JP4847756B2 - ヒトβディフェンシン分泌促進剤 - Google Patents

ヒトβディフェンシン分泌促進剤 Download PDF

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JP4847756B2
JP4847756B2 JP2005514130A JP2005514130A JP4847756B2 JP 4847756 B2 JP4847756 B2 JP 4847756B2 JP 2005514130 A JP2005514130 A JP 2005514130A JP 2005514130 A JP2005514130 A JP 2005514130A JP 4847756 B2 JP4847756 B2 JP 4847756B2
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acid
human
defensin
secretion
defensin secretion
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Expired - Lifetime
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JPWO2005027893A1 (ja
Inventor
幸代 五十嵐
英男 田中
修 高須
茂生 篠原
雅彦 田中
美里 矢後
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
JP2005514130A 2003-09-19 2004-09-17 ヒトβディフェンシン分泌促進剤 Expired - Lifetime JP4847756B2 (ja)

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JP2005514130A JP4847756B2 (ja) 2003-09-19 2004-09-17 ヒトβディフェンシン分泌促進剤

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Application Number Priority Date Filing Date Title
JP2003328704 2003-09-19
JP2003328704 2003-09-19
PCT/JP2004/014024 WO2005027893A1 (ja) 2003-09-19 2004-09-17 ヒトβディフェンシン分泌促進剤
JP2005514130A JP4847756B2 (ja) 2003-09-19 2004-09-17 ヒトβディフェンシン分泌促進剤

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JPWO2005027893A1 JPWO2005027893A1 (ja) 2006-11-24
JP4847756B2 true JP4847756B2 (ja) 2011-12-28

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US (1) US20070093416A1 (https=)
EP (1) EP1671629A4 (https=)
JP (1) JP4847756B2 (https=)
KR (1) KR20060076775A (https=)
CN (1) CN1852708B (https=)
AU (1) AU2004273738B2 (https=)
BR (1) BRPI0414543A (https=)
CA (1) CA2538760A1 (https=)
TW (1) TW200524585A (https=)
WO (1) WO2005027893A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5419451B2 (ja) 2006-06-28 2014-02-19 アース製薬株式会社 歯のエナメル質の溶解阻害剤
WO2008096730A1 (ja) * 2007-02-09 2008-08-14 National University Corporation Nagoya University 抗炎症剤及びその用途
JP2009007323A (ja) * 2007-05-29 2009-01-15 Earth Chem Corp Ltd ウイルス不活化剤、ウイルス感染予防方法及びそのウイルス不活化剤をも収納し得る容器
JP5511183B2 (ja) * 2007-12-28 2014-06-04 アース製薬株式会社 有機酸による歯のエナメル質の溶解が阻害される口腔用組成物
US8076088B2 (en) * 2008-02-22 2011-12-13 Case Western Reserve University Method of detecting human β-defensins
KR101489638B1 (ko) * 2008-04-01 2015-02-11 (주)네오팜 인간유래 항균 펩타이드의 분비를 촉진하는 신규화합물, 그제조방법, 및 이를 유효성분으로 함유하는피부외용제조성물
CN101591672B (zh) * 2009-05-22 2011-09-07 西北农林科技大学 一种包含hBD3乳腺特异性表达载体的重组牛胎儿成纤维细胞
GB0920846D0 (en) 2009-11-27 2010-01-13 Croda Int Plc Defenin inducing agent
WO2011130646A1 (en) 2010-04-15 2011-10-20 Marine Polymer Technologies, Inc. Anti-bacterial applications of poly -n-acetylglucosamine nanofibers
KR101249702B1 (ko) 2010-06-16 2013-04-05 주식회사 나이벡 항균 또는 항염증 활성을 가지는 펩타이드 및 이를 유효성분으로 함유하는 약제학적 조성물
SG187666A1 (en) 2010-08-27 2013-03-28 Neopharm Co Ltd Novel compound accelerating secretion of human-derived anti-microbial peptide, method for preparing same, and composition having same as active ingredient
NZ732118A (en) 2011-04-15 2018-11-30 Marine Polymer Tech Inc Treatment of disease with poly-n-acetylglucosamine nanofibers
SG10201602399SA (en) * 2011-09-27 2016-05-30 Santen Pharmaceutical Co Ltd Inhibitor for corneal epithelial cell death, inhibitor characterized by combining hyaluronic acid and flavin adenine dinucleotide
US9532946B2 (en) 2012-11-20 2017-01-03 Intervet Inc. Manufacturing of semi-plastic pharmaceutical dosage units
JP6222217B2 (ja) * 2013-02-14 2017-11-01 ライオン株式会社 口腔用組成物
JP6209062B2 (ja) * 2013-11-12 2017-10-04 株式会社ファンケル 抗菌性ペプチドの分泌促進剤
AU2017240069B2 (en) 2016-03-31 2024-03-07 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
EP3435765A1 (en) 2016-03-31 2019-02-06 Gojo Industries, Inc. Antimicrobial peptide stimulating sanitizing composition
WO2017173240A1 (en) 2016-03-31 2017-10-05 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
CN109152754A (zh) * 2016-05-17 2019-01-04 拥护者生物技术有限公司 用于治疗/预防鼻充血的羧酸
EP3544575A1 (en) 2016-11-23 2019-10-02 GOJO Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
KR102488864B1 (ko) * 2016-11-25 2023-01-17 (주)모아캠 가자 추출물 및 애엽 추출물을 함유하는 피부세균총의 생장 조절 또는 피부 면역 강화용 조성물
CN107918010A (zh) * 2017-11-27 2018-04-17 陕西科技大学 一种高灵敏液晶型非标记免疫传感器检测人类β防御素‑2的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03294227A (ja) * 1990-04-13 1991-12-25 Dai Ichi Seiyaku Co Ltd 口腔用組成物
JPH0669A (ja) * 1992-06-19 1994-01-11 Meiji Milk Prod Co Ltd 肝障害患者に有効な組成物
JP2000510152A (ja) * 1996-06-05 2000-08-08 ザ、プロクター、エンド、ギャンブル、カンパニー ティシュ・ペーパー製品用の抗ウイルス性水分非含有低刺激性スキンローション
JP2001089385A (ja) * 1999-09-22 2001-04-03 Kobayashi Pharmaceut Co Ltd 抗う蝕剤
JP2003512325A (ja) * 1999-10-19 2003-04-02 ザ、プロクター、エンド、ギャンブル、カンパニー 感冒およびインフルエンザ様症状の予防並びに治療用組成物、並びにそれらの使用方法
JP2003116486A (ja) * 2001-08-09 2003-04-22 Meiji Milk Prod Co Ltd 食後の血糖上昇抑制作用を有する食品組成物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58009A (en) * 1978-08-14 1982-11-30 Sterling Drug Inc Process and compositions comprising glutaric acid for neutralizing or destroying viruses
AU1271592A (en) * 1991-01-18 1992-08-27 Dexter Chemical Corporation Malic acid derivatives and compositions for the treatment of psoriasis
US5260083A (en) * 1992-03-25 1993-11-09 The J. M. Smucker Company Fruit spread and method of preparing same
CN1033421C (zh) * 1992-12-09 1996-12-04 何名富 一种药物牙膏的制备方法
DE4439858A1 (de) * 1994-11-08 1996-05-09 Merck Patent Gmbh Durch Co-Sprühtrocknung erhältliche Polyol-Zusammensetzung
JP3241955B2 (ja) * 1994-12-26 2001-12-25 花王株式会社 口腔用組成物
WO1996026707A1 (en) * 1995-02-28 1996-09-06 U.S. Meds - Bulgaria Ltd. Composition for hygiene, prophylaxis and treatment of the oral cavity
CN1229641A (zh) * 1998-03-20 1999-09-29 湖北医科大学附属第二医院 假牙清洁剂
US6469066B1 (en) * 1998-12-18 2002-10-22 Palladin Healthcare International, Ltd. Composition for pain mediation and apparatus and method of use thereof
AU2001245726A1 (en) * 2000-03-15 2001-09-24 Genaera Corporation A method for stimulation of defensin production
JP2002114704A (ja) * 2000-09-29 2002-04-16 Morinaga & Co Ltd 抗菌剤
JP2003000262A (ja) * 2001-06-22 2003-01-07 Morinaga & Co Ltd ほ乳類抗菌ペプチドの発現誘導及び／又は増強組成物、該組成物を含有する飲食品、医薬品及び医薬部外品
JP2003095938A (ja) * 2001-09-21 2003-04-03 Masami Moriyama 抗菌ペプチド分泌誘発剤
US20040063123A1 (en) * 2002-03-05 2004-04-01 Yoshihiro Abiko Method of collecting data for estimation of susceptibility to periodontal disease
FR2843125B1 (fr) * 2002-08-02 2012-11-16 Coletica Principes actifs stimulant les beta-defensives humaines de type 2 et/ou de type 3, et compositions cosmetiques ou pharmaceutiques comprenant de tels principes actifs
JP4554150B2 (ja) * 2002-11-28 2010-09-29 雅美 森山 薬剤耐性菌による感染症治療剤
JP4683844B2 (ja) * 2003-02-10 2011-05-18 雅美 森山 インフルエンザウイルス感染予防剤
US7041311B2 (en) * 2003-02-28 2006-05-09 International Flavors & Fragrances Inc. Preparation for saliva flow

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03294227A (ja) * 1990-04-13 1991-12-25 Dai Ichi Seiyaku Co Ltd 口腔用組成物
JPH0669A (ja) * 1992-06-19 1994-01-11 Meiji Milk Prod Co Ltd 肝障害患者に有効な組成物
JP2000510152A (ja) * 1996-06-05 2000-08-08 ザ、プロクター、エンド、ギャンブル、カンパニー ティシュ・ペーパー製品用の抗ウイルス性水分非含有低刺激性スキンローション
JP2001089385A (ja) * 1999-09-22 2001-04-03 Kobayashi Pharmaceut Co Ltd 抗う蝕剤
JP2003512325A (ja) * 1999-10-19 2003-04-02 ザ、プロクター、エンド、ギャンブル、カンパニー 感冒およびインフルエンザ様症状の予防並びに治療用組成物、並びにそれらの使用方法
JP2003116486A (ja) * 2001-08-09 2003-04-22 Meiji Milk Prod Co Ltd 食後の血糖上昇抑制作用を有する食品組成物

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CA2538760A1 (en) 2005-03-31
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HK1092057A1 (en) 2007-02-02
TW200524585A (en) 2005-08-01
JPWO2005027893A1 (ja) 2006-11-24
WO2005027893A1 (ja) 2005-03-31
AU2004273738B2 (en) 2011-02-03
AU2004273738A1 (en) 2005-03-31
CN1852708B (zh) 2010-09-22
BRPI0414543A (pt) 2006-11-07
CN1852708A (zh) 2006-10-25
TWI342773B (https=) 2011-06-01
US20070093416A1 (en) 2007-04-26
KR20060076775A (ko) 2006-07-04

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