JP4761476B2 - 磁性ナノチューブ - Google Patents
磁性ナノチューブ Download PDFInfo
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- JP4761476B2 JP4761476B2 JP2007503968A JP2007503968A JP4761476B2 JP 4761476 B2 JP4761476 B2 JP 4761476B2 JP 2007503968 A JP2007503968 A JP 2007503968A JP 2007503968 A JP2007503968 A JP 2007503968A JP 4761476 B2 JP4761476 B2 JP 4761476B2
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Description
本発明はナノスケールの磁性構造の分野に関し、特に、磁性ナノチューブおよびその製造方法に関する。
記憶媒体、スピントロニクス、撮像、およびセンサにおける新興技術は最近、ナノメータスケールの磁気材料ならびに該磁気材料を製造するための装置および方法の必要性を増加させている。ナノメータスケールのビルディングブロックは通常、このような磁性ナノ構造を製造するために使用される。最近、自己組織化磁気ナノ構造の分野においてかなりの取り組みがなされている。例えば、磁気デバイスのビルディングブロックに応用するために、磁気ナノ結晶の3次元組織化が広く調査されており、適切な触媒特性、光学特性、および磁性特性のためには、ナノ結晶の大きさ、形状、およびモルフォロジーの制御が重要である。ビルディングブロック構造の重要な分野の一つが磁性ナノワイヤである。合成磁性ナノワイヤが生産されているが、これらのナノワイヤの磁性特性を調製する能力は乏しいことが証明されている。
磁性ナノチューブの製造方法は、細菌由来磁性ナノ結晶を準備する工程を含み、各々の細菌由来磁性ナノ結晶が外層を有する。上記方法はさらに、内表面および外表面を有し、細菌由来磁性ナノ結晶を吸収可能な少なくとも1つのナノチューブを準備する工程を含む。上記方法はさらに、ナノチューブを細菌由来磁性ナノ結晶に接触させる工程を含む。
図1は、本発明に係る磁性ナノチューブの製造方法10の一実施形態の図示説明であり、本発明にしたがって形成された磁性ナノチューブ20の一実施形態の外観の説明である。一工程では、細菌由来磁性ナノ結晶26を準備する。図1に示される実施形態においては、細菌由来磁性ナノ結晶26を準備する工程は、少なくとも1つの細菌24を嫌気的に生育させることにより、ナノ結晶26を合成する工程22と、磁気ナノ結晶26を細菌から抽出する付加的な工程28とを含む。工程30では、磁気ナノ結晶26はナノチューブ32の少なくとも一表面に接触して、本発明の一実施形態に係る磁性ナノチューブ20を形成する。
Claims (24)
- 細菌由来磁性ナノ結晶の各々が、タンパク質を含む外層を有する複数の細菌由来磁性ナノ結晶を準備する工程と、
内表面および外表面を有し、前記細菌由来磁性ナノ結晶を吸収可能な少なくとも1つのペプチドナノチューブを準備する工程と、
前記少なくとも1つのペプチドナノチューブを、前記複数の細菌由来磁性ナノ結晶の少なくとも一部に接触させる工程と、
を含む、磁性ナノチューブの製造方法。 - 請求項1において、
前記少なくとも1つのペプチドナノチューブを準備する工程は、ペプチド双頭型両親媒性物質の自己組織化により、前記少なくとも1つのペプチドナノチューブを生成する工程を含む、磁性ナノチューブの製造方法。 - 請求項1において、
前記複数の細菌由来磁性ナノ結晶を準備する工程はさらに、
磁性細菌を嫌気的に生育させて、前記細菌由来磁性ナノ結晶を合成する工程と、
前記複数の細菌由来磁性ナノ結晶を抽出する工程と、
を含み、
前記抽出する工程は、
培養細胞を破砕する工程と、
カラム内で磁石を用いて前記複数の細菌由来磁性ナノ結晶を収集する工程と、
前記カラム内に形成された、前記細菌由来磁性ナノ結晶の懸濁液を含む上清を取り出す工程と、
を含む、磁性ナノチューブの製造方法。 - 請求項3において、
前記細菌は、Magnetospirillum magnetotactium MS-1、Magnetospirillum gryphiswaldense、およびMagnetospirillum magneticum AMB-1を含む群から選ばれる、磁性ナノチューブの製造方法。 - 請求項2において、
前記ペプチド双頭型両親媒性物質は、ビス(N−α−アミド−グリシルグリシン)−1,7−ヘプタンジカルボキシレートを含む、磁性ナノチューブの製造方法。 - 請求項1において、
前記接触させる工程は、
前記少なくとも1つのペプチドナノチューブを含むペプチドナノチューブ溶液を作製する工程と、
バッファーと所定濃度の前記複数の細菌由来磁性ナノ結晶とを含むナノ結晶溶液を作製する工程と、
前記ナノ結晶溶液における前記複数の細菌由来磁性ナノ結晶の濃度を最適化する工程と、
前記ナノ結晶溶液と前記ナノチューブ溶液とを混合する工程と、
前記複数の細菌由来磁性ナノ結晶の少なくとも一部が前記少なくとも1つのペプチドナノチューブの少なくとも一表面に接触するまで、前記ペプチドナノチューブ溶液とともに前記ナノ結晶溶液をインキュベートする工程と、
を含む、磁性ナノチューブの製造方法。 - 請求項6において、
前記インキュベートする工程は、
前記複数の細菌由来磁性ナノ結晶の少なくとも一部を前記少なくとも1つのペプチドナノチューブの内表面に選択的に包含させる工程を含み、
前記最適化する工程はさらに、
細菌由来磁性ナノ結晶を最適濃度に希釈する工程を含み、
前記最適濃度は、前記複数の細菌由来磁性ナノ結晶の少なくとも一部が前記少なくとも1つのペプチドナノチューブの内表面に包含され、かつ、前記外表面に接触する前記複数の細菌由来磁性ナノ結晶が存在しないことによって特徴付けられる、磁性ナノチューブの製造方法。 - 請求項7において、
前記最適濃度によって、前記混合する工程における前記ペプチドナノチューブに対する前記ナノ結晶の比(ナノ結晶:ペプチドナノチューブ)を27:1〜56:1の範囲にする、磁性ナノチューブの製造方法。 - 請求項6において、
前記複数の細菌由来磁性ナノ結晶の少なくとも一部は、前記少なくとも1つのペプチドナノチューブの外表面に固定化され、
前記最適濃度によって、前記混合する工程における前記ペプチドナノチューブに対する前記ナノ結晶の比(ナノ結晶:ペプチドナノチューブ)を550:1〜2800:1の範囲にする、磁性ナノチューブの製造方法。 - 請求項6において、
前記バッファーは、5〜9の範囲にあるpHによって特徴付けられる、磁性ナノチューブの製造方法。 - 請求項7において、
前記複数の細菌由来磁性ナノ結晶の少なくとも一部が、前記少なくとも1つのペプチドナノチューブの内表面に包含されて、該少なくとも1つのペプチドナノチューブの内表面に直鎖が配列形成される、磁性ナノチューブの製造方法。 - 細菌由来磁性ナノ結晶の各々が、タンパク質を含む外層を有する複数の細菌由来磁性ナノ結晶と、
内表面および外表面を有し、前記細菌由来磁性ナノ結晶を吸収可能であって、ペプチド双頭型両親媒性物質の自己組織化によって生成されたペプチドを含むペプチドナノチューブと、を含み、
前記ペプチドナノチューブの内表面および外表面のうち少なくとも一方において、前記細菌由来磁性ナノ結晶の外層のタンパク質と、前記ペプチドとが、結合している、磁性ナノチューブ。 - 請求項12において、
前記内表面および外表面のうち少なくとも一方は内表面であり、
前記複数の細菌由来磁性ナノ結晶は配列して、前記ペプチドナノチューブの内表面に直鎖が形成される、磁性ナノチューブ。 - 請求項12において、
前記複数の細菌由来磁性ナノ結晶は、Magnetospirillum magnetotactium MS-1、Magnetospirillum gryphiswaldense、およびMagnetospirillum magneticum AMB-1を含む群から選ばれる細菌によって合成される、磁性ナノチューブ。 - 請求項12において、
前記複数の細菌由来磁性ナノ結晶の各々は球状であり、50〜100ナノメーターの範囲の平均径を有する、磁性ナノチューブ。 - 請求項12において、
前記細菌由来磁性ナノ結晶は、マグネタイト(Fe3O4)およびグレイジャイト(Fe3S4)のうち少なくとも1つを含む、磁性ナノチューブ。 - 請求項12において、
磁性ナノワイヤとしての用途に適応させた、磁性ナノチューブ。 - 請求項12において、
強磁性体として特徴付けられ、少なくとも4mTの磁場を展開する、磁性ナノチューブ。 - 請求項12において、
細胞分離システム、生物学的アッセイシステム、および酵素回収システムのうち少なくとも1つの用途に適応させた、磁性ナノチューブ。 - 請求項12において、
細胞操作の用途に適応させた、磁性ナノチューブ。 - 請求項12において、
ペプチド、第2タンパク質、酵素、抗体、細胞、DNA、遺伝子、ウイルス、細菌、病原体、および膜を含む群から選ばれる少なくとも1つの生物材料をさらに含み、
前記少なくとも1つの生物材料は、前記ペプチドナノチューブの内表面および外表面のうち少なくとも一方に付着する、磁性ナノチューブ。 - 請求項21において、
前記生物材料は細胞を含み、
前記細胞は異常細胞であり、
細胞操作の用途に適応され、複数の正常細胞から前記異常細胞を分離するのに使用される、磁性ナノチューブ。 - 請求項12において、
前記内表面および外表面のうち少なくとも1つに付着させた薬剤および遺伝子の一方をさらに含み、
薬剤伝達システムおよび遺伝子伝達システムの一方の用途に適応され、
磁場は、前記薬剤および前記遺伝子の一方を所望の位置へと導く、磁性ナノチューブ。 - 請求項12において、
磁気共鳴撮像システムの用途に適応させた、磁性ナノチューブ。
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