | 2024-06-14 | 赛诺菲 | 用于药物递送装置的电子单元和移动电子装置 |
WO2023078858A1 (en) | 2021-11-03 | 2023-05-11 | Sanofi | Drug delivery device and electronic unit |
WO2023078857A1 (en) | 2021-11-03 | 2023-05-11 | Sanofi | Injection device and method of unlocking operation of the injection device |
WO2023078851A1 (en) | 2021-11-03 | 2023-05-11 | Sanofi | Add-on device for an injection device |
WO2023078847A1 (en) | 2021-11-03 | 2023-05-11 | Sanofi | Drug delivery device and electronic unit |
CN118176503A (zh) | 2021-11-03 | 2024-06-11 | 赛诺菲 | 用于药物输送装置的用户认证 |
CN118139665A (zh) | 2021-11-03 | 2024-06-04 | 赛诺菲 | 用于注射装置的附加装置 |
WO2023099513A1 (en) | 2021-12-01 | 2023-06-08 | Sanofi | Drug delivery device and dose recording system herewith |
CN118302215A (zh) | 2021-12-01 | 2024-07-05 | 赛诺菲 | 药物递送装置和具有该装置的剂量记录系统 |
WO2023099514A1 (en) | 2021-12-01 | 2023-06-08 | Sanofi | Drug delivery device and dose recording system herewith |
CN118302214A (zh) | 2021-12-01 | 2024-07-05 | 赛诺菲 | 药物递送装置和具有该装置的剂量记录系统 |
WO2023110879A1 (en) | 2021-12-15 | 2023-06-22 | Sanofi | Drug delivery device with improved needle cover |
CN118401267A (zh) | 2021-12-15 | 2024-07-26 | 赛诺菲 | 注射深度可调节的药物递送装置 |
WO2023131691A1 (en) | 2022-01-10 | 2023-07-13 | Sanofi | Carry case for a drug delivery device and drug delivery device |
WO2023135555A1 (en) | 2022-01-14 | 2023-07-20 | Philips-Medisize A/S | Dose delivery device with modified decoupling clutch |
WO2023152215A1 (en) | 2022-02-11 | 2023-08-17 | Sanofi | Electrical system for a drug delivery device and drug delivery device |
EP4249016A1 (en) | 2022-03-24 | 2023-09-27 | Sanofi | Actuating unit for a drug delivery device and related items |
CN114471768B (zh) * | 2022-04-09 | 2022-06-28 | 显陆(常州)科技有限公司 | 一种可重复使用的便携液体物料输送装置 |
CN114433266B (zh) * | 2022-04-09 | 2022-06-21 | 显陆(常州)科技有限公司 | 一种一次性使用的便携液体物料输送装置 |
WO2023203040A1 (en) | 2022-04-21 | 2023-10-26 | Sanofi | Drive mechanism for an injection device |
WO2023213755A1 (en) | 2022-05-03 | 2023-11-09 | Sanofi | Sensor assembly for detecting or recognizing operation an injection device |
WO2023213756A1 (en) | 2022-05-03 | 2023-11-09 | Sanofi | Sensor assembly for an injection device |
WO2023227491A1 (en) | 2022-05-24 | 2023-11-30 | Sanofi | An electronic module of a drug delivery device or of a supplemental device for a drug delivery device |
WO2023237584A1 (en) | 2022-06-09 | 2023-12-14 | Sanofi | Spacer for an add-on device |
WO2024046934A1 (en) | 2022-08-30 | 2024-03-07 | Sanofi | Injection device with add-on device |
WO2024046931A1 (en) | 2022-08-30 | 2024-03-07 | Sanofi | Injection device and add-on device |
WO2024046932A1 (en) | 2022-08-30 | 2024-03-07 | Sanofi | Add-on device for an injection device |
WO2024046935A1 (en) | 2022-08-30 | 2024-03-07 | Sanofi | Add-on device for an injection device |
WO2024046933A1 (en) | 2022-08-30 | 2024-03-07 | Sanofi | Injection device and add-on device |
CN117138165B (zh) * | 2023-10-27 | 2024-01-23 | 江苏万海医疗器械有限公司 | 预制物料推送装置、输送器以及使用方法 |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US533575A (en) | 1895-02-05 | wilkens | ||
DE3715258C2 (de) | 1987-05-08 | 1996-10-31 | Haselmeier Wilhelm Fa | Injektionsgerät |
GB8713810D0 (en) | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
US5226895A (en) | 1989-06-05 | 1993-07-13 | Eli Lilly And Company | Multiple dose injection pen |
GB9007113D0 (en) | 1990-03-29 | 1990-05-30 | Sams Bernard | Dispensing device |
US5226896A (en) | 1990-04-04 | 1993-07-13 | Eli Lilly And Company | Dose indicating injection pen |
AU641206B2 (en) | 1991-01-22 | 1993-09-16 | Eli Lilly And Company | Multiple dose injection pen |
ATE121953T1 (de) | 1991-07-24 | 1995-05-15 | Medico Dev Investment Co | Injektor. |
DK175491D0 (da) | 1991-10-18 | 1991-10-18 | Novo Nordisk As | Apparat |
US5279586A (en) | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Reusable medication delivery pen |
US5271527A (en) | 1992-04-02 | 1993-12-21 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
US5300041A (en) | 1992-06-01 | 1994-04-05 | Habley Medical Technology Corporation | Dose setting and repeating syringe |
US5391157A (en) | 1992-10-20 | 1995-02-21 | Eli Lilly And Company | End of dose indicator |
US5378233A (en) | 1992-11-18 | 1995-01-03 | Habley Medical Technology Corporation | Selected dose pharmaceutical dispenser |
US5320609A (en) | 1992-12-07 | 1994-06-14 | Habley Medical Technology Corporation | Automatic pharmaceutical dispensing syringe |
FR2701211B1 (fr) | 1993-02-08 | 1995-05-24 | Aguettant Lab | Instrument doseur, notamment d'injection |
US5383865A (en) | 1993-03-15 | 1995-01-24 | Eli Lilly And Company | Medication dispensing device |
ZA941881B (en) | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
US5582598A (en) | 1994-09-19 | 1996-12-10 | Becton Dickinson And Company | Medication delivery pen with variable increment dose scale |
CA2213682C (en) | 1995-03-07 | 2009-10-06 | Eli Lilly And Company | Recyclable medication dispensing device |
AU1860697A (en) | 1995-09-08 | 1997-07-28 | Visionary Medical Products Corporation | Pen-type injector drive mechanism |
US5674204A (en) | 1995-09-19 | 1997-10-07 | Becton Dickinson And Company | Medication delivery pen cap actuated dose delivery clutch |
US5688251A (en) | 1995-09-19 | 1997-11-18 | Becton Dickinson And Company | Cartridge loading and priming mechanism for a pen injector |
US5851079A (en) | 1996-10-25 | 1998-12-22 | The Procter & Gamble Company | Simplified undirectional twist-up dispensing device with incremental dosing |
DE19730999C1 (de) | 1997-07-18 | 1998-12-10 | Disetronic Licensing Ag | Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
US5957896A (en) | 1997-08-11 | 1999-09-28 | Becton, Dickinson And Company | Medication delivery pen |
US6004297A (en) * | 1998-01-30 | 1999-12-21 | Novo Nordisk A/S | Injection syringe |
US5961495A (en) | 1998-02-20 | 1999-10-05 | Becton, Dickinson And Company | Medication delivery pen having a priming mechanism |
US6221053B1 (en) | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
US6248095B1 (en) | 1998-02-23 | 2001-06-19 | Becton, Dickinson And Company | Low-cost medication delivery pen |
DE19900827C1 (de) | 1999-01-12 | 2000-08-17 | Disetronic Licensing Ag | Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
DE19900792C1 (de) | 1999-01-12 | 2000-06-15 | Disetronic Licensing Ag | Vorrichtung zur Verabreichung eines injizierbaren Produkts |
DE29900482U1 (de) | 1999-01-14 | 2000-08-31 | Medico Development Investment Co., Ascona | Injektionsgerät |
SE9901366D0 (sv) | 1999-04-16 | 1999-04-16 | Pharmacia & Upjohn Ab | Injector device and method for its operation |
JP4290366B2 (ja) | 1999-08-05 | 2009-07-01 | ベクトン・ディキンソン・アンド・カンパニー | 薬剤送出ペン |
GB0007071D0 (en) | 2000-03-24 | 2000-05-17 | Sams Bernard | One-way clutch mechanisms and injector devices |
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
AU2001292581B2 (en) | 2000-10-09 | 2006-05-18 | Eli Lilly And Company | Pen device for administration of parathyroid hormone |
US6899699B2 (en) | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
WO2002092153A2 (en) * | 2001-05-16 | 2002-11-21 | Eli Lilly And Company | Medication injector apparatus with drive assembly that facilitates reset |
WO2003080160A1 (en) | 2002-03-18 | 2003-10-02 | Eli Lilly And Company | Medication dispensing apparatus with gear set for mechanical advantage |
CN100431631C (zh) | 2002-10-01 | 2008-11-12 | 贝克顿·迪金森公司 | 药物输送笔 |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US6932794B2 (en) | 2003-04-03 | 2005-08-23 | Becton, Dickinson And Company | Medication delivery pen |
EP1541185A1 (en) | 2003-12-08 | 2005-06-15 | Novo Nordisk A/S | Automatic syringe with priming mechanism |
DE102004063645A1 (de) | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Vorrichtung zur dosierten Verabreichung eines fluiden Produkts mit Entkopplung für einen Behältniswechsel |
DE602006004452D1 (de) | 2005-02-11 | 2009-02-05 | Novo Nordisk As | Injektionsvorrichtung |
DE102005060929A1 (de) * | 2005-09-14 | 2007-03-15 | Tecpharma Licensing Ag | Injektionsvorrichtung mit Zweiwege-Rutschkupplung |
CN101588830A (zh) | 2006-09-15 | 2009-11-25 | 特克法马许可公司 | 防喷溅的注射仪器 |
US8647309B2 (en) * | 2008-05-02 | 2014-02-11 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
US8267900B2 (en) | 2008-05-02 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
BRPI1007907A2 (pt) * | 2009-02-05 | 2016-02-16 | Sanofi Aventis Deutschland | dispositivos de envio de medicamento |
US9623187B2 (en) * | 2009-06-01 | 2017-04-18 | Sanofi-Aventis Deutschland Gmbh | Resettable drug delivery device |
US8257319B2 (en) * | 2009-06-01 | 2012-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device inner housing having helical spline |
TWI530306B (zh) * | 2009-06-02 | 2016-04-21 | 賽諾菲阿凡提斯德意志有限公司 | 藥物傳送裝置總成及藥物傳送裝置 |
JP5756470B2 (ja) * | 2009-09-30 | 2015-07-29 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 再設定可能な駆動アセンブリ及び薬物送達デバイス |
TW201127434A (en) * | 2009-09-30 | 2011-08-16 | Sanofi Aventis Deutschland | Drug delivery device |
GB0918145D0 (en) * | 2009-10-16 | 2009-12-02 | Owen Mumford Ltd | Injector apparatus |
EP2560709B1 (en) * | 2010-04-23 | 2020-11-04 | Sanofi-Aventis Deutschland GmbH | Cartridge assembly having shared fastening means and drug delivery device |
JP5876039B2 (ja) * | 2010-06-11 | 2016-03-02 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス用の駆動機構及び薬物送達デバイス |
BR112013007164A2 (pt) * | 2010-09-30 | 2016-06-14 | Sanofi Aventis Deutschland | suporte de reservatório não separável para um dispositivo de entrega de fármaco |
CN103260677B (zh) * | 2010-10-13 | 2016-01-20 | 赛诺菲-安万特德国有限公司 | 剂量设定机构 |
TWI464003B (zh) * | 2010-11-18 | 2014-12-11 | Shl Group Ab | 藥物輸送裝置 |
KR102144138B1 (ko) * | 2012-04-05 | 2020-08-12 | 사노피-아벤티스 도이칠란트 게엠베하 | 펜형 주사기 |
EP2833947B1 (en) * | 2012-04-05 | 2018-02-28 | Sanofi-Aventis Deutschland GmbH | Pen-type injector with window element |
AU2013310947B2 (en) * | 2012-08-31 | 2017-04-13 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
-
2013
- 2013-08-29 AU AU2013310947A patent/AU2013310947B2/en active Active
- 2013-08-29 MX MX2015002634A patent/MX365296B/es active IP Right Grant
- 2013-08-29 BR BR112015004132-9A patent/BR112015004132B1/pt active IP Right Grant
- 2013-08-29 EP EP13758803.4A patent/EP2890435B1/en active Active
- 2013-08-29 KR KR1020157005661A patent/KR102166890B1/ko active IP Right Grant
- 2013-08-29 US US14/423,732 patent/US9345841B2/en active Active
- 2013-08-29 PL PL13758803T patent/PL2890435T3/pl unknown
- 2013-08-29 SG SG11201500322TA patent/SG11201500322TA/en unknown
- 2013-08-29 AR ARP130103065A patent/AR092276A1/es active IP Right Grant
- 2013-08-29 CN CN201380043578.9A patent/CN104661696B/zh active Active
- 2013-08-29 EP EP19213439.3A patent/EP3639872B1/en active Active
- 2013-08-29 DK DK19213439.3T patent/DK3639872T3/da active
- 2013-08-29 RU RU2015111241A patent/RU2648866C2/ru active
- 2013-08-29 HU HUE19213439A patent/HUE061532T2/hu unknown
- 2013-08-29 WO PCT/EP2013/067860 patent/WO2014033195A1/en active Application Filing
- 2013-08-29 ES ES19213439T patent/ES2941078T3/es active Active
- 2013-08-29 MY MYPI2015000483A patent/MY179718A/en unknown
- 2013-08-29 PL PL19213439.3T patent/PL3639872T3/pl unknown
- 2013-08-29 JP JP2015529016A patent/JP6314139B2/ja active Active
- 2013-08-30 TW TW102131176A patent/TWI595903B/zh active
-
2015
- 2015-01-15 IL IL236746A patent/IL236746B/en active IP Right Grant
- 2015-01-15 ZA ZA2015/00299A patent/ZA201500299B/en unknown
- 2015-02-25 CL CL2015000455A patent/CL2015000455A1/es unknown
- 2015-09-15 HK HK15108995.1A patent/HK1208387A1/xx unknown
-
2016
- 2016-04-26 US US15/138,533 patent/US10265479B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6314139B2 (ja) | 薬物送達デバイス | |
US11813438B2 (en) | Drug delivery device | |
JP6616410B2 (ja) | ばね配置およびばね配置を有する薬物送達デバイス | |
JP6629309B2 (ja) | ハウジングおよびそれを備えた薬物送達デバイス | |
JP2017520371A (ja) | 薬物送達デバイス | |
JP2016518901A (ja) | 注射デバイス | |
JP6412569B2 (ja) | 薬物送達デバイス | |
JP6754357B2 (ja) | 駆動スリーブ、薬物送達デバイス、および薬物送達デバイスを組み立てる方法 | |
JP2017534365A (ja) | 薬物カートリッジ交換時にピストンロッドの後退を可能にするリセット可能な機構を備えた薬物注射デバイス | |
JP6573666B2 (ja) | 薬物カートリッジ交換時にピストンロッドの後退を可能にするリセット可能な機構を備えた薬物注射デバイス | |
JP2016529013A (ja) | 外側金属部材および内側プラスチック部材で作られた注射デバイス用のハウジングおよびキャップ | |
JP6480924B2 (ja) | 薬物送達デバイス | |
JP2017520374A (ja) | 薬物送達デバイス | |
JP2017530798A (ja) | ハウジングおよびハウジングを有する薬物送達デバイス | |
JP2018505026A (ja) | 注射デバイス用の駆動機構 | |
JP2018503469A (ja) | トリガ機構およびトリガ機構を含む薬物送達デバイス | |
JP2017534364A (ja) | ハウジング、ハウジングを有する薬物送達デバイス、およびハウジングを製造する方法 | |
JP2018507749A (ja) | 薬物送達デバイス | |
JP6717822B2 (ja) | ディスプレイおよびディスプレイを有する薬物送達デバイス | |
JP6609248B2 (ja) | 薬物送達デバイス | |
JP2017530800A (ja) | インサートおよびインサートを有する薬物送達デバイス | |
JP2017536935A (ja) | 空間節約薬物注射デバイス |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160817 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170519 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170704 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180306 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180326 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6314139 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |