JP5033642B2 - マイクロ流体処理デバイス - Google Patents
マイクロ流体処理デバイス Download PDFInfo
- Publication number
- JP5033642B2 JP5033642B2 JP2007553713A JP2007553713A JP5033642B2 JP 5033642 B2 JP5033642 B2 JP 5033642B2 JP 2007553713 A JP2007553713 A JP 2007553713A JP 2007553713 A JP2007553713 A JP 2007553713A JP 5033642 B2 JP5033642 B2 JP 5033642B2
- Authority
- JP
- Japan
- Prior art keywords
- sample
- microfluidic
- microfluidic device
- holder
- pipette tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012545 processing Methods 0.000 claims abstract description 61
- 238000006243 chemical reaction Methods 0.000 claims abstract description 29
- 238000004458 analytical method Methods 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 4
- 238000000926 separation method Methods 0.000 claims description 21
- 230000003287 optical effect Effects 0.000 claims description 15
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 229920006254 polymer film Polymers 0.000 claims description 2
- 238000011068 loading method Methods 0.000 abstract description 28
- 239000000523 sample Substances 0.000 description 148
- 239000000499 gel Substances 0.000 description 40
- 238000012360 testing method Methods 0.000 description 33
- 238000000034 method Methods 0.000 description 26
- 238000003860 storage Methods 0.000 description 14
- 230000007246 mechanism Effects 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 230000005855 radiation Effects 0.000 description 11
- 238000001514 detection method Methods 0.000 description 10
- 239000011521 glass Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 239000000872 buffer Substances 0.000 description 9
- 230000033001 locomotion Effects 0.000 description 8
- 230000006835 compression Effects 0.000 description 6
- 238000007906 compression Methods 0.000 description 6
- 238000001962 electrophoresis Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 238000003384 imaging method Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 239000003086 colorant Substances 0.000 description 4
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 4
- 229960005542 ethidium bromide Drugs 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000001502 gel electrophoresis Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000007704 wet chemistry method Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 101150057615 Syn gene Proteins 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009149 molecular binding Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Robotics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Surgical Instruments (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Description
超高純度の脱塩水供給、
大量供給ボトル入りの緩衝剤試薬、
化学染色液又は染料、
ゲル粉末、
ゲル調製のための実験室のガラス器械、
ゲル調製(粉末を緩衝剤と混ぜる)のための加熱・攪拌装置、
ゲルタンク及びその付属品全て、
電源ユニット、
試料ロードピペット、
ゲル内の蛍光色素を活性化できるように、処理されたゲルがその上に搬送されるライトボックス、及び
その最も基本的な配置が、ライトボックスに対する対光性の配置に適合させることができる金属フードに取り付けられたインスタントカメラである、ゲルカメラ。
使用者がその中にゲルマトリックスを形成できる剛体のゲル板、
複数のプレキャスト又は自製ゲルを同時に処理できるが、多くのハンドリング及び湿式化学調製を要するゲルタンク、
ゲルタンク又は緩衝剤が不要であるプレキャストゲル、例えばインビトロジェン・コーポレーション(Invitrogen Corporation)により提供される「イーゲル(E‐Gel(商標))」システム(米国特許第5,582,702号及び第5,865,924号参照)。
さまざまな異なる標準実験用容器の種類において使用者が試料をロードできるようにすること、
微小規模の分離デバイスを使用して、ジュール加熱の危険性なく分子の分離を迅速化すること、
試料のスループットの改善を導く高度に並列な試験を達成すること、
使用される試薬及びテスト試料の量(従ってコスト)を低減すること、
処理を自動化して処理ステップを統合し使用者の介入を最小にすること、
非常に小さい設置面積によりこれらの改善を達成すること、
伝統的なスラブゲル処理にコストで競合できる方法で上記の全てを達成すること。
分別、単離、又は精製を含む試料調製、
ポリメラーゼ鎖反応、
生体分子分離、
親和力による分子結合、
任意の反応最終生成物の単離、
任意の反応最終生成物の回収。
‐低イオン強度緩衝剤で希釈され、グリセロールと混合された試料をロードし、それによって、ロードされた試料が重力下で上側キャビティ11の下端に沈むことによって可能になる。
‐カソード12とアノード16との間に低電圧DC電位(例えば10ボルト)を印加することにより、DNA試料が、ゲル表面15の上部に迅速に移動することになる。この方法は、不連続な緩衝剤を使用により積み重ねる、既に知られた方法である。この電圧によるゲルへの試料の移動は、5〜30秒の範囲内とすることができる積み重ね持続時間の間、(ゲルのイオン強度が高くなっているために)大きく遅延する。
‐例えば120〜200ボルトの範囲内の非常に高いレベルに電圧を切り替え、積み重ねた試料をゲルに入れて分離する。長さが20mmの分離カラムにより、標準的には60〜75秒で濃度0.8%のアガロースゲルを使用する際、25〜2000塩基対の範囲内のDNA試料の分離が可能になるだろう。
好適にはスクリーン印刷とすることができるが、インクジェット、ホットフォイル、フレキソ印刷又はその他同様の印刷技術とすることもできる処理により、電極12、13、16と同時に適用できる基準マークの実施形態、及び
器械を往復するマイクロ流体デバイスのロード及びアンロードの間、ハンドリングタブとして使用でき、また、デバイスの種類、使用期限、バッチコードによる使用等の有益なデータが組み込まれているので、このデータを1D又は2Dバーコードの形態とすることができる識別ラベルとしても使用できる側面ラベルの実施形態、である。
電極12、16の間に低DC電圧で(標準的には2V〜10Vの範囲内で)約20秒間電圧を印加し、ゲルの上面にテスト試料19を積み重ねる、
電極12、13の間に(標準的には150Vで20秒間)電圧を印加し、それにより、上側キャビティ11にある残りの任意のテスト試料19の、具体的には炭素からなる電極13への吸光度を生じさせ、従ってDNAの吸光度が高くなる(従って、残りの物質が吸収されることから、後続の分離過程の間、この上側キャビティ11内の残りのDNAにより汚れることが回避される)、及び、電極12、16の間に(標準的には150Vで60秒間)電圧を印加し、テスト試料19をキャピラリチャネル14内で動電学的に移動させ分離する、ことである。
Claims (7)
- 反応チャンバと、
穿通可能な材料を備えたキャリア層と、
試料を内部に注入可能な試料ロードチャンバと、
穿通可能な処理層と、
過剰分キャビティと
を備え、
前記試料ロードチャンバは、前記試料ロードチャンバに動作可能に接続された前記反応チャンバと、前記穿通可能な処理層との間に形成され、
前記過剰分キャビティは前記穿通可能な処理層と前記キャリア層との間の空間に形成され、いかなるあふれた分も受け入れるように構成されている、
マイクロ流体処理デバイス。 - 前記キャリア層及び前記穿通可能な処理層が、積層構造の部品である、請求項1に記載のマイクロ流体処理デバイス。
- 前記反応チャンバが分子分離媒体を含む、請求項1に記載のマイクロ流体処理デバイス。
- 前記キャリア層及び/又は前記穿通可能な処理層が、高分子フィルムから製造されている、請求項3に記載のマイクロ流体処理デバイス。
- 前記反応チャンバに対して既知の位置を有する光学的基準マークを含み、該光学的基準マークは、反応過程の位置を正確に識別するために分析器械の検出手段によって取得することができる、請求項3に記載のマイクロ流体処理デバイス。
- 前記反応チャンバがチャネルである、請求項3に記載のマイクロ流体処理デバイス。
- 前記マイクロ流体処理デバイスが、前記試料ロードチャンバから離れた前記反応チャネルの端部に、受けチャンバをさらに含む、請求項6に記載のマイクロ流体処理デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0502556.4A GB0502556D0 (en) | 2005-02-08 | 2005-02-08 | Analysis instrument |
GB0502556.4 | 2005-02-08 | ||
PCT/GB2006/000444 WO2006085071A2 (en) | 2005-02-08 | 2006-02-08 | Analysis instrument for processing a microfluidic device |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008530524A JP2008530524A (ja) | 2008-08-07 |
JP5033642B2 true JP5033642B2 (ja) | 2012-09-26 |
Family
ID=34355949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007553713A Active JP5033642B2 (ja) | 2005-02-08 | 2006-02-08 | マイクロ流体処理デバイス |
Country Status (11)
Country | Link |
---|---|
US (1) | US8101137B2 (ja) |
EP (2) | EP1855802B1 (ja) |
JP (1) | JP5033642B2 (ja) |
KR (1) | KR20080009055A (ja) |
CN (1) | CN101128262B (ja) |
AT (1) | ATE551119T1 (ja) |
AU (2) | AU2006212089B2 (ja) |
CA (1) | CA2597003C (ja) |
GB (2) | GB0502556D0 (ja) |
IL (1) | IL184846A0 (ja) |
WO (1) | WO2006085071A2 (ja) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9278321B2 (en) * | 2006-09-06 | 2016-03-08 | Canon U.S. Life Sciences, Inc. | Chip and cartridge design configuration for performing micro-fluidic assays |
DE102006061815A1 (de) | 2006-12-21 | 2008-06-26 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Wechselarmatur |
GB2445739A (en) | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Polymeric laminates containing heat seals |
TWI537203B (zh) * | 2007-11-27 | 2016-06-11 | 惠普研發公司 | 製備滴定系列之技術 |
US8174347B2 (en) | 2010-07-12 | 2012-05-08 | Correlated Magnetics Research, Llc | Multilevel correlated magnetic system and method for using the same |
US9105380B2 (en) | 2008-04-04 | 2015-08-11 | Correlated Magnetics Research, Llc. | Magnetic attachment system |
US8816805B2 (en) | 2008-04-04 | 2014-08-26 | Correlated Magnetics Research, Llc. | Magnetic structure production |
US8279032B1 (en) | 2011-03-24 | 2012-10-02 | Correlated Magnetics Research, Llc. | System for detachment of correlated magnetic structures |
US8760250B2 (en) | 2009-06-02 | 2014-06-24 | Correlated Magnetics Rsearch, LLC. | System and method for energy generation |
US9202616B2 (en) | 2009-06-02 | 2015-12-01 | Correlated Magnetics Research, Llc | Intelligent magnetic system |
US8576036B2 (en) | 2010-12-10 | 2013-11-05 | Correlated Magnetics Research, Llc | System and method for affecting flux of multi-pole magnetic structures |
US7800471B2 (en) | 2008-04-04 | 2010-09-21 | Cedar Ridge Research, Llc | Field emission system and method |
US8717131B2 (en) | 2008-04-04 | 2014-05-06 | Correlated Magnetics Research | Panel system for covering a glass or plastic surface |
US9202615B2 (en) | 2012-02-28 | 2015-12-01 | Correlated Magnetics Research, Llc | System for detaching a magnetic structure from a ferromagnetic material |
US8368495B2 (en) | 2008-04-04 | 2013-02-05 | Correlated Magnetics Research LLC | System and method for defining magnetic structures |
US8760251B2 (en) | 2010-09-27 | 2014-06-24 | Correlated Magnetics Research, Llc | System and method for producing stacked field emission structures |
US8779879B2 (en) | 2008-04-04 | 2014-07-15 | Correlated Magnetics Research LLC | System and method for positioning a multi-pole magnetic structure |
US8179219B2 (en) | 2008-04-04 | 2012-05-15 | Correlated Magnetics Research, Llc | Field emission system and method |
US9371923B2 (en) | 2008-04-04 | 2016-06-21 | Correlated Magnetics Research, Llc | Magnetic valve assembly |
US8937521B2 (en) | 2012-12-10 | 2015-01-20 | Correlated Magnetics Research, Llc. | System for concentrating magnetic flux of a multi-pole magnetic structure |
US8917154B2 (en) | 2012-12-10 | 2014-12-23 | Correlated Magnetics Research, Llc. | System for concentrating magnetic flux |
JP2012525591A (ja) * | 2009-04-27 | 2012-10-22 | プロテイン・デイスカバリー・インコーポレーテツド | プログラム可能な電気泳動ノッチフィルターシステムと方法 |
US9404776B2 (en) | 2009-06-02 | 2016-08-02 | Correlated Magnetics Research, Llc. | System and method for tailoring polarity transitions of magnetic structures |
US8704626B2 (en) | 2010-05-10 | 2014-04-22 | Correlated Magnetics Research, Llc | System and method for moving an object |
US9257219B2 (en) | 2012-08-06 | 2016-02-09 | Correlated Magnetics Research, Llc. | System and method for magnetization |
US9275783B2 (en) | 2012-10-15 | 2016-03-01 | Correlated Magnetics Research, Llc. | System and method for demagnetization of a magnetic structure region |
US20140111296A1 (en) * | 2012-10-24 | 2014-04-24 | Correlated Magnetics Research, Llc | System and method for producing magnetic structures |
GB2472236A (en) * | 2009-07-29 | 2011-02-02 | Iti Scotland Ltd | Apparatus for analysing microfluidic devices |
US9711268B2 (en) | 2009-09-22 | 2017-07-18 | Correlated Magnetics Research, Llc | System and method for tailoring magnetic forces |
DE102010015161B4 (de) | 2010-04-16 | 2014-03-13 | Technische Universität Dresden | Mikrofluidiksystem und Verfahren zu dessen Betreiben |
USD869308S1 (en) | 2010-04-29 | 2019-12-10 | Sony Corporation | Micro flow channel chip |
USD673286S1 (en) | 2010-04-29 | 2012-12-25 | Sony Corporation | Micro flow channel chip |
USD673287S1 (en) | 2010-11-24 | 2012-12-25 | Sony Corporation | Micro flow channel chip |
CN102918387B (zh) | 2010-05-21 | 2017-05-24 | 安捷伦科技有限公司 | western印迹分析技术 |
GB201008516D0 (en) | 2010-05-21 | 2010-07-07 | Lab901 Ltd | Extraction |
KR20130029128A (ko) * | 2010-07-23 | 2013-03-21 | 베크만 컬터, 인코포레이티드 | 실시간 pcr용 용기 |
US8638016B2 (en) | 2010-09-17 | 2014-01-28 | Correlated Magnetics Research, Llc | Electromagnetic structure having a core element that extends magnetic coupling around opposing surfaces of a circular magnetic structure |
US8702437B2 (en) | 2011-03-24 | 2014-04-22 | Correlated Magnetics Research, Llc | Electrical adapter system |
WO2012142306A2 (en) | 2011-04-12 | 2012-10-18 | Sarai Mohammad | Magnetic configurations |
US9140666B2 (en) | 2012-03-15 | 2015-09-22 | Advanced Analytical Technologies, Inc. | Capillary electrophoresis system |
US9297817B2 (en) * | 2011-05-13 | 2016-03-29 | Actrace, Llc | Methods and systems for automated pipette tracking |
ES2870874T3 (es) | 2011-05-18 | 2021-10-27 | Diasorin S P A | Sistemas y métodos para detectar la presencia de un volumen seleccionado de material en un dispositivo de procesamiento de muestra |
US8963380B2 (en) | 2011-07-11 | 2015-02-24 | Correlated Magnetics Research LLC. | System and method for power generation system |
US9219403B2 (en) | 2011-09-06 | 2015-12-22 | Correlated Magnetics Research, Llc | Magnetic shear force transfer device |
US8848973B2 (en) | 2011-09-22 | 2014-09-30 | Correlated Magnetics Research LLC | System and method for authenticating an optical pattern |
US11016057B2 (en) | 2012-03-15 | 2021-05-25 | Agilent Technologies, Inc. | Pulse-field multiplex capillary electrophoresis system |
US11340191B2 (en) | 2012-03-15 | 2022-05-24 | Agilent Technologies, Inc. | UV-absorbance multichannel capillary electrophoresis system |
US9245677B2 (en) | 2012-08-06 | 2016-01-26 | Correlated Magnetics Research, Llc. | System for concentrating and controlling magnetic flux of a multi-pole magnetic structure |
EP2906928A4 (en) | 2012-10-15 | 2016-11-09 | Nanocellect Biomedical Inc | SYSTEMS, APPARATUS AND METHODS FOR SORTING PARTICLES |
US9298281B2 (en) | 2012-12-27 | 2016-03-29 | Correlated Magnetics Research, Llc. | Magnetic vector sensor positioning and communications system |
AU2013202805B2 (en) * | 2013-03-14 | 2015-07-16 | Gen-Probe Incorporated | System and method for extending the capabilities of a diagnostic analyzer |
KR102126032B1 (ko) * | 2013-07-31 | 2020-07-08 | 삼성전자주식회사 | 다채널 형광 검출 모듈 및 이를 포함하는 핵산 분석 시스템 |
US10428374B2 (en) * | 2013-10-04 | 2019-10-01 | Kimantech, Llc | Liquid dispensing device |
JP6603675B2 (ja) | 2014-06-18 | 2019-11-06 | スカンジナビアン マイクロ バイオデバイシズ エイピーエス | マイクロ流体検出システム及びマイクロ流体カートリッジ |
US10078778B2 (en) * | 2015-01-15 | 2018-09-18 | Massachusetts Institute Of Technology | Systems, methods, and apparatus for in vitro single-cell identification and recovery |
CN107923923B (zh) * | 2015-07-29 | 2020-11-03 | 株式会社日立高新技术 | 自动分析装置 |
US10444184B2 (en) | 2015-12-28 | 2019-10-15 | International Business Machines Corporation | Operation of diagnostic devices involving microchannels and electrodes |
WO2019005907A1 (en) | 2017-06-27 | 2019-01-03 | Advanced Analytical Technologies, Inc. | PULSED FIELD MULTIPLEX CAPILLARY ELECTROPHORESIS SYSTEM |
EP3444603B1 (en) | 2017-08-15 | 2024-08-07 | Agilent Technologies, Inc. | Improved uv-absorbance multichannel capillary electrophoresis system |
CN108080054B (zh) * | 2017-12-22 | 2020-02-28 | 青岛大学附属医院 | 一种生物实验用的工具盘 |
CN108424845B (zh) * | 2018-01-24 | 2021-07-13 | 北京博奥晶典生物技术有限公司 | 一种易检的SNP/InDel分型检测系统及使用方法 |
WO2019177589A1 (en) * | 2018-03-13 | 2019-09-19 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
EP3608676B1 (de) * | 2018-08-08 | 2022-01-19 | CTC Analytics AG | Einfüllen der probe in den pipettenspitzenbehälter zur weiteren bearbeitung |
CN113841053B (zh) * | 2018-08-09 | 2024-05-28 | 港大科桥有限公司 | 用于将流体样本自动化处理成微流体液滴以用于体外诊断的系统 |
KR102212748B1 (ko) * | 2019-07-31 | 2021-02-04 | 국방과학연구소 | 소형 생물입자 식별장치 |
KR20220114061A (ko) * | 2019-12-27 | 2022-08-17 | 주식회사 씨젠 | 이동 가능한 용액셔틀을 포함하는 샘플 처리용 카트리지 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954237A (en) | 1987-03-16 | 1990-09-04 | Helena Laboratories | Automatic electrophoresis apparatus |
US5147522A (en) | 1987-03-16 | 1992-09-15 | Helena Laboratories Corporation | Automatic electrophoresis apparatus and method |
US5284570A (en) | 1991-06-26 | 1994-02-08 | Ppg Industries, Inc. | Fluid sample analyte collector and calibration assembly |
JPH0545363A (ja) * | 1991-08-19 | 1993-02-23 | Fuji Photo Film Co Ltd | 生化学分析フイルム用収容箱 |
JPH055734A (ja) * | 1991-08-22 | 1993-01-14 | Fuji Photo Film Co Ltd | 生化学分析装置 |
GB9219657D0 (en) | 1992-09-17 | 1992-10-28 | Unilever Plc | Tagged articles |
US5582702A (en) | 1995-04-26 | 1996-12-10 | Ethrog Biotechnology Ltd. | Apparatus and method for electrophoresis |
US6156565A (en) * | 1996-02-21 | 2000-12-05 | Biomerieux, Inc. | Incubation station for test sample cards |
JP3661320B2 (ja) * | 1996-11-19 | 2005-06-15 | 株式会社島津製作所 | マイクロチップ電気泳動装置 |
US6207031B1 (en) | 1997-09-15 | 2001-03-27 | Whitehead Institute For Biomedical Research | Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device |
US6787111B2 (en) | 1998-07-02 | 2004-09-07 | Amersham Biosciences (Sv) Corp. | Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis |
US6132582A (en) * | 1998-09-14 | 2000-10-17 | The Perkin-Elmer Corporation | Sample handling system for a multi-channel capillary electrophoresis device |
JP2001108619A (ja) * | 1999-10-12 | 2001-04-20 | Minolta Co Ltd | 分析装置、試料操作針および試料取り出し方法 |
CA2387064A1 (en) * | 1999-10-22 | 2001-05-03 | Torlief Ove Bjornson | Sealing for microfluidic devices |
GB0128350D0 (en) | 2001-11-27 | 2002-01-16 | Lab901 Ltd | Non-rigid apparatus for microfluidic applications |
US7241420B2 (en) * | 2002-08-05 | 2007-07-10 | Palo Alto Research Center Incorporated | Capillary-channel probes for liquid pickup, transportation and dispense using stressy metal |
JP2004101293A (ja) * | 2002-09-06 | 2004-04-02 | Fuji Kiki Kogyo Kk | 自動分析機器 |
EP1403644A1 (en) * | 2002-09-25 | 2004-03-31 | Agilent Technologies Inc. a Delaware Corporation | Fluid analyzer |
JP2004243455A (ja) * | 2003-02-13 | 2004-09-02 | Pentax Corp | ラボオンアチップおよびその製造方法 |
DE10307227A1 (de) * | 2003-02-14 | 2004-08-26 | Cytocentrics Ccs Gmbh | Verfahren und Vorrichtung zum Kontaktieren einer Mikrofluidstruktur |
DE10330804A1 (de) * | 2003-07-08 | 2005-04-28 | Fresenius Medical Care De Gmbh | Einwegkassette |
US20050220675A1 (en) * | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
US7570443B2 (en) * | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
US7578978B2 (en) * | 2003-10-28 | 2009-08-25 | BIOMéRIEUX, INC. | Carrier for holding test samples |
EP1756586B1 (en) * | 2004-05-21 | 2014-07-09 | Caliper Life Sciences, Inc. | Automated system for handling microfluidic devices |
-
2005
- 2005-02-08 GB GBGB0502556.4A patent/GB0502556D0/en not_active Ceased
-
2006
- 2006-02-08 GB GB0602570A patent/GB2422796A/en not_active Withdrawn
- 2006-02-08 CN CN2006800042686A patent/CN101128262B/zh active Active
- 2006-02-08 EP EP06709682.6A patent/EP1855802B1/en active Active
- 2006-02-08 JP JP2007553713A patent/JP5033642B2/ja active Active
- 2006-02-08 US US11/815,852 patent/US8101137B2/en active Active
- 2006-02-08 CA CA2597003A patent/CA2597003C/en active Active
- 2006-02-08 AT AT10158213T patent/ATE551119T1/de active
- 2006-02-08 EP EP10158213A patent/EP2206554B1/en active Active
- 2006-02-08 WO PCT/GB2006/000444 patent/WO2006085071A2/en active Application Filing
- 2006-02-08 AU AU2006212089A patent/AU2006212089B2/en not_active Ceased
- 2006-02-08 KR KR1020077020622A patent/KR20080009055A/ko not_active Application Discontinuation
-
2007
- 2007-07-26 IL IL184846A patent/IL184846A0/en unknown
-
2010
- 2010-05-25 AU AU2010202112A patent/AU2010202112B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2206554B1 (en) | 2012-03-28 |
KR20080009055A (ko) | 2008-01-24 |
ATE551119T1 (de) | 2012-04-15 |
CN101128262A (zh) | 2008-02-20 |
IL184846A0 (en) | 2007-12-03 |
AU2006212089A1 (en) | 2006-08-17 |
WO2006085071A3 (en) | 2006-12-21 |
EP1855802B1 (en) | 2015-06-17 |
US8101137B2 (en) | 2012-01-24 |
US20100126857A1 (en) | 2010-05-27 |
WO2006085071A2 (en) | 2006-08-17 |
GB2422796A (en) | 2006-08-09 |
AU2006212089B2 (en) | 2010-02-25 |
EP2206554A1 (en) | 2010-07-14 |
GB0602570D0 (en) | 2006-03-22 |
JP2008530524A (ja) | 2008-08-07 |
CA2597003C (en) | 2011-11-29 |
CA2597003A1 (en) | 2006-08-17 |
GB0502556D0 (en) | 2005-03-16 |
AU2010202112A1 (en) | 2010-06-17 |
CN101128262B (zh) | 2012-09-05 |
EP1855802A2 (en) | 2007-11-21 |
AU2010202112B2 (en) | 2012-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5033642B2 (ja) | マイクロ流体処理デバイス | |
EP2586861B1 (en) | Composition for preventing evaporation of reaction solution during nucleic acid amplification reaction | |
EP2017007A2 (en) | Chemical analysis device | |
EP2847135B1 (en) | Capillary electrophoresis system | |
EP2615160A1 (en) | Reaction vessel and reaction controller | |
JPH1164277A (ja) | 電気泳動分析装置及びそれに用いる試料容器 | |
EP2993466B1 (en) | Electrophoresis device | |
US20220155256A1 (en) | Capillary electrophoresis system | |
EP3444603B1 (en) | Improved uv-absorbance multichannel capillary electrophoresis system | |
WO2017159084A1 (ja) | 電気泳動チップ、電気泳動装置、及び電気泳動システム | |
WO1994026396A1 (en) | Application specific capillary electrophoresis | |
US7261800B1 (en) | Automatic in situ electrophoresis method and apparatus | |
KR20220114061A (ko) | 이동 가능한 용액셔틀을 포함하는 샘플 처리용 카트리지 | |
JPH11326340A (ja) | サンプル処理ユニット | |
CN115248323A (zh) | 检测座及poct血细胞分析仪 | |
US20040003998A1 (en) | Electrophoresis separation apparatus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090128 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100804 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20111014 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20111014 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120127 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120426 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120605 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120702 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5033642 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150706 Year of fee payment: 3 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |