JP4094543B2 - Capsule type medical device system - Google Patents

Capsule type medical device system Download PDF

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Publication number
JP4094543B2
JP4094543B2 JP2003432674A JP2003432674A JP4094543B2 JP 4094543 B2 JP4094543 B2 JP 4094543B2 JP 2003432674 A JP2003432674 A JP 2003432674A JP 2003432674 A JP2003432674 A JP 2003432674A JP 4094543 B2 JP4094543 B2 JP 4094543B2
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Prior art keywords
capsule medical
living
electrode
extracorporeal
capsule
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JP2005185644A5 (en
JP2005185644A (en
Inventor
昭夫 内山
武司 横井
宏尚 河野
寛伸 瀧澤
政敏 穂満
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オリンパス株式会社
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Priority to JP2003432674A priority Critical patent/JP4094543B2/en
Priority claimed from PCT/JP2004/016585 external-priority patent/WO2005044094A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041Capsule endoscopes for imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00147Holding or positioning arrangements
    • A61B1/00156Holding or positioning arrangements using self propulsion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00147Holding or positioning arrangements
    • A61B1/00158Holding or positioning arrangements using magnetic field
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/06Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A61B5/061Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • A61B5/062Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using magnetic field
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/06Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A61B5/065Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
    • A61B5/067Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe using accelerometers or gyroscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches

Description

The present invention relates to a capsule medical apparatus system that performs in-vivo observation, and in particular, can apply electrical stimulation to living tissue to move inside the body and observe a desired site.

  2. Description of the Related Art Conventionally, as a method for a subject to check his / her health condition, for example, methods using various examinations such as a human dock or an endoscopic examination are generally known. There is also known an inspection method using a capsule medical device that can easily inspect a health condition by swallowing and injecting an inspection body formed in a capsule shape. Various types of capsule-type medical devices are provided. For example, a local electrical stimulation is applied to a living tissue through an electrode, and the contracting action of the electrically stimulated living tissue is used. An electric propulsion type capsule medical device that moves in a living body is known (see, for example, Patent Document 1).

Normally, when a capsule medical device is inserted into the body, it naturally moves within the digestive tract, for example, by the peristaltic movement of the small intestine. To cause the living tissue to perform a contraction operation different from the peristaltic motion, it is possible to promote the movement in the advancing direction or to move in the direction opposite to the advancing direction. Accordingly, it is possible to make a detailed observation by quickly arriving at a desired site or staying at the same position, so that an efficient observation can be performed.
International Publication No. 01/08548 Specification

  However, the capsule medical device described in Patent Document 1 gives electrical stimulation regardless of the body part (for example, stomach, small intestine, large intestine, etc.) when the body tissue moves by applying electrical stimulation to the living tissue. Yes. Electrical stimulation to living tissue is particularly effective in areas where the internal space is relatively small, such as the small intestine. For example, even if electrical stimulation is performed in a region having a relatively internal space such as the stomach, Low effectiveness. Therefore, there is a possibility that power and the like are consumed wastefully, and the efficiency is inferior.

  The present invention has been made in consideration of such circumstances, and an object of the present invention is to provide a capsule medical device system that can stably and efficiently apply electrical stimulation to a living tissue.

In order to achieve the above object, the present invention provides the following means.
The invention according to claim 1 is a capsule medical device system including a capsule medical device that can be inserted into a living body, and the capsule medical device system detects a position of the capsule medical device in the living body. A position detection means; an electrode provided near an outer surface of the capsule medical device; and an electrode for applying a stimulus for contracting a living tissue to generate a force for the capsule medical device to advance and retreat; and a current passed through the electrode A capsule medical device system that controls the current flowing through the electrode in accordance with position information detected by the position detection means.

In the capsule medical device system according to the present invention, the position detecting means detects in which part of the living body, for example, the stomach, the small intestine, the large intestine, etc., the capsule medical device placed in the living body. To do. And a control means controls the electric current sent through an electrode according to the position detected by the position detection means. For example, when the capsule medical device is located in the stomach, it is not applied with stimulation (hereinafter referred to as electrical stimulation), and when it is located in the small intestine, the electrode is applied with electrical stimulation. Control the current flow. As a result, only when the capsule medical device reaches the small intestine, the body tissue is electrically stimulated to perform a contraction operation and remain in the same position for detailed observation, or in the direction of travel after the observation is completed. It can be moved quickly and discharged from the body.
Thus, since electrical stimulation can be given to a living tissue according to a site in the living body, efficient observation can be performed. In addition, useless consumption of electric power or the like can be suppressed, and stable operation can be ensured. In particular, it is possible to eliminate a useless operation at a site such as a stomach where electrical stimulation is less effective.





  The invention according to claim 2 is the capsule medical device system according to claim 1, wherein the capsule medical device includes an acquisition unit that acquires biological information, and uses the biological information acquired by the acquisition unit, Provided is a capsule medical device system in which the position detection means determines the position of the capsule medical device in a living body.

  In the capsule medical device system according to the present invention, the capsule medical device moves in the living body while acquiring biological information by the acquiring means. The position detection means can detect the position of the capsule medical device without adding a sensor or the like for detecting a new position by using the biological information acquired by the acquisition means.

  According to a third aspect of the present invention, in the capsule medical device system according to the second aspect, the acquisition unit is an imaging unit that images a living body, and the position detection unit acquires an image acquired by the imaging unit. The present invention provides a capsule medical device system that detects the position of the capsule medical device in a living body.

  In the capsule medical device system according to the present invention, a captured image captured by the imaging unit can be obtained as biological information. In addition, the position detection unit can detect the position of the capsule medical device based on the captured image. Thus, the captured image can be used for position detection of the capsule medical device.

According to a fourth aspect of the present invention , in the capsule medical device system according to the first aspect, the capsule medical device system includes an extracorporeal device that is installed outside a living body, and the capsule medical device and the extracorporeal device include: At least one of them includes a transmission unit that emits a physical quantity, and the other unit includes a detection unit that detects a physical quantity emitted from the transmission unit, and the position detection unit uses the physical quantity detected by the detection unit. Provided is a capsule medical device system for detecting a position of a medical device in a living body.

  In the capsule medical device system according to the present invention, physical quantities are transmitted and received between the capsule medical device inserted into the living body and the extracorporeal device via the transmitter and the detector. The position detection means can detect the position of the capsule medical device more accurately based on the intensity of the physical quantity.

The invention according to claim 5 is the capsule medical device system according to claim 1, wherein the capsule medical device system includes an extracorporeal device installed outside the living body, and the capsule medical device includes an in-vivo acceleration sensor. A capsule-type medical device, wherein the extracorporeal device includes an extracorporeal acceleration sensor, and the position detection unit detects a position of the capsule-type medical device in a living body based on a difference between the in-vivo acceleration sensor and the extracorporeal acceleration sensor. Provide a system.

  In the capsule medical device system according to the present invention, the in-vivo acceleration sensor measures the acceleration in the movement in the living body, and the extracorporeal acceleration sensor measures the acceleration outside the body. The position detection means can detect the position of the capsule medical device based on the difference in acceleration measured by both acceleration sensors. Thus, the position of the capsule medical device can be detected using acceleration.

According to a sixth aspect of the present invention , in the capsule medical device system according to the first aspect, the position detecting unit includes a setting unit, and the capsule medical device reaches a target site in the living body in the setting unit. Provided is a capsule medical device system in which necessary parameters are set in advance.

  In the capsule medical device system according to the present invention, the position detecting unit can detect that the capsule medical device has reached the target site in the living body by using the parameter set in the setting unit. . Therefore, electrical stimulation can be applied at a desired position in the living body with a simpler algorithm.

The invention according to claim 7 is the capsule medical device system according to any one of claims 1 to 6 , wherein the capsule medical device includes a balloon that can be expanded or contracted so as to be in close contact with a living tissue. The capsule is provided on the outer surface of the balloon, and the control means expands or contracts the balloon based on the position information .

  In the capsule medical device system according to the present invention, the control means expands the balloon based on the position information and closely contacts the living tissue, and applies electrical stimulation from the electrode to the living tissue, or stops the electrical stimulation from the electrode. At the same time, the balloon can be deflated and returned to its original state. Thus, by using a balloon, electrical stimulation can be more reliably applied in a state where the electrode is in close contact with the living tissue.

  According to an eighth aspect of the present invention, in the capsule medical device system according to any one of the first to seventh aspects, the control means controls supply or stop of a current to the electrode based on the position information. A capsule medical device system is provided.
  The invention according to claim 9 is the capsule medical device system according to claim 8, wherein the capsule medical device includes a plurality of the electrodes, and the control unit is configured to control the plurality of electrodes based on the position information. A capsule medical device system for selecting an electrode for supplying current from
  According to a tenth aspect of the present invention, in the capsule medical device system according to the ninth aspect, the position detecting means detects a direction of peristaltic movement based on the position information, and the control means is detected. A capsule medical device system is provided that selects an electrode that supplies the current based on the direction of the peristaltic motion.

  According to the capsule medical device system according to the present invention, electrical stimulation can be applied to a living tissue according to a site in the living body, so that efficient observation can be performed and wasteful consumption of electric power or the like can be performed. Stable operation can be ensured.

Hereinafter, a first embodiment of a capsule medical device system according to the present invention will be described with reference to FIGS. 1 to 5.
As shown in FIG. 1, a capsule medical device system 1 according to the present embodiment includes a capsule medical device 2 that can be introduced into the body (in vivo), an extracorporeal device 3 that is installed outside the body, and a capsule medical device inside the body. A position detection circuit (position detection means) 4 for detecting the position of the device 2, an electrode 5 provided near the outer surface of the capsule medical device 2 for applying electrical stimulation to living tissue, and a current flowing through the electrode 5 are controlled. And a control unit (control means) 6 for performing the above operation.

  The capsule medical device 2 transmits and receives radio waves (physical quantities) to the capsule-shaped housing 10, an acquisition unit (imaging unit) 11 that acquires biological information by imaging the inside of the living body, and the extracorporeal device 3. Wireless transmitter / receiver (transmitter, detector) 12 for transmitting and receiving information, balloon 13 that can be expanded or contracted so as to be in close contact with living tissue, and battery 14 that supplies power to these components. I have.

  The casing 10 is formed so as to be sealed with plastic or the like, and a transparent cover (not shown) is provided on one end side. Inside the transparent cover, an imaging device 20 that obtains a captured image by imaging each part in the body and an optical system 21 such as an LED that illuminates the field of view of the imaging device 20 by irradiating illumination light are arranged. . That is, the image pickup device 20 and the optical system 21 constitute the acquisition unit 11.

  The balloon 13 is attached around the casing 10 so as to wind the casing 10. The balloon 13 is formed of an elastic material such as rubber, which can be expanded and contracted. By an expansion / contraction mechanism 22 provided in the housing 10, for example, a fluid such as air is contained in the balloon 13 as shown in FIG. The balloon 13 can be deflated by supplying the fluid and expanding it, or by sucking the fluid from the inside of the balloon 13. The operation of the expansion / contraction mechanism 22 is controlled by the controller 6. The balloon 13 is in close contact with the outer surface of the housing 10 as shown in FIG. 1 when deflated.

  The electrode 5 is provided on the outer surface of the balloon 13. That is, the electrode 5 is positioned on the outer surface of the housing 10 when the balloon 13 is deflated. A plurality of electrodes 5 are provided on the outer surface of the balloon 13 so as to be arranged on one end side and the other end side with respect to the axial direction of the housing 10. In the present embodiment, it is assumed that the electrode 5 on one end side is located on the image sensor 20 side. In addition, the electrode 5 can apply an electrical stimulus by flowing a current (electric signal) supplied from a current generation circuit 23 incorporated in the control unit 6 to a living tissue. At this time, the control unit 6 controls the current flowing from the current generation circuit 23 to each electrode 5 based on the position information from the extracorporeal device 3. This will be described in detail later.

The wireless transmission / reception unit 12 includes a transmission / reception unit main body (not shown) and a transmission / reception antenna (transmission antenna, reception antenna) that transmits and receives radio waves, and the biological information, that is, a captured image captured by the imaging element 20. Wireless transmission to the extracorporeal device 3 is possible. The wireless transmission / reception unit 12 receives a control signal (information), which will be described later, wirelessly transmitted from the extracorporeal device 3 and sends the control signal (information) to the control unit 6.
The control unit 6 supplies current to the electrode 5 from the current generation circuit 23 or stops the current supplied from the current generation circuit 23 to the electrode 5 based on the control signal sent from the wireless transmission / reception unit 12. It has a function to make it. At the same time, the control unit 6 has a function of controlling (expanding or reducing) the balloon 13 by controlling the expansion / contraction mechanism 22 based on a control signal. The operation of the control unit 6 will be described in detail later. The control unit 6 has a function of comprehensively controlling each of the above components.

As shown in FIG. 1, the extracorporeal device 3 includes a main body 30, a wireless transmission / reception unit (transmitting unit, detection unit) 31 that transmits and receives information between the capsule medical device 2, and the biological information, that is, imaging. A recording unit 32 such as a memory for storing images, a control unit 33 for controlling each of these components, and a battery 34 for supplying power to each component are provided.
The main body 30 is formed in a box shape with a metal such as aluminum, plastic, or the like, and can be attached to the body via a subject's belt or the like, so that it is always disposed outside the subject's body ( Installation).
The wireless transmission / reception unit 31 includes a transmission / reception unit main body (not shown) and a transmission / reception antenna (transmission antenna, reception antenna) that transmits and receives radio waves, like the wireless transmission / reception unit 12 of the capsule medical device 2. The medical device 2 has a function of receiving a captured image that is biometric information transmitted wirelessly from the medical device 2 and sending it to the control unit 33.

  The control unit 33 records the sent captured image in the recording unit 34 after performing predetermined processing such as image processing. Further, the position detection circuit 4 is incorporated in the control unit 33. The position detection circuit 4 detects, for example, the position of the capsule medical device 2 in the body by setting a set image (reference image) in advance and comparing the set image with the captured image that has been sent. It is supposed to be. The position detection circuit 4 detects the position of the capsule medical device 2 by comparing the captured image with the setting image. However, the position detection circuit 4 is not limited to this, and a predetermined color or shape in the captured image is not limited to this. The position of the capsule medical device 2 may be detected based on the feature amount.

Furthermore, the control unit 33 sends a control signal corresponding to a living body part (for example, stomach, small intestine, or large intestine) where the capsule medical device 2 is detected, detected by the position detection circuit 4, via the wireless transmission / reception unit 31. The function of sending to the capsule medical device 2 is provided.
In this embodiment, the control unit 33 reaches the anus with a control signal for applying electrical stimulation when the capsule medical device 2 reaches the small intestine, and a control signal for expanding the balloon 13 when the capsule medical device 2 reaches the large intestine. Sometimes, it is set to send a control signal for stopping the electrical stimulation and reducing the balloon 13. The control signal corresponding to the living body part is not limited to the above setting, and can be set freely.

A case where the inside of the subject is observed with the capsule medical device system 1 configured as described above will be described below.
First, as shown in FIG. 3, after attaching the extracorporeal device 3 via a belt or the like, the subject orally inserts the capsule medical device 2. At this time, the capsule medical device 2 is switched on (not shown), and power is supplied from the battery 14 to each component. Thereby, the control unit 6 operates the acquisition unit 11, that is, the optical system 21 and the imaging element 20.
The capsule medical device 2 placed in the body images each part of the body with the imaging element 20 while moving through the digestive tract, and wirelessly transmits the captured image to the extracorporeal device 3 by the wireless transmission / reception unit 12. On the other hand, the extracorporeal device 3 receives a captured image via the wireless transmission / reception unit 31, and performs image processing of the captured image by the control unit 33 and records it in the recording unit 32 as needed.

  Here, when the capsule medical device 2 reaches the stomach as shown in FIG. 3, the imaging element 20 sends a captured image of the stomach as shown in FIG. 4 to the extracorporeal device 3. The position detection circuit 4 of the extracorporeal device 3 compares the transmitted captured image and the set image with brightness, color, frequency distribution, or surface property of the mucous membrane, so that the capsule medical device 2 can It is detected that it is located at. In this case, the control unit 33 does not transmit a control signal.

Next, when the capsule medical device 2 passes through the stomach and reaches the small intestine as shown in FIG. 3, the imaging element 20 sends an image of the small intestine as shown in FIG. 4 to the extracorporeal device 3. The position detection circuit 4 of the extracorporeal device 3 compares the transmitted captured image and the set image with brightness, color, frequency distribution, or surface property of the mucous membrane, so that the capsule medical device 2 can detect the small intestine. It is detected that it is located at. Receiving this, the control part 33 transmits the control signal which gives electrical stimulation. At this time, the position detection circuit 4 has a function of detecting the orientation of the capsule medical device 2 from the captured image. That is, the direction of movement due to the peristaltic motion of the small intestine is detected from the change in the captured image. For example, the position detection circuit 4 detects whether the image sensor is facing forward or backward with respect to the traveling direction. That is, the position detection circuit 4 can determine which electrode 5 on one end side or the other end side is positioned on the traveling direction side. In response to this result, the control unit 33 sends the control signal so as to apply electrical stimulation from one of the electrodes 5.
In the present embodiment, it is assumed that the imaging element 20 is positioned on the traveling direction side, that is, the electrode 5 on one end side is positioned on the traveling direction side.

  When the capsule medical device 2 reaches the small intestine, the wireless transmission / reception unit 12 receives the control signal transmitted from the extracorporeal device 3. Upon receipt of this control signal, the control unit 6 supplies current to the electrode 5 on the other end side, as shown in FIG. The electrode 5 on the other end supplied with the electric current contracts by applying electrical stimulation to the living tissue (intestinal wall) of the small intestine. Due to the contraction of the living tissue, the capsule medical device 2 advances in the traveling direction so as to be pushed out by the living tissue. Therefore, it is possible to move in the small intestine faster than the moving speed by the peristaltic movement of the small intestine, and it is possible to shorten the time and perform efficient observation in the small intestine.

  As shown in FIG. 3, when the small intestine is passed and reaches the large intestine, the imaging device 20 sends a captured image of the large intestine as shown in FIG. As described above, the position detection circuit 4 of the extracorporeal device 3 detects from the captured image that the capsule medical device 2 has reached the large intestine, and the control unit 33 sends a control signal corresponding to the large intestine to the capsule medical. Send to device 2. That is, the control unit 33 wirelessly transmits a control signal for applying an electrical stimulus from the electrode 5 on the other end side and expanding the balloon 13. In response to this, in the capsule medical device 2, as shown in FIGS. 2 and 3, the control unit 6 operates the expansion / contraction mechanism 22 to expand the balloon 13. As a result, electrical stimulation can be applied to the living tissue (intestinal wall) of the large intestine, which has a relatively large space compared to the small intestine, in a state where the electrode 5 is in close contact with each other, and the time is shortened as in the small intestine. Thus, inspection can be performed with efficient and stable driving.

As shown in FIG. 3, when reaching the anus through the large intestine, the imaging device 20 sends an image of the anus as shown in FIG. 4 to the extracorporeal device 3. Then, as described above, the position detection circuit 4 of the extracorporeal device 3 detects from the captured image that the capsule medical device 2 has reached the anus, and the control unit 33 sends a control signal corresponding to the anus to the capsule medical device. Send to device 2. That is, the control unit 33 wirelessly transmits a control signal for deflating the balloon 13 and stopping electrical stimulation from the electrode 5 on the other end side. In response to this, as shown in FIG. 3, the capsule medical device 2 returns to the original state by the controller 6 operating the expansion / contraction mechanism 22 to contract the balloon 13. Thereby, the excretion of the capsule medical device 2 after completion of the examination is improved.
On the other hand, the doctor or the like diagnoses the health condition of the subject based on the captured image that is the biological information recorded in the recording unit 32 of the extracorporeal device 3.

According to the capsule medical device system 1 described above, since electrical stimulation can be given to a living tissue according to a site in the body, efficient observation can be performed. Further, it is possible to suppress a wasteful consumption of the battery 14 and ensure a stable operation. For example, since electrical stimulation is not performed at a site such as a stomach where electrical stimulation is less effective, useless operation can be eliminated.
In addition, by providing the extracorporeal device 3 with a complicated configuration such as the position detection circuit 4, the capsule medical device 2 can be configured to the minimum necessary and can be made compact.
Further, since the captured image can be used not only as biological information but also as position detection information of the position detection circuit 4, a configuration for detecting separate information for position detection is not necessary. Therefore, simplification of the configuration can be achieved.

  In addition, since the balloon 13 is provided, even in a part having a relatively space such as the large intestine, the electrode 5 can be reliably brought into close contact with the living tissue to give electrical stimulation. In addition, the electrode 5 is arranged on one end side and the other end side, and the control unit 6 controls the electrical stimulation means 14 according to the orientation of the capsule medical device 2 detected by the position detection circuit 4. Regardless of the posture of the endoscope 2 in the living body, the movement direction can be reliably controlled.

In addition, in the said 1st Embodiment, although it was set as the structure which provided the balloon 13, it is not restricted to this, You may make it the structure which does not provide the balloon 13. FIG. In this case, the electrode 5 may be attached so as to be positioned on the outer surface of the housing 10.
In addition, as position detection means for detecting the position of the capsule medical device 2, the position detection circuit 4 is incorporated in the control unit 33 of the extracorporeal device 3, and the capsule type is based on a captured image that is biological information acquired by the image sensor 20. Although the position of the medical device 2 is detected, the present invention is not limited to this. For example, as illustrated in FIG. 6, the acquisition unit 11 of the capsule medical device 2 includes a pH sensor 40 that measures the pH value in the living body, and the position detection circuit 4 is based on the pH value measured by the pH sensor 40. The position of the capsule medical device 2 may be detected. In this case, what is necessary is just to set pH value (information) between the radio | wireless transmission / reception part 12 of the capsule medical device 2 and the radio | wireless transmission / reception part 31 of the extracorporeal apparatus 3 so that mutual communication is possible. By doing so, the position detection circuit 4 compares, for example, the measured pH value with a preset threshold value or the like, or changes in the measured pH value (for example, acidic in the stomach but neutral in the small intestine). The position of the capsule medical device 2 in the living body can be detected based on the above. In particular, the algorithm can be simplified compared to the position detection based on the captured image of the first embodiment.

Further, the position detection means may be configured to detect the position of the capsule medical device 2 based on the radio wave intensity transmitted from the capsule medical device 2.
That is, as shown in FIG. 7, the wireless transmission / reception unit 12 of the capsule medical device 2 can transmit a radio wave, and the position detection unit 45 is provided in the extracorporeal device 3 to measure the radio wave intensity of the radio wave. The receiving antenna 46 may be provided, and the position of the capsule medical device 2 may be detected based on the strength of the radio wave received by each receiving antenna 46. In this case, the position detecting means 45 includes each receiving antenna 46 and the position detecting circuit 4. Further, each receiving antenna 46 may be arranged so as to be positioned in the vicinity of a specific part, for example, stomach, small intestine or large intestine. By doing so, the position detection circuit 4 can detect that the capsule medical device 2 has reached the small intestine when the radio wave intensity received by the receiving antenna 46 arranged near the small intestine is the highest. In this manner, the position of the capsule medical device 2 can be reliably detected using the radio wave intensity.

Further, the position detection means may be configured to detect the position of the capsule medical device 2 using magnetic force.
That is, as shown in FIG. 8, the position detecting means 50 is provided in the capsule medical device 2 to generate magnetic force, and a magnetic force generating means 51 such as a magnet or a coil (not shown) and the extracorporeal device 3 are provided with magnetic force. A plurality of magnetic sensors to be measured, for example, external coils (magnetic force detection means) 52 are provided, and configured to detect the position of the capsule medical device 2 based on the strength of the magnetic field intensity measured by each external coil 52. It doesn't matter. In this case, each external coil 52 may be arranged so as to be positioned in the vicinity of a specific part, for example, stomach, small intestine or large intestine. In this way, when the magnetic field intensity measured by the external coil 52 disposed near the small intestine is the highest, it can be detected that the capsule medical device 2 has reached the small intestine. In the position detection means 50, the magnetic force generation means 51 may be a coil that generates an alternating magnetic field. In this case, by using an AC magnetic field, it is possible to realize position detection using a magnetic sensor in a state where there is little environment for interference due to a physical quantity or the like transmitted from the environment. Thus, the position of the capsule medical device 2 can be reliably detected by using the magnetic field strength.
In addition to the magnetic force, the same position can be detected using physical quantities such as electromagnetic waves, radio waves, light, and sound waves.

Further, the position detection means may be configured to detect the position of the capsule medical device 2 using acceleration information.
That is, as shown in FIG. 9, the position detection means 55 is provided in the capsule medical device 2 to measure the internal acceleration and transmit the internal acceleration information via the wireless transmission / reception unit 12; An extracorporeal acceleration sensor 57 that is provided in the extracorporeal device 3 and measures acceleration outside the extracorporeal body, and includes in-vivo acceleration information received via the wireless transmission / reception unit 31 of the extracorporeal device 3 and extracorporeal acceleration information measured by the extracorporeal acceleration sensor 57. On the basis of this, the position of the capsule medical device 2 may be detected.

In this case, for example, the extracorporeal acceleration sensor 57 may detect the position of the capsule medical device 2 by calculating the difference between the two acceleration information and calculating the distance from the difference in acceleration. By doing so, it is possible to reliably detect the position of the capsule medical device 2 using the acceleration information.
The position detection means 55 can also detect the position using other physical quantities such as electromagnetic waves, radio waves, light, and sound waves, as with the position detection means 50.

Further, the extracorporeal device 3 is configured to detect the position of the capsule medical device 2, but the capsule medical device 2 itself may be configured to detect the position.
For example, as illustrated in FIG. 10, the position detection unit 60 includes a plurality of magnets 61 arranged in the vicinity of a specific site outside the living body, and a magnet (not shown) that is provided in the capsule medical device 2 and detects the magnetic force of the magnet 61. The sensor may be configured to detect the position of the capsule medical device 2 based on the magnetic force detected by the magnetic sensor. In addition, in FIG. 10, the magnet 61 is distribute | arranged to the vicinity of the pyloric part of the stomach, the cecum, and the anus as a specific part. Thus, when the capsule medical device 2 reaches the pyloric region of the stomach, the cecum, and the vicinity of the anus, the magnetic sensor can detect the magnetic force of the magnet 61 to detect its own position.

  Furthermore, using each of the position detection means described above, as shown in FIG. 11, the position detection means is set so as to recognize the movement path of the capsule medical device 2, and the control unit 33 of the extracorporeal device 3 You may set so that each site | part, for example, a stomach, a small intestine, a large intestine, and an anus, may be specified. In this way, the position of the capsule medical device 2 can be detected based on the movement path pattern of the capsule medical device 2. In particular, the algorithm can be simplified as compared with the case where the capsule medical device 2 detects the position based on the captured image.

In the first embodiment, the position detection circuit is configured to detect the moving direction due to the peristaltic movement of the small intestine and change the direction of the capsule medical device based on a change in the captured image, but is not limited thereto. For example, as shown in FIG. 12, the orientation of the capsule medical device 2 may be detected using electrical stimulation.
For example, when reaching the small intestine, electrical stimulation is temporarily applied to the living tissue from the electrode 5 on one end side or the other end side, and the capsule medical device 2 is moved. By detecting the moving direction of the capsule medical device 2 at this time, the direction of the capsule medical device 2 can be detected in a shorter time. Thereafter, electrical stimulation may be applied to the living tissue from the electrode 5 on one end side or the other end side according to the orientation.

Moreover, although the direction of the capsule medical device in the body is detected by the above-described method, the direction of the capsule medical device may be regulated when passing through a specific part.
For example, as shown in FIG. 13, a permanent magnet 65 is provided inside the capsule medical device 2, and a permanent magnet 66 is disposed near a specific portion, for example, near the small intestine. By doing so, when moving through the stomach to the small intestine, the direction of the capsule medical device 2 is set in a fixed direction by the permanent magnet 65 of the capsule medical device 2 and the permanent magnet 66 disposed in the vicinity of the small intestine. Move to the small intestine in a regulated state. Further, instead of the permanent magnet 65 provided in the capsule medical device 2 or the permanent magnet 66 provided at a specific site, a coil may be employed. By doing so, it is possible to prevent a magnetic force from being generated except when necessary, and for example, it is possible to minimize interference and influence on the position detection means using the above-described magnetism. Therefore, it can be reliably advanced in a certain direction, and the electrical stimulation means can be easily controlled.
Further, the above-described direction control function (magnetic induction means) by magnetism may be always used together and used for the direction control during observation. Thereby, observation performance improves.

  In addition to the method using the magnet, for example, as shown in FIG. 14, the capsule 67 is inserted into the body with a detachable string 67 attached, and reaches a specific part such as the small intestine. After confirming, the string 67 may be cut off. By so doing, the direction of the capsule medical device 2 can be regulated and surely advanced in a certain direction, so that it is easy to control the electrical stimulation means.

  Moreover, in the said 1st Embodiment, although it was set as the structure which transmits / receives biometric information by the radio | wireless transmission / reception part 12 provided in the capsule type medical device 2, and the radio | wireless transmission / reception part 31 provided in the extracorporeal apparatus 3, it replaces with these. Thus, the biometric information may be transmitted by a transmission unit provided in at least one of the capsule medical device 2 or the extracorporeal device 3, and the biometric information may be detected by a detection unit provided in the other.

Next, a second embodiment of the capsule medical device according to the present invention will be described with reference to FIG. In the second embodiment, the same components as those in the first embodiment are denoted by the same reference numerals, and the description thereof is omitted.
The difference between the second embodiment and the first embodiment is that in the first embodiment, each part of the body is observed until the capsule medical device is orally injected and excreted, but in the second embodiment, the capsule medical device is used. The device 2 is inserted through the anus to observe the inside of the large intestine.

  That is, as shown in FIG. 15, the capsule medical device 2 is inserted into the body through the transanal area. At this time, the image sensor 20 is inserted into the body facing forward. The input capsule medical device 2 transmits a captured image of the large intestine captured by the image sensor 20 to the extracorporeal device 3. In response to this, the position detection circuit 4 of the extracorporeal device 3 detects that the capsule medical device 2 is located in the large intestine, and the control unit 33 expands the balloon 13 and gives a control signal for applying electrical stimulation to the capsule type. Transmit to the medical device 2. Upon receiving this control signal, the control unit 6 of the capsule medical device 2 operates the expansion / contraction mechanism 22 to expand the balloon 13 and sends current to the electrode 5 from the current generation circuit 23 to the living tissue (intestinal tract). Give electrical stimulation. At this time, the current generating circuit 23 supplies electric current to the electrode 5 on the other end side to apply electrical stimulation.

The living tissue subjected to electrical stimulation locally contracts on the other end side of the housing 10. Thereby, the capsule medical device 2 performs imaging in the large intestine by the imaging element 20 while moving in the large intestine so as to run backward from the anus toward the small intestine. Then, when reaching the cecum, the control unit 33 of the extracorporeal device 3 sends a control signal to the capsule medical device 2 to deflate the balloon 13 and stop electrical stimulation.
In response to this, as shown in FIG. 15, the control unit 6 of the capsule medical device 2 operates the expansion / contraction mechanism 22 to contract the balloon 13 and stops the current supplied to the electrode 5. End electrical stimulation. Thereafter, the capsule medical device 2 is naturally excreted. At this time, since the balloon 13 is contracted, excretion is improved.
As described above, according to this embodiment, it is possible to drive only in the large intestine where observation is necessary, and more efficient observation can be performed.

  In the second embodiment, when the cecum is reached, the balloon 13 is contracted and the electrical stimulation is stopped. However, the present invention is not limited to this. For example, as shown in FIG. When it reaches, the electrical stimulation from the electrode 5 on the other end side may be switched to the electrical stimulation from the electrode 5 on the one end side. By doing so, the capsule medical device 2 that has reached the cecum can be moved again toward the anus by electrical stimulation. Then, when the anus is reached, the balloon 13 is deflated and the electrical stimulation is stopped. By doing so, it is possible to take an image twice in and out of the large intestine, and oversight or the like can be reduced and more accurate observation can be performed. Moreover, since it is possible to guide to the anus, it can be excreted early.

The technical field of the present invention is not limited to the above embodiment, and various modifications can be made without departing from the spirit of the present invention.
For example, in each of the above embodiments, the electrodes are provided on one end side and the other end side with respect to the axial direction of the housing. However, the present invention is not limited to this, and either one or more may be provided. I do not care. In each of the above embodiments, the electrode is provided on the outer surface of the housing or the outer surface of the balloon. However, the outer surface is formed of a highly conductive material in which the electrode is disposed in the vicinity of the outer surface of the housing. The member may cover the electrode. In this case, in order to prevent a short circuit from the positive electrode to the negative electrode on the outer surface of the housing, the member covering the positive electrode and the member covering the negative electrode are insulated. In this way, even if the electrode has a small shape, it is possible to perform electrical stimulation over a wide range of living tissue via the member on the outer surface of the housing.
The function of the control unit of the extracorporeal device may be provided to the control unit of the capsule medical device. By doing so, it is possible to change the wireless communication between the capsule medical device and the extracorporeal device to one-way transmission (biological information) from the capsule medical device to the extracorporeal device.

Moreover, you may make it the structure which provided the recording means in the capsule type medical device instead of an extracorporeal device. That is, the capsule medical device according to the present invention shown in FIG. 17 may be used. The capsule medical device 70 includes the recording unit 32 in the housing 10, and the control unit 71 includes the current generation circuit 23 and the position detection circuit 4. According to the capsule medical device 70, when moving inside the body, the self-position is detected by the position detection circuit 4 while the captured image, which is biological information captured by the image sensor 20, is recorded in the recording means 32, and the control unit 71 can control the current generation circuit 23 in accordance with the part to give an electrical stimulus. Therefore, since the subject does not need to include an extracorporeal device, it is simple.
In this capsule medical device, a pH sensor and a balloon may be provided as in the capsule medical device system described above.

Further, in each of the above embodiments, the position detection means for detecting the position of the capsule medical device is provided. However, as shown in FIG. 18, the position detection means includes a determination circuit (not shown) provided in the control unit, A determination unit having a timer (setting unit) (not shown) in which parameters such as a time required to reach the target site are preset.
This timer has a preset time from when it is put into the living body until it reaches a specific part. When this capsule medical device is applied to the second embodiment, it can be determined by the time of a timer until it reaches the cecum after being introduced into the body from the transanus, and further until it reaches the anus from the cecum. Can be determined by the time of the timer. Then, the control unit may be set so as to perform balloon expansion / contraction and electrical stimulation according to the living body part determined by the determination unit.
Note that the parameter is not limited to the above time, and for example, as shown in FIG. 19, it may be an electrical stimulation amount such as the number of pulses generated at the electrode, and the target site may be determined based on the number of pulses. . In this case, the current generation circuit is set to supply power to the electrodes in pulses, the number of generated pulses is stored in the memory, and a pulse is generated when the preset number is reached. It is also possible to make a decision such as to stop.
Note that the amount of electrical stimulation may be not only the number of pulses but also the sum of pulse widths, the distribution of pulse intensity, and the integrated amount of current generated at the electrodes.

It is a block diagram which shows 1st Embodiment of the capsule type medical device system which concerns on this invention. It is sectional drawing which shows the state which expanded the balloon of the capsule type medical device. It is a figure which shows the state which has injected | thrown-in a capsule type medical device in a body and given electrical stimulation according to each site | part. It is the figure which showed the example of the position of the captured image which imaged the stomach, the small intestine, the large intestine, and the anus with the capsule type medical device. It is a figure which shows the state which has given the electrical stimulation to the biological tissue with the capsule type medical device in the small intestine. It is sectional drawing which shows the capsule type medical device provided with the pH sensor. It is a figure which shows an example of the position detection means which detects the position of a capsule type medical device using radio wave intensity. It is a figure which shows an example of the position detection means which detects the position of a capsule type medical device using magnetic field intensity. It is a figure which shows an example of the position detection means which detects the position of a capsule type medical device using acceleration information. It is a figure which shows an example of the position detection means which detects the position of a capsule type medical device using magnetic force. It is a figure which shows an example of the position detection means which detects the position of a capsule type medical device using the movement path | route pattern of a capsule type medical device. It is a figure which shows the state which gave electrical stimulation to the biological tissue temporarily in order to detect the direction of a capsule type medical device. It is a figure which shows an example which has arrange | positioned the permanent magnet outside the body and in a capsule type medical device in order to regulate the direction of a capsule type medical device. It is a figure which shows the state put into the body in the state which attached the string which can be attached or detached to a capsule type medical device in order to regulate the direction of a capsule type medical device. It is a figure which shows 2nd Embodiment of the capsule type medical device system which concerns on this invention, Comprising: It is a figure which shows the state which has injected | thrown-in a capsule type medical device from the transanus to the large intestine and observed between the cecum. It is a figure which shows the state in which the inside of a large intestine is observed, throwing a capsule type medical device into a large intestine from a transanus, moving to a cecum, and moving to an anus again. It is sectional drawing which shows an example of the capsule type medical device which concerns on this invention. It is sectional drawing which shows another example of the capsule type medical device which concerns on this invention. It is sectional drawing which shows another example of the capsule type medical device which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Capsule type medical device system 2 Capsule type medical device 3 Extracorporeal device 4 Position detection circuit (position detection means)
5 Electrode 6 Control part (control means)
10 Housing 11 Acquisition means (imaging means)
12 Wireless transmitter / receiver (transmitter, detector)
13 balloon 20 image sensor 31 wireless transmission / reception unit (transmitting unit, detection unit)
32 Recording means 40 pH sensor 45, 50, 55, 60 Position detecting means 46 Receiving antenna 51 Magnetic force generating means 52 External coil (magnetic force detecting means)
56 Internal acceleration sensor 57 External acceleration sensor 61 Magnet

Claims (10)

  1. In a capsule medical device system including a capsule medical device that can be inserted into a living body,
    The capsule medical device system is provided in the vicinity of an outer surface of the capsule medical device with position detecting means for detecting the position of the capsule medical device in the living body, and the capsule medical device is moved forward and backward An electrode for applying a stimulus for contracting a living tissue to generate a force, and a control means for controlling a current flowing through the electrode,
    The capsule medical device system, wherein the control unit controls a current flowing through the electrode according to position information detected by the position detection unit.
  2. The capsule medical device system according to claim 1,
    The capsule medical device includes an acquisition unit that acquires biological information,
    A capsule medical device system, wherein the position detection unit determines the position of the capsule medical device in a living body using the biological information acquired by the acquisition unit.
  3. The capsule medical device system according to claim 2,
    The acquisition means is an imaging means for imaging the inside of a living body;
    The capsule medical device system, wherein the position detection unit detects a position of the capsule medical device in a living body based on an image acquired by the imaging unit.
  4. The capsule medical device system according to claim 1,
    The capsule medical device system includes an extracorporeal device installed outside the living body,
    The capsule medical device and the extracorporeal device are provided with a transmission unit that emits a physical quantity in at least one of them, and the other is provided with a detection unit that detects a physical quantity emitted from the transmission unit,
    The capsule medical device system, wherein the position detection unit detects the position of the capsule medical device in a living body using the physical quantity detected by the detection unit.
  5. The capsule medical device system according to claim 1,
    The capsule medical device system includes an extracorporeal device installed outside the living body,
    The capsule medical device includes an internal acceleration sensor,
    The extracorporeal device includes an extracorporeal acceleration sensor,
    The capsule medical device system, wherein the position detection unit detects a position of the capsule medical device in a living body based on a difference between the internal acceleration sensor and the external acceleration sensor.
  6. The capsule medical device system according to claim 1,
    The position detection means includes a setting unit,
    The capsule medical device system according to claim 1, wherein a parameter necessary for the capsule medical device to reach a target site in a living body is preset in the setting unit.
  7. The capsule medical device system according to any one of claims 1 to 6,
    The capsule medical device includes a balloon that can be expanded or contracted so as to be in close contact with a living tissue,
    The electrode is provided on an outer surface of the balloon;
    The capsule medical device system, wherein the control means expands or contracts the balloon based on the position information.
  8. The capsule medical device system according to any one of claims 1 to 7,
    The capsule medical device system, wherein the control unit controls supply or stop of a current to the electrode based on the position information.
  9. The capsule medical device system according to claim 8,
    The capsule medical device includes a plurality of the electrodes,
    The capsule medical device system, wherein the control means selects an electrode that supplies current from the plurality of electrodes based on the position information.
  10. The capsule medical device system according to claim 9,
    The position detecting means detects a direction of peristaltic movement based on the position information;
    The capsule medical device system, wherein the control means selects an electrode to supply the current based on the detected direction of the peristaltic motion.
JP2003432674A 2003-12-26 2003-12-26 Capsule type medical device system Expired - Fee Related JP4094543B2 (en)

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JP2003432674A JP4094543B2 (en) 2003-12-26 2003-12-26 Capsule type medical device system
PCT/JP2004/016585 WO2005044094A1 (en) 2003-11-11 2004-11-09 Capsule type medical device system and capsule type medical device
EP20040818231 EP1690490B1 (en) 2003-11-11 2004-11-09 Capsule type medical device system
US10/984,279 US7918786B2 (en) 2003-11-11 2004-11-09 Capsule type medical device system, and capsule type medical device
US12/417,140 US8303490B2 (en) 2003-11-11 2009-04-02 Capsule type medical device system, and capsule type medical device

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