JP4757547B2 - Specimen slide glass - Google Patents

Description

The present invention relates to a specimen slide glass for a blood smear preparation apparatus that performs blood smearing and staining to prepare a blood smear .

  Conventionally, a specimen plate capable of displaying specimen-related information such as specimen preparation date, specimen number, and name is known (see, for example, Patent Document 1). Patent Document 1 discloses a slide glass having a specimen preparation area where a specimen is prepared and an information display area for displaying specimen-related information. In the slide glass of Patent Document 1, text data that can visually recognize sample related information and a one-dimensional barcode that holds sample related information in only one direction are entered in the information display area. The

  Conventionally, there are a method in which only text data is entered in the information display area of the slide glass, and a method in which both text data and a one-dimensional barcode are entered. When entering only text data, the text data is generally divided into a plurality of lines. When both text data and one-dimensional bar code are entered, only one line of text data is entered so that the operator can visually recognize the sample information, and below the text data of one line. It is common to enter a one-dimensional barcode. In recent years, it has become mainstream to write both text data and a one-dimensional barcode in the information display area of the slide glass.

Japanese Utility Model Publication No. 6-87844

  However, in the case where specimen related information is displayed in the information display area of the slide glass, in the conventional method of entering text data or one-dimensional barcode corresponding to the specimen related information in the information display area, the slide glass can hold the information. There is an inconvenience that the amount of possible specimen related information is small. Specifically, the text data has a disadvantage that the number of characters such as characters and numbers that can be entered in the information display area of the slide glass is limited. One-dimensional barcodes can store more specimen-related information than text data, while more detailed specimen-related information such as analysis results of specimens produced on a slide glass (specimen preparation area) Is stored, there is a disadvantage that the capacity is insufficient. Thus, in the conventional method of entering text data and one-dimensional barcode corresponding to the specimen related information in the information display area of the slide glass, the amount of specimen related information that can be held on the slide glass is small. There is an inconvenience that it is difficult to read a lot of detailed information such as specimen analysis results from the slide glass (information display area). As a result, there is a problem that it is necessary to query the host computer for sample-related information when confirming a lot of detailed sample-related information such as the analysis result of the sample prepared on the slide glass (specimen preparation area). .

The present invention has been made to solve the above-described problems, and one object of the present invention is to be used in a blood smear preparation apparatus that creates a blood smear by smearing and staining blood. Specimens that can be visually recognized by the operator and that can confirm a lot of detailed specimen-related information without querying the host computer for specimen-related information. Is to provide a glass slide .

Means for Solving the Problems and Effects of the Invention

To achieve the above object, a specimen slide glass according to one aspect of the present invention is a specimen slide glass for a blood smear preparation apparatus that performs blood smearing and staining to prepare a blood smear, A specimen preparation area in which a blood smear specimen is prepared and an information display area in which a coating film capable of printing specimen-related information is formed . The information display area includes a first display area in which a two-dimensional code holding the specimen-related information in a horizontal direction and a vertical direction as viewed in plan is printed , and a second display area in which the specimen-related information is printed in text . look including a display area, two-dimensional code and the text by the ink is not eluted into an alcohol and xylene is printed, coated film formed on the information display region is not eluted in alcohol and xylene.

In the specimen slide glass according to this aspect, as described above, the two-dimensional code that holds the specimen-related information in a horizontal direction and a vertical direction in a plan view is displayed in the information display area of the specimen slide glass. By displaying the sample-related information in a two-dimensional code that holds the sample-related information in a horizontal direction and a vertical direction when viewed two-dimensionally , more information is stored than a barcode that holds the sample-related information in only one direction. Therefore, a lot of detailed specimen related information can be held on the specimen slide glass . As a result, by reading the 2-dimensional code displayed on the predetermined specimen slide glass, without querying the sample-related information of a given specimen slide glass, etc. to the host computer (sample), a predetermined specimen slide glass ( A lot of detailed specimen related information about the specimen) can be confirmed. In this case, the amount of information that can be stored in the two-dimensional code is large by displaying the specimen-related information that can be visually recognized in addition to the two-dimensional code in the information display area of the specimen slide glass. Thus, the display area of the two-dimensional code can be reduced, so that the display area of the specimen related information that can be visually recognized can be increased accordingly. Thereby, a lot of specimen-related information can be displayed in a manner that can be visually recognized in the information display area of the specimen slide glass . Therefore, for example, when it is difficult to read a two-dimensional code displayed on a predetermined specimen slide glass , the host computer uses the specimen-related information displayed in a visually recognizable manner. without inquiring the sample-related information of a given specimen slide glass (sample) and the like can be confirmed many sample-related information for a given specimen slide glass (sample).

In the specimen slide glass according to the above aspect, the information display area is preferably arranged in an area on one end side in the longitudinal direction of the specimen slide glass , and the first display area and the second display area are The slide glass for specimen is arranged so as to be adjacent to each other in the short direction. With this configuration, in the sample slide glass in which the information display region is arranged in the region on one end side in the longitudinal direction of the sample slide glass , the first display region and the second display region are used as the sample slide. than placing adjacent to each other in the longitudinal direction of the glass, it is possible to increase the length in the longitudinal direction of the specimen preparation area of the sample slide glass. Thereby, in the specimen slide glass in which the information display area is arranged in the one end side in the longitudinal direction of the specimen slide glass , the first display area and the second display area are arranged in the information display area. However, the specimen preparation area of the specimen slide glass is not reduced.

In the configuration in which the first display area and the second display area are arranged so as to be adjacent to each other in the short direction of the specimen slide glass , preferably, the two-dimensional code has a substantially square shape when seen in a plan view. Have. With this configuration, even if the arrangement direction of the two-dimensional code displayed in the first display area is changed, the size of the second display area does not change.

In the specimen slide glass according to the aforementioned aspect preferably, the second display region, date, name and sample number Ru is text printed. If comprised in this way, the sample relevant information displayed on the 2nd display area can be made easy to read easily.

In the specimen slide glass according to the above aspect , preferably, the specimen preparation area and the information display area are disposed adjacent to each other in the longitudinal direction of the specimen slide glass , and the coating film sandwiches the specimen preparation area. Further, it is formed so as to extend from the information display area along the longitudinal direction of the specimen slide glass . If comprised in this way, even if it overlaps with the several slide glass for specimens, it can suppress that the slide glass for specimens mutually_contact | adhere.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

  FIG. 1 is a perspective view showing an overall configuration of a specimen preparation analysis system according to an embodiment of the present invention, and FIG. 2 is a schematic diagram of the specimen preparation analysis system according to the embodiment shown in FIG. FIG. 3 is a plan view of the internal structure of the specimen preparation analysis system according to the embodiment shown in FIG. 4 is an enlarged view of a frosted portion of a slide glass used in the specimen preparation analysis system according to the embodiment shown in FIG. 1, and FIGS. 5 and 6 show specimen preparation according to the embodiment shown in FIG. It is a perspective view of the cassette and slide glass used for an analysis system. 7 to 17 are detailed views showing the structure of the sample preparation device of the sample preparation analysis system according to the embodiment shown in FIG. First, with reference to FIGS. 1-3, the whole structure of the sample preparation analysis system by this embodiment is demonstrated.

  As shown in FIG. 1, the sample preparation / analysis system of the present embodiment includes a blood smear preparation apparatus 100, a transport apparatus 200, and an automatic blood cell analysis apparatus 300. The blood cell automatic analyzer 300 is a device that automatically classifies blood cells while performing digital image processing on the specimen prepared by the blood smear preparation apparatus 100. The blood smear preparation apparatus 100 prepares two types of specimens, an automatic analysis specimen that can be analyzed by the blood cell automatic analyzer 300 and a visual specimen that can be analyzed visually. It is a device to do. The transport apparatus 200 is installed on the front surface of the blood smear preparation apparatus 100, and the blood cell automatic analyzer 300 is installed on one side of the blood smear preparation apparatus 100. Further, as shown in FIG. 2, a host computer 400 is connected to the control unit 110 of the blood smear preparation apparatus 100.

  As shown in FIG. 1, the transport apparatus 200 is provided to automatically transport a sample rack 150 that houses a test tube 151 that contains blood to the blood smear preparation apparatus 100. The blood smear preparation apparatus 100 includes a display operation unit 101 including a touch panel, a start switch 102, a power switch 103, and a cover 104. The blood smear preparing apparatus 100 is provided with a hand member 160 for transporting the test tube 151 containing blood from the transport apparatus 200 side to the blood smear preparing apparatus 100 side. A rubber stopper 151a is attached to the test tube 151 containing blood.

  In addition, as shown in FIG. 3, the blood smear preparation apparatus 100 includes a suction dispensing mechanism unit 1, a smear unit 2, a resin cassette 3, a cassette housing unit 4, and a first cassette transport unit 5. The slide glass insertion unit 6, the staining unit 7, the second cassette transport unit 8, and the storage unit 9 are provided. The suction dispensing mechanism unit 1 has a function of sucking blood from the test tube 151 transported to the blood smear preparation apparatus 100 side by the hand member 160 (see FIG. 1) and dropping the sucked blood onto the slide glass 10. Have. As shown in FIG. 3, the suction / dispensing mechanism unit 1 includes a piercer (aspiration needle) 1a for sucking blood from a test tube 151, a pipette 1b for dispensing the sucked blood to a slide glass 10, and The syringe pump 1c connected to the piercer 1a and the pipette 1b, the valve 1d for opening and closing the flow path between the piercer 1a and the syringe pump 1c, and the flow path between the pipette 1b and the syringe pump 1c And a valve 1e.

  Here, in the present embodiment, the suction dispensing mechanism unit 1 dispenses the same blood (specimen) into each of the two slide glasses 10, and the amount of the blood dispensed is a sample for automatic analysis. And a function of adjusting to an amount corresponding to a sample for visual observation.

  The smearing unit 2 is provided for supplying the slide glass 10 to the dispensing / smearing position 20, smearing and drying blood dropped on the slide glass 10, and printing on the slide glass 10. . The smearing unit 2 includes a slide glass supply unit 2a, a slide glass storage unit 2b, a draw glass 2c, feed belts 2d and 2e, a fan 2f, a printing unit 2g, and a slide glass transport unit 2h. It has been.

  Further, the slide glass supply unit 2a supplies the slide glass 10 stored in the two slide glass storage units 2b onto the feed belt 2e using a take-out mechanism (not shown) and a chuck (not shown) attached to the feed belt 2d. Has the function of The feed belt 2e is configured to convey the slide glass 10 to the dispensing / smearing position 20 and the drying positions 21a and 21b. The pulling glass 2c is movable to a position where it abuts on the slide glass 10 so that blood dispensed on the slide glass 10 can be smeared at the dispensing / smearing position 20, and the longitudinal direction of the slide glass 10 It is configured to be movable. The fan 2f is provided for drying the smeared blood on the slide glass 10 conveyed to the drying positions 21a and 21b.

  Here, in the present embodiment, the printing unit 2g is a thermal transfer printer. As shown in FIG. 4, the printing unit 2g is a two-dimensional barcode 10b in which specimen information such as a specimen number, date, reception number, and name is stored in a frosted part (information display area) 10a of the slide glass 10. And three lines of text data including date (07/06/04) 10c, name (Sysmex) 10d, and specimen number (BA15617) 10e as attribute information included in the sample information. . The two-dimensional bar code is a bar code that holds information in two directions, a horizontal direction and a vertical direction as viewed in a plan view. The two-dimensional barcode 10b printed on the frosted portion 10a of the slide glass 10 includes a data matrix and a QR code. The amount of information (number of characters that can be stored) of the two-dimensional barcode 10b is 50 digits at maximum for half-width characters and 25 digits for full-width characters.

  In addition, as the ink for the printing unit 2g (thermal transfer printer), the two-dimensional barcode 10b and text data (10c to 10e) printed on the frosted part 10a of the slide glass 10 are alcohol used for staining operation and microscopic examination. Ink having a durability not to be eluted by an organic solvent such as xylene is used.

  In the present embodiment, as shown in FIGS. 4 and 5, the frosted portion (information display area) 10 of the slide glass 10 is adjacent to the specimen preparation area 10 f in the longitudinal direction of the slide glass 10. 10 is arranged in a region on one end side. Further, the barcode printing area F1 on which the two-dimensional barcode 10b of the frosted part 10a is printed and the text printing area F2 on which three lines of text data (10c to 10e) are printed are mutually in the short direction of the slide glass 10. It is arranged to be adjacent. The two-dimensional barcode 10b has a square shape when seen in a plan view. Each of the three lines of text data (10c to 10e) has a longitudinal direction of the slide glass 10 such that the barcode print area F1 and the text print area F2 have the same length in the longitudinal direction of the slide glass 10. Are adjacent to each other at a predetermined interval. Further, the letters and numbers constituting each of the three lines of text data (10c to 10e) are arranged along the short direction of the slide glass 10. In this case, the maximum number of characters of text data that can be printed is 8 single-byte characters.

  In the present embodiment, a printable coating film 10g made of a coating agent such as a resin is formed on a region corresponding to the frosted portion 10a of the slide glass 10. The coating agent constituting the coating film 10g has excellent durability against an organic solvent such as alcohol or xylene used in the staining operation and the microscopic examination. The above-described two-dimensional barcode 10b and three lines of text data (10c to 10e) are printed on the upper surface of the coating film 10g located in the frost portion 10a. The coating film 10g is formed so as to extend along the longitudinal direction of the slide glass 10 from the frost portion 10a so as to sandwich the specimen preparation region 10f.

  As shown in FIG. 3, the slide glass transport unit 2 h moves the slide glass 10 from the end of the feed belt 2 e to the printing unit 2 g and moves the slide glass 10 after printing to the storage position of the cassette 3. It is provided for. The slide glass transport unit 2h includes a lateral movement piece 2i for moving the slide glass 10 laterally (in the X direction in FIG. 3) from the end of the feed belt 2e to a lateral position 21c for printing, and a slide A vertical movement piece 2j for moving the glass 10 in the vertical direction (Y direction in FIG. 3) to the vertical position 21d for printing and the storage position 21e of the cassette 3 is included.

  As shown in FIGS. 5 and 6, the resin-made cassette 3 is configured so as to be able to accommodate a smeared slide glass 10 and a liquid (staining liquid) used in a staining process. Specifically, as shown in FIGS. 5 and 6, the cassette 3 includes a slide glass storage hole 3a, a staining liquid suction / dispensing hole 3b, partition portions 3c and 3d, a slide glass support portion 3e, and a magnet. It includes two magnet adsorbing members 3f made of metal that can be adsorbed to the surface, a conveyor belt engaging portion 3g, side surface portions 3h and 3i, and side surface portions 3j and 3k. The slide glass storage hole 3a and the staining liquid suction / dispensing hole 3b are connected inside. Further, the side surface portions 3j and 3k protrude by a predetermined amount from the side surface portions 3h and 3i, respectively, and are arranged on the upper portion of the cassette 3.

  Moreover, as shown in FIG. 3, the cassette accommodating part 4 is provided in order to carry in the cassette 3, and contains the infeed belt 4a.

  Further, the first cassette transport section 5 shown in FIG. 3 is provided for transporting the cassette 3 carried in from the cassette housing section 4 to the slide glass insertion section 6 and the staining section 7. The first cassette transport section 5 transports a cassette transport member 5a that can move in the horizontal direction, a drive belt 5b for moving the cassette transport member 5a in the horizontal direction, and the cassette 3 that is supplied from the cassette housing section 4. And a transport path 5c.

  The slide glass insertion portion 6 shown in FIG. 3 is provided to store the slide glass 10 that has been smeared and printed in the slide glass storage hole 3 a of the cassette 3. The slide glass insertion portion 6 includes a cassette rotation mechanism portion 6a for placing the cassette 3 in the horizontal direction so that the slide glass 10 can be inserted.

  The staining section 7 shown in FIG. 3 is provided for staining the smeared slide glass 10 by supplying the staining liquid to the staining liquid suction / dispensing hole 3b of the cassette 3 conveyed by the cassette conveying member 5a. It has been. The staining unit 7 is configured to transport the cassette 3 transported by the cassette transporting member 5a to the second suction / discharge unit 7d of the staining unit 7 and to transport the cassette 3 fed from the feeding member 7a. It includes a conveyor belt 7b, first to fifth suction / discharge sections 7c to 7g for supplying and discharging the staining liquid to and from the cassette 3, and a fan 7h for drying the stained slide glass 10. Yes.

  Here, in this embodiment, the second cassette transport unit 8 stores the cassette 3 in which the stained slide glass 10 is stored in the inlet 300a of the blood cell automatic analyzer 300 and the blood smear preparation apparatus 100. It is comprised so that it can convey to both the carrying-in ports 9a of the part 9. FIG. With reference to FIGS. 3 and 7 to 13, the detailed structure of the second cassette transport unit 8 according to the present embodiment will be described. As shown in FIG. 7, the second cassette transport unit 8 includes a transport unit 8b attached to the frame 8a, a cassette detection unit 8c, and transport paths 8d and 8e. As shown in FIGS. 8, 10, and 11, a hole 8f is provided in a lower region corresponding to the transport portion 8b of the frame 8a, and a region corresponding to the cassette detection portion 8c is provided in the region corresponding to the cassette detection portion 8c. A hole 8g is provided.

  As shown in FIGS. 7 and 9, the transport unit 8 b includes a moving member 81, a moving member detection sensor 82, pulleys 83 a and 83 b, a driving belt 84, a linear guide 85, and a driving motor 86. And is composed of. As shown in FIG. 7, the moving member detection sensor 82 and the driving motor 86 are arranged inside the frame 8 a, and pulleys 83 a and 83 b, a driving belt 84, and a linear guide 85 Is arranged outside the frame 8a.

  As shown in FIGS. 7 to 9, the moving member 81 is made of sheet metal and has two contact portions 81a and 81b, a detection portion 81c, and an attachment portion 81d. As shown in FIGS. 7 and 10, the two contact portions 81a and 81b of the moving member 81 and the detection portion 81c are arranged inside the frame 8a, and the attachment portion 81d is shown in FIG. And as shown in FIG. 11, it arrange | positions on the outer side of the flame | frame 8a through the hole 8f of the flame | frame 8a.

  As shown in FIG. 8, the contact portions 81a and 81b of the moving member 81 have a function of moving the cassette 3 by contacting the side portions 3h and 3j of the cassette 3, respectively. As shown in FIG. 9, the detection unit 81 c of the moving member 81 is provided for detecting the position of the moving member 81 by the moving member detection sensor 82. The attachment portion 81 d of the moving member 81 is attached to the linear motion guide 85. Further, a belt connecting portion 81 e is provided on the attachment portion 81 d of the moving member 81. The belt connecting portion 81e is connected to the drive belt 84 using an attachment piece 81f. As shown in FIG. 7, the drive belt 84 is attached to pulleys 83 a and 83 b, and the pulley 83 a is connected to a drive motor 86. As a result, the drive motor 86 is driven to rotate the pulley 83a and the drive belt 84 is driven, so that the moving member 81 connected to the drive belt 84 is moved. The distance between the pulley 83a and the pulley 83b to which the drive belt 84 is attached is such that the contact portions 81a and 81b of the moving member 81 connected to the drive belt 84 reach the introduction port 300a of the blood cell automatic analyzer 300. It is set to be possible.

  Moreover, as shown in FIG. 11, the cassette detection part 8c is arrange | positioned on the outer side of the flame | frame 8a. The region where the cassette detection unit 8c is installed is a region where the cassette 3 conveyed from the staining unit 7 (see FIG. 3) reaches, and is a conveyance start position 80. The cassette detection unit 8c includes a cassette detection sensor 87, a detection piece 88, and two brackets 89 and 90. As shown in FIG. 12, the detection piece 88 has a leaf spring structure and includes a curved portion 88a and a detection portion 88b. The curved portion 88a of the detection piece 88 is arranged so that the convex side protrudes to the inside of the frame 8a through the hole 8g of the frame 8a. Further, as shown in FIG. 13, when an external force is applied to the curved portion 88a of the detection piece 88 from the inside of the frame 8a, the curved portion 88a and the detection portion 88b of the detection piece 88 move in the outward direction of the frame 8a. Is done. Further, as shown in FIGS. 12 and 13, the cassette detection sensor 87 has a function of detecting the detection portion 88 b of the detection piece 88. Further, as shown in FIG. 11, the cassette detection sensor 87 and the detection piece 88 are attached to the frame 8a via brackets 89 and 90, respectively.

  Further, as shown in FIG. 7, the transport paths 8d and 8e are made of sheet metal. One end of the transport path 8d is disposed in a region corresponding to the transport start position 80, and the other end is adjacent to the inlet 300a (see FIG. 3) of the blood cell automatic analyzer 300. The blood smear preparation apparatus 100 is arranged in a predetermined region. The conveyance path 8e is disposed in the introduction port 300a of the blood cell automatic analyzer 300. The transport paths 8d and 8e serve as paths for the cassette 3 that is moved by being pushed by the moving member 81.

  The storage unit 9 shown in FIG. 3 is provided for storing the cassette 3 in which the slide glass 10 stained by the staining unit 7 is stored. The stained slide glass (specimen) 10 carried into the storage unit 9 is analyzed visually. The storage unit 9 is provided with a feeding unit 9b and a conveyor belt 9c.

  In the present embodiment, as shown in FIG. 7, the feeding section 9 b is attached to the frame 8 a of the second cassette transport section 8 and is disposed in an area corresponding to the carry-in port 9 a of the storage section 9. The feeding section 9b is provided to move the cassette 3 transported to the carry-in port 9a of the storage section 9 by the second cassette transport section 8 to the storage section 9 side.

  Here, with reference to FIG. 3, FIG. 16, and FIG. 17, the detailed structure of the feeding unit 9b of the storage unit 9 according to the present embodiment will be described. As shown in FIG. 16, the feeding portion 9b includes a swing member 91 made of sheet metal, a metal support shaft 92, an attachment member 93 made of sheet metal, pulleys 94a and 94b, a drive belt 95, and a drive The motor 96 is configured. As shown in FIG. 17, the swing member 91 is provided to press the cassette 3 and move it to the storage unit 9 (see FIG. 3) side. The swing member 91 has a swing piece 91 a and the swing piece 91 a is swung so as to press the upper portion of the cassette 3. Further, as shown in FIG. 16, the swing member 91 is integrally provided with a detection piece 91b for detecting that the swing member 91 is in a stationary position (non-oscillating position). A light transmission sensor 97 for detecting the detection piece 91b of the swing member 91 is attached to the frame 8a via a bracket 98. Further, as shown in FIGS. 16 and 17, the support shaft 92 is pressed against the swing member 91 by the mounting member 93. As a result, the support shaft 92 is fixed to the swing member 91. The pulley 94 a is connected to one end of the support shaft 92, and the pulley 94 b is connected to the drive motor 96. The drive belt 95 is attached to the pulleys 94a and 94b. Further, as shown in FIG. 3, the storage unit 9 is provided with a transport belt 9c for transporting the cassette 3 moved to the storage unit 9 side by the infeed unit 9b.

  Moreover, in this embodiment, the control part 110 of the blood smear sample preparation apparatus 100 conveys the cassette 3 in which the stained slide glass 10 was accommodated to the inlet 9a of the storage part 9, or blood cell automatic It has a function of controlling whether it is conveyed to the inlet 300a of the analyzer 300. The operations of the second cassette transport unit 8 and the feeding unit 9b of the storage unit 9 are controlled by the control unit 110. Further, the control unit 110 is provided with a memory 111 that stores specimen information such as specimen preparation conditions.

  As shown in FIG. 3, the blood cell automatic analyzer 300 includes a feeding unit 301, a cassette storage unit 302, a slide glass extraction unit 303, a barcode reading unit 304, an analysis unit 305, and a control unit 306. I have. The feeding section 301 has the same configuration as the feeding section 9b of the storage section 9 of the blood smear preparation apparatus 100 shown in FIG. 16, and is installed in a region corresponding to the inlet 300a of the blood cell automatic analyzer 300. Yes. The feeding unit 301 is provided to move the cassette 3 transported to the inlet 300a of the blood cell automatic analyzer 300 to the cassette housing unit 302 side. The cassette housing unit 302 has the same configuration as the storage unit 9 of the blood smear preparation apparatus 100. The cassette housing 302 is provided with a pair of transport belts 302a. The slide glass extraction unit 303 has a function of taking out the stained slide glass 10 from the cassette 3 and transporting it to the barcode reading unit 304. The barcode reading unit 304 has a function of reading the two-dimensional barcode 10b (see FIG. 4) printed on the frosted part 10a of the slide glass 10. The analysis unit 305 has a function of performing digital image processing on the stained specimen of the slide glass 10 and automatically classifying blood cells.

  Next, with reference to FIGS. 1-18, operation | movement of the sample preparation analysis system by this embodiment is demonstrated.

  First, as a suction dispensing operation, as shown in FIG. 1, in a state where the activation switch 102 is pressed and the blood smear preparation apparatus 100 is activated, a sample rack 150 in which a test tube 151 in which a blood sample is accommodated is accommodated. Is set in the carry-in unit 201 of the transport apparatus 200. Then, the automatic suction start switch displayed on the display operation unit 101 is pressed. As a result, the sample rack 150 is transported to the take-out unit 202 of the transport device 200. Thereafter, the hand member 160 of the blood smear preparation apparatus 100 holds the test tube 151 in which the blood in the sample rack 150 is stored. Then, the test tube 151 is lifted by raising the hand member 160, and the test tube 151 is stirred by rotating the hand member 160, and then the test tube 151 is disposed in the suction dispensing mechanism unit 1 shown in FIG. 3. To do. Then, the piercer 1a is pierced into the rubber stopper 151a of the test tube 151 to suck blood. In this suction operation, the valve 1d is opened (on state) and the valve 1e is shut off (off state). After completing the blood suction operation, the valve 1d is turned off (off state) and the valve 1e is opened (on state). Thereafter, the pipette 1b is moved to the dispensing / smearing position 20 shown in FIG.

  Next, in parallel with the suction dispensing operation, the cassette 3 is carried in by the cassette housing portion 4 shown in FIG. Specifically, first, the cassette 3 is set in the cassette housing portion 4. As a result, the cassette 3 is transported and fed to the cassette standby position 40 in a state where the transport belt engaging portion 3g (see FIGS. 5 and 6) of the cassette 3 is engaged with the feed belt 4a of the cassette housing portion 4. . The first cassette 3 among the cassettes 3 at the cassette standby position 40 is arranged in the transport path 5c.

  Next, in step S1 of the flowchart of FIG. 18, the control unit 110 of the blood smear preparation apparatus 100 acquires specimen information from the host computer 400 (see FIG. 2). The specimen information includes information such as the specimen number of the smear specimen and the number of smear preparations. Specimen information also includes information such as whether to produce only one of the visual sample and the sample for automatic analysis or whether to produce both the visual sample and the sample for automatic analysis. Yes. Furthermore, the specimen information includes information such as whether or not to analyze with the blood cell automatic analyzer 300. In step S2, a smear condition is called from the database stored in the control unit 110 based on the specimen information. The smearing conditions are preset conditions for preparing a smear, and the amount of blood dropped, the angle of the pulling glass, the moving speed of the pulling glass, and the like are set corresponding to the desired smear. . Thereafter, in step S3, blood is dropped (dispensed) on the slide glass 10 using the pipette 1b based on the called smearing conditions. At this time, when both a sample for automatic analysis and a sample for visual observation are prepared, the same blood is dispensed into each of the two glass slides 10. Then, when preparing a sample for automatic analysis, an amount of blood corresponding to the sample for automatic analysis is dispensed, and when preparing a sample for visual observation, it corresponds to the sample for visual observation. An amount of blood is dispensed.

  Next, in step S4, a smearing operation by the smearing unit 2 is performed based on the smearing conditions. The smearing operation by the smearing unit 2 is performed in parallel with the suction dispensing operation by the suction dispensing mechanism unit 1 described above or after the suction dispensing operation. As shown in FIG. 3, the smearing unit 2 supplies the slide glass 10 to the dispensing / smearing position 20, smears and dries the blood dropped on the slide glass 10, and prints on the slide glass 10. I do. Specifically, the slide glass 10 stored in the two slide glass storage units 2b of the slide glass supply unit 2a is supplied onto the feed belt 2e by a take-out mechanism and a feed belt 2d (not shown). Then, the slide glass 10 is conveyed to the dispensing / smearing position 20 by the feed belt 2e. The operation of transporting the slide glass 10 to the dispensing / smearing position 20 is performed before the above-described suction dispensing operation. In this state, blood is dropped (dispensed) on the slide glass 10 using the pipette 1b.

  Thereafter, the drag glass 2c is moved so as to contact the slide glass 10 and is reciprocated in the longitudinal direction of the slide glass 10 so that the blood dropped on the slide glass 10 at the dispensing / smearing position 20 is transferred. Smeared. At this time, the contact angle of the pulling glass 2c with respect to the slide glass 10 and the speed of reciprocating movement of the pulling glass 2c are adjusted depending on whether a sample for automatic analysis or a sample for visual observation is prepared. Specifically, the thickness of the sample for automatic analysis is adjusted to be smaller than the thickness of the sample for visual observation. Thereafter, the smeared slide glass 10 is conveyed to the drying position 21a by the feed belt 2e. Then, at the drying position 21a, the blood smeared on the slide glass 10 is dried with cold air by the fan 2f. The slide glass 10 is dried twice at two adjacent drying positions 21a and 21b. Thereafter, the smeared slide glass 10 is moved to the printing unit 2g by the slide glass transport unit 2h. In the printing unit 2g, three lines including a two-dimensional barcode 10b in which specimen information such as a specimen number, a date, a reception number, and a name is stored in the frosted part 10a of the slide glass 10, and a kanji for the date and the name, etc. The text 10c is printed.

  Next, the cassettes 3 arranged in the conveyance path 5 c are conveyed one by one to the slide glass insertion unit 6 by the cassette conveyance unit 5. That is, the cassette transport member 5a constituting the cassette transport unit 5 moves from the transport start position 50 while pushing the side surface part 3h (see FIGS. 5 and 6) of the cassette 3, whereby the cassette 3 is moved to the slide glass insertion unit 6. To be transported.

  Next, in step S5, the smeared slide glass 10 is housed in the cassette 3, and is transported to the staining section 7 by the cassette transport member 5a and subjected to a staining process.

  Specifically, by rotating the cassette rotation mechanism 6a in a predetermined direction, the cassette 3 is moved from the vertical position to the horizontal position (the position of the two-dot chain line in FIG. 3), and the slide glass 10 is moved. Make it insertable. In this state, the slide glass 10 that has been smeared is inserted into the slide glass housing hole 3a of the cassette 3 by moving the longitudinally moving piece 2j of the smearing section 2 forward. Thus, the smeared slide glass 10 is stored in the cassette 3. After that, the cassette 3 is returned to the original vertical position by rotating the cassette rotating mechanism 6a in the direction opposite to the predetermined direction. Thereafter, in the staining section 7, first, the smeared slide glass 10 is lifted from the slide glass storage hole 3a of the cassette 3 by the first suction discharge section 7c, and methanol is introduced into the staining liquid suction dispensing hole 3b of the cassette 3. Dispense. Then, after the smeared slide glass 10 is returned to the cassette 3, the cassettes 3 containing the smeared slide glasses 10 are placed one by one on the transport belt 7b by the feeding member 7a. And the cassette 3 is conveyed by the conveyance belt 7b to the 2nd suction discharge part 7d.

  In the second suction / discharge section 7d, the smeared slide glass 10 is lifted from the slide glass storage hole 3a of the cassette 3, and the blown air from the fan 7j is applied to the smear surface of the slide glass 10 for about 1 second to about 60 seconds. Dry by evaporating the liquid component above. The time (immersion time) from when the smeared slide glass 10 is immersed in methanol by the first suction / discharge unit 7c to when the slide glass 10 is lifted by the second suction / discharge unit 7d is about 20 seconds to about 120. Seconds.

  Next, a dyeing process (Maygrunwald / Giemsa double dyeing process) is performed. First, in the second suction / discharge unit 7 d, methanol is sucked and discharged from the staining liquid suction / dispensing hole 3 b of the cassette 3, and then the slide glass 10 is returned to the slide glass storage hole 3 a of the cassette 3. Next, the May-Grunwald solution (main component is 99% methanol) is dispensed from the staining solution suction dispensing hole 3b of the cassette 3, and the smeared slide glass 10 is immersed in the May-Grunwald solution. Thereby, the May Grünwald Giemsa double staining process is started. And while the cassette 3 is conveyed by the conveyance belt 7b, the smeared slide glass 10 is immersed in the May-Grunwald solution as a staining process for about 1 minute to about 5 minutes. Then, after the May-Grunwald liquid is sucked and discharged from the staining liquid suction / dispensing hole 3b of the cassette 3 by the third suction / discharge section 7e, the May-Grunwald diluted liquid is dispensed into the staining liquid suction / dispensing hole 3b of the cassette 3. Noted. And while the cassette 3 is conveyed by the conveyance belt 7b, the smeared slide glass 10 is immersed in the May-Grunwald diluent for about 1 minute to about 5 minutes. Then, after the May Grunwald diluted liquid is sucked and discharged from the staining liquid suction dispensing hole 3b of the cassette 3 by the fourth suction discharge section 7f, the Giemsa diluted liquid is dispensed into the staining liquid suction dispensing hole 3b of the cassette 3. Noted. And while the cassette 3 is conveyed by the conveyance belt 7b, the smeared slide glass 10 is immersed in the Giemsa diluted solution for about 1 minute to about 20 minutes.

  Next, after the Giemsa diluted solution is sucked and discharged from the staining liquid suction / dispensing hole 3b of the cassette 3 by the fifth suction / discharge section 7g, the cleaning liquid is dispensed into the staining liquid suction / dispensing hole 3b of the cassette 3. The slide glass 10 that has been poured and sucked and stained is washed with water. Thereafter, the stained slide glass 10 is dried by the fan 7h.

  Next, in step S <b> 6, when the cassette detection sensor 87 of the cassette detection unit 8 c of the second cassette transport unit 8 is turned on, sample information is called from the database stored in the control unit 110. Specifically, first, the cassette 3 in which the stained slide glass 10 is stored is transported from the smearing section 7 to the transport start position 80 of the second cassette transport section 8. At this time, as shown in FIG. 13, the curved portion 88 a of the detection piece 88 of the cassette detection portion 8 c is pressed by the cassette 3 toward the outside of the frame 8 a. Thereby, since the detection part 88b of the detection piece 88 moves to the outer side direction of the flame | frame 8a, the cassette detection sensor 87 turns on. As a result, the sample information is called from the database stored in the memory 111 in the control unit 110.

  Next, in step S7, the control unit 110 determines the transport destination of the cassette 3 in which the stained slide glass 10 is stored based on the specimen information. That is, it is determined whether the cassette 3 is to be transported to the carry-in port 9 a of the storage unit 9 of the blood smear preparation apparatus 100 or the inlet 300 a of the automatic blood cell analyzer 300.

  Next, in step S8, based on the transport destination information determined by the control unit 110, the second cassette transport unit 8 transports the cassette 3 containing the stained slide glass 10 to the determined transport destination. . Specifically, as shown in FIG. 10, first, the drive belt 84 is driven by driving the drive motor 86, thereby moving the moving member 81 connected to the drive belt 84 in the direction of arrow C. . Thereby, the contact parts 81a and 81b of the moving member 81 contact the side parts 3h and 3j of the cassette 3, respectively. As a result, the cassette 3 moves in the direction of arrow C while being pushed by the contact portions 81a and 81b of the moving member 81. In addition, the cassette 3 that moves in the direction of the arrow C is divided into a conveyance path 8d disposed in a predetermined region in the blood smear preparation apparatus 100 and a conveyance path 8e disposed in the inlet 300a of the blood cell automatic analyzer 300. Move along.

  At this time, in the present embodiment, the number of pulses of the drive motor 86 is controlled based on the transport destination information determined by the control unit 110. Specifically, when the cassette 3 containing the stained slide glass 10 is transported to the carry-in port 9a (see FIG. 3) of the storage unit 9 of the blood smear preparation apparatus 100, as shown in FIG. The amount of movement of the moving member 81 in the direction of arrow C is adjusted so that the movement of the cassette 3 in the direction of arrow C ends at the carry-in port 9a. Further, when the cassette 3 in which the stained slide glass 10 is stored is transported to the inlet 300a (see FIG. 3) of the automatic blood cell analyzer 300, as shown in FIG. The movement amount of the moving member 81 in the direction of arrow C is adjusted so that the movement of the moving member 81 ends at the introduction port 300a. The transport of the cassette 3 by the second cassette transport unit 8 ends the operation flow shown in FIG.

  Next, as shown in FIG. 3, the cassette 3 in which the stained slide glass 10 transported to the carry-in port 9 a of the storage unit 9 of the blood smear preparation apparatus 100 is stored is stored in the feeding unit 9 b of the storage unit 9. It moves to the storage unit 9 side by function. Specifically, first, as shown in FIG. 17, the driving belt 96 is driven by rotating the driving motor 96 to rotate the swing member 91 in the same direction as the rotation direction of the driving motor 96. Let Thereby, the swing piece 91 a of the swing member 91 presses the upper portion of the cassette 3. The cassette 3 moves to the storage unit 9 (see FIG. 3) side by the pressing operation of the swing piece 91a to the upper portion of the cassette 3. The operation of the sending unit 9b is controlled by the control unit 110. Thereafter, as shown in FIG. 3, the cassette 3 is transported to the storage unit 9 by the transport belt 9c and stored.

  On the other hand, the cassette 3 in which the stained slide glass 10 conveyed to the introduction port 300a of the blood cell automatic analyzer 300 is accommodated is pressed toward the cassette accommodating portion 302 by the feeding portion 301 and is also conveyed by the conveying belt 302a. It is conveyed to the cassette housing part 302. The operation of the feeding unit 301 of the blood cell automatic analyzer 300 at this time is the same as the operation of the feeding unit 9b of the storage unit 9. Thereafter, the stained glass slide 10 is taken out from the cassette 3 in the slide glass take-out unit 303, and the dyed slide glass 10 is conveyed to the barcode reading unit 304. Next, the barcode reading unit 304 reads the two-dimensional barcode 10b printed on the frosted part 10a of the slide glass 10. Then, after the specimen number of the stained slide glass 10 read by the barcode reading unit 304 is sent to the control unit 306, the control unit 306 inquires the host computer 400 about the sample number. Thus, it is confirmed whether the stained slide glass (specimen) 10 needs to be analyzed before being transported to the analysis unit 305. Finally, when it is necessary to analyze the stained glass slide (specimen) 10, the analysis unit 305 digitally processes the stained glass slide (specimen) 10 and classifies blood cells. Done automatically. Thereafter, the stained slide glass (specimen) 10 subjected to blood cell classification is accommodated in a storage (not shown) for storing the analyzed specimen. When analysis of the stained slide glass (specimen) 10 is not required, the analysis unit 305 does not analyze the stained slide glass (specimen) 10 and stores the analysis specimen (see FIG. (Not shown). Note that the operations of the slide glass extraction unit 303 and the analysis unit 305 are controlled by the control unit 306.

  In the present embodiment, as described above, the blood smear preparation apparatus 100 is configured to transfer the cassette 3 containing the stained glass slide (specimen) 10 to the inlet 300a of the blood cell automatic analyzer 300. By providing the two-cassette transport unit 8, the second cassette transport unit 8 can automatically perform a specimen supply operation from the blood smear preparation apparatus 100 to the blood cell automatic analyzer 300. Thereby, the sample supply operation from the blood smear preparation apparatus 100 to the blood cell automatic analyzer 300 can be performed without imposing a burden on the operator.

  Further, in this embodiment, the second cassette transport unit 8 also has a function of transporting the cassette 3 in which the stained slide glass 10 is stored to the carry-in port 9a of the storage unit 9 of the blood smear preparation apparatus 100. In the blood smear preparation apparatus 100, when two kinds of specimens, that is, a specimen supplied to the blood cell automatic analyzer 300 and a specimen stored in the storage unit 9, are prepared, a stained slide glass (specimen) 10 is stored. The cassette 3 can be distributed to the carry-in port 9 a of the storage unit 9 and the introduction port 300 a of the blood cell automatic analyzer 300 by one second cassette transport unit 8.

  In this embodiment, the blood smear sample preparation apparatus 100 transports the cassette 3 in which the stained slide glass 10 is stored to the carry-in port 9a of the storage unit 9 or the introduction port 300a of the blood cell automatic analyzer 300. By providing the control unit 110 for controlling the second cassette transport unit 8 as described above, the stained slide glass 10 is easily stored in the carry-in port 9a of the storage unit 9 and the introduction port 300a of the blood cell automatic analyzer 300. The cassettes 3 that have been made can be sorted.

  Further, in the present embodiment, the storage unit 9 of the blood smear preparation apparatus 100 is provided with a feeding unit 9b for moving the cassette 3 conveyed to the carry-in port 9a of the storage unit 9 to the storage unit 9 side, and the second cassette When the cassette 3 in which the stained glass slide 10 is stored by the transport unit 8 is transported to the carry-in port 9a of the storage unit 9, the feed unit 9b is moved to the storage unit 9 side so that the control unit 110 moves the cassette 3 to the storage unit 9 side. By controlling according to the above, it is possible to easily move the cassette 3 storing the stained slide glass 10 conveyed to the carry-in port 9a of the storage unit 9 to the storage unit 9 side.

  Further, in the present embodiment, by providing the second cassette transport unit 8 with the moving member 81 that contacts the cassette 3 and moves the cassette 3 and the driving motor 86 that drives the moving member 81, The cassette 3 can be transported to the inlet 300 a of the blood cell automatic analyzer 300 by the moving member 81 of the second cassette transport unit 8.

  Further, in the present embodiment, the moving member 81 of the second cassette transport unit 8 includes a contact part 81 a that contacts the side surface part 3 h of the cassette 3 and a contact part 81 b that contacts the side surface part 3 j of the cassette 3. With this configuration, the abutting portions 81a and 81b of the moving member 81 can be brought into contact with the side surface portions 3h and 3j of the cassette 3, respectively, so that the inlet port 300a of the blood cell automatic analyzer 300 is stable. Thus, the cassette 3 can be transported.

  In the present embodiment, the transport path 8d disposed in a predetermined area in the blood smear preparation apparatus 100 and the transport path 8e disposed in the introduction port 300a of the blood cell automatic analyzer 300 are provided, thereby providing the first. 2 Along the conveyance path 8d and the conveyance path 8e from the conveyance start position 80 of the cassette conveyance unit 8 to the introduction port 300a of the blood cell automatic analyzer 300 through the conveyance port 9a of the storage unit 9 of the blood smear preparation apparatus 100. Since the cassette 3 can be moved, the cassette 3 can be easily transported to the inlet 9a of the storage unit 9 of the blood smear preparation apparatus 100 or the inlet 300a of the automatic blood cell analyzer 300.

  Moreover, in this embodiment, by providing the cassette detection part 8c for detecting that the cassette 3 in which the dyed slide glass 10 was accommodated arrived at the conveyance start position 80 of the second cassette conveyance part 8, The cassette detector 8c can easily detect that the cassette 3 has reached the transfer start position 80 of the second cassette transfer unit 8.

  In the present embodiment, the same blood (specimen) is dispensed to each of the two slide glasses 10, and the dispensed amount of the same blood dispensed to each of the two slide glasses 10 is for visual observation. By providing the aspirating and dispensing mechanism unit 1 having a function of adjusting the amount corresponding to the sample of the blood sample and the amount corresponding to the sample analyzed by the blood cell automatic analyzer 300, the blood cell automatic analyzer 300 can easily perform the adjustment. The specimen to be analyzed and the visual specimen can be made from the same blood.

  In the present embodiment, the blood smear preparation apparatus 100 is provided with a printing unit 2g for printing the two-dimensional barcode 10b in which the specimen information is stored in the frosted part 10a of the slide glass 10, and the two-dimensional barcode 10b. Since the two-dimensional barcode 10b can store a larger amount of information than the one-dimensional barcode by providing the barcode reading unit 304 for reading the blood cell in the blood cell automatic analyzer 300, the frosted portion of the slide glass 10 The amount of specimen information printed on 10a can be increased. In this case, even if the cassette 3 in which the stained slide glass (specimen) 10 is stored in the blood cell automatic analyzer 300 is automatically supplied by the second cassette transport unit 8, the barcode is analyzed before the specimen is analyzed. If sample information is confirmed by the reading unit 304, it is possible to suppress the occurrence of mistakes in sample mixing.

  In the present embodiment, the two-dimensional barcode 10b is printed with the two-dimensional barcode 10b on which the specimen information is stored on the frosted portion 10a of the slide glass 10, so that the two-dimensional barcode 10b has more information than the one-dimensional barcode. Therefore, a lot of detailed specimen information can be held on the slide glass 10. As a result, by reading the two-dimensional barcode 10b printed on the predetermined slide glass 10, the predetermined slide glass (specimen) 10 is not inquired of the host computer 400 about the specimen information of the predetermined slide glass (specimen) 10. A lot of detailed specimen information about can be confirmed. In this case, by printing text data (10c to 10e) as specimen information in addition to the two-dimensional barcode 10b on the frosted portion 10a of the slide glass 10, the amount of information that can be stored in the two-dimensional barcode 10b is increased. Since the printing area of the two-dimensional barcode 10b can be reduced by increasing the number, the printing area of the text data (10c to 10e) can be increased accordingly. Thereby, the text data (10c-10e) as many sample information can be displayed on the slide glass 10. FIG. For this reason, for example, when it is difficult to read the two-dimensional barcode 10b printed on the predetermined slide glass 10, the host computer uses visually recognizable text data (10c to 10e). It is possible to confirm a lot of specimen information related to the predetermined slide glass (specimen) 10 without inquiring the specimen information of the predetermined slide glass (specimen) 10 to 400.

  Further, in the present embodiment, the barcode printing area F1 in which the two-dimensional barcode 10b is printed and the text on the slide glass 10 in which the frost portion 10a is disposed in one end side in the longitudinal direction of the slide glass 10 and text By arranging the text print area F2 on which data (10c to 10e) is printed so as to be adjacent to each other in the short direction of the slide glass 10, the barcode print area F1 and the text print area F2 are arranged on the slide glass 10. The length of the specimen preparation region 10f in the longitudinal direction of the slide glass 10 can be increased as compared with the case where they are arranged adjacent to each other in the longitudinal direction. As a result, even if the barcode printing area F1 and the text printing area F2 are arranged in the frost portion 10a in the slide glass 10 in which the frost portion 10a is arranged in the one end side region in the longitudinal direction of the slide glass 10. The specimen preparation region 10f of the slide glass 10 is not reduced. In this case, even if the arrangement direction of the two-dimensional barcode 10b is changed by making the two-dimensional barcode 10b square when viewed in plan, the text print area F2 does not change.

  In this embodiment, the text data (10c to 10e) is divided into three lines of date 10c, name 10d, and sample number 10e, which are different types of data, so that the date 10c, name 10d, and sample number 10e are divided. The text data (10c to 10e) can be made easier to read than when three are displayed together in one line. In this case, each of the three lines of text data (10c to 10e) is arranged so as to be adjacent to each other in the longitudinal direction of the slide glass 10, and the characters and numbers constituting each of the text data (10c to 10e) are By arranging the slide glass 10 along the short direction, the text data (10c to 10e) can be more easily read.

  In the present embodiment, each of the three lines of text data (10c to 10e) is arranged such that the length in the longitudinal direction of the slide glass 10 is the same between the barcode print area F1 and the text print area F2. As a result, in the frosted part 10a of the slide glass 10, it is possible to suppress an increase in a useless area where sample information is not arranged.

  In the present embodiment, a printable coating film 10g is formed on a region corresponding to the frosted portion 10a of the slide glass 10, and a two-dimensional bar is formed on the upper surface of the coating film 10g located on the frosted portion 10a. By printing the code 10b and three lines of text data (10c to 10e), the specimen information (specimen number, date, reception number and name) can be easily displayed on the frosted part 10a of the slide glass 10. In this case, the coating film 10g is formed so as to extend from the frost portion 10a along the longitudinal direction of the slide glass 10 so as to sandwich the specimen preparation region 10f. It can suppress that glass 10 adheres mutually.

  The embodiment disclosed this time should be considered as illustrative in all points and not restrictive. The scope of the present invention is shown not by the above description of the embodiments but by the scope of claims for patent, and further includes all modifications within the meaning and scope equivalent to the scope of claims for patent.

  For example, in the above-described embodiment, an example in which the present invention is applied to a sample preparation / analysis system including a blood smear preparation apparatus has been described. However, the present invention is not limited thereto, and a sample preparation apparatus other than the blood smear preparation apparatus It is also applicable to the sample preparation analysis system provided.

  In the above embodiment, the present invention is applied to the sample preparation / analysis system including the blood cell automatic analyzer. However, the present invention is not limited thereto, and the sample preparation includes a sample analyzer other than the blood cell automatic analyzer. It can also be applied to analysis systems.

  In the above embodiment, the blood smear sample preparation device is provided with a storage unit, and the sample prepared by the blood smear sample preparation device is distributed to the carry-in port of the storage unit and the introduction port of the blood cell automatic analyzer. However, the present invention is not limited to this, and all specimens prepared by the blood smear preparation apparatus may be transported to the introduction port of the blood cell automatic analyzer without providing a storage unit in the blood smear preparation apparatus.

  Further, in the above embodiment, the cassette is transported by the moving member having a contact portion that contacts the side surface portion of the cassette in which the stained slide glass is stored. However, the present invention is not limited to this, and the cassette is not limited to this. The cassette may be conveyed by engaging the drive belt and driving the drive belt.

  In the above embodiment, the cassette containing the stained slide glass is transported to the inlet of the blood cell automatic analyzer. However, the present invention is not limited to this, and the stained slide glass is transferred from the cassette. After removal, only the stained slide glass may be conveyed to the inlet of the blood cell automatic analyzer. In this case, the specimen preparation / analysis system including the blood smear preparation apparatus and the automatic blood cell analysis apparatus is preferably configured as in the first reference example shown in FIG.

  Specifically, the specimen preparation analysis system according to the first reference example of the present embodiment shown in FIG. 19 includes a blood smear preparation apparatus 500 and an automatic blood cell analysis apparatus 600. The blood smear preparation apparatus 500 according to the first reference example includes a suction dispensing mechanism section, a smear section, a resin cassette (not shown), a cassette housing section 4, The cassette conveyance part 5, the slide glass insertion part, the dyeing | staining part 7, the 2nd cassette conveyance part 8, the storage part 9, and the control part 110 are included. The control unit 110 is connected to the host computer 400.

  Here, the blood smear preparation apparatus 500 of the specimen preparation analysis system according to the first reference example of the present embodiment further includes a slide glass take-out unit 501, a cassette storage unit 502, and a slide glass transport unit 503. The slide glass take-out unit 501 is provided for taking out a stained slide glass (not shown) from the cassette conveyed from the staining unit 7 by the second cassette conveyance unit 8. The slide glass take-out unit 501 has a chuck mechanism (not shown) for pulling up the slide glass and placing the slide glass on the slide glass transport unit 503. The cassette housing portion 502 is provided for housing the cassette after the dyed slide glass is taken out. The slide glass transport unit 503 is provided for transporting the stained slide glass taken out from the cassette by the slide glass take-out unit 501 to the inlet 600a of the blood cell automatic analyzer 600. The slide glass transport unit 503 has a pair of transport belts (not shown), like the cassette housing unit 4 and the storage unit 9.

  In addition, the blood cell automatic analyzer 600 of the sample preparation / analysis system according to the first reference example of the present embodiment includes a slide glass conveyance unit 601, a barcode reading unit 602, an analysis unit 603, and a control unit 604. The slide glass transport unit 601 is provided to transport the stained slide glass transported to the inlet 600 a by the slide glass transport unit 503 of the blood smear preparation apparatus 500 to the barcode reading unit 602. The barcode reading unit 602 is provided for reading a two-dimensional barcode (not shown) printed on the slide glass. The analysis unit 603 is provided for performing digital image processing on a stained slide glass specimen and automatically classifying blood cells. The control unit 604 is provided to control the operations of the barcode reading unit 602 and the analysis unit 603.

  In the sample preparation / analysis system according to the first reference example of the present embodiment, as described above, the blood cell automatic analysis device 600 introduces the stained slide glass (specimen) taken out from the cassette into the blood smear preparation device 500. By providing the slide glass transport unit 503 for transporting to the mouth 600a, the slide glass transport unit 503 automatically performs the operation of supplying the specimen (slide glass) from the blood smear sample preparation device 500 to the blood cell automatic analyzer 600. Can be done automatically. Thereby, the supply operation of the specimen (slide glass) from the blood smear preparation apparatus 500 to the blood cell automatic analyzer 600 can be performed without imposing a burden on the operator.

  Further, in the sample preparation / analysis system according to the first reference example of the present embodiment, the blood smear preparation apparatus 500 is configured to take out the stained slide glass from the cassette transported from the staining unit 7 by the second cassette transport unit 8. By providing the slide glass take-out portion 501, the slide glass take-out portion 501 can easily take out the stained slide glass from the cassette. Thus, the slide glass transport section 503 can easily transport the stained slide glass taken out from the cassette to the inlet 600a of the blood cell automatic analyzer 600.

  In the above embodiment, the cassette in which the stained slide glass is stored is transported to the introduction port of the automatic blood cell analyzer. However, the present invention is not limited to this, and the stained slide glass is stored. A separate unit that accommodates the cassette and supplies it to the automatic blood cell analyzer may be provided, and the cassette containing the stained slide glass may be conveyed to the inlet of the separate unit. In this case, the specimen preparation / analysis system including the blood smear preparation apparatus and the automatic blood cell analysis apparatus is preferably configured as in the second reference example shown in FIG.

  Specifically, in the sample preparation analysis system according to the second reference example of the present embodiment shown in FIG. 20, the cassette housing unit 302 of the automatic blood cell analyzer 300 shown in FIG. Are included in a separately provided cassette supply unit 700. In addition, the cassette storage unit 302 of the cassette supply unit 700 is provided with a supply unit 701 for supplying a cassette containing a stained slide glass to the blood cell automatic analyzer 300. In the cassette housing unit 302 of the cassette supply unit 700, a cassette containing a stained slide glass transported by the second cassette transport unit 8 from the staining unit 7 of the blood smear preparation apparatus 100 is introduced into the inlet 700a. Is housed through. Then, the cassette in which the stained slide glass stored in the cassette storage unit 302 of the cassette supply unit 700 is stored is supplied to the blood cell automatic analyzer 300 by the supply unit 701. The cassette supply unit 700 includes a cassette storage unit 307. The cassette storage unit 307 of the cassette supply unit 700 is configured to remove the stained slide glass from the cassette after the slide glass take-out unit 303 of the blood cell automatic analyzer 300 removes the stained slide glass. It is provided for storing cassettes. In addition, the other structure of the sample preparation analysis system by the 2nd reference example of this embodiment is the same as that of the said embodiment.

  In the sample preparation / analysis system according to the second reference example of the present embodiment, as described above, the cassette supply unit 700 that houses the cassette containing the stained slide glass and supplies it to the automatic blood cell analyzer 300 is provided. Thus, the supply operation of the cassette in which the stained slide glass is stored can be automatically performed from the blood smear preparation apparatus 100 to the blood cell automatic analysis apparatus 300 via the cassette supply unit 700. Thereby, the supply operation | movement of the cassette in which the stained slide glass from the blood smear preparation apparatus 100 to the blood cell automatic analyzer 300 was accommodated can be performed, without burdening an operator. Further, since the cassette containing the stained glass slide is supplied to the blood cell automatic analyzer 300 using the cassette supply unit 700 which is a separate unit from the blood cell automatic analyzer 300, the cassette supply unit By removing 700, the blood cell automatic analyzer 300 can be easily operated alone.

  Further, in the present embodiment, the same coating film as the coating film formed on the frost portion of the slide glass is formed so as to extend along the longitudinal direction of the slide glass from the frost portion so as to sandwich the specimen preparation region. The present invention is not limited to this, and a coating film made of a material different from the coating film formed on the frost portion is formed so as to extend from the frost portion along the longitudinal direction of the slide glass so as to sandwich the specimen preparation region. May be.

  In this embodiment, specimen information such as the specimen number, date, reception number, and name is stored in the two-dimensional barcode. However, the present invention is not limited to this, and the analysis result measured by the blood analyzer, WBC (white blood cell) ), RBC (red blood cells), HGB (hemoglobin concentration), HCT (hematocrit), MCV (average red blood cell volume), MCH (average red blood cell pigment content), MCHC (average red blood cell pigment concentration), PLT (platelet count) and white blood cell 5 classification (Neutrophils, eosinophils, basophils, monocytes and lymphocytes) Information selected from the results may be stored in the two-dimensional barcode as sample information. In the present embodiment, by configuring the specimen information to be stored in the two-dimensional barcode, a lot of information such as the analysis result described above can be held on the slide glass. When the above analysis results are held on a slide glass, after storing the slide glass, when re-analyzing the specimen prepared on the stored slide glass, the two-dimensional barcode is read. In addition to the specimen information such as the specimen number, it is possible to recognize the analysis result performed on the specimen. This eliminates the need to inquire the host computer about the analysis results described above when re-analyzing the specimen prepared on the stored slide glass.

  In this embodiment, the text data to be displayed on the frosted portion of the slide glass is composed of numbers or alphabetic characters, but the present invention is not limited to this, and kanji, hiragana, and katakana are used in addition to numbers or alphabetic characters. May be.

1 is a perspective view showing an overall configuration of a specimen preparation analysis system according to an embodiment of the present invention. It is the schematic of the sample preparation analysis system by one Embodiment shown in FIG. It is a top view of the internal structure of the sample preparation analysis system by one Embodiment shown in FIG. It is an enlarged view of the frost part of the slide glass used for the sample preparation analysis system by one Embodiment shown in FIG. It is a perspective view of the cassette and slide glass used for the sample preparation analysis system by one Embodiment shown in FIG. It is a perspective view of the cassette and slide glass used for the sample preparation analysis system by one Embodiment shown in FIG. It is a top view of the 2nd cassette conveyance part of the sample preparation apparatus of the sample preparation analysis system by one Embodiment shown in FIG. It is a perspective view at the time of seeing the 2nd cassette conveyance part shown in FIG. 7 from A direction. It is a perspective view at the time of seeing the 2nd cassette conveyance part shown in FIG. 7 from the B direction. It is a top view at the time of seeing the 2nd cassette conveyance part shown in FIG. 7 from A direction. It is a top view at the time of seeing the 2nd cassette conveyance part shown in FIG. 7 from the B direction. It is an enlarged view of the cassette detection part of the 2nd cassette conveyance part shown in FIG. It is an enlarged view of the cassette detection part of the 2nd cassette conveyance part shown in FIG. It is a top view for demonstrating operation | movement of the 2nd cassette conveyance part of the sample preparation apparatus of the sample preparation analysis system by one Embodiment shown in FIG. It is a top view for demonstrating operation | movement of the 2nd cassette conveyance part of the sample preparation apparatus of the sample preparation analysis system by one Embodiment shown in FIG. It is a perspective view of the feeding part of the storage part of the sample preparation apparatus of the sample preparation analysis system by one Embodiment shown in FIG. It is a side view for demonstrating operation | movement of the infeed part of the storage part shown in FIG. It is a flowchart for demonstrating operation | movement of the sample preparation analysis system by one Embodiment of this invention. It is the schematic of the sample preparation analysis system by the 1st reference example of this embodiment. It is the schematic of the sample preparation analysis system by the 2nd reference example of this embodiment .

Explanation of symbols

10 slide glass (specimen slide glass)
10a Frost section (information display area)
10b 2D barcode ( 2D code)
With 10c Date <br/> 10d name before <br/> 10e specimen number 10f sample preparing region 10g coating film 11 labels F1 barcode printing area (first display area)
F2 Text printing area (second display area)

Claims (5)

A slide glass for a specimen for a blood smear preparation device that smears and stains blood to create a blood smear,
A specimen preparation area where a blood smear is prepared;
An information display area on which a coating film capable of printing specimen-related information is formed ,
The information display area includes a first display area on which a two-dimensional code holding the specimen-related information in a horizontal direction and a vertical direction as viewed in plan is printed , and a first display area on which the specimen-related information is printed in text . and a second display region seen including,
A slide glass for a specimen in which the two-dimensional code and the text are printed with ink that does not elute into alcohol and xylene, and the coating film formed in the information display area does not elute into alcohol and xylene . The information display area is arranged in an area on one end side in the longitudinal direction of the specimen slide glass ,
The specimen slide glass according to claim 1, wherein the first display area and the second display area are arranged so as to be adjacent to each other in a short direction of the specimen slide glass . The two-dimensional code has a substantially square shape in plan view, the specimen slide glass according to claim 1 or 2. Wherein the second display region, date, name and sample number Ru is text printed, specimen slide glass according to any one of claims 1-3. The specimen preparation area and the information display area are arranged so as to be adjacent in the longitudinal direction of the specimen slide glass ,
The coating film, so as to sandwich the specimen preparation area, the information is from the display area is formed to extend along the longitudinal direction of the slide glass the specimen, according to any one of claims 1 to 4 Glass slide for specimens.

Images