JP6312440B2 - Capillary blood collection tool - Google Patents
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- JP6312440B2 JP6312440B2 JP2014001656A JP2014001656A JP6312440B2 JP 6312440 B2 JP6312440 B2 JP 6312440B2 JP 2014001656 A JP2014001656 A JP 2014001656A JP 2014001656 A JP2014001656 A JP 2014001656A JP 6312440 B2 JP6312440 B2 JP 6312440B2
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- 239000008280 blood Substances 0.000 title claims description 108
- 210000004369 blood Anatomy 0.000 title claims description 108
- 239000007789 gas Substances 0.000 claims description 22
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 18
- 229910052731 fluorine Inorganic materials 0.000 claims description 18
- 239000011737 fluorine Substances 0.000 claims description 18
- 238000004381 surface treatment Methods 0.000 claims description 12
- 230000004323 axial length Effects 0.000 claims description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 7
- 229910001882 dioxygen Inorganic materials 0.000 claims description 7
- 239000000088 plastic resin Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000010241 blood sampling Methods 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 230000032683 aging Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
Description
本発明は、糖尿病患者などの採血に使用するキャピラリー採血具に関する。 The present invention relates to a capillary blood collection device used for blood collection of a diabetic patient or the like.
従来のキャピラリー採血具として、軸方向にストレートな筒状本体の先端部から毛細管現象を利用して血液を吸収するものが知られている（例えば、特許文献１，２参照）。また、毛細管現象を利用して血液を吸収する筒状本体を高分子材料から製作し、かつ、筒状本体の内面を親水性に処理し、また筒状本体内の所定の位置には吸引した血液量を所定の位置で止めるために液状封止用樹脂を配置し、この液状封止用樹脂の挿入を容易にするために筒状本体の吸引側先端部には外側に向かうに従って広がるテーパー面状の端部加工を施したものが知られている（例えば、特許文献３参照）。 As a conventional capillary blood collection device, one that absorbs blood from the distal end portion of a cylindrical main body that is straight in the axial direction by using a capillary phenomenon is known (for example, see Patent Documents 1 and 2). In addition, a cylindrical body that absorbs blood using capillary action is manufactured from a polymer material, and the inner surface of the cylindrical body is treated to be hydrophilic, and sucked to a predetermined position in the cylindrical body. In order to stop the blood volume at a predetermined position, a liquid sealing resin is arranged, and in order to facilitate the insertion of the liquid sealing resin, a tapered surface that widens toward the outside on the suction side tip of the cylindrical body What performed the shape edge part process is known (for example, refer patent document 3).
しかしながら、従来のキャピラリー採血具は、基本的にはいずれも軸方向にストレートな筒状本体の端部から血液を吸い上げる構成であり、また特許文献３では、液状封止用樹脂の挿入を容易にするために筒状本体の吸引側先端部に外側に向かうに従って広がるテーパー面状の端部加工を施しているが、端部以外の内面が基本的には軸方向にほぼストレートな孔となっているため、毛細管現象による吸い上げが必ずしも効果的ではなかった。しかも、ほぼ一定の血液量を吸い上げて採血を効果的に行うためには、液状封止用樹脂を内部に挿入配置する必要があり、構造が複雑なものとなっていた。 However, all conventional capillary blood collection devices are basically configured to suck blood from the end of a cylindrical body that is straight in the axial direction. In Patent Document 3, it is easy to insert a liquid sealing resin. In order to do this, the end part of the tapered surface that widens toward the outside is applied to the suction side tip of the cylindrical main body, but the inner surface other than the end is basically a straight hole in the axial direction Therefore, siphoning by capillary action is not always effective. In addition, in order to suck up a substantially constant amount of blood and perform blood collection effectively, it is necessary to insert and arrange a liquid sealing resin inside, which makes the structure complicated.
本発明の目的は、毛細管現象による吸い上げを一層効果的に行うことができるようにしたキャピラリー採血具を提供するにある。 An object of the present invention is to provide a capillary blood sampling device that can perform suction more effectively by capillary action.
本発明は上記目的を達成するために、毛細管現象を利用して血液を吸い上げる筒状本体を有したキャピラリー採血具において、前記筒状本体の吸い上げ側先端部に、透明または半透明のプラスチック樹脂製の毛細管吸引筒部が形成され、前記毛細管吸引筒部の内部には、吸引した血液を保持可能な吸引採血保持孔が形成されており、前記吸引採血保持孔は、吸い上げ側から反吸い上げ側に向かって内径が縮小された逆テーパー形状面を有するとともに、少なくとも前記逆テーパー形状内面がフッ素ガスと酸素ガスによる表面処理によって、親水化されていると共に、前記吸引採血保持孔は、吸い上げ側の内径をＡ、反吸い上げ側の内径をＢ、前記吸い上げ側から前記反吸い上げ側までの軸長をＣとしたとき、０．５≦Ａ≦１．５［ｍｍ］、０．４≦Ｂ≦１．４［ｍｍ］、２．０≦Ｃ≦６．０［ｍｍ］であるとして形成し、更に、前記吸引採血保持孔の吸い上げ側の一部に、０．１５〜０．３０［ｍｍ］のＲ面取り加工を施し、更に、前記筒状本体は、前記吸引採血保持孔の前記反吸い上げ側に隣接する位置に中間筒部が形成され、前記中間筒部の内部には、前記吸引採血保持孔の前記反吸い上げ側と連通し、かつ、前記反吸い上げ側の内径Ｂよりも径の大きな中間室を形成したことを特徴とする。 In order to achieve the above object, the present invention provides a capillary blood collection device having a cylindrical main body that sucks blood by utilizing capillary action, and is made of a transparent or translucent plastic resin at the suction side tip of the cylindrical main body. The capillary suction tube portion is formed with a suction blood collection holding hole capable of holding the sucked blood, and the suction blood collection holding hole extends from the suction side to the anti-suction side. And having at least the reverse tapered inner surface made hydrophilic by surface treatment with fluorine gas and oxygen gas , and the suction blood collection holding hole has an inner diameter on the suction side Is 0.5, A ≦ 1.5 [mm], 0 where A is the inner diameter of the anti-siphoning side and B is the axial length from the siphoning side to the anti-siphoning side. 4 ≦ B ≦ 1.4 [mm] and 2.0 ≦ C ≦ 6.0 [mm], and further, 0.15 to .0. 30 [mm] R chamfering is performed, and further, the cylindrical main body has an intermediate cylindrical portion formed at a position adjacent to the suction side of the suction blood collection holding hole. An intermediate chamber communicating with the suction side of the suction blood collection holding hole and having a diameter larger than the inner diameter B of the suction side is formed .
上記構成によれば、上記構成によれば、吸引採血保持孔は逆テーパー形状面を有するとともに、少なくとも逆テーパー形状内面がフッ素ガスによる表面処理によって、親水化されているため、その吸い上げ側先端部を血液に接触させると、毛細管現象によって血液を効果的に吸い上げることができる。このように簡単な構成で所定の採血量を一層効果的に、かつ容易に得ることができる。また、吸引採血保持孔は、内径Ａ、内径Ｂ、軸長Ｃを上述のように最適な寸法に設定しているため、その吸い上げ側先端部を血液に接触させると、毛細管現象によって血液を効果的に吸い上げることができる。このとき、毛細管吸引筒部における吸引採血保持孔の容積は、内径Ａ、内径Ｂ、軸長Ｃによってほぼ決定することができるので、逆テーパー形状面を利用した簡単な構成で所定の採血量を一層効果的に、かつ容易に得ることができる。更に、端面加工により、前記吸引採血保持孔への採血がスムーズかつ、確実に行われる。更に又、前記吸引採血保持孔の吸い上げ側先端部を血液に接触させると、吸引採血保持孔に形成した逆テーパー形状面による毛細管現象によって、吸引採血保持孔へ血液を効果的に吸い上げることができ、しかも、毛細管吸引筒部の毛細管現象によって吸い上げられる血液は吸引採血保持孔を満たすが、中間室側への毛細管現象による吸い上げは殆ど生じることがないので、所定の採血量を簡単な構成で容易に得ることができる。 According to the above configuration, according to the above configuration, the suction blood collection holding hole has a reverse tapered shape surface, and at least the reverse tapered shape inner surface is hydrophilized by surface treatment with fluorine gas. When blood is brought into contact with blood, blood can be effectively sucked up by capillary action. Thus, a predetermined blood collection amount can be obtained more effectively and easily with a simple configuration. Further, since the suction blood collection holding hole has the inner diameter A, the inner diameter B, and the axial length C set to the optimum dimensions as described above, if the suction side tip is brought into contact with blood, the blood is effective by capillary action. Can be sucked up. At this time, since the volume of the suction blood collection holding hole in the capillary suction tube portion can be substantially determined by the inner diameter A, the inner diameter B, and the shaft length C, a predetermined blood collection amount can be obtained with a simple configuration using a reverse tapered surface. It can be obtained more effectively and easily. Furthermore, blood collection into the suction blood collection holding hole is smoothly and reliably performed by the end face processing. Furthermore, when the suction side tip of the suction blood collection holding hole is brought into contact with blood, blood can be effectively sucked into the suction blood collection holding hole by capillary action due to the reverse tapered shape formed in the suction blood collection holding hole. In addition, the blood sucked up by the capillary action of the capillary suction tube portion fills the suction blood collection holding hole, but sucking up by the capillary action to the intermediate chamber hardly occurs, so that a predetermined blood collection amount can be easily made with a simple configuration. Can get to.
本発明によるキャピラリー採血具によれば、吸引採血保持孔は逆テーパー形状面を有するとともに、少なくとも逆テーパー形状内面がフッ素ガスによる表面処理によって、親水化されているため、その吸い上げ側先端部を血液に接触させると、毛細管現象によって血液を効果的に吸い上げることができる。このように簡単な構成で所定の採血量を一層効果的に、かつ容易に得ることができる。また、フッ素ガスによる表面処理は、親水化度の制御が可能であり、あらゆる形状の製品に適用できるとともに、経年安定性に優れている等の特徴を有しており、したがって、コスト、精度、および品質に優れたキャピラリー採血具を実現することができる。 According to the capillary blood collection device of the present invention, the suction blood collection holding hole has a reverse tapered surface, and at least the reverse tapered inner surface is hydrophilized by surface treatment with fluorine gas. When in contact with blood, blood can be sucked up effectively by capillary action. Thus, a predetermined blood collection amount can be obtained more effectively and easily with a simple configuration. In addition, the surface treatment with fluorine gas can control the degree of hydrophilization, and can be applied to products of all shapes, and has characteristics such as excellent aging stability. In addition, it is possible to realize a capillary blood sampling device with excellent quality.
以下、本発明の実施の形態を図面に基づいて説明する。 Hereinafter, embodiments of the present invention will be described with reference to the drawings.
図１は、キャピラリー採血具を示しており、全体はポリプロピレンなどのプラスチック樹脂製で透明もしくは半透明の筒状本体として構成され、患者の血液に接触させて毛細管現象を利用して吸い上げる毛細管吸引筒部１と、その後方に設けた中間筒部２と、図示しない分析装置側と接続する接続筒部３とを有し、各部１〜３はその内部空間が連通している。 FIG. 1 shows a capillary blood collection device, which is entirely made of a plastic resin such as polypropylene, and is configured as a transparent or translucent cylindrical main body, which is brought into contact with a patient's blood and sucks up using a capillary phenomenon. It has the part 1, the intermediate | middle cylinder part 2 provided in the back, and the connection cylinder part 3 connected with the analyzer side which is not shown in figure, and each part 1-3 has the internal space connected.
毛細管吸引筒部１は、全体的な外観は先細形状であるが、毛細管吸引筒部の内部には、吸引採血保持孔５が形成されており、吸引採血保持孔５は、吸い上げ側から反吸い上げ側に向かって内径が縮小された逆テーパー形状面４を有し、かつ、その容積はほぼ所定の採血量となるように設計されている。 Although the capillary suction tube portion 1 has a tapered appearance as a whole, a suction blood collection holding hole 5 is formed inside the capillary suction tube portion, and the suction blood collection holding hole 5 is anti-sucked from the suction side. It has an inversely tapered surface 4 whose inner diameter is reduced toward the side, and its volume is designed to be approximately a predetermined blood collection amount.
プラスチック樹脂製の筒状本体は、フッ素ガスによる表面処理によって、カルボキシル基が導入され親水化されている。この表面処理の際、フッ素ガス濃度、酸素ガス濃度、および反応時間は所定の値に設定され、親水化度が制御されて採血具として最適化が図られている。なお、本実施の形態では、作業性の観点から筒状本体全体をフッ素ガスによって表面処理を施した例を示したが、少なくとも毛細管吸引筒部１の内面を親水化することで所望の効果を挙げることができる。 The cylindrical body made of plastic resin is rendered hydrophilic by introducing carboxyl groups by surface treatment with fluorine gas. During this surface treatment, the fluorine gas concentration, the oxygen gas concentration, and the reaction time are set to predetermined values, and the degree of hydrophilization is controlled to optimize the blood collection tool. In the present embodiment, an example in which the entire cylindrical main body is surface-treated with fluorine gas from the viewpoint of workability has been shown. However, at least the inner surface of the capillary suction tube portion 1 can be made hydrophilic to achieve a desired effect. Can be mentioned.
フッ素ガスによる表面処理は、具体的には０℃〜１００℃の温度で、混合ガス中の濃度が０．１ｖｏｌ％〜２０ｖｏｌ％であるフッ素ガスと、酸素ガスとを混合し、その混合ガスに、キャピラリー採血具を接触させるものである。接触時間は１分〜１日である。なお、混合ガスには窒素ガス、ヘリウムガス等の不活性ガスが含まれていてもよい。 Specifically, the surface treatment with fluorine gas is performed by mixing fluorine gas having a concentration of 0.1 vol% to 20 vol% with oxygen gas at a temperature of 0 ° C. to 100 ° C. and oxygen gas. The capillary blood collection tool is brought into contact. The contact time is 1 minute to 1 day. Note that the mixed gas may contain an inert gas such as nitrogen gas or helium gas.
フッ素ガスによる表面処理の温度を０℃〜１００℃の範囲にすることで、親水化処理の速度が向上し、かつ、キャピラリー採血具がフッ素ガスとの過剰な反応によって分解されるのを抑制できるため、好ましい。より好ましくは０℃〜５０℃である。 By setting the temperature of the surface treatment with fluorine gas in the range of 0 ° C. to 100 ° C., the speed of the hydrophilic treatment can be improved, and the capillary blood collection tool can be prevented from being decomposed by excessive reaction with fluorine gas. Therefore, it is preferable. More preferably, it is 0 degreeC-50 degreeC.
また、混合ガス中のフッ素ガス濃度を０．１ｖｏｌ％〜２０ｖｏｌ％とすることで、親水化処理の速度が向上し、かつ、キャピラリー採血具がフッ素ガスとの過剰な反応によって分解されるのを抑制できるため、好ましい。より好ましくは１ｖｏｌ％〜１０ｖｏｌ％である。混合ガス中の酸素ガス濃度は特に限定されないが、親水性を示すカルボキシル基が生成しやすくなるため、１ｖｏｌ％〜９９ｖｏｌ％の範囲が好ましい。 In addition, by setting the fluorine gas concentration in the mixed gas to 0.1 vol% to 20 vol%, the speed of the hydrophilization treatment is improved, and the capillary blood collection device is decomposed by excessive reaction with the fluorine gas. Since it can suppress, it is preferable. More preferably, it is 1 vol%-10 vol%. The oxygen gas concentration in the mixed gas is not particularly limited, but is preferably in the range of 1 vol% to 99 vol% because a carboxyl group showing hydrophilicity is easily generated.
中間筒部２も全体として円筒状であり、毛細管吸引筒部１側の端部は吸引採血保持孔５の逆テーパー形状面４の延長ではなく、吸引採血保持孔５に比べて開口面積が急激に大きくなっている。また、この開口面積が急激に大きくなった部分を起点として、接続筒部３側に向かって、内径が拡大されたテーパー形状面６を有し、かつ吸引採血保持孔５の容積と比較して大きな容積を持つ、中間室７が形成されている。また中間筒部２の軸方向長は、毛細管吸引筒部１の軸方向長に比べて長く、キャピラリー採血具単位としての取り扱いを容易にしている。 The intermediate tube portion 2 is also cylindrical as a whole, and the end portion on the capillary suction tube portion 1 side is not an extension of the reverse tapered surface 4 of the suction blood collection holding hole 5, and the opening area is sharper than that of the suction blood collection holding hole 5. Is getting bigger. In addition, starting from the portion where the opening area suddenly increases, it has a tapered surface 6 with an inner diameter enlarged toward the connecting tube portion 3 side, and compared with the volume of the suction blood collection holding hole 5 An intermediate chamber 7 having a large volume is formed. Further, the axial length of the intermediate tube portion 2 is longer than the axial length of the capillary suction tube portion 1 and facilitates handling as a capillary blood collection tool unit.
接続筒部３は図示しない分析装置側の接続部に対応して接続可能な外観構造と、吸引採血保持孔５および中間室７に連通し分析装置へと導く開口８とを有している。 The connecting tube portion 3 has an external structure that can be connected to a connecting portion on the analyzer side (not shown), and an opening 8 that communicates with the suction blood collection holding hole 5 and the intermediate chamber 7 and leads to the analyzer.
さらに、毛細管吸引筒部１および中間筒部２の詳細について図２を用いて説明する。毛細管吸引筒部１に形成した逆テーパー形状面４の中心軸に対する傾きは４．３度程度が好ましい。吸引採血保持孔５における左方の吸い上げ側の内径をＡとし、一方、吸引採血保持孔５における右方の反吸い上げ側端の内径をＢとし、また吸引採血保持孔５の軸長をＣとして示している。ここで、好ましくは、０．５≦Ａ≦１．５［ｍｍ］、０．４≦Ｂ≦１．４［ｍｍ］、２．０≦Ｃ≦６．０［ｍｍ］である。また、吸引採血保持孔５の吸い上げ側の内径部に、Ｒ面取り加工を施し、このＲ面取り加工の径は０．１５〜０．３０［ｍｍ］であることが好ましい。 Further, the details of the capillary suction tube portion 1 and the intermediate tube portion 2 will be described with reference to FIG. The inclination with respect to the central axis of the inversely tapered surface 4 formed in the capillary tube 1 is preferably about 4.3 degrees. The inner diameter of the suction side on the left side in the suction blood collection holding hole 5 is A, while the inner diameter of the right side suction side of the suction blood collection holding hole 5 is B, and the axial length of the suction blood collection holding hole 5 is C. Show. Here, preferably, 0.5 ≦ A ≦ 1.5 [mm], 0.4 ≦ B ≦ 1.4 [mm], and 2.0 ≦ C ≦ 6.0 [mm]. Further, the inner diameter portion of the intake have raised side of the suction blood holding hole 5, subjecting the R chamfering, it is preferable diameter of the R chamfering is 0.15 to 0.30 [mm].
このように吸引採血保持孔５は、吸い上げ側の内径Ａ、反吸い上げ側の内径Ｂ、軸長Ｃが上述のように設定され、かつ、その内面はフッ素ガスによる表面処理によって、親水化されているため、その吸い上げ先端部を血液に接触させると、毛細管現象によって血液を吸い上げることができる。単に、筒状本体にストレートな孔を形成した場合に比べて、効果的な毛細管現象によって素早く吸い上げることができる。また、吸引採血保持孔５の容積は、吸い上げ側の内径Ａ、反吸い上げ側の内径Ｂ、軸長Ｃによって決定することができるため、簡単な構成で採血量が不安定になることなく、所定の採血量を容易に吸い上げることができる。また、フッ素ガスによる表面処理は、親水化度の制御が可能であり、あらゆる形状の製品に適用できるとともに、経年安定性に優れている等の特徴を有しており、したがって、コスト、精度、および品質に優れたキャピラリー採血具を実現することができる。さらに、毛細管吸引筒部１を透明または半透明のポリプロピレンなどのプラスチック樹脂製とすると、採血状況を容易に確認することができる。 As described above, the suction blood collection holding hole 5 has the suction-side inner diameter A, the anti-sucking-side inner diameter B, and the axial length C set as described above, and the inner surface is hydrophilized by surface treatment with fluorine gas. Therefore, when the suction tip is brought into contact with blood, blood can be sucked up by capillary action. Compared to the case where a straight hole is simply formed in the cylindrical main body, it can be quickly sucked up by an effective capillary phenomenon. Further, since the volume of the suction blood collection holding hole 5 can be determined by the inner diameter A on the suction side, the inner diameter B on the anti-suction side, and the shaft length C, the blood collection amount becomes a simple configuration without being unstable. The amount of blood collected can be sucked up easily. In addition, the surface treatment with fluorine gas can control the degree of hydrophilization, and can be applied to products of all shapes, and has characteristics such as excellent aging stability. In addition, it is possible to realize a capillary blood sampling device with excellent quality. Furthermore, if the capillary suction tube portion 1 is made of a plastic resin such as transparent or translucent polypropylene, the blood collection status can be easily confirmed.
また毛細管吸引筒部１の後方に形成された中間筒部２には、吸引採血保持孔５の逆テーパー形状面４における反吸い上げ側の内径Ｂと比較して、内径が十分に大きな中間室７が形成されているため、毛細管吸引筒部１の吸い上げ側先端部を血液に接触させると、吸引採血保持孔５に形成された逆テーパー形状面４による毛細管現象によって、血液が吸引採血保持孔５へと効果的に吸い上げることができると同時に、毛細管吸引筒部１の毛細管現象によって吸い上げられた血液は、吸引採血保持孔５は満たすが、中間筒部２側への毛細管現象による吸い上げは殆ど生じない。 An intermediate chamber 7 formed at the rear of the capillary suction tube portion 1 has an intermediate chamber 7 having a sufficiently large inner diameter as compared to the inner diameter B on the anti-sucking side of the reverse tapered surface 4 of the suction blood collection holding hole 5. Therefore, when the tip of the suction side of the capillary suction tube portion 1 is brought into contact with blood, the blood is sucked into the suction blood collection holding hole 5 due to the capillary phenomenon caused by the reverse tapered surface 4 formed in the suction blood collection holding hole 5. At the same time, the blood sucked up by the capillary phenomenon of the capillary suction tube portion 1 fills the suction blood collection holding hole 5, but is almost sucked up by the capillary phenomenon toward the intermediate tube portion 2 side. Absent.
ここで、反吸い上げ側の内径Ｂと比較して十分に内径を大きくした中間室７は、吸引採血保持孔５だけでなく中間室７内にまで積極的に毛細管現象によって血液が吸い込まれることを阻止するためのものであり、内径の増大の程度は適宜設定することができる。こうして吸い上げられた血液は、ほぼ吸引採血保持孔５だけを満たす所定容積の採血量となる。仮に、少量が吸引採血保持孔５から中間室７内に吸引されたとしても、特に問題とはならない。従って、中間筒部２は、採血量に応じて容積を決定する必要はなく、主に取り扱いの面からその長さおよび大きさを決定することができる。 Here, the intermediate chamber 7 having a sufficiently larger inner diameter than the inner diameter B on the anti-sucking side indicates that blood is actively sucked not only into the suction blood collection holding hole 5 but also into the intermediate chamber 7 by capillary action. The degree of increase in the inner diameter can be set as appropriate. The blood sucked up in this way becomes a blood collection amount of a predetermined volume that almost fills only the suction blood collection holding hole 5. Even if a small amount is sucked into the intermediate chamber 7 from the suction blood collection holding hole 5, there is no particular problem. Therefore, it is not necessary to determine the volume of the intermediate tube portion 2 according to the blood collection amount, and the length and size can be determined mainly from the viewpoint of handling.
また、筒状本体は、透明または半透明のポリプロピレンなどのプラスチック樹脂製としているため、逆テーパー形状面４を有する吸引採血保持孔５や中間室７を一体的に簡単に構成することができ、従来のように採血量を決めるために別部材の液状封止用樹脂を配置する必要はなく、その挿入のための加工も不要となり、構成を簡略化することができる。 Moreover, since the cylindrical main body is made of plastic resin such as transparent or translucent polypropylene, the suction blood collection holding hole 5 and the intermediate chamber 7 having the reverse tapered surface 4 can be easily and integrally configured. There is no need to dispose a liquid sealing resin as a separate member in order to determine the blood collection amount as in the conventional case, and processing for the insertion is not required, and the configuration can be simplified.
（実施例１）
キャピラリー採血具（図１に示す形状において、Ａ＝０．９０[ｍｍ]、 Ｂ＝０．６０[ｍｍ]、Ｃ＝４．０[ｍｍ]）をフッ素表面処理容器に入れ、真空ポンプにて減圧した後、フッ素ガス５ｖｏｌ％、酸素ガス９５ｖｏｌ％の混合ガスを導入してキャピラリー採血具全体に接触させた。その後、２０℃で６０分間反応させて親水化処理を行った。
Example 1
A capillary blood collection tool (A = 0.90 [mm], B = 0.60 [mm], C = 4.0 [mm] in the shape shown in FIG. 1) is placed in a fluorine surface treatment container, and a vacuum pump is used. After decompression, a mixed gas of 5 vol% fluorine gas and 95 vol% oxygen gas was introduced and brought into contact with the entire capillary blood sampling device. Then, it was made to react for 60 minutes at 20 degreeC, and the hydrophilic treatment was performed.
（比較例１）
キャピラリー採血具（図１の寸法の箇所を参照して、Ａ＝０．６０[ｍｍ]、 Ｂ＝０．９０[ｍｍ]、Ｃ＝４．０[ｍｍ]としたもの）を実施例１と同じ条件で親水化処理を行った。
(Comparative Example 1)
A capillary blood sampling device (with reference to the dimensions shown in FIG. 1, A = 0.60 [mm], B = 0.90 [mm], C = 4.0 [mm]) and Example 1 Hydrophilic treatment was performed under the same conditions.
（比較例２）
親水化処理を行わなかった以外は実施例１と同じキャピラリー採血具を用いた。
(Comparative Example 2)
The same capillary blood collecting tool as in Example 1 was used except that the hydrophilic treatment was not performed.
（血液吸い上げ速度試験）
以上のキャピラリー採血具について、血液吸い上げ速度試験を行った。吸い上
げ側先端部を血液に接触させ、キャピラリー採血具の毛細管吸引筒部を液面と垂直になるようにした状態で血液が吸引採血保持孔を満たすまでの時間を計測した。結果を表１に示す。
(Blood suction speed test)
A blood suction speed test was performed on the above capillary blood collection tool. The time until the blood filled the suction blood collection holding hole was measured in a state where the tip of the suction side was brought into contact with blood and the capillary suction tube portion of the capillary blood collection device was perpendicular to the liquid surface. The results are shown in Table 1.
表１より吸引採血保持孔の内面が親水化され、かつ内径Ａ、内径Ｂおよび軸長Ｃが適切な範囲内である実施例１が吸い上げ速度が最も速いことが分かった。
１ 毛細管吸引筒部
２ 中間筒部
３ 接続部
４ 逆テーパー形状面
５ 吸引採血保持孔
６ テーパー形状面
７ 中間室
８ 開口
DESCRIPTION OF SYMBOLS 1 Capillary suction cylinder part 2 Intermediate | middle cylinder part 3 Connection part 4 Reverse taper shape surface 5 Suction blood collection holding hole 6 Taper shape surface 7 Intermediate chamber 8 Opening
Claims (1)
前記筒状本体の吸い上げ側先端部に、透明または半透明のプラスチック樹脂製の毛細管吸引筒部が形成され、前記毛細管吸引筒部の内部には、吸引した血液を保持可能な吸引採血保持孔が形成されており、前記吸引採血保持孔は、吸い上げ側から反吸い上げ側に向かって内径が縮小された逆テーパー形状面を有するとともに、少なくとも前記逆テーパー形状内面がフッ素ガスと酸素ガスによる表面処理によって、親水化されていると共に、前記吸引採血保持孔は、吸い上げ側の内径をＡ、反吸い上げ側の内径をＢ、前記吸い上げ側から前記反吸い上げ側までの軸長をＣとしたとき、０．５≦Ａ≦１．５［ｍｍ］、０．４≦Ｂ≦１．４［ｍｍ］、２．０≦Ｃ≦６．０［ｍｍ］であるとして形成し、更に、前記吸引採血保持孔の吸い上げ側の一部に、０．１５〜０．３０［ｍｍ］のＲ面取り加工を施し、更に、前記筒状本体は、前記吸引採血保持孔の前記反吸い上げ側に隣接する位置に中間筒部が形成され、前記中間筒部の内部には、前記吸引採血保持孔の前記反吸い上げ側と連通し、かつ、前記反吸い上げ側の内径Ｂよりも径の大きな中間室を形成したことを特徴としたキャピラリー採血具。
In a capillary blood collection tool having a cylindrical body that sucks blood using capillary action,
A capillary suction cylinder made of transparent or translucent plastic resin is formed at the suction side tip of the cylindrical main body, and a suction blood collection holding hole capable of holding the sucked blood is formed inside the capillary suction cylinder. The suction blood collection holding hole is formed with a reverse tapered surface having an inner diameter reduced from the suction side to the anti-suction side, and at least the reverse tapered inner surface is subjected to surface treatment with fluorine gas and oxygen gas . When the suction blood collection holding hole is A, the inner diameter on the suction side is B, the inner diameter on the counter suction side is B, and the axial length from the suction side to the counter suction side is C. 5 ≦ A ≦ 1.5 [mm], 0.4 ≦ B ≦ 1.4 [mm], 2.0 ≦ C ≦ 6.0 [mm], and further, the suction blood collection holding hole Part of suction side R5 chamfering of 0.15 to 0.30 [mm] is performed, and the cylindrical main body has an intermediate cylindrical portion formed at a position adjacent to the suction side of the suction blood collection holding hole. A capillary blood collecting tool, characterized in that an intermediate chamber is formed inside the cylindrical portion, which communicates with the suction side of the suction blood collection holding hole and has a diameter larger than the inner diameter B of the anti suction side .
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| JP6613026B2 (en) * | 2014-12-22 | 2019-11-27 | 日精株式会社 | Blood collection tool |
| JP2017051459A (en) * | 2015-09-10 | 2017-03-16 | 東洋炭素株式会社 | Cylindrical resin component |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE2848535C2 (en) * | 1978-11-09 | 1982-12-02 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | Blood collection device |
| EP0082263A1 (en) * | 1981-12-10 | 1983-06-29 | The Perkin-Elmer Corporation | Sample introduction for chemical analysis by spectrometry/liquid chromatography |
| JPS5956544U (en) * | 1982-10-05 | 1984-04-13 | 新日本製鐵株式会社 | Suction tube for solution sample analysis |
| JPS6249752U (en) * | 1985-04-30 | 1987-03-27 | ||
| US4707337A (en) * | 1986-08-11 | 1987-11-17 | Multi-Technology, Inc. | Medical micro pipette tips for difficult to reach places and related methods |
| JPS63248404A (en) * | 1987-04-01 | 1988-10-14 | Kuraray Co Ltd | Permeable membrane for red blood corpuscule |
| JPH01276042A (en) * | 1988-04-27 | 1989-11-06 | Fuji Photo Film Co Ltd | Liquid fixed quantity collecting instrument |
| US5260030A (en) * | 1992-06-03 | 1993-11-09 | Bio-Plas, Inc. | Calibrated pipette tip and method |
| US5975153A (en) * | 1998-02-13 | 1999-11-02 | Roche Diagnostics Corporation | Capillary fill test device with improved fluid delivery |
| JP2000232972A (en) * | 1999-02-15 | 2000-08-29 | Daikin Ind Ltd | Sample spot-sticking instrument |
| JP4009683B2 (en) * | 2002-09-26 | 2007-11-21 | アークレイ株式会社 | Method for manufacturing analytical tool |
| EP1667581A1 (en) * | 2003-09-01 | 2006-06-14 | Inverness Medical Switzerland GmbH | Sampling device with capillary action |
| DE10354806A1 (en) * | 2003-11-21 | 2005-06-02 | Boehringer Ingelheim Microparts Gmbh | sample carrier |
| JP2006105849A (en) * | 2004-10-07 | 2006-04-20 | Maruishi Kasei Kk | Saliva/effusion inspection tool |
| JP5698978B2 (en) * | 2008-09-19 | 2015-04-08 | 東洋炭素株式会社 | Method for producing hydrophilized fine particles and hydrophilized fine particles obtained by the method |
| JP6012198B2 (en) * | 2012-02-22 | 2016-10-25 | 日精株式会社 | Capillary blood collection tool |
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