JP4813771B2 - 血管内皮型一酸化窒素合成酵素活性促進剤 - Google Patents
血管内皮型一酸化窒素合成酵素活性促進剤 Download PDFInfo
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- JP4813771B2 JP4813771B2 JP2004119331A JP2004119331A JP4813771B2 JP 4813771 B2 JP4813771 B2 JP 4813771B2 JP 2004119331 A JP2004119331 A JP 2004119331A JP 2004119331 A JP2004119331 A JP 2004119331A JP 4813771 B2 JP4813771 B2 JP 4813771B2
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Description
中根正樹,「NO研究の新しい展開」,実験医学,1999年,第17巻,第8号,p.914−917
〔eNOS活性促進剤〕
本発明のeNOS活性促進剤は、ヒハツ抽出物を有効成分として含有するものである。
ここで、本発明において、「ヒハツ抽出物」には、ヒハツを抽出原料として得られる抽出液、該抽出液の希釈液若しくは濃縮液、該抽出液を乾燥して得られる乾燥物、又はこれらの粗精製物若しくは精製物のいずれもが含まれる。
ヒハツは、コショウ科コショウ属に属する常緑のつる性植物であり、東南アジアに広く分布し、これらの地域から容易に入手することができる。また、ヒハツの果穂は、多肉質の太い円筒状であり、香辛料として利用されている。
上記ヒハツ抽出物は、デキストリン、シクロデキストリン等の薬学的に許容され得るキャリアーその他任意の助剤を用いて、錠剤、カプセル剤、散剤、顆粒剤、シロップ剤、トローチ剤等、任意の剤形に製剤化することができる。この際、助剤としては、例えば、賦形剤、結合剤、崩壊剤、滑沢剤、安定剤、矯味・矯臭剤等を用いることができる。
上記eNOS活性促進剤に含まれるヒハツ抽出物は、eNOS活性促進作用を有しており、消化管で消化されるようなものではないことが確認されており、また安全性に優れているため、一般食品、健康食品、保健機能食品又は栄養補助食品等、任意の飲食品に配合するのに好適である。
インドネシア産ヒハツの果穂部1000gに水4000mLを加え、還流下で1時間、90℃の温度条件下で加熱抽出し、熱時濾過した。残渣についてさらに同様の抽出処理を行った。得られた各抽出液を合わせて減圧下に濃縮し、その濃縮物にデキストリンを加えて全量が1000gになるように調整した後、乾燥して、ヒハツ抽出組成物100gを得た。
製造例1で得られたヒハツ抽出組成物について、下記の試験法によりeNOS活性促進作用を試験した。
eNOS活性促進率(%)=(A/B)×100
なお、上記式中、「A」は「ヒハツ抽出組成物添加試料のeNOSタンパク質のバンド強度値」を、「B」は「ヒハツ抽出組成物無添加試料のeNOSタンパク質のバンド強度値」を表す。
この試験の結果を表1に示す。
試料濃度(μg/mL) eNOS活性促進率(%)
50 132.9
100 152.6
下記の原料を均一に混合し、常法に従って顆粒状にした後に打錠機により打錠して、錠剤状健康食品を製造した。
ヒハツ抽出組成物(製造例1) 20質量部
イチョウ葉抽出物 10質量部
生姜抽出物 10質量部
マルチトール 72質量部
乳糖 80質量部
グリセリン脂肪酸エステル 8質量部
原料の混合作業及び打錠機による打錠作業は容易に行うことができ、得られた錠剤状健康食品は、呈味が良好であった。
下記の原料を均一に混合し、流動層造粒機によりインスタントティー顆粒を製造した。
ヒハツ抽出組成物(製造例1) 20質量部
高麗ニンジン抽出物 5質量部
ヨモギ抽出物 20質量部
エリスリトール 40質量部
クエン酸 50質量部
ラクチュロース 50質量部
デキストリン 810質量部
原料の混合作業及び流動層造粒機による顆粒化作業は容易に行うことができ、得られたインスタントティー顆粒は、呈味が良好であった。
下記の原料を用いてドウを作製し、延展後これを成形してばい焼し、ビスケットを製造した。
ヒハツ抽出組成物(製造例1) 2g
小麦粉 1000g
コーンスターチ 100g
グルコース 250g
マーガリン 125g
食塩 5g
炭酸ソーダ 25g
炭酸アンモニウム 9g
レシチン 6g
全卵 75g
乳酸カルシウム 50g
ゴマ 5g
水 350g
得られたビスケットは、呈味が良好であった。
パラチノース330gとソルビトール140gと精製水270gとを混合して加熱した。その加熱した混合物に、ヒハツ抽出組成物(製造例1)10gを精製水150gに溶解したヒハツ抽出組成物水溶液160g、紅花抽出物1g、ゼラチン80g及び50質量%リン酸水溶液8gを混合し、その混合物を型に流し込んで冷却することにより、グミキャンディーを製造した。得られたグミキャンディーは、呈味が良好であった。
チューインガム試作用ミキサーに、ガムベース25質量部とパラチニットシロップ14質量部とを投入し混合した。続いて、その混合物に、粉末キシリトール35質量部、粉末マルチトール25質量部、イチョウ葉抽出物5質量部、ヒハツ抽出組成物(製造例1)14質量部及びステビア甘味料(丸善製薬株式会社製,商品名:マルミロン50)0.4質量部をあらかじめ混合しておいたものを、数回に分けて加え、よく練り合わせた。さらに、グリセリンを1質量部加えて十分混合した後、ミキサーから混合物を取り出し、ローラーで圧延することにより、チューインガムを製造した。得られたチューインガムは、呈味が良好であった。
下記の原料を用いて、常法に従いマウスウォッシュを製造した。
ヒハツ抽出組成物(製造例1) 0.4質量部
エタノール 15質量部
ソルビット 10質量部
クエン酸 0.05質量部
クエン酸ナトリウム 0.2質量部
安息香酸ナトリウム 0.2質量部
ラウリル硫酸ナトリウム 0.2質量部
サッカリンナトリウム 0.05質量部
L−メントール 0.05質量部
精製水 残部(全量を100質量部とする)
得られたマウスウォッシュは、使用感に問題のない良好な味を呈した。
Claims (3)
- ヒハツ(Piper longum Linn.)抽出物を有効成分として含有することを特徴とする血管内皮型一酸化窒素合成酵素活性促進剤(血小板凝集に起因する疾患、高血圧症又は炎症性疾患の治療又は予防の用途を除く。)。
- 前記抽出物が、抽出溶媒として極性溶媒を用いて得られる抽出物であることを特徴とする請求項1に記載の血管内皮型一酸化窒素合成酵素活性促進剤(血小板凝集に起因する疾患、高血圧症又は炎症性疾患の治療又は予防の用途を除く。)。
- 前記極性溶媒が、水、エタノール又はこれらの混合溶媒であることを特徴とする請求項2に記載の血管内皮型一酸化窒素合成酵素活性促進剤(血小板凝集に起因する疾患、高血圧症又は炎症性疾患の治療又は予防の用途を除く。)。
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