JP3187328U - Antibacterial / antiviral hospital bedding and clothing - Google Patents
Antibacterial / antiviral hospital bedding and clothing Download PDFInfo
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 33
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 24
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 48
- 150000007524 organic acids Chemical class 0.000 claims abstract description 33
- 239000011787 zinc oxide Substances 0.000 claims abstract description 24
- 239000002105 nanoparticle Substances 0.000 claims abstract description 22
- 239000011701 zinc Substances 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 19
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 16
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000007864 aqueous solution Substances 0.000 claims abstract description 15
- 229940079593 drug Drugs 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 8
- 239000011670 zinc gluconate Substances 0.000 claims description 8
- 229960000306 zinc gluconate Drugs 0.000 claims description 8
- 235000011478 zinc gluconate Nutrition 0.000 claims description 8
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 150000003893 lactate salts Chemical class 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims 1
- 238000004040 coloring Methods 0.000 abstract description 3
- 239000004744 fabric Substances 0.000 abstract description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 17
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 14
- 239000000174 gluconic acid Substances 0.000 description 14
- 235000012208 gluconic acid Nutrition 0.000 description 14
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 12
- 241000233866 Fungi Species 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 229910052697 platinum Inorganic materials 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 229910052709 silver Inorganic materials 0.000 description 5
- 239000004332 silver Substances 0.000 description 5
- 241000712461 unidentified influenza virus Species 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 235000012209 glucono delta-lactone Nutrition 0.000 description 4
- 229960003681 gluconolactone Drugs 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- -1 Silver ions Chemical class 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 230000005923 long-lasting effect Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 239000005708 Sodium hypochlorite Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 108010056594 Avian Proteins Proteins 0.000 description 1
- 241000145144 Cygnus columbianus Species 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108020004460 Fungal RNA Proteins 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229910010413 TiO 2 Inorganic materials 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
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- 230000002459 sustained effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
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Abstract
【課題】着色のない抗菌・抗ウイルス性病院用寝具及び衣類を安価に提供する。
【解決手段】有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤を、病院用寝具及び衣類であるドクターウエア１、看護士ウエア２、病衣としてのパジャマ３、シーツ４、布団、包布５又はこれらの洗濯物に付着させてなる。
【選択図】図１An antibacterial / antiviral hospital bedding and clothing without coloring are provided at low cost.
A medicine obtained by dispersing zinc oxide nanoparticles in an organic acid aqueous solution so as to contain an organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm is used as a hospital bedding and a garment, a doctor wear 1, and a nurse. It is made to adhere to the wear 2, the pajamas 3 as sick clothes, the sheet 4, the futon, the wrapping cloth 5, or these laundry.
[Selection] Figure 1
Description
本考案は一般に病院で使用される病院用寝具及び衣類に関するものであり、より特定的には、抗菌・抗ウイルス性の機能が持続するように改良された抗菌・抗ウイルス性病院用寝具及び衣類に関する。 The present invention relates to hospital bedding and clothing generally used in hospitals, and more specifically, antibacterial and antiviral hospital bedding and clothing improved to maintain antibacterial and antiviral functions. About.
従来、布団やシーツや包布、病衣、白衣など、病院や介護施設において利用されているこれらの洗濯物は、使用開始から時間の経過に伴い、次第に細菌やウイルスに汚染される。病院などのシーツや包布は、１週間〜２週間に一回の洗濯を行っているのが現状であるから、４日目以降の洗濯物は細菌やウイルスに酷く汚染されている。 Conventionally, these laundry items used in hospitals and care facilities such as futons, sheets, wrapping cloths, sick clothes, and white robes are gradually contaminated with bacteria and viruses with the passage of time from the start of use. Currently, sheets and wraps in hospitals are washed once a week or two weeks, so the laundry from the fourth day onwards is heavily contaminated with bacteria and viruses.
これらの病院用寝具及び衣類の清潔と安全を確保するには毎日洗濯をする必要があるが、患者の移動やベッドメーキングに計り知れない経費が必要になる。 To ensure the cleanliness and safety of these hospital bedding and clothing, daily washing is required, but immense expense is required for patient movement and bed making.
洗濯の際に殺菌処理をしてはいるが、殺菌剤はその効果が持続しない薬剤（次亜塩素酸ナトリウム）を使用しているから、シーツなどの清潔は保てない。そこで、銀、銅、鉄などの金属イオンを洗濯時に殺菌剤として加工処理すれば、殺菌効果が持続する。 Although it is sterilized at the time of washing, the disinfectant uses a chemical (sodium hypochlorite) whose effect does not last, so it cannot keep the sheets clean. Then, if metal ions, such as silver, copper, and iron, are processed as a bactericidal agent during washing, the bactericidal effect is sustained.
しかし、鉄や銅の金属イオンを利用すると洗濯物が赤や青に染まるという課題がある。また銀イオンは高価である。 However, if iron or copper metal ions are used, there is a problem that the laundry is dyed red or blue. Silver ions are expensive.
考案者らは、この考案に関連して、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含む薬剤が、鳥インフルエンザウイルスを不活性化する能力があることを見出し、鳥インフルエンザウイルス不活性化薬剤として利用することを提案した（特許文献１）。 In connection with this idea, the inventors have found that a drug containing an organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm has the ability to inactivate avian influenza virus, and avian influenza virus inactivation It proposed using as a chemical | medical agent (patent document 1).
考案者らは、上記課題に関連させて、有機酸亜鉛を含む上記薬剤についてさらに鋭意研究を続けていたところ、この薬剤を病院用寝具及び衣類に付着又は練り込むと、抗菌・抗ウイルス性の効果を発揮し、その効果が長く持続することを見出し、本考案を完成するに到った。 In connection with the above-mentioned problems, the inventors have continued to intensively study the above-mentioned drug containing zinc organic acid. When this drug is attached or kneaded to hospital bedding and clothing, it has antibacterial and antiviral properties. We found out that the effect was effective, and that the effect lasted for a long time.
それゆえに本考案は、抗菌・抗ウイルス性の効果が持続するように改良された抗菌・抗ウイルス性病院用寝具及び衣類を提供することを目的とする。 Therefore, an object of the present invention is to provide an antibacterial / antiviral hospital bedding and clothing improved so as to maintain the antibacterial / antiviral effect.
本考案の他の目的は、着色のない抗菌・抗ウイルス性病院用寝具及び衣類を提供することにある。 Another object of the present invention is to provide anti-bacterial and anti-viral hospital bedding and clothing without coloring.
本考案のさらに他の目的は、安価に抗菌・抗ウイルス性を発揮させる病院用寝具及び衣類を提供することにある。 Still another object of the present invention is to provide hospital bedding and clothing that can exhibit antibacterial and antiviral properties at low cost.
本考案のさらに他の目的は、皮膚に優しい抗菌・抗ウイルス性を発揮させる病院用寝具及び衣類を提供することにある。 Still another object of the present invention is to provide a hospital bedding and clothing that exhibit antibacterial and antiviral properties that are gentle to the skin.
本考案に係る抗菌・抗ウイルス性病院用寝具及び衣類は、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤を病院用寝具及び衣類又はその洗濯物に付着させてなる。この付着は、繊維に練り込みをして付着させる場合を含む。 The antibacterial / antiviral hospital bedding and clothing according to the present invention is a medicine for hospitals in which zinc oxide nanoparticles are dispersed in an organic acid aqueous solution so that the organic acid zinc is contained at a concentration of 2,000 ppm to 10,000 ppm. It is attached to bedding and clothes or its laundry. This adhesion includes the case where the fibers are kneaded and adhered.
有機酸水溶液は、水に溶かせると一部ラクトン化する有機酸を４０〜５０重量％含むのが好ましい。 The aqueous organic acid solution preferably contains 40 to 50% by weight of an organic acid that partially lactates when dissolved in water.
有機酸は、グルコン酸、酢酸、クエン酸、酒石酸、りんご酸、乳酸等であり、中でも水に溶かせると一部ラクトン化するグルコン酸が好ましい。 The organic acid is gluconic acid, acetic acid, citric acid, tartaric acid, malic acid, lactic acid or the like. Among them, gluconic acid that is partially lactated when dissolved in water is preferable.
上記酸化亜鉛ナノ粒子は、直径５０ｎｍ〜７０ｎｍ（１ナノは１０億分の１）の酸化亜鉛ナノ粒子を含むのが好ましい。白金ナノコロイド溶液を追加的に用いても良い。超微粒子の酸化亜鉛は有機酸に良く分散することも利点である。金属イオンには、Ｈｇ＞Ａｇ＞Ｃｕ＞Ｚｎ＞Ｆｅ＞ＴｉＯ２の順で殺菌力があるといわれ、一般に銀系抗菌剤が用いられているが、酸化亜鉛を超微粒子にすることにより、銀に劣らない消毒性、殺菌性を示すようになった。超微粒子の酸化亜鉛の殺菌メカニズムは銀イオンと同じと考えられ、金属の毒性、殺菌性によるものでなく、空気中あるいは水中の酸素の一部を活性酸素化し、菌の細胞膜を破壊すると考えられる。ナノ粒子を使うことにより、比表面積が大きくなり、菌の表面での接触が拡大されて、菌の増殖が抑制されると考えられる。金属イオン粉は溶出が少なく、抑制効果維持性が高く安全であり、直接接触する菌に対しては、銀と同等の抗菌性を示す。なお、菌の径は７５ｎｍである。菌の径に近い径を有する超微粒子の酸化亜鉛を選んで、有機酸水溶液に分散させることにより、菌を不活性化させることができることが見出された。 The zinc oxide nanoparticles preferably include zinc oxide nanoparticles having a diameter of 50 nm to 70 nm (one nano is one billionth). A platinum nanocolloid solution may additionally be used. It is also advantageous that ultrafine zinc oxide is well dispersed in organic acids. Metal ions are said to have sterilizing power in the order of Hg>Ag>Cu>Zn>Fe> TiO 2 , and silver antibacterial agents are generally used. It has come to show disinfection and bactericidal properties not inferior. The mechanism of sterilization of ultrafine zinc oxide is considered to be the same as that of silver ions, and is not due to the toxicity and bactericidal properties of metals. It is thought that some oxygen in the air or water is activated to destroy the cell membrane of the fungus . By using nanoparticles, the specific surface area is increased, the contact on the surface of the fungus is expanded, and the growth of the fungus is suppressed. Metal ion powder has little elution, high inhibitory effect maintenance and safety, and exhibits antibacterial properties equivalent to silver against bacteria that come into direct contact. In addition, the diameter of bacteria is 75 nm. It has been found that by selecting ultrafine zinc oxide having a diameter close to that of the fungus and dispersing it in an organic acid aqueous solution, the fungus can be inactivated.
上記薬剤を病院用寝具及び衣類に付着させる場合、固形物に換算して、上記酸化亜鉛ナノ粒子の付着量は、５ｇ/ｍ２〜１５ｇ/ｍ２であるのが好ましい。 If you are depositing the drug in hospital bedding and clothing, in terms of solid coating weight of the zinc oxide nanoparticles are preferably 5g / m 2 ~15g / m 2 .
上記有機酸亜鉛はグルコン酸亜鉛を含むのが好ましい。この場合、より好ましくは、グルコン酸亜鉛を約７５００ｐｐｍ含むように濃度を調整する。 The organic acid zinc preferably contains zinc gluconate. In this case, more preferably, the concentration is adjusted to include about 7500 ppm of zinc gluconate.
グルコン酸を水に溶かすと、次の［化１］に示すように、一部はグルコノラクトンになる。これを平衡という。グルコノラクトンとグルコン酸の割合は、温度、濃度、ｐＨなどによって変わる。酸性にすると水中の酸が多くなるので、グルコノラクトンの割合が多くなる。アルカリ性にするとグルコン酸は塩になって安定化するので、グルコノラクトンの割合は少なくなる。平衡とは２つの水槽をチューブで連結したようなもので、左側の水槽に水を入れると、バランスを保つために水はチューブを通って右側に流れる。
酸化亜鉛ナノ粒子とグルコン酸を併用することによる相乗効果が生じることの説明について、タンパク質である鳥インフルエンザウイルスにグルコン酸が触れた場合を考える。［化２］に示すように、タンパク質には酸性のアミノ酸と塩基性のアミノ酸が含まれている。酸性のアミノ酸は、-COOHなどを持っており、マイナスイオンに(COO-)になる。塩基性のアミノ酸は、-NH2を持っていて、プラスイオン(-NH3+)になる。タンパク質中のプラスイオンが多かったり、マイナスイオンが多かったりするとタンパク質は水に溶けるが、マイナスとプラスのイオンが同じだけ（等電点という）だと、ちょうど中性になり電荷を持たないので水に溶けなくなる。菌を等電点にすると、菌は溶けなくなり、固まり死滅する。
本考案によれば、酸化亜鉛ナノ粒子がグルコン酸と反応し、グルコン酸亜鉛となり、これが上記等電点の調整をうまく行ない、菌の細胞を破壊させ、これを不活性化させたものと考えられる。 According to the present invention, the zinc oxide nanoparticles react with gluconic acid to become zinc gluconate, which successfully adjusts the isoelectric point to destroy the fungal cells and inactivate them. It is done.
上記病院用寝具及び衣類は、ドクターウエア、看護士ウエア、術衣、病衣、白衣、ケアウエア、シーツ、布団、マットレス又は包布を含む。 The hospital bedding and clothes include doctor wear, nurse wear, surgical clothes, sick clothes, white robes, care wear, sheets, futons, mattresses or wrappings.
本考案に係る抗菌・抗ウイルス性病院用寝具及び衣類によれば、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤が、少量で抗菌・抗ウイルス性を発揮するので、効果が持続する。着色もせず、処理を安価に行うことができる。皮膚にも優しい。 According to the antibacterial / antiviral hospital bedding and clothing according to the present invention, there is provided an agent obtained by dispersing zinc oxide nanoparticles in an organic acid aqueous solution so as to contain organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm. Because it exhibits antibacterial and antiviral properties in a small amount, the effect lasts. It can be processed at low cost without coloring. Gentle on the skin.
効果が持続する抗菌・抗ウイルス性病院用寝具及び衣類を提供するという目的を、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤を病院用寝具及び衣類又はその洗濯物に付着させることによって実現した。以下、この考案の実施の形態を、図面を用いて説明する。 For the purpose of providing antibacterial and antiviral hospital bedding and clothing that have long-lasting effects, zinc oxide nanoparticles are dispersed in an organic acid aqueous solution so as to contain organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm. This was achieved by adhering the resulting drug to hospital bedding and clothing or laundry. Hereinafter, embodiments of the present invention will be described with reference to the drawings.
図１は、本考案を適用する病院用寝具及び衣類を例示したものである。病院用寝具及び衣類として、ドクターウエア１、看護士ウエア（女性用）２、病衣としてのパジャマ（上下）３、布団、シーツ４又は包布５が例示されている。その他、術衣、白衣、ケアウエアなどにも適用できる。 FIG. 1 illustrates hospital bedding and clothing to which the present invention is applied. Examples of hospital bedding and clothing include doctor wear 1, nurse wear (for women) 2, pajamas (upper and lower) 3 as bedclothes, futons, sheets 4 or wrapping 5. In addition, it can be applied to surgical clothes, white robes, and care wear.
このような病院用寝具及び衣類及び布団の洗濯物に、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤を含浸させている。酸化亜鉛ナノ粒子の付着量は、５ｇ/ｍ２〜１５ｇ/ｍ２である。 Such hospital bedding and clothes and bedclothes are impregnated with an agent in which zinc oxide nanoparticles are dispersed in an organic acid aqueous solution so as to contain organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm. Yes. Adhesion amount of the zinc oxide nanoparticles are 5g / m 2 ~15g / m 2 .
本考案によれば、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤が抗菌力及び抗ウイルス力を発揮する。 According to the present invention, a drug obtained by dispersing zinc oxide nanoparticles in an organic acid aqueous solution so as to contain organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm exhibits antibacterial and antiviral power.
有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含む薬剤は、化粧品と同じ素材であり、肌荒れしないどころか、肌を守る力がある。この薬剤は、強力な殺菌力と持続力があり、アルコールの殺菌持続力はこれに及ばない。水溶液だから温度を上げてもアルコールのように激しく気化しない。 A drug containing organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm is the same material as cosmetics, and has the ability to protect the skin rather than roughening the skin. This drug has a strong bactericidal power and long-lasting power, and the bactericidal power of alcohol does not reach this. Because it is an aqueous solution, it does not vaporize as hard as alcohol even if the temperature is raised.
本考案に用いる、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含む薬剤は、グルコン酸を４０〜５０重量％含むグルコン酸水溶液に、直径５０ｎｍ〜７０ｎｍの酸化亜鉛ナノ粒子を、得られるグルコン酸亜鉛の濃度が２，０００ｐｐｍ〜１０，０００ｐｐｍになるように、室温で、温度を上昇させないように、かき混ぜて分散させることによって得た。グルコン酸水溶液に酸化亜鉛ナノ粒子を分散させていくと、発熱し、温度が上がり過ぎるとゲル化することが認められた。また、グルコン酸亜鉛の濃度が６０，０００ｐｐｍを超えると、真っ白にゲル化することが認められた。したがって、分散させるときの温度、グルコン酸亜鉛の濃度の調整は厳格にすることが留意すべき点である。 The drug containing organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm used in the present invention can obtain zinc oxide nanoparticles having a diameter of 50 nm to 70 nm in a gluconic acid aqueous solution containing 40 to 50% by weight of gluconic acid. It was obtained by stirring and dispersing at room temperature so as not to raise the temperature so that the concentration of zinc gluconate was 2,000 ppm to 10,000 ppm. It was observed that when zinc oxide nanoparticles were dispersed in an aqueous gluconic acid solution, heat was generated, and gelation occurred when the temperature was too high. Moreover, when the density | concentration of the zinc gluconate exceeded 60,000 ppm, it was recognized that it gelatinizes purely. Therefore, it should be noted that the temperature during dispersion and the concentration of zinc gluconate are strictly adjusted.
ここでは、鳥インフルエンザウイルスを用いた場合について、さらにこの薬剤の効能を、詳細に説明する。 Here, the effect of this drug will be described in detail in the case of using avian influenza virus.
グルコン酸５０％水溶液に、直径５０ｎｍ〜７０ｎｍの酸化亜鉛ナノ粒子を室温で、温度を上げないように、かき混ぜて分散させ、グルコン酸亜鉛(Gluconic Zn)を３０，０００ｐｐｍ、１０，０００ｐｐｍ、７，５００ｐｐｍ、５，０００ｐｐｍ、３，７５０ｐｐｍ、２，０００ｐｐｍ含む薬剤の試験品を６種類作成した。それぞれの試料０．５ｍｌ(対照として滅菌蒸留水)と鳥インフルエンザウイルス（A/whistling swan/Shimane/499/83(H5N3)107.5EID50/0.1ml）０．５ｍｌを加え、ボルテックスで混合し、室温（２０℃）で１０分間反応させた。試験品と菌混合液を抗生物質を含む滅菌ＰＢＳで１０倍段階希釈し、３個の１０日齢発育鶏卵の漿尿膜腔内に０．１ｍｌずつ接種する。発育鶏卵を３７℃、２日間培養した後、赤血球凝集試験により漿尿膜腔内での菌増殖の有無を確認し、菌感染価をReed and Munchの方法により算出した。結果を表１に示す。
なお、上記実施の形態では、有機酸としてグルコン酸を例示したが、この考案はこれに限られるものでなく、酸化亜鉛と相乗して、タンパク質の膜を破壊するものはいずれも使用できる。 In the above embodiment, gluconic acid is exemplified as the organic acid. However, the present invention is not limited to this, and any one that breaks the protein membrane in synergy with zinc oxide can be used.
また、上記実施の形態では、有機酸亜鉛を用いた場合を例示したが、有機酸白金を用いても良い。この場合、白金ナノコロイドクエン酸蒸留水溶液が好ましく用いられる。１リットルあたり０．０２２５ｇの白金を含む溶液を病院用寝具及び衣類の洗濯物に染み込ませ、粒径４ナノメートルの白金ナノ粒子を均一に分散させて抗菌・抗ウイルス性病院用寝具及び衣類を形成する。白金の触媒作用で菌のＲＮＡ（リボ核酸）のリン酸結合を切断して、菌を不活性化する。 Moreover, although the case where the organic acid zinc was used was illustrated in the said embodiment, organic acid platinum may be used. In this case, a platinum nanocolloid citric acid distilled aqueous solution is preferably used. A solution containing 0.0225 g of platinum per liter is impregnated into hospital bedding and clothes laundry, and platinum nanoparticles with a particle size of 4 nanometers are uniformly dispersed to provide antibacterial and antiviral hospital bedding and clothing. Form. The phosphoric acid bond of fungal RNA (ribonucleic acid) is cleaved by the catalytic action of platinum to inactivate the fungus.
本考案に係る抗菌・抗ウイルス性病院用寝具及び衣類は、皮膚に優しい、さらに消毒殺菌可能な病院用寝具及び衣類として利用者に供給することができる。 The antibacterial and antiviral hospital bedding and clothing according to the present invention can be supplied to users as hospital bedding and clothing that are gentle to the skin and can be disinfected.
また病院用寝具及び衣類１，２，３，４，５の洗濯物に、抗菌と抗ウイルスの効果を持つ上述の薬剤を付着させることにより、病院用寝具及び衣類の内部に侵入した細菌やウイルスをほぼ１００％死滅させることが出来る。ここに使用する抗菌と抗ウイルス剤として最適な薬剤は、有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤であるＧＺ−０８（株式会社シガドライ・ウィザース製）である。ＧＺ−０８は、表１に示す性能を示す、強力な殺菌力を持つ消毒剤であるが、薬剤でありながら全く人畜に害が無く、様々な病気を持つ体力の弱った患者にも、安全で清潔な病院用寝具及び衣類として利用することができる。 Bacteria and viruses that have entered the hospital bedding and clothing by attaching the above-mentioned drugs having antibacterial and antiviral effects to the laundry of hospital bedding and clothing 1, 2, 3, 4 and 5 Can be killed almost 100%. The most suitable drug as an antibacterial and antiviral agent used here is a drug obtained by dispersing zinc oxide nanoparticles in an organic acid aqueous solution so as to contain organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm. 08 (manufactured by Shiga Dry Withers Co., Ltd.). GZ-08 is a disinfectant with strong bactericidal activity, which shows the performance shown in Table 1, but it is safe for patients with weak physical strength and various illnesses. It can be used as clean hospital bedding and clothing.
病院用寝具及び衣類として、図１（Ａ）に示すドクターウエア１を例にして説明する。ドクターウエア１の洗濯は、１）洗い、２）濯ぎ、３）糊加工、４）プレスという順序で完成する。糊加工３）の工程で、ＧＺ−０８を添加することにより、ドクターウエア１に有機酸亜鉛を２，０００ｐｐｍ〜１０，０００ｐｐｍの濃度で含むように酸化亜鉛ナノ粒子を有機酸水溶液に分散させてなる薬剤を付着させることができる。事前に糊にＧＺ−０８を添加しておいて、その糊を糊付け工程で、ＧＺ−０８を添加していない糊と混合して用いるとよい。このようにして、薬剤を病院用寝具及び衣類に付着させると、次亜塩素酸ナトリウムを使用した場合に比べて、抗菌・抗ウイルス性の効果が著しく長く（約１ヶ月）持続した。 A doctor wear 1 shown in FIG. 1A will be described as an example of hospital bedding and clothing. The washing of the doctor wear 1 is completed in the order of 1) washing, 2) rinsing, 3) glue processing, and 4) pressing. In the step of paste processing 3), by adding GZ-08, the zinc oxide nanoparticles are dispersed in the organic acid aqueous solution so that doctorware 1 contains organic acid zinc at a concentration of 2,000 ppm to 10,000 ppm. Can be attached. GZ-08 may be added to the glue in advance, and the glue may be mixed with the glue to which GZ-08 is not added in the gluing step. In this way, when the drug was adhered to hospital bedding and clothing, the antibacterial and antiviral effects lasted significantly longer (about 1 month) than when sodium hypochlorite was used.
大型ロールプレス機によるプレス４）の加工を行う場合は、ロールプレス機のローラの前に噴霧ノズルを設置して、この噴霧ノズルでＧＺ−０８を噴霧するとよい。 When processing the press 4) with a large roll press machine, it is preferable to install a spray nozzle in front of the roller of the roll press machine and spray GZ-08 with this spray nozzle.
なお、上記実施例では、病院用寝具及び衣類の洗濯物に薬剤を付着させる場合を例示したが、この考案はこれに限られるものでなく、新品の病院用寝具及び衣類に薬剤を噴霧などにより付着させてもよい。 In the above embodiment, the case where the medicine is attached to the laundry of the hospital bedding and clothes is illustrated, but the present invention is not limited to this, and the medicine is sprayed on the new hospital bedding and clothes. It may be attached.
今回開示された実施例はすべての点で例示であって制限的なものではないと考えられるべきである。本考案の範囲は上記した説明ではなくて実用新案登録請求の範囲によって示され、実用新案登録請求の範囲と均等の意味および範囲内でのすべての変更が含まれることが意図される。 It should be understood that the embodiments disclosed herein are illustrative and non-restrictive in every respect. The scope of the present invention is indicated not by the above description but by the scope of the utility model registration request, and is intended to include all modifications within the meaning and scope equivalent to the scope of the utility model registration request.
本考案は、皮膚に優しい、持続性の抗菌・抗ウイルス性病院用寝具及び衣類を利用者に供給することができる。 The present invention can provide users with skin-friendly, long-lasting antibacterial / antiviral hospital bedding and clothing.
１ ドクターウエア
２ 看護士ウエア（女性用）
３ 病衣としてのパジャマ（上下）
４ シーツ
５ 包布
1 Doctor wear 2 Nurse wear (for women)
3 Pajamas (up and down) as sick clothes
4 sheets 5 wrapping
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