JP5435689B2 - catheter - Google Patents

Description

  The present invention relates to a catheter for experimental animals, for example.

  In the development of pharmaceuticals and functional foods, animal experiments are indispensable for evaluating the effectiveness and safety. In the past, samples were administered either orally by free ingestion or by forced oral administration using a sonde, and blood collection was performed from the tail vein or the like.

Conventionally, there has been a drug solution administration catheter having a structure capable of reducing the diameter (see, for example, Patent Document 1). The medicinal solution administration catheter includes a catheter tube having a single lumen, and a balloon bonded to the outer periphery of the distal end of the catheter tube. The catheter tube has a lumen that is narrower in the narrow diameter portion on the distal end side than the communication hole than in the portion other than the small diameter portion.
Japanese Unexamined Patent Publication No. 2004-329552 (first page, FIG. 1 etc.)

  However, the conventional catheter has a problem that a great amount of stress is applied to the experimental animal at the time of sample administration or blood sampling.

The catheter of the first aspect of the invention has a shape with a pointed tip and is connected to the first flexible tubular member having the first flexibility and the first flexible tubular member, A second flexible tubular member having a second degree of softness greater than the first degree of softness and connected to the second flexible tubular member and less soft than the second degree of softness possess a third flexible tubular member having a third degree of flexibility, the inner diameter of said second flexible tubular member, said first flexible tubular member, and said third flexible The catheter is characterized by being larger than the inner diameter of the tubular member .

  With this configuration, sample administration and blood collection can be facilitated, and for example, sample administration and blood collection can be performed accurately without stressing experimental animals.

The present catheter of the second invention, characterized with respect to the first invention, the the second flexible tubular member, that is storing the blood coagulation preventing solution that can prevent coagulation of the blood It is a catheter.

  With this configuration, blood coagulation in the catheter can be prevented.

In addition, the catheter of the third invention is a catheter further comprising a fourth flexible tubular member connected to the third flexible tubular member with respect to the first or second invention. .

  Such a configuration facilitates insertion when inserted into a living body.

Further, the catheter of the fourth invention is a catheter characterized in that blood coagulation preventing liquid is stored in the fourth flexible tubular member, as compared with the third invention.

  With this configuration, blood coagulation in the catheter can be prevented.

Further, the catheter of the fifth invention is a catheter in which each flexible tubular member is connected by a suture thread to any one of the first to fourth inventions.

  With this configuration, an unnecessary load can be prevented from being applied to the living body.

Further, the catheter of the sixth invention is the side of the fourth flexible tubular member that is not connected to the third flexible tubular member, relative to any of the third to fifth inventions. The end portion of the catheter is wider than the central portion, and is a catheter that functions as a stopper.

  With this configuration, the catheter can be fixed when used as a gastric catheter.

Further, in the catheter of the seventh invention, the first flexible tubular member and the third flexible tubular member are made of polyethylene relative to the first or second invention, The second flexible tubular member is a catheter made of silicon.

  With this configuration, the catheter can be easily inserted into the living body.

  According to the catheter of the present invention, for example, sample administration and blood collection can be easily performed.

Hereinafter, embodiments of a catheter and the like will be described with reference to the drawings. In addition, since the component which attached | subjected the same code | symbol in embodiment performs the same operation | movement, description may be abbreviate | omitted again.
(Embodiment 1)

  In the present embodiment, a catheter in which a plurality of members (for example, a first flexible tubular member, a second flexible tubular member, and a third flexible tubular member) are connected is not an end. The flexibility of the inner member (eg, the second flexible tubular member) is that of the end member (eg, the first flexible tubular member and the third flexible tubular member). A catheter that is high compared to the flexibility will be described. In the present embodiment, the inner diameter of the inner member (for example, the second flexible tubular member) is connected to other members (for example, the first flexible tubular member and the third flexible member). A catheter that is larger than the inner diameter of the flexible tubular member will be described. Moreover, in this Embodiment, the catheter which stores the heparin solution in the member (for example, 2nd flexible tubular member) is demonstrated. Further, in the present embodiment, a catheter having a fourth flexible tubular member and storing a heparin solution in the fourth flexible tubular member will be described. In the present embodiment, a catheter in which each member is connected by a suture will be described. Further, in the present embodiment, a catheter in which the end portion of the fourth flexible tubular member is a stopper will be described. The softness is the degree of softness and is equivalent to the hardness. The hardness is the softness degree of the hardness. High (large) flexibility means the same meaning as low (small) hardness.

  FIG. 1 is a cross-sectional view of a catheter in the present embodiment. This catheter is, for example, a portal vein catheter. Hereinafter, the structure of the catheter will be described.

  The catheter also includes a first flexible tubular member 1, a second flexible tubular member 2, a third flexible tubular member 3, a fourth flexible tubular member 4, and a joining means 5. To do.

  The first flexible tubular member 1 is a member inserted into the body of a living body and having a first flexibility. The first flexible tubular member 1 is a tube made of a material having a lower flexibility (harder) than the second flexible tubular member 2, such as polyethylene, and having a hollow inside. That is, the first flexible tubular member 1 is a tubular member having flexibility. Moreover, it is suitable for the 1st flexible tubular member 1 that the front-end | tip has a sharp shape. That is, it is preferable that the distal end of the first flexible tubular member 1 has a cutout portion that is cut out partly (cut obliquely) and is sharp. That is, the tip of the first flexible tubular member 1 is usually in the shape of an injection needle. This shape is easy to insert into the portal vein (see FIG. 2). Further, as shown in FIG. 2, the entire length of the first flexible tubular member 1 is, for example, about 9 mm. Further, of the first flexible tubular member 1, for example, about 2 mm, the second flexible tubular member 2 is inserted into the second flexible tubular member 2. The second flexible tubular member 2 is joined.

  The joining means 5 is, for example, a suture thread. More specifically, the joining means 5 is, for example, a silk suture thread. Moreover, it is suitable that the joining means 5 is a silk suture thread for medical use. Furthermore, when the joining means 5 is a silk suture thread for medical use, the joining means 5 is No. 3 and having a diameter of about 0.20 mm to 0.27 mm.

  When the joining means 5 is a suture thread, as shown in FIG. 2, a part of the first flexible tubular member 1 that has entered a part of the second flexible tubular member 2 is used. It is preferable that the joining means 5 is located approximately in the middle.

  Further, it is preferable that the joining means 5 is provided at a position of about 5 mm from the end of the first flexible tubular member 1 on the side entering the second flexible tubular member 2. It is.

  The inner diameter of the first flexible tubular member 1 is preferably about 0.28 mm, for example. Furthermore, the outer diameter of the first flexible tubular member 1 is preferably about 0.61 mm, for example. In addition, the blood volume in the catheter at the time of blood collection can be decreased by using the 1st flexible tubular member 1 with a small internal diameter.

The second flexible tubular member 2 is connected to the first flexible tubular member 1 and has a second softness greater (softer) than the first softness. The second flexible tubular member 2 is a tube made of, for example, silicone and having a hollow inside. That is, the second flexible tubular member 2 is a tubular member having flexibility. Further, as shown in FIG. 2, the entire length of the second flexible tubular member 2 is, for example, about 50 mm. The inner diameter of the second flexible tubular member 2 is preferably about 0.5 mm, for example. The outer diameter of the second flexible tubular member 2 is preferably about 1.0 mm, for example. In addition, it is preferable to store a blood coagulation preventing liquid (for example, heparin solution) that prevents blood coagulation in the second flexible tubular member 2. By storing the heparin solution, blood coagulation can be prevented. Furthermore, the second flexible tubular member 2 has one end connected to the first flexible tubular member 1 and the other end connected to the third flexible tubular member 3. Note that a flash solution containing an anticoagulant may be used as the blood coagulation preventing liquid.

  The third flexible tubular member 3 is connected to the second flexible tubular member 2 and has a third softness that is smaller (harder) than the second softness. The third flexible tubular member 3 is a tube made of, for example, polyethylene and having a hollow inside. That is, the third flexible tubular member 3 is a tubular member having flexibility. Further, as shown in FIG. 2, the entire length of the third flexible tubular member 3 is, for example, about 550 mm. Further, of the third flexible tubular member 3, for example, about 2 mm, the second flexible tubular member 2 is inserted into the second flexible tubular member 2. The second flexible tubular member 2 is joined.

The fourth flexible tubular member 4 is connected to the third flexible tubular member 3. The fourth flexible tubular member 4 is a tube made of, for example, silicone and having a hollow inside. That is, the fourth flexible tubular member 4 is a tubular member having flexibility. Further, as shown in FIG. 2, the entire length of the fourth flexible tubular member 4 is, for example, about 200 mm. Further, the inner diameter of the fourth flexible tubular member 4 is preferably about 0.5 mm, for example, and the outer diameter is preferably about 1.0 mm, for example. The fourth flexible tubular member 4 is preferably filled with a heparin solution. The heparin solution has a function of preventing blood coagulation in the catheter. Usually, blood collection is performed from the fourth flexible tubular member 4.

  Next, a method for using the catheter will be described.

  First, a case where the catheter is used as a portal vein catheter will be described. The user inserts the distal end of the portal vein catheter (the pointed end of the first flexible tubular member 1) directly into the portal vein, and fixes the portal vein and the catheter in parallel using an instantaneous adhesive. To do.

  Then, the user turns one of the catheters inserted and placed in the portal vein to the back through a subcutaneous tunnel and connects to the swivel through a harness made of a stainless tube and a stainless coil. The swivel can be freely moved by the experimental animal even during sample administration and blood collection, and is shown in FIG.

  In FIG. 3, the swivel includes an injection needle 6, a sealing rubber 7, fixing solder 8, and a syringe barrel 9. The injection needle 6 is preferably an 18G or higher injection needle.

  Next, a case where the tape is used as a gastric catheter will be described. FIG. 4 shows a schematic view of a gastric catheter. FIG. 4A is a perspective view of the gastric catheter. FIG. 4B is a side view of the gastric catheter. FIG. 4C is a top view of the gastric catheter.

  The user heats one of the stomach catheters (vinyl tube) on, for example, a hot plate of about 180 degrees to form a button-like stopper 10 (see FIG. 4). That is, the end portion of the fourth flexible tubular member 4 on the side not connected to the third flexible tubular member is wider than the central portion and functions as a stopper.

  In addition, the user opens a fistula in the stomach with an 18G or more injection needle 6 and inserts a gastric catheter therefrom. Then, the user sutures the periphery of the fistula with a blood vessel suture thread and fixes the catheter. As with the portal vein catheter, the user inserts one of the catheters inserted into the stomach and turns one of the catheters to the back through a subcutaneous tunnel and connects it to the swivel through a harness made of stainless steel tubes and stainless steel coils. The swivel allows the experimental animal to freely move during sample administration and blood collection (see FIG. 3).

  As described above, according to the present embodiment, it is possible to easily administer a sample and collect blood by inserting and placing dedicated catheters in laboratory animals (eg, rats), for example, in the stomach and blood vessels (eg, portal vein). Thus, it is possible to accurately administer the sample and collect blood without applying stress to the experimental animal. More specifically, by using this catheter as, for example, a portal vein catheter, portal blood can be collected over a long period of time without anesthesia and without restraint. Portal vein blood is blood immediately before components absorbed from the small intestine undergo liver metabolism. By collecting portal vein blood, it is possible to directly measure the absorbed component, so that it is possible to measure with higher sensitivity than measurement with whole body blood. Further, if the catheter in the present embodiment is used, blood can be collected without the influence of anesthesia and without applying experimental animal stress. As a result, variation in the dose of the sample is reduced when the sample is administered. Also, reduce variation in intake during blood collection.

  The present invention is not limited to the above-described embodiments, and various modifications are possible, and it goes without saying that these are also included in the scope of the present invention.

  As described above, the catheter according to the present invention has an effect that, for example, sample administration and blood collection can be easily performed, and is useful as a portal vein catheter or the like.

Sectional view of catheter in the present embodiment Cross section of the catheter Cross section of the swivel Schematic diagram of the same stomach catheter

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 1st flexible tubular member 2 2nd flexible tubular member 3 3rd flexible tubular member 4 4th flexible tubular member 5 Joining means 6 Injection needle 7 Sealing rubber 8 Fixing solder 9 Syringe 10 Stopper

Claims (7)

A first flexible tubular member having a pointed tip shape and having a first softness;
A second flexible tubular member connected to the first flexible tubular member and having a second softness greater than the first softness;
Connected to said second flexible tubular member, possess a third flexible tubular member having a second flexibility than flexibility is small third flexibility,
The inner diameter of the second flexible tubular member is
A catheter that is larger than the inner diameter of the first flexible tubular member and the third flexible tubular member . Wherein the second flexible tubular member, the catheter according to claim 1, characterized in that it stores a blood coagulation preventing solution that can prevent coagulation of the blood. The catheter according to claim 1 or 2, further comprising a fourth flexible tubular member connected to the third flexible tubular member. The catheter according to claim 3 , wherein a blood coagulation preventing liquid is stored in the fourth flexible tubular member. The catheter according to any one of claims 1 to 4 , wherein each of the flexible tubular members is connected by a suture thread. The end of the fourth flexible tubular member that is not connected to the third flexible tubular member is:
The catheter according to any one of claims 3 to 5, which is wider than a central portion and functions as a stopper. The first flexible tubular member and the third flexible tubular member are:
Made of polyethylene,
The second flexible tubular member is
The catheter according to claim 1 or 2, wherein the catheter is made of silicone .

Images