JP5138612B2 - メトキシポリエチレングリコールチオエステルキレートおよびその使用 - Google Patents

メトキシポリエチレングリコールチオエステルキレートおよびその使用 Download PDF

Info

Publication number
JP5138612B2
JP5138612B2 JP2008555298A JP2008555298A JP5138612B2 JP 5138612 B2 JP5138612 B2 JP 5138612B2 JP 2008555298 A JP2008555298 A JP 2008555298A JP 2008555298 A JP2008555298 A JP 2008555298A JP 5138612 B2 JP5138612 B2 JP 5138612B2
Authority
JP
Japan
Prior art keywords
compound
pharmaceutical composition
pharmaceutically acceptable
acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008555298A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009527474A5 (https=
JP2009527474A (ja
Inventor
カール エイ． シェレンベルク
フランク エイ． ラタンジオ
ジェイムズ シャーファー
Original Assignee
イースタン バージニア メディカル スクール
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イースタン バージニア メディカル スクール filed Critical イースタン バージニア メディカル スクール
Publication of JP2009527474A publication Critical patent/JP2009527474A/ja
Publication of JP2009527474A5 publication Critical patent/JP2009527474A5/ja
Application granted granted Critical
Publication of JP5138612B2 publication Critical patent/JP5138612B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Steroid Compounds (AREA)
JP2008555298A 2006-02-14 2007-02-14 メトキシポリエチレングリコールチオエステルキレートおよびその使用 Expired - Fee Related JP5138612B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77287406P 2006-02-14 2006-02-14
US60/772,874 2006-02-14
PCT/US2007/003682 WO2007095178A2 (en) 2006-02-14 2007-02-14 Methoxypolyethylene glycol thioester chelate and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011177877A Division JP2012031173A (ja) 2006-02-14 2011-08-16 メトキシポリエチレングリコールチオエステルキレートおよびその使用

Publications (3)

Publication Number Publication Date
JP2009527474A JP2009527474A (ja) 2009-07-30
JP2009527474A5 JP2009527474A5 (https=) 2011-09-15
JP5138612B2 true JP5138612B2 (ja) 2013-02-06

Family

ID=38372058

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008555298A Expired - Fee Related JP5138612B2 (ja) 2006-02-14 2007-02-14 メトキシポリエチレングリコールチオエステルキレートおよびその使用
JP2011177877A Pending JP2012031173A (ja) 2006-02-14 2011-08-16 メトキシポリエチレングリコールチオエステルキレートおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011177877A Pending JP2012031173A (ja) 2006-02-14 2011-08-16 メトキシポリエチレングリコールチオエステルキレートおよびその使用

Country Status (8)

Country Link
US (3) US8008347B2 (https=)
EP (2) EP1986631B1 (https=)
JP (2) JP5138612B2 (https=)
CN (1) CN101394844A (https=)
AT (1) ATE552833T1 (https=)
AU (1) AU2007215211B2 (https=)
CA (1) CA2642453A1 (https=)
WO (1) WO2007095178A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1986631B1 (en) 2006-02-14 2012-04-11 Eastern Virginia Medical School Methoxypolyethylene glycol thioester chelate and uses thereof
WO2010035768A1 (ja) * 2008-09-25 2010-04-01 参天製薬株式会社 ポリアルキレングリコールを有効成分として含有する網膜疾患の予防又は治療剤
TWI568453B (zh) * 2011-11-22 2017-02-01 原創生醫股份有限公司 具有螯合型複合微胞之藥物載體及其應用
JP6086576B2 (ja) * 2012-04-24 2017-03-01 公立大学法人首都大学東京 抗酸化剤
WO2018236221A2 (en) * 2017-06-03 2018-12-27 Can Holding B.V. Neurodegenerative peptide deposit dissolution

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
JP2722250B2 (ja) 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
JPH0680964A (ja) * 1991-12-27 1994-03-22 Sogo Yatsukou Kk 活性酸素消去剤
EP0955044B1 (en) * 1995-06-26 2005-11-16 Chelator LLC Method of inhibiting bacterial or fungal growth using a complexing agent
AU7454796A (en) 1995-10-20 1997-05-07 Eastern Virginia Medical School Chelate derivatives as protectors against tissue injury
US6020373A (en) * 1995-10-20 2000-02-01 Eastern Virginia Medical School Chelate derivatives as protectors against tissue injury
NZ540885A (en) * 2002-12-20 2009-02-28 Chakshu Res Inc Ophthalmic formulation for the prevention and treatment of ocular conditions
EP1986631B1 (en) * 2006-02-14 2012-04-11 Eastern Virginia Medical School Methoxypolyethylene glycol thioester chelate and uses thereof

Also Published As

Publication number Publication date
CA2642453A1 (en) 2007-08-23
US20080039524A1 (en) 2008-02-14
EP1986631A4 (en) 2010-10-27
EP1986631A2 (en) 2008-11-05
JP2012031173A (ja) 2012-02-16
CN101394844A (zh) 2009-03-25
WO2007095178A3 (en) 2008-04-17
WO2007095178A2 (en) 2007-08-23
US7388028B2 (en) 2008-06-17
EP2428234A1 (en) 2012-03-14
US8008347B2 (en) 2011-08-30
US20120016030A1 (en) 2012-01-19
ATE552833T1 (de) 2012-04-15
US20090306205A1 (en) 2009-12-10
US8796336B2 (en) 2014-08-05
JP2009527474A (ja) 2009-07-30
AU2007215211B2 (en) 2010-08-26
EP1986631B1 (en) 2012-04-11
AU2007215211A1 (en) 2007-08-23

Similar Documents

Publication Publication Date Title
EP1313695B1 (en) Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
AU2014340182B2 (en) Cromolyn derivatives and related methods of imaging and treatment
JP6762094B2 (ja) 薬剤のデリバリーのためのジスルフィド化合物
US6184249B1 (en) Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
SK76894A3 (en) Pyropheophorbides and their use in photodynamic therapy
JP7202314B2 (ja) ウイルスベースの治療薬と修飾ポリ（β－アミノエステル）との複合体
JP5138612B2 (ja) メトキシポリエチレングリコールチオエステルキレートおよびその使用
US20190210969A1 (en) Intraesophageal administration of targeted nitroxide agents for protection against ionizing irradiation-induced esophagitis
US20150265549A1 (en) Stable aqueous formulation of (e)-4-carboxystyryl-4-chlorobenzyl sulfone
JP2019523260A (ja) キラルペプチド
EP1981862B1 (en) Lanthionine-related compounds for the treatment of inflammatory diseases
CN101522692A (zh) 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
ES3002189T3 (en) Para-hydroquinone derivatives as vegf, tnf and/or il inhibitors for the treatment of neuroinflammatory diseases
CZ300455B6 (cs) Stabilní diester, farmaceutický prostredek jej obsahující a jeho použití
CN115894281B (zh) 阳离子脂质化合物、其制备方法、组合物及应用
EP1289945B1 (en) Aniline disulfide derivatives for treating allergic diseases
EP3866773A1 (en) Carbon monoxide prodrugs for the treatment of medical disorders
WO2010056710A1 (en) Compositions and methods for treating eye diseases
EP0621779B1 (fr) Lysinate d'indomethacine pour l'utilisation therapeutique en ophtalmologie
HK1050677B (en) Aniline disulfide derivatives for treating allergic diseases

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100126

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110729

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120611

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120911

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20121024

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20121114

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20151122

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees