JP4958388B2 - 発光性化合物に関する組成物、方法並びにキット - Google Patents

発光性化合物に関する組成物、方法並びにキット Download PDF

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Publication number
JP4958388B2
JP4958388B2 JP2003542146A JP2003542146A JP4958388B2 JP 4958388 B2 JP4958388 B2 JP 4958388B2 JP 2003542146 A JP2003542146 A JP 2003542146A JP 2003542146 A JP2003542146 A JP 2003542146A JP 4958388 B2 JP4958388 B2 JP 4958388B2
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group
compound
enzyme
luminophore
luminescence
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JP2005515977A (ja
JP2005515977A5 (https=
Inventor
キース ウッド
エリカ ホーキンズ
マイク スカーリア
ディーター クラウバート
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Promega Corp
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Promega Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Electroluminescent Light Sources (AREA)
JP2003542146A 2001-11-02 2002-11-01 発光性化合物に関する組成物、方法並びにキット Expired - Lifetime JP4958388B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/053,482 US7268229B2 (en) 2001-11-02 2001-11-02 Compounds to co-localize luminophores with luminescent proteins
US10/053,482 2001-11-02
PCT/US2002/034972 WO2003040100A1 (en) 2001-11-02 2002-11-01 Compositions, methods and kits pertaining to luminescent compounds

Publications (3)

Publication Number Publication Date
JP2005515977A JP2005515977A (ja) 2005-06-02
JP2005515977A5 JP2005515977A5 (https=) 2006-01-05
JP4958388B2 true JP4958388B2 (ja) 2012-06-20

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JP2003542146A Expired - Lifetime JP4958388B2 (ja) 2001-11-02 2002-11-01 発光性化合物に関する組成物、方法並びにキット

Country Status (10)

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US (2) US7268229B2 (https=)
EP (2) EP1894933B1 (https=)
JP (1) JP4958388B2 (https=)
CN (2) CN101440089A (https=)
AT (1) ATE399784T1 (https=)
CA (1) CA2462506C (https=)
DE (1) DE60227408D1 (https=)
DK (1) DK1451155T3 (https=)
ES (1) ES2307829T3 (https=)
WO (1) WO2003040100A1 (https=)

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JP5844029B2 (ja) * 2006-10-24 2016-01-13 ジーン ストリーム ピーティーワイ エルティーディ ルシフェラーゼシグナルを増強する組成物
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EP2326953B1 (en) 2008-07-22 2018-03-21 Promega Corporation Adp detection based luminescent phosphotransferase or atp hydrolase assay
US8288559B2 (en) 2008-08-18 2012-10-16 Promega Corporation Luminogenic compounds and methods to detect cytochrome P450 3A enzymes
WO2010090319A1 (ja) 2009-02-09 2010-08-12 チッソ株式会社 セレンテラジン類縁体及びその製造方法
ES2795287T3 (es) 2009-05-01 2020-11-23 Promega Corp Luciferasas de Oplophorus sintéticas con mayor emisión de luz
JP5605727B2 (ja) * 2010-04-06 2014-10-15 Ｊｎｃ株式会社 セレンテラジン類縁体及びセレンテラミド類縁体
SG185481A1 (en) 2010-05-10 2012-12-28 Univ California Endoribonuclease compositions and methods of use thereof
CN103180324A (zh) * 2010-11-02 2013-06-26 普罗美加公司 腔肠素衍生物及其使用方法
SG10202103336SA (en) 2010-11-02 2021-04-29 Promega Corp Novel coelenterazine substrates and methods of use
JP6067019B2 (ja) * 2011-09-02 2017-01-25 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにｎａｄ（ｐ）／ｎａｄ（ｐ）ｈを測定するための方法
JP6511720B2 (ja) 2013-02-28 2019-05-15 Jnc株式会社 コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法
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JP6484987B2 (ja) 2013-10-21 2019-03-20 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
JP6442825B2 (ja) 2013-12-26 2018-12-26 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
EP3099691B1 (en) 2014-01-29 2019-11-20 Promega Corporation Pro-substrates for live cell applications
JP6265020B2 (ja) 2014-04-16 2018-01-24 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
US9732373B2 (en) * 2014-09-11 2017-08-15 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
JP6814132B2 (ja) 2014-09-12 2021-01-13 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 内部タンパク質タグ
US9677117B2 (en) 2014-10-08 2017-06-13 Promega Corporation Bioluminescent succinate detection assay
WO2016210294A1 (en) 2015-06-25 2016-12-29 Promega Corporation Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases
JP7092677B2 (ja) 2016-02-15 2022-06-28 プロメガ コーポレイション セレンテラジン類似体
WO2018049241A1 (en) 2016-09-09 2018-03-15 Promega Corporation Dual protected pro-coelenterazine substrates
JP7200102B2 (ja) 2016-11-01 2023-01-06 プロメガ コーポレイション エネルギー受容体に係留されたセレンテラジン類縁体
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JP7419260B2 (ja) 2018-05-01 2024-01-22 プロメガ コーポレイション ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物
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Also Published As

Publication number Publication date
ES2307829T3 (es) 2008-12-01
CA2462506A1 (en) 2003-05-15
CN101440089A (zh) 2009-05-27
EP1451155B1 (en) 2008-07-02
JP2005515977A (ja) 2005-06-02
EP1451155A1 (en) 2004-09-01
DK1451155T3 (da) 2008-11-10
EP1894933A3 (en) 2008-03-26
US7537912B2 (en) 2009-05-26
WO2003040100A1 (en) 2003-05-15
ATE399784T1 (de) 2008-07-15
EP1451155A4 (en) 2006-03-01
CA2462506C (en) 2010-04-06
DE60227408D1 (de) 2008-08-14
EP1894933B1 (en) 2013-07-03
US20080050760A1 (en) 2008-02-28
US7268229B2 (en) 2007-09-11
EP1894933A2 (en) 2008-03-05
CN100439338C (zh) 2008-12-03
CN1612860A (zh) 2005-05-04
US20030153090A1 (en) 2003-08-14

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