JP5563290B2 - Implant material - Google Patents

Description

  The present invention relates to an implant material. In detail, it is related with the implant material used for an artificial tooth root, an artificial joint, an artificial bone, etc.

In recent years, various studies have been conducted on implant materials such as artificial tooth roots and artificial joints. Among them, an implant material in which a non-woven fabric or a woven fabric made of metal fibers is used as a cell induction layer is known to have a high binding property with an embedded bone, and the binding is performed at an early stage (Patent Document). 1, 2).
However, in recent years, there has been a demand for compactness in order to further improve the strength of the implant material and reduce the burden on the patient. Various studies have been conducted on the arrangement and fixation of the induction layer in the implant material (Patent Document 3).

WO2004 / 012781 WO2006 / 033435 JP-A-5-305132

  An object of the present invention is to provide an implant material such as an artificial tooth root and an artificial joint, which has higher strength and is made compact.

The implant material of the present invention is characterized by comprising a base material and a fibrous body formed by winding a plurality of titanium wires substantially regularly around a part of the outer periphery of the base material.
According to a second aspect of the implant material of the present invention, a first base material having a fitting portion for mechanically coupling with the body, a second base material connected to the first base material, It consists of a cylindrical fibrous body sandwiched between a base material and a second base material, and one of the first base material and the second base material inserts a fibrous body and the shaft portion The first base material and the second base material are connected by having a male part formed at the lower end, the other part having a female part, and inserting the male part into the female part. Yes.

(1) In the implant material of the present invention, a porous space in which a large number of small holes are arranged almost continuously and regularly is formed by a fibrous body in which titanium wires are wound in a regular and multiple manner. As a result, cells enter their regular small pores, and a cell array without defects, particularly hard tissues such as bones, are formed. Furthermore, since the titanium wire is continuously wound around the base material, the base material is reinforced by the titanium wire, and the strength of the implant itself is increased. Moreover, since it is the structure which wound the titanium wire, it is integrated by the structure itself, and it is not necessary to join the whole by sintering etc. like the conventional titanium web thru | or a titanium nonwoven fabric.
(2) Implant material in which the fibrous body is formed by repeatedly winding a titanium wire on the outer periphery of a base material from one side to the other, and then winding the wound wire on the wound layer from the other side to the one side. Then, it can be wound in multiple layers with a single titanium wire and is easy to manufacture. Moreover, since the titanium wire has almost no breaks, the strength is further improved.
(3) The second aspect of the implant material of the present invention includes a first base material having a fitting portion for mechanically coupling with the body, and a second base material connected to the first base material. A cylindrical fiber body sandwiched between the first base material and the second base material, and one of the first base material and the second base material inserts a fiber body and The first base and the second base are connected by having a male part formed at the lower end of the shaft part, the other having a female part, and inserting the male part into the female part. The male part inserted into the female part can be thickened and the strength as an implant material can be improved. Moreover, since the male part is inserted into the female part and the first base material and the second base material are connected, the whole can be shortened. In addition, since the fibrous body formed of fibers has a complicated three-dimensional structure, after implant material is embedded in the body, the cell is highly inductive at that site, and the implant material and the body are bound early. To do.
(4) When any of the above implant materials is formed of a titanium wire having a fiber body diameter of 40 to 100 μm, the fiber body has a three-dimensional structure that is most preferable for the cell. Inductivity is further improved.

FIG. 1A and FIG. 2a and 2b are schematic views showing an example of use of the implant material of the present invention. 3a and 3b are a side view and a part assembly view showing another embodiment of the implant material of the present invention, and FIG. 3c is a part assembly view showing another embodiment of the implant material of the present invention, and FIG. Fig. 3e is a side view showing still another embodiment of the implant material of the present invention, Fig. 3f is a side view showing still another embodiment of the implant material of the present invention. 4a is a perspective view showing still another embodiment of the implant material of the present invention, FIG. 4b is a schematic view showing an application example thereof, FIG. 4c is an end view of the implant material of FIG. 4b, and FIG. It is the schematic which shows the other application example of an implant material.

  The implant material 10 in FIG. 1a is used as an artificial tooth root, and a first base material 11 whose lower part is mechanically coupled to the jawbone, and a second base material 12 connected to the upper end of the first base material 11. And a fibrous body 13 that is mechanically fixed between the first base material 11 and the second base material 12 and induces cells. At the upper end of the implant material 10, a hole 14 for engaging with the attachment is formed downward. The length of the implant material 10 is preferably 5 to 24 mm, particularly preferably 7.2 to 20 mm.

  The first base material 11 in FIG. 1b has a cylindrical shape, and includes a fitting portion 16 having a male screw formed on the outer periphery, and a columnar flange portion 17 provided at the upper end thereof. A central hole 18 is formed downward from the center of the upper surface of the substrate. The length of the first substrate is preferably 2 to 12 mm, particularly preferably 2 to 4 mm.

  The external thread formed on the outer periphery of the fitting portion 16 has a taper of 2.5 or less, especially 1 thread at the tip, and the tip is fan-shaped and cut to 1/12 to 1/4, especially 1/8. It is a tapping screw. However, the tip of the male screw may not be tapered. This male screw has a screw pitch of 0.8 to 1.5 mm, and the number of threads is 1 to 5 threads, particularly 3 threads. The fitting portion 16 is a portion to be embedded in a bone such as a jawbone, and is configured to occupy 20 to 50%, particularly 25 to 40% with respect to the entire length of the implant material 10. Thereby, it can fix firmly to the jawbone or bone to be embedded. In addition, there exists a kind whose outer diameter is 3.3-6.0 mm with an implant material.

The outer diameter of the flange portion 17 is configured to be substantially the same as the outer diameter of the thread of the fitting portion 16.
The center hole 18 has an upper portion 18a having a female screw formed on the upper surface (near the flange portion) of the inner surface, a smaller diameter than the upper portion, the same diameter as the lower end inner diameter of the second base material described later, and the lower end of the attachment. And a lower portion 18b having a bottom portion 18c. That is, the lower end of the center hole 18 is closed. Further, a step portion with which the lower end of the second base material 12 abuts is formed between the upper portion 18a and the lower portion 18b.

  The second base material 12 of FIG. 1b is a cylindrical one in which a through hole 21 penetrating vertically is formed, and a connecting portion 22 screwed into the upper portion 18a of the center hole of the first base material, The shaft portion 23 is provided with an enlarged diameter from the upper end, and the head portion 24 is provided with an enlarged diameter from the upper end. The length of the second substrate 12 is preferably 2 to 20 mm, particularly preferably 2.5 to 10 mm.

The through-hole 21 includes a tapered portion 21a formed in a tapered shape so as to reduce in diameter downward, and a cylindrical portion 21b extending downward from the lower end thereof. By connecting the first base material 11 and the second base material 12, the lower portion 18b of the center hole of the first base material communicates with the cylindrical portion 21b of the through hole 12 of the second base material, and the implant material 10 Hole 14 is formed.
The connecting portion 22 is a cylindrical portion having a male screw threadedly engaged with the female screw of the upper portion 18a of the center hole 18 on the outer periphery. The male screw of this connection part should just be a screw of the 1st base material 11, and a reverse screw, and a pitch, the number of strips, etc. are not specifically limited.

  As the first base material 11 and the second base material 12, titanium having a high biocompatibility, titanium alloy, stainless steel, gold, platinum, cobalt alloy, or the like is used.

  The fibrous body 13 is a substantially cylindrical structure configured by regularly and multiply winding titanium wires around the shaft portion 23 of the second substrate 12. What is necessary is just to wind a titanium wire around the thing which couple | bonded the 1st base material 11 and the 2nd base material 12, and was made into the bobbin shape beforehand. In this case, it is not necessary to join the titanium wires together by sintering or the like. In this configuration, the shape cannot be maintained if the fibrous body 13 is actually removed from the second substrate 12. However, in FIG. 1b, it has shown as an independent component for convenience. In addition, when the 1st base material 11 and the 2nd base material 12 are isolate | separated like the implant material 10 of FIG. 1b, the fiber body 13 of the titanium wire formed cylindrical can also be mounted | worn later. . In that case, after winding a titanium wire around a bar or the like, the fibers are joined by sintering or the like to form a cylindrical shape.

The length of the fiber body 13 is preferably 2 to 20 mm, particularly preferably 2 to 18 mm, and is configured to occupy 20 to 100%, particularly 30 to 80% with respect to the entire implant material 10. In addition, you may make it cover the whole base material with a fibrous body. Thereby, the induction | guidance | derivation of a cell can be performed efficiently so that the whole intensity | strength may not be lost. The titanium wire constituting the fibrous body 13 has an outer diameter of 40 to 100 μm, preferably 50 to 80 μm. Further, it may be rolled and wound as a flat plate material or a strip-like or ribbon-like titanium wire.
The winding pitch of the titanium wire around the second substrate 12 is preferably about 5 to 30 times the wire diameter, that is, about 0.5 to 3 mm. In addition, the winding is performed in multiple layers to form a multiple structure. The fiber body obtained has a porosity of 50 to 90%, preferably 60 to 87%. The pore size is preferably 20 to 500 μm, particularly preferably 100 to 250 μm.

  When winding one titanium wire, for example, the number of layers to be wound from the upper end toward the lower end, when reaching the lower end, winding toward the upper end, and when reaching the upper end, the number of layers to be wound toward the lower end. Just repeat. In the case of winding with a machine, for example, a titanium wire wound around a bobbin is guided toward the periphery of the second base material 12 while being drawn out, and is sequentially wound around the second base material 12 in an aligned state. In this case, a guide for guiding the titanium wire is made to circulate around the second base material 12, or conversely, the second base material 12 is rotated about its own axis. In the meantime, either one or both of the guide for guiding the titanium wire and the second substrate 12 are reciprocated in the axial direction.

  Since it is comprised in this way, the flange part 17 of the 1st base material by connecting the upper part 18a of the center hole of the 1st base material 11 and the connection part 22 of the 2nd base material 12 by screw fitting. And the head 24 of the second base material sandwich the fibrous body 13 and mechanically hold the fibrous body 13. Since this implant material 10 has a connecting portion formed by screw fitting between the first base material 11 and the second base material 12 below the position where the fibrous body is provided (the shaft portion of the second base material), the second base The diameters of the male screw of the material connecting portion 22 and the female screw of the upper portion 18a of the center hole of the first base material can be increased, and the strength of the entire implant material 10 is improved. Moreover, since a part of 2nd base material 12 is inserted and connected to the 1st base material 11, the length of the implant material 10 whole can be made small. In addition, the 1st base material 11 and the 2nd base material 12 can also be made into an integral component from the beginning, without making it a separate component.

This implant material 10 is used as shown in FIG. 2a. First, the implant material (artificial tooth root) 10 is embedded in the jawbone B by surgery. In this case, a male screw with a cutting edge of the fitting portion 16 is screwed into a prepared hole formed in the jawbone B and temporarily fixed. Then, it is left in this state until the implant 10 and the jawbone B are sufficiently combined, that is, until the implant material 10 and the cells in the vicinity of the jawbone are sufficiently combined. At this time, since the implant 10 includes the fibrous body 13, it is possible to induce osteoblasts and the like early. After coupling the implant 10 and the jawbone B, an attachment A (base) for attaching the artificial tooth T is installed. Finally, the artificial tooth T is attached and completed.
Since the implant material 10 includes the fibrous body 13, a firm connection can be obtained even when the fitting portion and the jawbone are relatively shallow. In other words, the fitting portion 16 mainly serves to temporarily fix the fiber body 13 and the cells until the bonding is sufficiently obtained, and thus the length of the fitting portion 16 may be shortened as in the related art. Thereby, the whole length of the implant material 10 can be shortened. Furthermore, since the fiber body 13 is held by being sandwiched between the first base material 11 and the second base material 12, there is no possibility that the fiber body 13 is detached from other components. Further, since the first base material 11 and the second base material 12 are connected with a screw having a relatively large diameter, the fiber body 13 is firmly held between the first base material 11 and the second base material 12. However, the strength is strong against the external force applied in the radial direction.

Although FIG. 1 and FIG. 2a demonstrated the implant material of this invention for using as an artificial tooth root, you may use as an artificial joint (artificial bone) like FIG. 2b. In this case, after the implant material 10 is embedded in the bone B, the artificial joint portion 27 is provided instead of the artificial tooth through an abutment (not shown). An artificial joint may be provided directly without using a connecting tool such as an abutment.
When used as an artificial joint, the implant material 10 is provided with a fibrous body at the joint with the bone. Then respond with a rod.

Next, another embodiment of the present invention will be described.
The implant material 30 of FIG. 3a is sandwiched between a first base material 31 mechanically coupled to the jawbone, a second base material 32 connected to the lower end of the first base material 31, and a cell. It consists of the fiber body 33 which guide | induces. This implant material 10 is also used for an artificial tooth root, and the length is preferably 5 to 24 mm, particularly 7.2 to 20 mm. The fiber body 33 is substantially the same as the fiber body 13 of FIG.

As shown in FIG. 3b, the first base material 31 has a cylindrical shape, a fitting portion 34 having a female screw formed on the outer periphery, a columnar head portion 35 provided at the upper end thereof, and a fitting. The shaft portion 36 is formed at the lower end of the joint portion 34 and the connecting portion 37 is formed at the lower end thereof. A center hole 38 is formed downward from the center of the upper surface of the flange portion 35.
A plurality of titanium wires are wound around the shaft portion 36 to form the fiber body 33 described above. The connecting portion 37 has a cylindrical shape with a male screw formed on the outer periphery, and the size thereof is substantially the same as that of the connecting portion 22 in FIG. The center hole 38 is a part engaged with the lower part of the apartment. The fitting portion 34 is substantially the same as the fitting portion 16 in FIG. 1, and the head portion 35 is substantially the same as the head portion 24 in FIG. 1.

  The second substrate 32 is hemispherical as shown in FIG. 3b. A connecting hole 40 extending downward is formed at the center of the upper surface. The upper surface of the second base material 32 has a larger diameter than the shaft portion 36 of the first base material 31, and prevents the fiber body 33 to be inserted from coming off from the shaft portion 36. A female screw into which the male screw of the connecting portion 37 of the first base material 31 is screwed is formed in the connecting hole 40.

Since it is comprised in this way, the connection part 37 of the 1st base material 31 and the connection hole 40 of the 2nd base material 32 are connected, The fitting part 34 of a 1st base material, and a 2nd base material 32 sandwiches the fibrous body 33 and mechanically holds the fibrous body 33. Since this implant material 30 performs the connection by screw fitting between the first base material 31 and the second base material 32 below the fiber body 33 (position of the fiber body), the connection portion 37 of the first base material. The diameter of the male screw and the female screw of the connection hole of the second base material can be increased, and the strength of the entire implant material 30 is large. Further, since a part of the first base material 31 is connected so as to be inserted into the second base material 32, the entire length of the implant material 30 can be reduced.
The implant material 30 is also for an artificial tooth root, but may be used for an artificial joint (or an artificial bone) as shown in FIG. 2b.

The appearance of the implant material 30a in FIG. 3c after the first base material 41 and the second base material 42 are connected is the implant material 30 in FIG. 3a. As shown in FIG. 3c, the first base material 41 has a cylindrical shape, and includes a fitting portion 46 having a male screw formed on the outer periphery, a columnar head portion 47 provided at the upper end thereof, and a fitting. The connecting portion 48 is formed at the lower end of the joint portion 46, and a through hole 49 is formed downward from the center of the upper surface of the head portion 47. There is no shaft for winding the titanium wire.
The connection part 48 is a cylindrical thing by which the external thread was formed in the outer periphery, and the structure is substantially the same as the connection part 22 of FIG. The through hole 49 is a hole penetrating the first base material 41, and is a part into which the lower part of the attachment is inserted. The fitting portion 46 is substantially the same as the fitting portion 16 in FIG. 1, and the flange portion 47 is substantially the same as the flange portion 17 in FIG.

The 2nd base material 42 consists of the cylindrical axial part 51 which winds a titanium wire, and the hemispherical latching | locking part 52 provided so that the lower end might be closed, as shown in FIG. 3c. A central hole 53 extending downward from the upper end is formed in the shaft portion 51.
The locking part 52 is a hemispherical part and is formed to protrude outward from the lower end of the shaft part 51.
The center hole 53 includes an upper portion 53a in which a female screw is formed on the upper surface of the inner surface, and a lower portion 53b that is the same diameter as the inner diameter of the through hole 49 of the first base material and engages with the lower end of the attachment and is closed.

  Since it is comprised in this way, the connection part 48 of the 1st base material 41 and the upper part 53a of the center hole of the 2nd base material 42 are connected, The fitting part 46 of a 1st base material, and 2nd The base material engaging portion 52 sandwiches the fiber body 43 and mechanically holds the fiber body 43. Since the implant material 30 is connected by screw fitting between the first base material 41 and the second base material 42 at the same position as the fiber body, the male screw and the second screw of the connecting portion 48 of the first base material are used. The diameter of the female screw in the upper part 53a of the center hole of the base material is smaller than that of the implant 10 in FIG. However, since a part of the second base material 52 is connected so as to be inserted into the first base material 51, the entire length of the implant material 10 can be reduced.

The implant material 55 in FIG. 3d is composed of a cylindrical base material 56 and a fibrous body 57 around which a titanium wire is wound. As shown in FIG. 3e, the base material 56 includes a cylindrical shaft portion 56a and a flange portion 56b provided at the upper end thereof, and a fibrous body 57 is provided on the outer periphery of the shaft portion 56a. In this case, the fiber body 57 is not held by the two base materials, but is held by the frictional force between the fiber body 57 wound around the base material 56 and the shaft portion 56a. Alternatively, the base material 56 and the fiber body 57 may be connected, and the fiber body 57 may be fused to the base material 56 by sintering or the like.
The implant material 30 in FIG. 3a, the implant material 30a in FIG. 3c, and the implant material 55 in FIG. 3d all have spherical bases 32, 52, and 56a. As in 56 and 56, the lower end may be flattened, and the fiber body 57 may be provided to the end.
As shown in FIGS. 4a, 4b, 4c, and 4d, the implant material 55 can be used to connect fractured portions or fill bone defects, as shown in FIGS. 4a, 4b, 4c, and 4d. Can be used to

  The implant material 60 of FIG. 4a consists of a flat substrate 61 and a fibrous body 62 composed of a titanium wire wound around the outer periphery thereof. The base material 61 is the same as the first base material 11, the second base material 12, etc. of FIG. 1a except that it is flat, and can be manufactured by substantially the same method. The fibrous body 62 is substantially the same as the fibrous body 13 of FIG. 1a and can be formed in a similar manner. The implant material 60 can be used as a plate to be fixed along with the fractured part or as a bone prosthetic material.

  Further, as shown in FIGS. 4b and 4c, a titanium wire may be directly wound around the fracture portion B1 to form a fibrous body 57, or may be connected to be used as a bone prosthesis material. In this case, the base material is natural bone. Moreover, as shown to FIG. 4 d, the shape of a base material can be prepared previously and it can connect with the defect | deletion part of iliac B2.

A abutment B bone T artificial tooth 10 implant material 11 first base material 12 second base material 13 fiber body 14 hole 16 fitting part 17 flange part 18 center hole 18a upper part 18b lower part 18c bottom part 21 through hole 21a taper part 21b cylinder Part 22 connecting part 23 shaft part 24 head part 24a cylindrical part 24b truncated cone part 27 artificial joint part 30 implant material 31 first base material 32 second base material 33 fiber body 34 fitting part 35 flange part 36 shaft part 37 connecting part 38 Center hole 39 Locking portion 40 Connection hole 41 First base material 42 Second base material
43 Fiber body 46 Fitting part 47 Flange part 48 Connection part 49 Through hole 51 Shaft part 52 Locking part 53 Center hole 53a Upper part 53b Lower part 55 Implant material 56 Base material 56a Shaft part 56b Flange part 57 Fiber body 60 Implant material 61 Base Material 62 Textile

Claims (1)

An implant material comprising a base material and a fibrous body formed by winding a plurality of titanium wires substantially regularly around a part of the outer periphery of the base material, wherein the base material is mechanically coupled to the body. A cylinder having a first base material having a fitting portion for the first base material and a second base material connected to the first base material, and sandwiched between the first base material and the second base material One of the first base material and the second base material has a shaft portion into which the fiber body is inserted and a male portion formed at the lower end of the shaft portion, and the other has a female portion. Then, by inserting the male part into the female part, the first base material and the second base material are connected, and the fibrous body multiplexes one titanium wire directly and regularly on the shaft part. wound, generally cylindrical structure der formed without being sintered, the first substrate includes a fitting portion a male screw is formed on the outer periphery, a cylindrical shape provided at the upper end Franc A center hole is formed downward from the center of the upper surface of the flange portion, and the second base material is provided with a connecting portion screwed into the upper portion of the center hole and a diameter increased from the upper end thereof. The shaft portion and a head portion that is further expanded from the upper end thereof, and by connecting the upper portion of the center hole and the connecting portion by screw fitting, the flange portion, and a head portion that holds across the fiber body, the implant material.

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