JP3273812B2 - Cosmetics - Google Patents
CosmeticsInfo
- Publication number
- JP3273812B2 JP3273812B2 JP26406292A JP26406292A JP3273812B2 JP 3273812 B2 JP3273812 B2 JP 3273812B2 JP 26406292 A JP26406292 A JP 26406292A JP 26406292 A JP26406292 A JP 26406292A JP 3273812 B2 JP3273812 B2 JP 3273812B2
- Authority
- JP
- Japan
- Prior art keywords
- senna
- ethanol
- cosmetics
- solution
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
【0001】[0001]
【産業上の利用分野】本発明は、美白作用が高く、且つ
肌荒れなどに有効な化粧料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high whitening effect and effective for rough skin.
【0002】センナは、チンネベリセンナ(学名:Ca
ssia angustfoliaVahl)やアレキ
サンドリアセンナ(学名:Cassia acutif
olia Delile)の葉で緩下剤として利用され
る。また、望江南は、ハブソウ(学名:Cassia
occidentalisL.)の種子で、緩下剤・健
胃剤として利用される。[0002] Senna is a chinneri bell senna (scientific name: Ca
ssia angustofoliaVahl) and Alexandria senna (scientific name: Cassia acutif)
(Olia Delie) leaves are used as laxatives. In addition, Mogang South is a hub saw (scientific name: Cassia
occidentalisL. ) Seeds are used as laxatives and stomachic.
【0003】一方、化粧料の原料として使用できる美白
作用のある物質としては、種々の物質が知られている
が、合成品は、長期間人間の肌に適応した場合の安全性
の保証がなく、使用が制限されつつある。他方、天然物
では、美白作用が弱いものが多い。しかし、人の肌に対
する安全性の面から天然物で、多年、人が食したりし
て、安全性の面で保証されており、しかも美白作用が強
く、更に皮膚に対する他の効果も合わせてもつ物質が望
まれていた。[0003] On the other hand, various substances having a whitening effect that can be used as a raw material for cosmetics are known, but synthetic products have no guarantee of safety when applied to human skin for a long time. , Use is being restricted. On the other hand, many natural products have a weak whitening effect. However, it is a natural product from the aspect of safety for human skin, and is eaten by humans for many years, is guaranteed in terms of safety, and has a strong whitening effect, and also has other effects on skin The substance was desired.
【0004】[0004]
【発明が解決しようとする課題】本発明の目的は、皮膚
に適用して安全であると共に、美白作用が大きく且つ、
肌荒れなどに有効な成分を含んだ化粧料を提供すること
である。SUMMARY OF THE INVENTION An object of the present invention is to apply the composition to the skin, which is safe, has a large whitening effect, and
An object of the present invention is to provide a cosmetic containing an effective ingredient for rough skin and the like.
【0005】[0005]
【課題を解決するための手段】本発明者らは、前記の課
題を解決するため、すでに多年にわたって食用に供さ
れ、人体に対する安全性が確認されている植物をスクリ
ーニングして調べ、化粧品として利用価値のあるものを
検討した。その結果、センナ、望江南が非常に化粧品原
料として、或いは医薬部外品としての有効性を有するこ
とを見い出した。確認された効果として美白作用、抗酸
化性が確認された。Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have screened and examined plants which have been used for food for many years and whose safety to the human body has been confirmed, and used them as cosmetics. We considered something worthwhile. As a result, they found that Senna and Wanggang Minami are very effective as raw materials for cosmetics or as quasi-drugs. As the confirmed effects, a whitening effect and an antioxidant property were confirmed.
【0006】すなわち、本発明は、センナ、望江南の少
なくとも1種の溶媒抽出物を含む化粧料である。[0006] That is, the present invention is a cosmetic comprising at least one solvent extract of Senna and Bogang South.
【0007】本発明において、センナ、望江南の植物抽
出物の利用方法としては、親水性有機溶媒或いは水を含
む親水性有機溶媒、例えば、エタノール、メタノール、
アセトン等で抽出する。しかしながら、化粧品原料の抽
出であるから、エタノール或いは水とエタノールの混液
での抽出が好ましいのは当然である。また、場合によっ
ては、グリセリン、1,3ブチレングリコール、プロピ
レングリコール等の多価アルコール又は多価アルコール
と水の混液も抽出に利用できる。更にまた、凍結乾燥し
て粉体として利用することも利用方法によっては有効で
ある。In the present invention, as a method of using the plant extract of Senna and Bogangnam, a hydrophilic organic solvent or a hydrophilic organic solvent containing water, for example, ethanol, methanol,
Extract with acetone or the like. However, it is natural that extraction with ethanol or a mixture of water and ethanol is preferable because it is an extraction of cosmetic raw materials. In some cases, a polyhydric alcohol such as glycerin, 1,3-butylene glycol, propylene glycol, or a mixture of polyhydric alcohol and water can also be used for extraction. Furthermore, it is effective to freeze-dry and use as a powder depending on the method of use.
【0008】これらの溶媒抽出物質を他の化粧品原料、
例えば、スクワラン、ホホバ油等の液状油、ミツロウ、
セチルアルコール等の固体油、各種の活性剤、グリセリ
ン、1,3−ブチレングリコール等の保湿剤や各種薬剤
等を添加してさまざまな剤形の化粧料を調製することが
できる。例えば、後述する参考例1のローションの組
成、または、参考例2のクリーム(クリーム組成A)の
組成に配合したり、または、乳夜、パック等の用途に応
じて利用形態を考えればよい。[0008] These solvent-extracted substances are used as other cosmetic raw materials,
For example, squalane, liquid oil such as jojoba oil, beeswax,
Cosmetics in various dosage forms can be prepared by adding solid oils such as cetyl alcohol, various activators, humectants such as glycerin and 1,3-butylene glycol, various drugs, and the like. For example, it may be blended with the composition of the lotion of Reference Example 1 described later, or the composition of the cream (cream composition A) of Reference Example 2, or the form of use may be considered depending on the use such as milky night and pack.
【0009】[0009]
【実施例】以下に、実際の利用方法である実施例を記載
するが、本発明はこの実施例によって何ら限定されるも
のではない。本発明で使用したセンナ、望江南の植物の
抽出物の製造例を次に示す。The following is a description of an embodiment which is an actual use method, but the present invention is not limited to this embodiment. Production examples of the extract of Senna, a plant of Bogang South used in the present invention are shown below.
【0010】(実施例1) センナ(乾燥品)を10gにエタノール300mlを加
えて時々撹拌しつつ5日間放置した。これを濾過後凍結
乾燥した。Example 1 10 g of senna (dry product) was added to 300 ml of ethanol, and left for 5 days with occasional stirring. This was lyophilized after filtration.
【0011】(実施例2) センナ(乾燥品)を10gに50%エタノール水溶液3
00mlを加えて時々撹拌しつつ5日間放置した。これ
を濾過後凍結乾燥した。(Example 2) Senna (dry product) was added to 10 g of a 50% aqueous ethanol solution 3
After adding 00 ml, the mixture was left for 5 days with occasional stirring. This was lyophilized after filtration.
【0012】(実施例3) 望江南(乾燥品)を10gにエタノール300mlを加
えて時々撹拌しつつ5日間放置した。これを濾過後凍結
乾燥した。Example 3 To 10 g of Bogang Minami (dry product) was added 300 ml of ethanol, and the mixture was left for 5 days with occasional stirring. This was lyophilized after filtration.
【0013】 〔参考例1、ローションの組成、配合量全量:100重量%〕 オリーブ油 0.5 ポリオキシエチレン(20E.O.)ソルビタンモノステアレート 2.0 ポリオキシエチレン(60E.O.)硬化ヒマシ油 2.0 エタノール 10.0 1.0%ヒアルロン酸ナトリウム水溶液 5.0 精製水 80.0Reference Example 1, Lotion Composition, Total Amount: 100% by Weight Olive Oil 0.5 Polyoxyethylene (20E.O.) Sorbitan Monostearate 2.0 Polyoxyethylene (60E.O.) Cured Castor oil 2.0 Ethanol 10.0 1.0% aqueous solution of sodium hyaluronate 5.0 Purified water 80.0
【0014】 〔参考例2、クリームの組成、配合量全量:100重量%〕 A スクワラン 20.0 オリーブ油 2.0 ミンク油 1.0 ホホバ油 5.0 ミツロウ 5.0 セトステアリルアルコール 2.0 グリセリンモノステアレート 1.0 ソルビタンモノステアレート 2.0 B 精製水 47.9 ポリオキシエチレン(20E.O.)ソルビタンモノステアレート 2.0 ポリオキシエチレン(60E.O.)硬化ヒマシ油 1.0 グリセリン 5.0 1.0%ヒアルロン酸ナトリウム水溶液 5.0 パラオキシ安息香酸 0.1 上記AとBとをそれぞれ計量し、70℃まで加温し、B
にAを撹拌しつつ徐々に加えたのち、ゆっくり撹拌しつ
つ30℃まで冷却した。[Reference Example 2, Composition and total amount of cream: 100% by weight] A Squalane 20.0 Olive oil 2.0 Mink oil 1.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin Monostearate 1.0 Sorbitan monostearate 2.0 B Purified water 47.9 Polyoxyethylene (20E.O.) Sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 Glycerin 5.0 1.0% aqueous solution of sodium hyaluronate 5.0 Paraoxybenzoic acid 0.1 The above A and B are each weighed and heated to 70 ° C.
Was gradually added with stirring, and then cooled to 30 ° C. with slow stirring.
【0015】(チロシナーゼ活性阻害) (試験方法) マックルバルン(Mcllvaln)緩衝液0.9m
l、1.66mMチロシン(Tyrosine)溶液
1.0ml、前記製造例(凍結乾燥品)の0.1wt/
v%水溶液(溶解しにくい場合はエタノールを加えて溶
解したのち精製水を加えて、エバポレートし、エタノー
ルを除去したのち、0.1wt/v%になるように調製
した)1.0mlをスクリューバイアルにとり、37℃
恒温水槽中で5分以上加温した。チロシナーゼ溶液(S
igma社製、マッシュルーム由来、914ユニット/
ml)0.1mlを加え、37℃恒温水槽中で保温し、
10分後に475nmで吸光度を測定した。対照とし
て、上記試料液のかわりに純水を加え同様に測定した。
この試験では試料の終濃度は0.033%となる。この
結果を下記表1に示す。 (計算式) チロシナーゼ活性阻害率(%)={B−(A−P)}/B×100 但し、A:試料検体の吸光度 B:対照の吸光度 P:試料検体の着色による吸光度(3倍希釈)(Inhibition of Tyrosinase Activity) (Test Method) Mcllvaln buffer 0.9 m
1, 1.66 mM tyrosine (1.0 ml) solution, 0.1 wt /
1.0 ml of a v% aqueous solution (if it is difficult to dissolve, add ethanol to dissolve, add purified water, evaporate, remove ethanol, and adjust to 0.1 wt / v%) in a screw vial. 37 ℃
The mixture was heated in a constant temperature water bath for 5 minutes or more. Tyrosinase solution (S
igma, mushroom-derived, 914 units /
ml), add 0.1 ml, and keep in a constant temperature water bath at 37 ° C.
After 10 minutes, the absorbance was measured at 475 nm. As a control, pure water was added instead of the sample solution, and the measurement was performed in the same manner.
In this test, the final concentration of the sample is 0.033%. The results are shown in Table 1 below. (Calculation formula) Tyrosinase activity inhibition rate (%) = {B− (AP)} / B × 100 where A: absorbance of sample specimen B: absorbance of control P: absorbance of sample specimen by coloring (3 times dilution) )
【0016】[0016]
【表1】 [Table 1]
【0017】(抗酸化試験) 以下の試験液をネジキャップ付50ml試験管に作成し
た。 検体 5mg 2%リノール酸エタノール溶液 10ml 0.1M,pH7.0リン酸緩衝液 10ml 精製水 5ml これを50℃の恒温槽に遮光して放置した。これを恒温
槽に入れる前、3日後、6日後、8日後に以下の測定を
した。試験液0.125ml、75%エタノール12.
125ml、30%チオシアン酸アンモニウム0.12
5mlを加えて撹拝し3分間放置後、0.02N塩化第
一鉄3.5%HCl水溶液0.125mlを加えて撹拌
し、3分間放置後波長500nmで吸光度を測定した。
セル長10mm、対照セルは試験液を水に置き換えたも
の。この結果を下記表2及び表3に示す。(Antioxidant Test) The following test solutions were prepared in 50 ml test tubes with screw caps. Specimen 5 mg 2% ethanol solution of linoleic acid 10 ml 0.1 M, pH 7.0 phosphate buffer 10 ml Purified water 5 ml This was allowed to stand in a constant temperature bath at 50 ° C. while being shielded from light. Before putting it in a thermostat, the following measurements were made after 3, 6 and 8 days. 0.125 ml of test solution, 75% ethanol
125 ml, 30% ammonium thiocyanate 0.12
After adding 5 ml and stirring and leaving the mixture for 3 minutes, 0.125 ml of a 0.02N ferrous chloride 3.5% HCl aqueous solution was added and stirred. After leaving for 3 minutes, the absorbance was measured at a wavelength of 500 nm.
The cell length was 10 mm, and the control cell was one in which the test solution was replaced with water. The results are shown in Tables 2 and 3 below.
【0018】[0018]
【表2】 [Table 2]
【0019】[0019]
【表3】 [Table 3]
【0020】上記表1の結果から明らかなように実施例
1〜3は、チロシナーゼ活性阻害率が高く、また、表2
及び表3の結果から明らかなように、実施例1,2は抗
酸化作用が極めて大きく、比較的抗酸化作用が小さい実
施例3についても、現在抗酸化剤として使用されている
ビタミンEよりその作用が大きいことが判った。As is clear from the results in Table 1, Examples 1 to 3 have a high tyrosinase activity inhibition rate.
As is clear from the results of Table 3 and Table 3, Examples 1 and 2 have an extremely large antioxidant effect, and Example 3 having a relatively small antioxidant effect also has a higher antioxidant effect than vitamin E currently used as an antioxidant. The effect was found to be large.
【0021】[0021]
【発明の効果】本発明の化粧料によれば、原料となるセ
ンナ、望江南は古くより漢方薬等で使用され、人体に対
する安全性は保証されており、その抽出物を含むものは
美白作用が強く、また肌荒れを防止し、抗酸化作用も強
いものが提供される。According to the cosmetics of the present invention, Senna and Bogang Minami, which are the raw materials, have been used for herbal medicines for a long time, and their safety to the human body has been guaranteed. Strong, anti-roughness and strong antioxidant action is provided.
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 平3−275609(JP,A) 特開 平3−190809(JP,A) 特開 昭62−33124(JP,A) 特開 平4−342519(JP,A) (58)調査した分野(Int.Cl.7,DB名) A61K 7/00 - 7/50 ──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-3-275609 (JP, A) JP-A-3-190809 (JP, A) JP-A-62-33124 (JP, A) JP-A-4- 342519 (JP, A) (58) Field surveyed (Int. Cl. 7 , DB name) A61K 7/ 00-7/50
Claims (1)
抽出物を含む化粧料。1. A cosmetic composition comprising at least one solvent extract of Senna and Bogang South.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26406292A JP3273812B2 (en) | 1992-09-08 | 1992-09-08 | Cosmetics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26406292A JP3273812B2 (en) | 1992-09-08 | 1992-09-08 | Cosmetics |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0687731A JPH0687731A (en) | 1994-03-29 |
JP3273812B2 true JP3273812B2 (en) | 2002-04-15 |
Family
ID=17398002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP26406292A Expired - Fee Related JP3273812B2 (en) | 1992-09-08 | 1992-09-08 | Cosmetics |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3273812B2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0725746A (en) * | 1993-07-13 | 1995-01-27 | Suntory Ltd | Whitening cosmetic composition |
JP2000128728A (en) * | 1998-10-20 | 2000-05-09 | Ichimaru Pharcos Co Ltd | Cosmetic composition |
KR20010007652A (en) * | 1999-11-18 | 2001-02-05 | 김찬호 | Skin treatment and the manufacturing method thereof |
US8007852B2 (en) | 2002-11-18 | 2011-08-30 | Olam West Coast, Inc. | Method for production of frozen vegetables or fruits |
US7438943B2 (en) | 2003-11-25 | 2008-10-21 | Conagra Foods Food Ingredients Company | Method for dehydro-roasting |
JP2007320970A (en) * | 2007-09-10 | 2007-12-13 | Naris Cosmetics Co Ltd | Cosmetic |
JP2011132195A (en) * | 2009-12-25 | 2011-07-07 | Kose Corp | Slac2-a PROTEIN LEVEL-CUTTING AGENT, myosin Va PROTEIN LEVEL-CUTTING AGENT, AND Slp2-a PROTEIN LEVEL-CUTTING AGENT |
CN105106049B (en) * | 2015-08-19 | 2018-10-16 | 周南燕 | A kind of composition and preparation method for eye-care |
JP2021102589A (en) * | 2019-12-25 | 2021-07-15 | サムライ金沢株式会社 | Fermented product of plant belonging to chamaecrista and cosmetic and topical skin preparation containing the same |
-
1992
- 1992-09-08 JP JP26406292A patent/JP3273812B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0687731A (en) | 1994-03-29 |
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