JP5021466B2 - 複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法 - Google Patents
複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法 Download PDFInfo
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Images
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K27/00—Construction of housing; Use of materials therefor
- F16K27/003—Housing formed from a plurality of the same valve elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/1842—Simulated moving beds characterized by apparatus features
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B11/00—Connecting constructional elements or machine parts by sticking or pressing them together, e.g. cold pressure welding
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
- F16D1/00—Couplings for rigidly connecting two coaxial shafts or other movable machine elements
- F16D1/06—Couplings for rigidly connecting two coaxial shafts or other movable machine elements for attachment of a member on a shaft or on a shaft-end
- F16D1/064—Couplings for rigidly connecting two coaxial shafts or other movable machine elements for attachment of a member on a shaft or on a shaft-end non-disconnectable
- F16D1/068—Couplings for rigidly connecting two coaxial shafts or other movable machine elements for attachment of a member on a shaft or on a shaft-end non-disconnectable involving gluing, welding or the like
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
- F16D3/00—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive
- F16D3/16—Universal joints in which flexibility is produced by means of pivots or sliding or rolling connecting parts
- F16D3/26—Hooke's joints or other joints with an equivalent intermediate member to which each coupling part is pivotally or slidably connected
- F16D3/38—Hooke's joints or other joints with an equivalent intermediate member to which each coupling part is pivotally or slidably connected with a single intermediate member with trunnions or bearings arranged on two axes perpendicular to one another
- F16D3/382—Hooke's joints or other joints with an equivalent intermediate member to which each coupling part is pivotally or slidably connected with a single intermediate member with trunnions or bearings arranged on two axes perpendicular to one another constructional details of other than the intermediate member
- F16D3/387—Fork construction; Mounting of fork on shaft; Adapting shaft for mounting of fork
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/42—Flow patterns using counter-current
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
- F16D1/00—Couplings for rigidly connecting two coaxial shafts or other movable machine elements
- F16D1/06—Couplings for rigidly connecting two coaxial shafts or other movable machine elements for attachment of a member on a shaft or on a shaft-end
- F16D2001/062—Couplings for rigidly connecting two coaxial shafts or other movable machine elements for attachment of a member on a shaft or on a shaft-end characterised by adaptors where hub bores being larger than the shaft
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/6851—With casing, support, protector or static constructional installations
- Y10T137/7043—Guards and shields
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Description
質量流量の全ての異常を、圧力制御によってできるだけ早く正確に補償しなければならず、ある場合では、圧力制御自体が、操作に関連した圧力変動(例えば、周期的な切換えによる圧力変動など)に起因して相当に乱される。
圧力制御で物質収支を合わせるには、長期にわたる閉ループの循環が必要である。それゆえ、例えば不純物を排出する等のために、循環を一時的に開放することが不可能である。
内部の循環ポンプには、質量流量が連続的に変化する問題が生じ得る。更に、切換えに起因してデッド・スペースが変化するという必然的な不具合が生じ、それを補償しなければならない。上述したように、かかる不具合を補償することは困難であり、このことは、サイクル時間が短く、より厳密な分離を行う場合には特に困難といえる。
(式1)
QI=QD+QIV
QII=QI−QEx
QIII=QII+QF
QIV=QIII−QRaf
開/閉に際して閉鎖時間が極めて短い
磨耗することなく、多くの切換えサイクルを行うことができる
生成物が流れることになるデッド・スペース(または生成物スペース)が非常に小さい
構造的な寸法が小さい
バルブの両側から生成物が流れることができる
逆方向に流すことによって洗浄を行える
CIP(定置洗浄:Cleaning in place)またはSIP(定置滅菌:Sterilization in Place)を簡単に実施できる
更には、高圧および高温のプロセス条件によってバルブ機能が制約を受けないバルブが好ましい。非常に狭いスペースに多くのバルブを備えた回路を得る場合には特に、モジュール設計の点で部品が少なくコンパクトになっており、ホールドアップが少なく、更には、切換えプロセスで分離特性が良いバルブが必要とされる。また、短い切換え経路であってもユーザーが実際のバルブ位置を常時確認できるように、バルブが位置表示器を備えていることが理想的である。制御エネルギーが異常となった場合に生成物スペースが所定の安全状態となるように自動的または機械的に切換えが行われることが好ましい。
以上のような条件を完全に満足するようなバルブは、従来技術の既知のバルブについて言えば存在しない。
図Aは、マスターボードに設けられた4バルブブロックを示している。
図A`は、種々の部品を備えた本発明のバルブを示している。
図Bは、六角形のマスターボードまたはロッドを例示的に示している。
図Cは、好ましい態様の同心状シール領域を示している。
図Dは、封止を供するバルブスピンドル輪郭形状についての所定の設計を示している。
(式2)
QD 0=QEx+QRaf−QF+QDest
新たに加えられる脱着剤(脱離液)の流れは次のようになる:
(式3)
QD=QD 0+△QD LIC
そして、この値は、脱着剤量の流れ制御で調整でき、連続流れ測定によってモニタリングすることができる。
10・・・マスターボード
11・・・シールシート
12・・・シールシートのシール
13・・・供給チャンネル
14・・・横断方向チャンネル
15・・・排出チャンネル
20・・・バルブハウジング
21・・・中央プレート
22・・・中央プレートのシール
23・・・中央プレートのドリル穴
24・・・バルブハウジングの横断方向ドリル穴
30・・・制御ハウジング
31・・・ピストン
32・・・シール
33・・・下方制御スペース
34・・・上方制御スペース
35・・・閉プレート
36・・・閉プレートのシール
37・・・バルブスピンドル
37'・・・球体
38・・・圧力スプリング
Claims (5)
- 擬似移動床式クロマトグラフィー法によって物質混合物を分離する方法であって、
吸着体が充填され、かつ、直列に接続された2つ以上のクロマトグラフィーカラムから成るカラム回路に対して、溶離液と分離される物質混合物とを連続的に供給し、
溶離液と分離される物質混合物とが供給されたカラム回路の箇所とは異なるカラム回路の箇所から、分離された成分を少なくとも1種類含んで成る抽出液ストリームと、その分離された成分とは異なる成分を少なくとも1種類含んで成るラフィネート・ストリームとを連続的に抜き出し、
液体が供給されるカラムおよび液体が抜出されるカラムが順次切り替わるように液体供給箇所および液体抜出箇所を順次開けることによって、物質混合物と溶離液とから成る液体の移動相と固体相の吸着体とを相対的に移動させており、
1つの溶離液供給ポンプおよび溶離液補償容器のみを用い、該溶離液供給ポンプは、該溶離液補償容器の後方側に位置し、循環用の循環ポンプに取って替わり、
前記溶離液補償容器の後方側に位置する前記溶離液供給ポンプによって、一定の流れの溶離液ストリームを前記直列に接続された2つ以上のクロマトグラフィーカラムの第1カラムにのみ直接的に送液し、また
質量流れの制御に際して、溶離液補償容器の充填レベルを制御することによって、全体の物質収支を合わせている、ことを特徴とする方法。 - 擬似移動床式クロマトグラフィー法での循環に、多くとも4つのポンプを用いることを特徴とする、請求項1に記載の方法。
- 抽出液またはラフィネートの抜出しを行う排出ポンプを制御バルブの代わりに少なくとも1つ用いることを特徴とする、請求項1に記載の方法。
- オンライン検出および制御バルブを用いることによって、循環に際して汚染された溶離液を自動的に抜き出すことを特徴とする、請求項1に記載の方法。
- 循環に際して戻されるストリームを測定することによって質量流れの制御の精度を向上させており、それゆえ、測定データの収支を用いて冗長化が達成されることを特徴とする、請求項1に記載の方法。
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DE102004025000.6 | 2004-05-21 | ||
DE200410025000 DE102004025000A1 (de) | 2004-05-21 | 2004-05-21 | Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie |
PCT/EP2005/005313 WO2005113101A2 (de) | 2004-05-21 | 2005-05-14 | Verfahren zur herstellung von chemischen und pharmazeutischen produkten mit integrierter mehrsäulen-chromatographie |
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JP2011280228A Division JP5122679B2 (ja) | 2004-05-21 | 2011-12-21 | 複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法 |
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JP2008500544A JP2008500544A (ja) | 2008-01-10 |
JP2008500544A5 JP2008500544A5 (ja) | 2008-06-26 |
JP5021466B2 true JP5021466B2 (ja) | 2012-09-05 |
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JP2011097192A Active JP5122667B2 (ja) | 2004-05-21 | 2011-04-25 | 複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法 |
JP2011280228A Active JP5122679B2 (ja) | 2004-05-21 | 2011-12-21 | 複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法 |
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JP2011280228A Active JP5122679B2 (ja) | 2004-05-21 | 2011-12-21 | 複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法 |
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US (2) | US7615159B2 (ja) |
EP (2) | EP2336617B1 (ja) |
JP (3) | JP5021466B2 (ja) |
CN (2) | CN103157294B (ja) |
BR (1) | BRPI0510143B1 (ja) |
DE (1) | DE102004025000A1 (ja) |
HK (1) | HK1127311A1 (ja) |
IL (1) | IL179451A (ja) |
MX (1) | MXPA06013419A (ja) |
NO (1) | NO340260B1 (ja) |
WO (1) | WO2005113101A2 (ja) |
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FR2889077B1 (fr) * | 2005-07-26 | 2007-10-12 | Novasep Soc Par Actions Simpli | Procede et dispositif de separation chromatographique de fractions d'un melange |
EP1982752B1 (de) * | 2007-04-17 | 2010-08-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Vorrichtung zur chromatographischen Trennung von Komponenten mit teilweiser Rückführung von Gemischfraktionen |
FR2976500B1 (fr) * | 2011-06-16 | 2013-05-31 | IFP Energies Nouvelles | Procede et dispositif de sepation chromatographique a contre-courant simule a faible perte de charge et nombre de zones eleve. |
CN103331036B (zh) * | 2013-06-21 | 2014-11-26 | 浙江大学宁波理工学院 | 一种从混合物中分离与富集目标组分的色谱分离方法 |
CN104415573B (zh) * | 2013-09-10 | 2017-03-22 | 中国科学院大连化学物理研究所 | 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法 |
ES2886960T3 (es) | 2016-01-27 | 2021-12-21 | Koch Glitsch Lp | Dispositivo con paletas de entrada con traviesa interior para dar rigidez y recipiente que contiene el mismo |
DE102017107089B4 (de) | 2017-04-03 | 2019-08-22 | Karlsruher Institut für Technologie | Vorrichtung und Verfahren zur selektiven Fraktionierung von Feinstpartikeln |
CN107185273A (zh) * | 2017-06-15 | 2017-09-22 | 苏州麦可旺志生物技术有限公司 | 一种连续色谱的方法及其设备 |
CN112203737A (zh) * | 2018-05-31 | 2021-01-08 | 沃特世科技公司 | 用于分离和制备药物产品中的未知痕量杂质的高分离度和半制备型再循环色谱系统 |
US11346460B2 (en) * | 2019-02-05 | 2022-05-31 | Swagelok Company | Integrated actuator manifold for multiple valve assembly |
WO2020194343A1 (en) * | 2019-03-22 | 2020-10-01 | Indian Institute Of Technology Delhi | An nir based real-time control of loading in protein a chromatography |
CN111841073B (zh) * | 2019-09-12 | 2022-02-22 | 浙江大学宁波理工学院 | 从原料中分离与浓缩目标组分的多柱切换循环色谱分离系统及其方法 |
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2004
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- 2005-05-14 EP EP05742674.4A patent/EP1753517B1/de active Active
- 2005-05-14 CN CN201210551546.7A patent/CN103157294B/zh active Active
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US8658040B2 (en) | 2014-02-25 |
JP2012115832A (ja) | 2012-06-21 |
CN103157294B (zh) | 2015-07-29 |
WO2005113101A3 (de) | 2008-04-17 |
EP2336617B1 (de) | 2014-02-26 |
IL179451A (en) | 2011-07-31 |
JP5122667B2 (ja) | 2013-01-16 |
CN101321567B (zh) | 2013-03-06 |
EP1753517A2 (de) | 2007-02-21 |
DE102004025000A1 (de) | 2005-12-08 |
WO2005113101A2 (de) | 2005-12-01 |
US7615159B2 (en) | 2009-11-10 |
MXPA06013419A (es) | 2007-01-23 |
JP5122679B2 (ja) | 2013-01-16 |
US20080135483A1 (en) | 2008-06-12 |
CN101321567A (zh) | 2008-12-10 |
IL179451A0 (en) | 2007-05-15 |
US20090294364A1 (en) | 2009-12-03 |
BRPI0510143A (pt) | 2007-10-02 |
EP1753517B1 (de) | 2013-07-10 |
JP2008500544A (ja) | 2008-01-10 |
EP2336617A2 (de) | 2011-06-22 |
BRPI0510143B1 (pt) | 2017-12-19 |
EP2336617A3 (de) | 2012-09-12 |
HK1127311A1 (en) | 2009-09-25 |
WO2005113101A8 (de) | 2008-07-17 |
NO340260B1 (no) | 2017-03-27 |
JP2011174941A (ja) | 2011-09-08 |
NO20065865L (no) | 2007-02-21 |
CN103157294A (zh) | 2013-06-19 |
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