JP4733986B2 - ＨＩＶインテグラーゼ阻害薬として有用なテトラヒドロ−４Ｈ−ピリド［１，２−ａ］ピリミジン類および関連する化合物 - Google Patents

ＨＩＶインテグラーゼ阻害薬として有用なテトラヒドロ−４Ｈ−ピリド［１，２−ａ］ピリミジン類および関連する化合物 Download PDF

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JP4733986B2
JP4733986B2 JP2004563339A JP2004563339A JP4733986B2 JP 4733986 B2 JP4733986 B2 JP 4733986B2 JP 2004563339 A JP2004563339 A JP 2004563339A JP 2004563339 A JP2004563339 A JP 2004563339A JP 4733986 B2 JP4733986 B2 JP 4733986B2
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oxo
hydroxy
fluorobenzyl
amino
tetrahydro
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JP2006513200A (ja
JP2006513200A5 (https=
Inventor
クレシエンツイ，ベネデツタ
キンツエル，オラフ
ムラグリア，エステル
オルビエート，フエデリカ
ペスカトーレ，ジヨバンナ
ローリー，マイケル
スンマ，ビンセンツオ
Original Assignee
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2004563339A 2002-12-27 2003-12-18 ＨＩＶインテグラーゼ阻害薬として有用なテトラヒドロ−４Ｈ−ピリド［１，２−ａ］ピリミジン類および関連する化合物 Expired - Fee Related JP4733986B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43683002P 2002-12-27 2002-12-27
US60/436,830 2002-12-27
US52877603P 2003-12-12 2003-12-12
US60/528,776 2003-12-12
PCT/GB2003/005536 WO2004058756A1 (en) 2002-12-27 2003-12-18 Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors

Publications (3)

Publication Number Publication Date
JP2006513200A JP2006513200A (ja) 2006-04-20
JP2006513200A5 JP2006513200A5 (https=) 2008-01-31
JP4733986B2 true JP4733986B2 (ja) 2011-07-27

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JP2004563339A Expired - Fee Related JP4733986B2 (ja) 2002-12-27 2003-12-18 ＨＩＶインテグラーゼ阻害薬として有用なテトラヒドロ−４Ｈ−ピリド［１，２−ａ］ピリミジン類および関連する化合物

Country Status (20)

Country Link
US (2) US7414045B2 (https=)
EP (1) EP1578748B1 (https=)
JP (1) JP4733986B2 (https=)
KR (1) KR20050087865A (https=)
CN (1) CN100343253C (https=)
AT (1) ATE481401T1 (https=)
AU (2) AU2003292437A1 (https=)
BR (1) BR0317749A (https=)
CA (1) CA2509554C (https=)
DE (1) DE60334248D1 (https=)
EC (1) ECSP055890A (https=)
HR (1) HRP20050593A2 (https=)
IS (1) IS7892A (https=)
MA (1) MA27583A1 (https=)
MX (1) MXPA05007010A (https=)
NO (1) NO20053624L (https=)
NZ (1) NZ540729A (https=)
PL (1) PL377354A1 (https=)
RU (1) RU2329265C2 (https=)
WO (2) WO2004058757A1 (https=)

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EA200801144A1 (ru) 2005-10-27 2008-10-30 Сионоги Энд Ко., Лтд. Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич
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Also Published As

Publication number Publication date
CA2509554C (en) 2011-02-01
EP1578748B1 (en) 2010-09-15
US20080176869A1 (en) 2008-07-24
PL377354A1 (pl) 2006-01-23
NO20053624D0 (no) 2005-07-26
MXPA05007010A (es) 2005-08-18
CA2509554A1 (en) 2004-07-15
AU2003292436A1 (en) 2004-07-22
AU2003292437A1 (en) 2004-07-22
NO20053624L (no) 2005-09-26
ATE481401T1 (de) 2010-10-15
US7414045B2 (en) 2008-08-19
IS7892A (is) 2005-06-13
EP1578748A1 (en) 2005-09-28
HRP20050593A2 (en) 2006-03-31
KR20050087865A (ko) 2005-08-31
US20060046985A1 (en) 2006-03-02
ECSP055890A (es) 2005-09-20
AU2003292436B2 (en) 2009-07-30
DE60334248D1 (de) 2010-10-28
US7968553B2 (en) 2011-06-28
CN100343253C (zh) 2007-10-17
CN1753892A (zh) 2006-03-29
RU2329265C2 (ru) 2008-07-20
BR0317749A (pt) 2005-11-22
JP2006513200A (ja) 2006-04-20
MA27583A1 (fr) 2005-10-03
RU2005123807A (ru) 2006-01-20
WO2004058757A1 (en) 2004-07-15
NZ540729A (en) 2008-03-28
WO2004058756A1 (en) 2004-07-15

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