JP4527884B2 - 化学的及び生物化学的アッセイ方法及び装置 - Google Patents

化学的及び生物化学的アッセイ方法及び装置 Download PDF

Info

Publication number
JP4527884B2
JP4527884B2 JP2000600105A JP2000600105A JP4527884B2 JP 4527884 B2 JP4527884 B2 JP 4527884B2 JP 2000600105 A JP2000600105 A JP 2000600105A JP 2000600105 A JP2000600105 A JP 2000600105A JP 4527884 B2 JP4527884 B2 JP 4527884B2
Authority
JP
Japan
Prior art keywords
component
beads
solution
amount
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000600105A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002537563A (ja
JP2002537563A5 (https=
Inventor
カッセルス・ジョン
Original Assignee
ティーティーピー ラブテック リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティーティーピー ラブテック リミテッド filed Critical ティーティーピー ラブテック リミテッド
Publication of JP2002537563A publication Critical patent/JP2002537563A/ja
Publication of JP2002537563A5 publication Critical patent/JP2002537563A5/ja
Application granted granted Critical
Publication of JP4527884B2 publication Critical patent/JP4527884B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/15—Inorganic acid or base [e.g., hcl, sulfuric acid, etc. ]

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000600105A 1999-02-16 2000-02-16 化学的及び生物化学的アッセイ方法及び装置 Expired - Fee Related JP4527884B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9903555.2A GB9903555D0 (en) 1999-02-16 1999-02-16 Chemical and biological assay method and apparatus
GB9903555.2 1999-02-16
PCT/GB2000/000549 WO2000049415A1 (en) 1999-02-16 2000-02-16 Chemical and biochemical assay method and apparatus

Publications (3)

Publication Number Publication Date
JP2002537563A JP2002537563A (ja) 2002-11-05
JP2002537563A5 JP2002537563A5 (https=) 2007-05-17
JP4527884B2 true JP4527884B2 (ja) 2010-08-18

Family

ID=10847903

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000600105A Expired - Fee Related JP4527884B2 (ja) 1999-02-16 2000-02-16 化学的及び生物化学的アッセイ方法及び装置

Country Status (8)

Country Link
US (1) US6730521B1 (https=)
EP (1) EP1153299B1 (https=)
JP (1) JP4527884B2 (https=)
AT (1) ATE359517T1 (https=)
AU (1) AU2561400A (https=)
DE (1) DE60034315T2 (https=)
GB (1) GB9903555D0 (https=)
WO (1) WO2000049415A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1239284A1 (en) * 2001-03-08 2002-09-11 The Technology Partnership Public Limited Company Non-separation assay method and system using opaque particles
DE60326228D1 (de) * 2002-05-08 2009-04-02 Panasonic Corp Biomolekulares substrat und testvorrichtung
US7368082B1 (en) * 2002-12-12 2008-05-06 Tung-Lian Huang Formulation of spotting solution to achieve uniform spot size and morphology and for nondestructive quality control of assay articles
US20040171167A1 (en) * 2002-12-13 2004-09-02 Affymetrix, Inc. Chip-in-a-well scanning
US7092843B2 (en) * 2003-10-21 2006-08-15 X-Ray Optical Systems, Inc. Apparatus and method for suppressing insignificant variations in measured sample composition data, including data measured from dynamically changing samples using x-ray analysis techniques
US7877212B2 (en) * 2004-08-04 2011-01-25 Agilent Technologies, Inc. Methods and compositions for assessing partially saturated pixel signals
US7767404B2 (en) * 2005-08-16 2010-08-03 Chipotle Business Group, Inc. Apparatus and method for single-step immunosorbent assay for single and multiple analytes
US8735142B2 (en) * 2005-08-16 2014-05-27 Chipotle Business Group, Inc. Systems and methods for immunosorbent assays for single and multiple analytes
CN102622746B (zh) 2005-09-21 2016-05-25 卢米尼克斯股份有限公司 图像数据处理的方法和系统
WO2009117678A1 (en) 2008-03-21 2009-09-24 Abbott Point Of Care, Inc. Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample
WO2009117664A2 (en) 2008-03-21 2009-09-24 Abbott Point Of Care, Inc. Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
EP2269038B1 (en) 2008-03-21 2016-07-27 Abbott Point Of Care, Inc. Method for analyzing individual cells or particulates in blood using fluorescence and absorption of a colorant
JP5082010B2 (ja) * 2008-03-21 2012-11-28 アボット ポイント オブ ケア インコーポレイテッド 赤血球中に含まれるヘモグロビンの固有色素を利用して血液試料のヘマトクリットを測定する方法及び装置
JP5184697B2 (ja) * 2008-03-21 2013-04-17 アボット ポイント オブ ケア インコーポレイテッド 血小板を個々に、及び凝集塊として検出及び計数するための方法及び装置
US8221985B2 (en) * 2008-04-02 2012-07-17 Abbott Point Of Care, Inc. Self-calibrating gradient dilution in a constituent assay and gradient dilution apparatus performed in a thin film sample
WO2009126505A1 (en) * 2008-04-09 2009-10-15 Abbott Point Of Care, Inc. Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber
CA2720077C (en) * 2008-04-09 2014-08-05 Abbott Point Of Care, Inc. Method for measuring the area of a sample disposed within an analysis chamber
US20100255605A1 (en) * 2009-04-02 2010-10-07 Abbott Point Of Care, Inc. Method and device for transferring biologic fluid samples
US8837803B2 (en) * 2009-12-31 2014-09-16 Abbott Point Of Care, Inc. Method and apparatus for determining mean cell volume of red blood cells
WO2011116305A1 (en) 2010-03-18 2011-09-22 Abbott Point Of Care, Inc. Method and apparatus for optically determining at least one hemoglobin related parameter of a whole blood sample
US9459272B2 (en) 2010-03-22 2016-10-04 BioNex Solutions, Inc. Transfer or interrogation of materials by carrier and receiving devices moving independently and simultaneously on multiple axes
JP5433517B2 (ja) * 2010-07-14 2014-03-05 株式会社日立ハイテクノロジーズ 解析装置及び解析方法
US10190986B2 (en) * 2011-06-06 2019-01-29 Abbott Laboratories Spatially resolved ligand-receptor binding assays
KR101979287B1 (ko) 2011-10-18 2019-08-28 루미넥스 코포레이션 이미지 데이터를 처리하기 위한 방법 및 시스템
WO2018168819A1 (ja) * 2017-03-14 2018-09-20 凸版印刷株式会社 解析デバイス、解析キット、及び解析システム
WO2020025808A1 (en) * 2018-08-03 2020-02-06 In Singulo Solutions Ab A method for determining the interaction between a ligand and a receptor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816419A (en) * 1983-08-01 1989-03-28 University Of Health Sciences/The Chicago Medical School Fluorescence ligand binding assay using charge-matched dye and solvent components
US5830769A (en) * 1985-03-18 1998-11-03 Wieder; Irwin Homogeneous fluorassay methods employing fluorescent background rejection and water-soluble rare earth metal chelates
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
JP3211389B2 (ja) * 1992-06-30 2001-09-25 株式会社島津製作所 蛍光検出型ゲル電気泳動装置
GB9326450D0 (en) * 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
EP0713086B1 (en) * 1994-11-17 1999-04-14 Chemunex Apparatus and process for the detection and counting of rarely occurring mammalian cells
EP0713087B1 (en) * 1994-11-17 1999-04-14 Chemunex Apparatus and process for rapid and ultrasensitive detection and counting of microorganisms by fluorescence

Also Published As

Publication number Publication date
DE60034315D1 (de) 2007-05-24
DE60034315T2 (de) 2008-01-03
WO2000049415A1 (en) 2000-08-24
US6730521B1 (en) 2004-05-04
EP1153299B1 (en) 2007-04-11
JP2002537563A (ja) 2002-11-05
EP1153299A1 (en) 2001-11-14
ATE359517T1 (de) 2007-05-15
GB9903555D0 (en) 1999-04-07
AU2561400A (en) 2000-09-04

Similar Documents

Publication Publication Date Title
JP4527884B2 (ja) 化学的及び生物化学的アッセイ方法及び装置
US20240377397A1 (en) Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US20240310367A1 (en) Compositions and methods for the detection and molecular profiling of membrane bound vesicles
US9551663B2 (en) Methods and systems for extending dynamic range in assays for the detection of molecules or particles
CN107121396B (zh) 用于检测分析物的方法
TW412637B (en) Optical quantification of analytes in membranes
CA2458802C (en) Rapid and sensitive detection of molecules
US20060170918A1 (en) Detection Apparatus and Detection Method for Plasmon Resonance and Fluorescence
JP2002507762A (ja) 共焦点顕微鏡イメージングシステム
US20100196914A1 (en) Rare cell detection using flat-panel imager and chemiluminescent or radioisotopic tags
KR20120132668A (ko) 라만 분석 기반 고속 다중 약물 고속 스크리닝 장치
JP3340715B2 (ja) 被検体、その相互作用又は反応動力学を定量的又は定性的に測定する方法及びサンプルキャリア
EP1239284A1 (en) Non-separation assay method and system using opaque particles
JPH01501893A (ja) 細胞スクリーニング、装置および方法
JPH11183381A (ja) 蛍光顕微鏡評価方法および装置
CN114217073A (zh) 一种基于数字等离子免疫吸附测定法的蛋白质结合动力学超灵敏动态成像分析方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20040721

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20040721

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20040721

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070214

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070222

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091208

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100308

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20100308

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100308

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100331

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100407

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100511

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100604

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130611

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees