JP5237809B2 - 分析装置 - Google Patents
分析装置 Download PDFInfo
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- JP5237809B2 JP5237809B2 JP2008527781A JP2008527781A JP5237809B2 JP 5237809 B2 JP5237809 B2 JP 5237809B2 JP 2008527781 A JP2008527781 A JP 2008527781A JP 2008527781 A JP2008527781 A JP 2008527781A JP 5237809 B2 JP5237809 B2 JP 5237809B2
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- 238000004458 analytical method Methods 0.000 title claims description 35
- 238000005259 measurement Methods 0.000 claims description 64
- 238000012937 correction Methods 0.000 claims description 47
- 239000003153 chemical reaction reagent Substances 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 230000003287 optical effect Effects 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000012491 analyte Substances 0.000 claims description 3
- 238000012360 testing method Methods 0.000 description 28
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 230000008020 evaporation Effects 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 5
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 5
- 101710107035 Gamma-glutamyltranspeptidase Proteins 0.000 description 4
- 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 description 4
- 102000006640 gamma-Glutamyltransferase Human genes 0.000 description 4
- 239000004973 liquid crystal related substance Substances 0.000 description 3
- 108010023302 HDL Cholesterol Proteins 0.000 description 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 208000012826 adjustment disease Diseases 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- IXZISFNWUWKBOM-ARQDHWQXSA-N fructosamine Chemical compound NC[C@@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O IXZISFNWUWKBOM-ARQDHWQXSA-N 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000004420 Creatine Kinase Human genes 0.000 description 1
- 108010042126 Creatine kinase Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00712—Automatic status testing, e.g. at start-up or periodic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00455—Controlling humidity in analyser
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/023—Controlling conditions in casing
- G01N2201/0231—Thermostating
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/023—Controlling conditions in casing
- G01N2201/0238—Moisture monitoring or controlling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/121—Correction signals
- G01N2201/1214—Correction signals for humidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/222—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating moisture content
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Quality & Reliability (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
分析装置Aによる分析の一例として、血液に含まれる特定成分であるALPについての測定結果を表1に示す。表1に示されたデータは、ALPの濃度が異なる2つの検体X,Yのそれぞれについて、導入される空気の条件を変えながら測定したものである。温度センサ22によって測定された温度T、湿度センサ23によって測定された相対湿度Hmによって、水分量Aqが求められている。ALPについては、あらかじめ行われた試験により、上述した補正式の係数a,bが、それぞれa=0.0089、b=0.9037として求められている。この係数a,bに基づいて係数cを算出する。この係数cによって補正前X(X1)、補正前Y(Y1)の測定結果Mdに対して、上述した補正を施した結果得られたものが、補正後X(X2)、補正後Y(Y2)の測定結果Mdrである。
分析装置Aによる分析の他の例として、血液に含まれる特定成分であるUNについての測定結果を表2に示す。UNについては、係数a,bがそれぞれa=−0.0034、b=1.0120である。また、水分量Aqと補正前後の乖離率Esとの関係を図5に示す。
分析装置Aによる分析のさらに他の例として、血液に含まれる特定成分であるGGTについての測定結果を表3に示す。GGTについては、係数a,bがそれぞれa=0.0074、b=0.9306である。また、水分量Aqと補正前後の乖離率Esとの関係を図6に示す。
Claims (6)
- 水分を含む検体を乾燥状態である試薬と反応させるための温度調整反応空間と、
上記検体および上記試薬の反応後の状態に基づいて、上記検体に含まれる特定成分濃度を測定する特定成分濃度測定手段と、
を備えた分析装置であって、
上記温度調整反応空間に含まれる空気に含まれる水分量を直接的または間接的に測定する水分量測定手段と、
上記水分量測定手段による水分量測定結果に基づいて、上記特定成分濃度測定手段による測定結果を補正する補正手段と、
上記温度調整反応空間に導入するための空気を上記分析装置外から吸気する吸気口を備えており、
上記水分量測定手段は、上記吸気口から上記温度調整反応空間に至るまでの経路において、上記空気に含まれる水分量を測定することを特徴とする、分析装置。 - 上記試薬は、上記検体との反応前において乾燥状態とされている、請求項1に記載の分析装置。
- 上記温度調整反応空間内の温度を一定に保つ温度調節手段をさらに備えている、請求項1に記載の分析装置。
- 上記補正手段は、上記空気の水分量を変数とする多項式を用いて、上記特定成分濃度測定手段による測定結果に対する補正を行う、請求項1に記載の分析装置。
- 上記多項式は1次式である、請求項4に記載の分析装置。
- 上記特定成分濃度測定手段は、光学的手法を用いて測定を行う、請求項1に記載の分析装置。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008527781A JP5237809B2 (ja) | 2006-08-04 | 2007-08-02 | 分析装置 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006212849 | 2006-08-04 | ||
JP2006212849 | 2006-08-04 | ||
JP2008527781A JP5237809B2 (ja) | 2006-08-04 | 2007-08-02 | 分析装置 |
PCT/JP2007/065131 WO2008016096A1 (fr) | 2006-08-04 | 2007-08-02 | Méthode et appareil d'analyse |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2008016096A1 JPWO2008016096A1 (ja) | 2009-12-24 |
JP5237809B2 true JP5237809B2 (ja) | 2013-07-17 |
Family
ID=38997270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008527781A Active JP5237809B2 (ja) | 2006-08-04 | 2007-08-02 | 分析装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090311797A1 (ja) |
EP (1) | EP2048498B1 (ja) |
JP (1) | JP5237809B2 (ja) |
CN (1) | CN101501491B (ja) |
WO (1) | WO2008016096A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9726595B2 (en) | 2015-08-17 | 2017-08-08 | Hamamatsu Photonics K.K. | Measurement apparatus |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6134210B2 (ja) * | 2013-06-19 | 2017-05-24 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び自動分析方法 |
WO2018155289A1 (ja) * | 2017-02-24 | 2018-08-30 | パナソニックIpマネジメント株式会社 | 乾燥度センサ |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04507144A (ja) * | 1990-06-04 | 1992-12-10 | ベーリング ダイアグノスティクス インコーポレイテッド | 分析アッセイ |
JPH07218512A (ja) * | 1994-01-28 | 1995-08-18 | Fuji Photo Film Co Ltd | 乾式分析フイルムの保管装置 |
JP2001133406A (ja) * | 1999-11-02 | 2001-05-18 | Ebara Corp | 呈色反応テープ式ガス測定装置を用いたモニタリングシステム |
JP2006125981A (ja) * | 2004-10-28 | 2006-05-18 | Arkray Inc | 分析装置 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US643647A (en) * | 1897-06-12 | 1900-02-20 | F H Farrell | Velocipede. |
US4256694A (en) * | 1978-06-05 | 1981-03-17 | Minnesota Mining And Manufacturing Company | Carbon monoxide monitoring system |
JP3541902B2 (ja) | 1995-06-08 | 2004-07-14 | 富士写真フイルム株式会社 | 化学分析スライド用インキュベータ |
JPH10160669A (ja) * | 1996-10-02 | 1998-06-19 | Satake Eng Co Ltd | 食品の灰分測定方法及び装置 |
JPH1194818A (ja) * | 1997-09-17 | 1999-04-09 | Matsushita Electric Ind Co Ltd | 分析装置 |
SE512283C2 (sv) * | 1999-01-21 | 2000-02-21 | Mincor Ab | Kolorimetrisk koldioxidindikatoranordning |
WO2002016043A1 (en) * | 2000-08-18 | 2002-02-28 | Arkray, Inc. | Centrifugal separator and analyzer with the separator |
-
2007
- 2007-08-02 EP EP07791811A patent/EP2048498B1/en active Active
- 2007-08-02 US US12/376,215 patent/US20090311797A1/en not_active Abandoned
- 2007-08-02 JP JP2008527781A patent/JP5237809B2/ja active Active
- 2007-08-02 CN CN2007800289429A patent/CN101501491B/zh active Active
- 2007-08-02 WO PCT/JP2007/065131 patent/WO2008016096A1/ja active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04507144A (ja) * | 1990-06-04 | 1992-12-10 | ベーリング ダイアグノスティクス インコーポレイテッド | 分析アッセイ |
JPH07218512A (ja) * | 1994-01-28 | 1995-08-18 | Fuji Photo Film Co Ltd | 乾式分析フイルムの保管装置 |
JP2001133406A (ja) * | 1999-11-02 | 2001-05-18 | Ebara Corp | 呈色反応テープ式ガス測定装置を用いたモニタリングシステム |
JP2006125981A (ja) * | 2004-10-28 | 2006-05-18 | Arkray Inc | 分析装置 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9726595B2 (en) | 2015-08-17 | 2017-08-08 | Hamamatsu Photonics K.K. | Measurement apparatus |
Also Published As
Publication number | Publication date |
---|---|
JPWO2008016096A1 (ja) | 2009-12-24 |
EP2048498A4 (en) | 2009-12-30 |
WO2008016096A1 (fr) | 2008-02-07 |
EP2048498B1 (en) | 2012-10-03 |
CN101501491A (zh) | 2009-08-05 |
CN101501491B (zh) | 2012-08-29 |
EP2048498A1 (en) | 2009-04-15 |
US20090311797A1 (en) | 2009-12-17 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |