JP4644438B2 - Brim lacrimal stent - Google Patents

Brim lacrimal stent Download PDF

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Publication number
JP4644438B2
JP4644438B2 JP2004141322A JP2004141322A JP4644438B2 JP 4644438 B2 JP4644438 B2 JP 4644438B2 JP 2004141322 A JP2004141322 A JP 2004141322A JP 2004141322 A JP2004141322 A JP 2004141322A JP 4644438 B2 JP4644438 B2 JP 4644438B2
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thin
tube
lacrimal
mm
portion
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JP2005319190A (en
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克昭 栗橋
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有限会社エム・エル・シー
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Description

  The present invention relates to a lacrimal stent suitable for treatment of lacrimal passage obstruction and dry eye.

  The present inventor is easy to operate for treatment of lacrimal passage obstruction and dry eye, has little pain to the patient, and can be inserted into the lacrimal passage accurately and quickly, and is more effective and less difficult to remove than conventional ones. We have been studying a good lacrimal stent for many years. Nunchaku-type silicone tube (hereinafter referred to as NST) consisting of a thin part (40) and a thick part (42) attached to both sides shown in FIG. Invented brim NST, punctal plug with thread, etc. shown in 3-6. As shown in FIG. 3, the brim NST has a shape in which NST is cut in half and attached with a brim (23). The probe (61) is inserted through the small cut (49) formed in the thick tube (42), and NST or brim NST is pushed into the lacrimal passage from the punctum (1, 2). The punctal plug is used for dry eye treatment, but Brim NST is also useful as an alternative to the punctal plug. 5 to 6 show a state where the conventional brim NST is placed in the lacrimal passage. NST and Brim NST are already manufactured and sold by Kaneka Medix and used by many doctors. For example, US Patent No. US6,383,192B1, US Patent No.US6,238,363B1, US Patent No.US5,437,625, Katsuaki Kurihashi, "Dacriology-Clinical Teatology-" Medical Saga Publishing 1998, Kuriaki Kurihashi “Lacrimal Surgery and Dry Eye (Video)” Production: Intermedica Planning: Japan Ophthalmologists Association, Sponsor: Banyu Pharmaceutical Co., Ltd., 2003, Japanese Patent Application 2003-154328.

As shown in FIG. 1, lacrimal fluid is secreted from the lacrimal gland (14), moisturizes the surface of the eyeball (17) where the cornea (15) and conjunctiva (16) are present, and then passes through the lacrimal passage (18). ). The lacrimal passage consists of the upper punctum (1), the lower punctum (2), the upper lacrimal tubule vertical part (3), the lower lacrimal tubule vertical part (4), and the boundary between the upper lacrimal tubule vertical part and the horizontal part (5) , The border between the vertical part and the horizontal part of the lower lacrimal canal (6), the horizontal part of the upper lacrimal duct (7), the horizontal part of the lower lacrimal duct (8), the total lacrimal duct (9), the inner total punctum (10), the tears It consists of a sac (11) and a nasolacrimal duct (12). The lower end (13) of the nasolacrimal duct (12) is open to the lower nasal passage (18). The length of the canalicular tubule measured from the punctum is about 10 mm. The total length of the punctum and the vertical portion of the lacrimal canal is 2.4 mm on average, and the total length of the horizontal portion of the lacrimal canal and the total lacrimal tube is 7.6 mm on average. For example, Katsuaki Kurihashi: Dacology-Clinical tears-. Medical Samurai Publishing, Tokyo, 1998. reference.
JP 2000-70296 A U.S. Pat. US 6,383,192B1 US Patent No. US 6,238,363 B1 US Patent No. US5,437,625 Japanese Patent Application No. 2003-154328 Japanese Patent Application No. 2003-198779 Special Table 2002-529144 Japanese Patent Application No. 2003-295664 Japanese Patent Application No. 2003-311886 JP 10-33584 A Japanese Patent Application No.11-122927 Kuriaki Kuriaki, "Dacriology-Clinical Lacrimation-" Medical Tatsu Publishing 1998 Carter KD et al: Size variation of the lacrimal punctum in adults. Ophthalmic Plast Reconstr Surg 4: 231, 1988 Shikako Suzuki "Study on slit lamp test for eye disease, 2nd stage, Study on punctum" Clinical Ophthalmology 10: 114 1956 Fayet B, et al: Canalicular stenoses complicating the insertion of lacrimal plugs. Incidence and mechanisms. J Fr Ophthalmol 15: 25-33, 1992 Katsuaki Kurihashi "Lacrimal Surgery and Dry Eye (Video)" Production: Intermedica Planning: Japan Ophthalmologists Association Sponsor: Banyu Pharmaceutical Co., Ltd. 2003 Katsuaki Kurihashi "Eye and Health Series No. 22—Special Feature: Diseases of the Lacrimal Path and Lacrimal Gland" Supervision: Sadao Hori Planning and Production: Soshinsha Co., Ltd.

  In the conventional brim NST shown in FIGS. 4 to 6, the thin rod (40) has the same thickness and hardness over its entire length and lacks flexibility, and therefore, at the bent portion between the lacrimal tubule vertical portion and the lacrimal tubule horizontal portion. The thin rod (40) that coincides does not bend sufficiently. Therefore, as shown in FIGS. 5 to 6, the collar (23) is inclined with respect to the punctal opening. Therefore, the edge of the brim (23) may enter into the tissue on the ear side of the punctum, and granulation may occur.

  As shown in FIGS. 7 to 21, the solution of the present invention has a thin portion (40), that is, a thin rod (or tube) (40), which is sufficiently aligned with the bend between the vertical portion of the lacrimal canal and the horizontal portion. The thin tube portion (28) is provided between the thin rods (or tubes) for the purpose of softening a part of the thin portion (40) to bend.

  The thin rod (or tube) (40) near the brim (23) as shown in FIGS. 7-21 becomes flexible by making it a thin-walled tube, and as shown in FIGS. 3, 4) and the thin rod (or tube) (40) bend sufficiently to coincide with the bent portion between the horizontal portions (7, 8). As a result, the collar (23) does not become oblique with respect to the opening of the punctum.

  In the embodiment of the present invention, a thick tube (42) is connected to one end of a thin rod (or tube) (40), and a brim (23) is attached to the other end. As shown in FIGS. 7-21, the thin part (40), that is, the thin rod (or tube) (40) coincides with the bent part between the lacrimal canal vertical part (3, 4) and the horizontal part (7, 8). A thin tube is provided between the thin part (40) from 1.5 to 3.0 mm from a part 0.8 to 1.2 mm away from the collar (23) so that it can be bent sufficiently. In order to maintain the stability in the lacrimal passage of the present invention, it is important that the thin portion (40) is partially more supple and longer than the length of the lacrimal canal, and the thick portion (42) is heavy. That is, the supple thin part (40) inserted from the punctum passes through the bent part in the lacrimal tubule and exits to the lacrimal sac (11), and is lowered downward by gravity by the heavy thick part (42) connected thereto. The present invention maintains stability by being pulled.

  FIG. 19 is a diagram for explaining the dimensions of the present invention.

  The collar (23) may be circular or elliptical. When the collar (23) is circular, the diameter (a) of the collar (23) is 0.5 to 3.5 mm, desirably 0.8 to 3.0 mm, and optimally 1.8 to 2.5 mm. As shown in FIGS. 7 to 21, the collar (23) is thicker toward the center, but the thickness (b) of the center of the collar (23) is 0.2 to 0.8 mm, preferably 0.3. -0.7 mm, optimally 0.35-0.45 mm. The length (c) from the brim (23) to the upper end of the thin tube is 0.2 to 1.8 mm, preferably 0.5 to 1.5 mm, and most preferably 0.7 to 1.2 mm. The length (d) of the thin-walled tube (28) is 1.0 to 4.0 mm, desirably 1.5 to 3.0 mm, and optimally 1.8 to 2.5 mm. The wall thickness (e) of the thin tube (28) is 0.01 to 0.30 mm, preferably 0.05 to 0.25 mm, and most preferably 0.15 to 0.20 mm. The diameter (f) of the cavity of the thin-walled tube (28) is 0.1 to 0.5 mm, desirably 0.2 to 0.4 mm, and optimally 0.25 to 0.35 mm. The diameter of the thin tube (28) is the same as the diameter of the thin part (40). The diameter (g) of the thin part (40) is 0.2 to 0.9 mm, desirably 0.4 to 0.7 mm, and optimally 0.5 to 0.6 mm. The diameter (h) of the thick portion (42), that is, the thick tube (42) is 0.7 to 1.5 mm, desirably 0.8 to 1.2 mm, and optimally 0.9 to 1.1 mm. In the brim NST shown in FIGS. 7, 10, 13, and 19 to 21, the wall thickness of the thick tube (42) is the same over the entire length, but the wall thickness (i ) Is 0.05 to 0.6 mm, preferably 0.1 to 0.3 mm, and most preferably 0.15 to 0.25 mm. The diameter (j) of the cavity of the thick tube (42) is 0.1 to 1.0 mm, desirably 0.3 to 0.8 mm, and optimally 0.4 to 0.6 mm. The slope (k) between the thin portion (40) and the thick portion (42) is 0.5 to 4.0 mm, preferably 1.0 to 3.0 mm, and most preferably 1.5 to 2.5 mm. The length (l) of the thick part (42) is 10 to 60 mm, desirably 20 to 50 mm, and optimally 30 to 45 mm. The length (m) of the thin part (40) is 10-20 mm, desirably 12-18 mm, optimally 14-15 mm. The shortest distance (n) between the cavities (25) of the thick part (42) is 0.3-3.0 mm, preferably 0.5-2.0 mm, optimally 0.8-1.5 mm.

  FIG. 20 is a typical example when a thin tube portion (28) having a cavity (27) is interposed between rods when the thin portion (40) is a rod. As shown in FIGS. 7 to 9, 16, and 20, a thin tube is disposed between the thin rods (42) to make the portion flexible. As shown in FIG. 20, the thin tube portion (28) starts at a point 1 mm away from the brim (23), has a length of 2 mm, and has a cavity diameter of 0.3 mm. The thin rod (42) has a diameter of 0.6 mm, and the wall thickness (e) of the cavity portion is 0.15 mm.

  FIG. 21 is a typical example when the thin portion (40) is a tube. When the thin portion is a tube as shown in FIGS. 17, 18 and 21, the thin tube portion (28) whose wall thickness is further reduced to soften a portion of the thin portion is a tube (40). It is interposed between them. Furthermore, as shown in FIGS. 13 to 15 and FIG. 21, a hole is provided in the center of the collar (23) so that it can be washed, a hole is also provided in the tip of the thick part (42), and the center of the collar (23) is provided. A cavity is provided over the entire length so that the cleaning liquid is injected from the hole and the cleaning water comes out from the hole at the tip.

  When the step (s) is placed in the cavity (25) of the thick tube (42) as shown in FIGS. 8, 11, and 14, it is easy to push the tube into the lacrimal passage with the probe (61) (US) Patent No. US 6,383,192B1, Japanese Patent Application No. 11-122927). In addition, as shown in FIGS. 9, 12, and 15, even if the shape of the cavity of the thick tube (42) becomes a truncated cone shape that becomes smaller toward the tip, the tube can be easily pushed into the lacrimal passage (US). Patent No. US 6,383,192B1, Japanese Patent Application No. 11-122927).

  By making a thin tube (40) near the brim into a thin tube, the lacrimal passage becomes more stable and can sufficiently close the opening of the punctum. As well as serving as a dry eye treatment tool.

Schematic showing the lacrimal passage Schematic showing a conventional nunchaku type silicone tube (NST) Schematic showing a conventional brim NST Central sectional view showing a conventional brim NST Schematic for explaining the implementation method of the conventional brim NST Schematic showing the problems when implementing the conventional brim NST Central sectional view showing an example of the present invention Central sectional view showing an example of the present invention Central sectional view showing an example of the present invention Central sectional view showing an example of the present invention Central sectional view showing an example of the present invention Central sectional view showing an example of the present invention (A) is an end view showing one end of an example of the present invention, (B) is a central sectional view showing an example of the present invention , and (C) is an end view showing one end of an example of the present invention. (A) is an end view showing one end of an example of the present invention, (B) is a central sectional view showing an example of the present invention , and (C) is an end view showing one end of an example of the present invention. (A) is an end view showing one end of an example of the present invention, (B) is a central sectional view showing an example of the present invention , and (C) is an end view showing one end of an example of the present invention. Schematic showing the advantages of implementing an example of the invention Schematic showing the advantages of implementing an example of the invention Schematic showing the advantages of implementing an example of the invention Central sectional view showing dimensions of an example of the present invention Central sectional view showing dimensions of a typical example of the present invention Central sectional view showing dimensions of a typical example of the present invention

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Upper punctum 2 Lower punctum 3 Upper lacrimal tubule vertical part 4 Lower lacrimal tubule vertical part 5 Upper lacrimal tubule vertical part and horizontal part boundary 6 Lower lacrimal tubule vertical part and horizontal part boundary 7 Upper lacrimal tubule horizontal part 8 Lacrimal canal horizontal part 9 Total lacrimal duct 10 Inner total punctum 11 Lacrimal sac 12 Nasal lacrimal duct 13 Lower end of nasolacrimal duct 14 Lacrimal gland 15 Cornea 16 Conjunctiva 17 Eyeball surface 18 Lower nasal passage 23 Head 25 Thick part (42) Cavity 27 Cavity of thin tube portion (28) 28 Thin tube, thin tube portion 40 Thin rod (or tube), thin portion 42 Thick tube, thick portion 49 Small cut 61 Probe a Diameter of brim (23) b (23) Center thickness c Length from brim (23) to upper end of thin tube (28) d Length of thin tube (28) e Wall thickness of thin tube (28) f Thin wall The Chu The diameter of the cavity (27) of the tube (28) g The diameter of the thin part (40) h The diameter of the thick tube (42) i The wall thickness of the thick tube (42) j The thickness of the cavity (25) of the thick tube (42) Diameter k Slope between thin part (40) and thick part (42) l Length of thick part (42) m Length of thin part (40) n Between tip of thick part (42) and cavity (25) The shortest distance s of the step attached to the cavity (25) of the thick tube (42)

Claims (3)

  1. In a lacrimal stent having a thick tube (42) connected to one end of the thin portion (40) and a collar (23) on the other end of the thin portion (40), the lacrimal duct vertical portion (3, 4) a horizontal section (as thin portions corresponding to the bent portion between 7,8) (40) bends sufficiently, have cavities (27) into the narrow part of the solid (40) is formed A lacrimal stent characterized in that the cavity (27) is in the form of a thin tube (28).
  2.   The length (c) from the brim (23) to the upper end of the thin tube (28) is 0.5 to 1.5 mm, and the length (d) of the thin tube (28) is 1.5 to 3.0 mm. The wall thickness (e) of the thin tube (28) is 0.05 to 0.25 mm, and the diameter of the thin tube (28) is the same as the diameter (g) of the thin portion (40). The lacrimal stent according to claim 1.
  3. In a lacrimal stent having a thick tube (42) connected to one end of the thin portion (40) and a collar (23) on the other end of the thin portion (40), the lacrimal duct vertical portion (3, 4) and a cavity (27) is formed in the thin portion (40) so that the thin portion (40) is sufficiently bent corresponding to the bent portion between the horizontal portion (7, 8), The cavity (27) is in the form of a thin tube (28), and there is a hole in the middle of the collar (23), and there is a hole at the tip of the thick tube (42). A lacrimal stent , characterized in that the cavity penetrates the entire length of the lacrimal stent so that the lavage fluid injected from the middle hole can exit the hole at the tip of the thick tube (42).
JP2004141322A 2004-05-11 2004-05-11 Brim lacrimal stent Expired - Fee Related JP4644438B2 (en)

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
EP2377569A1 (en) 2004-07-02 2011-10-19 QLT Plug Delivery, Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
EP2010096B1 (en) 2006-03-31 2017-07-19 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
KR20100050566A (en) 2007-09-07 2010-05-13 큐엘티 플러그 딜리버리, 인코포레이티드 Lacrimal implants and related methods
RU2010136822A (en) 2008-02-18 2012-03-10 Клт Плаг Диливери, Инк. (Us) Lacrimal implants and related ways
WO2009134371A2 (en) 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
BRPI0912182A2 (en) 2008-05-09 2015-10-06 Qlt Plug Delivery Inc prolonged release distribution of active agents to treat glaucoma and ocular hypertension
US8235932B2 (en) * 2009-01-09 2012-08-07 Becker Bruce B Side-by-side lacrimal intubation threader and method
CA2752645C (en) 2009-02-23 2017-10-03 Qlt Inc. Lacrimal implants and related methods
CN102573716A (en) * 2009-10-22 2012-07-11 株式会社钟化 Tube device for insertion into lacrimal passage
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
EP3290024B1 (en) 2011-08-29 2019-04-17 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US20140364790A1 (en) * 2012-01-26 2014-12-11 Kaneka Corporation Lacrimal duct tube

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05505957A (en) * 1990-03-29 1993-09-02
JP2000070296A (en) * 1998-08-27 2000-03-07 M L C:Kk Intra-lacrimal duct intubation appliance
JP2001000469A (en) * 1999-06-17 2001-01-09 M L C:Kk Intubator ingredient for reconstruction of lacrimal passage
US6383192B1 (en) * 1999-04-28 2002-05-07 Mlc Limited Company Apparatus for intubation of lacrimal duct

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605108B2 (en) * 2001-04-13 2003-08-12 Eagle Vision, Inc. Monocanalicular stent
FR2844182B1 (en) * 2002-09-11 2004-12-03 Humanoptics Ag Seal plug a canaliculus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05505957A (en) * 1990-03-29 1993-09-02
JP2000070296A (en) * 1998-08-27 2000-03-07 M L C:Kk Intra-lacrimal duct intubation appliance
US6383192B1 (en) * 1999-04-28 2002-05-07 Mlc Limited Company Apparatus for intubation of lacrimal duct
JP2001000469A (en) * 1999-06-17 2001-01-09 M L C:Kk Intubator ingredient for reconstruction of lacrimal passage

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