JP2895298B2 - Active oxygen scavenging and removing agent - Google Patents

Active oxygen scavenging and removing agent

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Publication number
JP2895298B2
JP2895298B2 JP3359877A JP35987791A JP2895298B2 JP 2895298 B2 JP2895298 B2 JP 2895298B2 JP 3359877 A JP3359877 A JP 3359877A JP 35987791 A JP35987791 A JP 35987791A JP 2895298 B2 JP2895298 B2 JP 2895298B2
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active oxygen
removing agent
aspalathus linearis
oxygen scavenging
table
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JP3359877A
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Japanese (ja)
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JPH05271063A (en
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昌俊 中野
邦彦 加藤
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昌俊 中野
邦彦 加藤
株式会社ユニエ
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【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【産業上の利用分野】本発明は、豆科に属するアスパラサス・リネアリスの含有成分を有効成分とする生体内の活性酸素消去・除去剤( 皮膚疾患・免疫反応による組織 BACKGROUND OF THE INVENTION This invention, active oxygen scavenging-removing agent in vivo as an active ingredient-containing components of Aspalathus linearis belonging to the legume (tissue by skin diseases or immune response
障害改善治療剤を除く )に関する。 About except for the disorder improving therapeutic agents).

【0002】 [0002]

【従来の技術】従来より、活性酸素が原因で起こる疾患は数多く知られている。 BACKGROUND ART Conventionally, a disease in which the active oxygen occurs because the known number. 活性酸素は各種のガンを誘発し、生体膜障害、肝疾患、脳血管障害、虚血(虚血性心疾患)、肺疾患、動脈硬化、高血圧、糖尿病、白内障、 Active oxygen induces various cancers, biological membrane disorders, liver diseases, cerebrovascular disorders, ischemic (ischemic heart disease), pulmonary disease, atherosclerosis, hypertension, diabetes, cataract,
アトピー性皮膚炎、リウマチ、ストレス性潰瘍(胃、十二指腸、大腸など)、自己免疫疾患、パーキンソン病、 Atopic dermatitis, rheumatism, stress ulcer (gastric, duodenal, colon, etc.), autoimmune diseases, Parkinson's disease,
脳卒中、パラコート中毒、火傷、老化の進行などに深く関わっている。 Stroke, paraquat poisoning, burns, deeply involved, such as the progression of aging. これらの活性酸素に対する防御機構として、ビタミンC、ビタミンA、ビタミンE、尿酸、グルタチオンなどの低分子物質に加えて、カタラーゼ、スーパーオキシドジスムターゼ(SOD)、グルタチオンペルオキシダーゼなどが動物の身体には存在している。 As a defense mechanism against these active oxygen, vitamin C, vitamin A, vitamin E, uric acid, in addition to the low molecular substances such as glutathione, catalase, superoxide dismutase (SOD), such as glutathione peroxidase exist in the body of an animal ing.

【0003】 [0003]

【発明が解決しようとする課題】しかし、活性酸素を防御するものとしてビタミンC、ビタミンEなどを摂取しても、効果が明確でなく、特に治療の難しい白内障、高血圧、動脈硬化、アレルギー疾患、ウイルス・細菌性皮膚疾患、また難治性皮膚疾患に有効な治療剤は知られていない。 [0006] However, vitamin C as to protect the active oxygen, even taking vitamin E, the effect is not clear, particularly in the treatment of difficult cataracts, hypertension, arteriosclerosis, allergic diseases, virus bacterial skin diseases, also effective therapeutic agents intractable skin diseases is not known.

【0004】また、アレルギー疾患を根治させるには体質改善による方法があり、その際飲食等による方法も行われているが、飲食によるアレルギー性疾患を改善する方法は、効果が薄いか長時間を要するため、十分な効果のあるものは知られていなかった。 Further, in order to complete cure allergic diseases there is a method by constitution improvement that time have been carried out a method according to food or the like, a method of improving allergic diseases with food, the effect is thin or long it takes, some of the sufficient effect was not known.

【0005】本発明は、前記課題を解決し、老化、アレルギー疾患、火傷あるいは白内障など活性酸素によって発病する各種疾患に有効な症状の改善治療剤( 皮膚疾患 [0005] The present invention is to solve the above problems, aging, allergic diseases, improving therapeutic agent effective symptom to various diseases pathogenesis by active oxygen such as burns or cataracts (skin diseases
・免疫反応による組織障害改善治療剤を除く )を提供することを目的とする。 · And to provide a excluded) tissue disorder improving therapeutic agent by the immune reaction.

【0006】 [0006]

【課題を解決するための手段】そこで、本発明者らは、 Means for Solving the Problems] The present inventors,
前記目的を解決するために鋭意研究を重ねた結果、豆科に属するアスパラサス・リネアリス抽出物が、活性酸素によって生じる白内障など各種疾患に対し優れた効果を有し、かつ副作用がなく安全に改善できるとの知見を得て本発明を完成した。 Result of intensive studies to solve the above objects, Aspalathus linearis extract belonging to leguminous has an excellent effect against various diseases such as cataract caused by active oxygen, and safely improved without side effects the present invention was completed to obtain the knowledge that can be.

【0007】本発明の有効成分は、アスパラサス・リネアリスの葉または茎を、水及び/または有機溶媒で抽出し、該抽出液より抽出溶媒を留去する方法、またはアスパラサス・リネアリスの葉または茎を粉砕することによって得ることができる。 [0007] The active ingredient of the present invention, the leaves or stems of Aspalathus linearis, followed by extraction with water and / or an organic solvent, a method for distilling off the extraction solvent from the extract or leaves Aspalathus linearis, or can be obtained by grinding stems. また、通常の日本茶、中国茶、 In addition, usually of Japanese tea, Chinese tea,
紅茶の製法と同様に抽出してもよい。 Tea may be extracted in the same manner as preparation.

【0008】水で抽出する場合には、アスパラサス・リネアリスの50〜1000倍の水を加え、90〜100 [0008] In the case of extraction with water, a 50 to 1000 times the water of Aspalathus linearis In addition, 90 to 100
度で5〜30分間程度抽出するのが好ましい。 Preferably it extracts about 5-30 minutes in degrees. また、通常の茶と同様にするときは、アスパラサス・リネアリスの乾燥葉の50〜1000倍の水を加え、90〜100 Also, when the same as for regular tea, a 50 to 1000-fold of water dried leaves of Aspalathus linearis addition, 90-100
度で5〜30分間程度沸騰させ抽出液を得る。 Obtaining extracts were boiled 5 to 30 minutes in degrees.

【0009】有機溶媒の具体例としては、メタノール、 [0009] Specific examples of the organic solvents include methanol,
エタノール、アセトン等が挙げられ、抽出にあたって温時抽出等慣用手段を用いることができる。 Ethanol, include acetone, such as extraction conventional means when the temperature when the extraction can be used. また、抽出液の分離も、デカンテーションや遠心分離等の慣用手段を用いることができる。 Further, the separation of the extract can also be used conventional means such as decantation or centrifugal separation.

【0010】抽出溶媒の留去も凍結乾燥等の慣用手段を用いることができる。 [0010] evaporation of the extraction solvent may be used conventional means such as freeze-drying. また、アスパラサス・リネアリスそのものを粉砕し、粉末化して用いることもできる。 Further, the Aspalathus linearis itself crushed, may be used in powdered.

【0011】本発明は、混合してそのまま溶液、粉末顆粒、錠剤、乳剤、ゼリー状など任意の形態で単独投与、 [0011] The present invention is mixed as it is a solution, powder granules, tablets, emulsions, alone administered in any form such as jelly,
または、他の飲食物に混合して飲食することもできる。 Or it may be food by mixing with other food.
さらに、焙煎したアスパラサス・リネアリスを浴槽に入れ、火傷、皮膚炎等の患部を浸すことによっても効果を得ることができる。 Furthermore, placed Aspalathus linearis roasted in a bath, burns, it is possible to obtain the effect by dipping the affected area of ​​dermatitis.

【0012】投与量は、対象となる疾患の種類、程度により異なるが、飲料として常用する場合には、1〜3g [0012] The dosage depends on the type of disease of interest, but differ by the degree, in the case of commonly used as beverage, 1 to 3 g
乾燥葉/l溶液を100ml〜1500ml/日飲食するのが好ましい。 The dried leaves / l solution is preferable to 100ml~1500ml / day eating and drinking. また、浴槽に入れるときは、乾燥葉アスパラサス・リネアリス2〜10gを用いるのが好ましい。 Further, when put into the bathtub, it is preferable to use dry leaves Aspalathus linearis 2 to 10 g.

【0013】アスパラサス・リネアリスは、ラットに対する急毒性試験で死亡例は皆無であり、生化学血液検査及び病理組織学的検査においても異常が認められなかった。 [0013] Aspalathus linearis is, deaths at a rapid toxicity tests on rats is none, did not abnormality is observed even in biochemical blood test and histopathological examination.

【0014】 [0014]

【効果】本発明は、活性酸素を除去し、ヒトを含む哺乳動物の活性酸素によって発症すると思われる白内障、動脈硬化、脳血管障害、皮膚疾患など活性酸素が深く関わっている疾患を副作用なく、かつ迅速に改善することができ、副作用がないため飲食等により服用し、アレルギー性疾患を根治することができる。 [Effect] The present invention is to eliminate active oxygen, cataracts appear to develop by the active oxygen in a mammal, including a human, arteriosclerosis, cerebrovascular disorders, diseases active oxygen such as skin diseases deeply involved without side effects, and can be rapidly improved, taking with food or the like because there is no side effect, it is possible to eradicate allergic diseases.

【0015】 [0015]

【実施例】 【Example】

製造例 採取したアスパラサス・リネアリスの葉(茎つき)を、 Leaves (with stems) of Aspalathus linearis produced examples collected,
5mm長に切断後、ローリング、酵素醗酵、天日乾燥の工程を経て乾燥葉とする。 After cutting to 5mm length, rolling, enzyme fermentation, the dried leaves through solar drying process. 乾燥葉1〜5gを水1.5〜 The dried leaves 1~5g water 1.5
2リットルで5〜30分間沸騰させ抽出液を得た。 To obtain an extract boiled for 5 to 30 minutes with 2 liters.

【0016】実施例1(皮膚疾患の改善) 製造例で得た抽出液を表1に示す各種皮膚炎およびアレルギーの患者に、1日約1000mlを2週間飲ませて症状の改善を調べ、その結果を表1に示す。 [0016] The extract obtained in Example (Improvement of skin disease) prepared in Example 1 in patients with various dermatitis and allergic shown in Table 1, investigated the improvement in symptoms drink 2 weeks to about 1000 ml 1 day, the the results are shown in Table 1.

【表1】 [Table 1]

【0017】実施例2(皮膚疾患の改善) 製造例で得た乾燥葉アスパラサス・リネアリス5gを3 [0017] Example 2 (improvement of skin diseases) the dried leaves Aspalathus linearis 5g obtained in Production Example 3
00リットルの浴槽に入れ20分以上放置した後、表2 After standing for more than 20 minutes put 00 liters of bath, Table 2
に示す各種患者を2週間繰り返し入浴させ、改善を調べた。 A variety of patient shown in to two weeks repeatedly bathing, were examined for improvement. その結果を表2に示す。 The results are shown in Table 2.

【表2】 [Table 2]

【0018】実施例3(白内障の改善) 白内障の患者11人に毎食時250から350ml(一日約1リットル)飲用して2ヶ月後、症状を調べた。 [0018] Example 3 (improvement of cataracts) 350ml (about 1 liter per day) from each meal during the 250 in 11 patients with cataract after two months and drinking, were examined for symptoms. その結果、9人に症状の改善がみられ、飲食前に比して目のかすみ肩こりの症状が改善され日常生活に支障もなくなった。 As a result, improvement in symptoms was observed in nine, compared to before eating and drinking symptoms of blurred vision stiff neck no longer be obstacle to improved day-to-day life. また、飲食後1年を経過しているが安定した状態が続いている。 In addition, it has passed one year after meal is followed by a stable state.

【0019】実施例4(血圧降下および安定作用) 血圧160以上の高血圧の患者10名に製造例で得られた溶液を実施例3に準じて飲用させたところ、飲用後2 [0019] Example 4 (antihypertensive and stabilizing effect) where the solution obtained in Preparation Example in 10 patients blood pressure over 160 hypertension was drinking in accordance with Example 3, drinking after 2
0日から60日で8名において正常血圧になり以後血圧が安定した。 After that blood pressure be from 0 days to normal blood pressure in 8 people in the 60 days it is stable. また、低血圧も同様に正常血圧になることが認められ、このことより単なる血圧降下作用のみでなく活性酸素が除去されて高低血圧が正常になったと思われる。 Further, it is recognized that low blood pressure becomes Similarly normotensive, the active oxygen not only mere antihypertensive effect than it is removed by high and low blood pressure appears to have become normal.

【0020】実施例5(脳代謝促進) 2ヶ月、6ヶ月、12ヶ月齢のラット(SD系、雄) [0020] Example 5 (brain metabolism acceleration) 2 months, 6 months, 12-month-old rats (SD-based, male)
に、製造例に準じてでアスパラサス・リネアリスの乾燥葉4g/500mlを15分間沸騰して抽出液を得、得られた抽出液1ml/100g体重を腹腔内に投与した投与群と、同量の生理食塩水を投与した対象群にわけ、 To give an extract with boiling according to Production Example in the dried leaves 4g / 500 ml of Aspalathus linearis for 15 minutes, and the group administered the extract 1 ml / 100 g body weight obtained was administered intraperitoneally, the same amount divided the saline control group administered,
投与後のラットの脳線状体のドパミン、セロトニンの代謝変動をマイクロダイアリシス法で、HPLCおよび電気化学検出器を用いて調べた。 Dopamine brain striatum of the rat after administration, the metabolic fluctuations of serotonin in microdialysis was examined using HPLC and electrochemical detectors. その結果を表3、表4に示す。 The results in Table 3, Table 4.

【表3】 [Table 3]

【表4】 [Table 4] 表3、4より、投与群ではドパミン代謝産物のDOP From Table 3, 4, DOP of dopamine metabolites in treated group
C、HVAが増加し、またセロトニン代謝産物の5HI C, HVA increases, also the serotonin metabolite 5HI
AAが増加したことがわかる。 It can be seen that the AA was increased. このことは、抽出液投与によって脳内神経伝達物質の代謝が活発になっていると考えられる。 This is believed to metabolism in the brain neurotransmitters is turned active by extract administration.

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl. 6識別記号 FI A61K 35/78 ADA A61K 35/78 ADA (58)調査した分野(Int.Cl. 6 ,DB名) A61K 35/78 ────────────────────────────────────────────────── ─── of the front page continued (51) Int.Cl. 6 identification symbol FI A61K 35/78 ADA A61K 35/78 ADA ( 58) investigated the field (Int.Cl. 6, DB name) A61K 35/78

Claims (1)

    (57)【特許請求の範囲】 (57) [the claims]
  1. 【請求項1】アスパラサス・リネアリス抽出物を有効成分とする活性酸素消去・除去剤( 皮膚疾患・免疫反応に To 1. A free radical scavenging and removing agent comprising as an active ingredient Aspalathus linearis extract (skin diseases, immune reactions
    よる組織障害改善治療剤を除く )。 According except for the tissue damage improved therapeutic agents).
JP3359877A 1991-12-27 1991-12-27 Active oxygen scavenging and removing agent Expired - Fee Related JP2895298B2 (en)

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JP2895298B2 true JP2895298B2 (en) 1999-05-24

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2895298B2 (en) * 1991-12-27 1999-05-24 昌俊 中野 Active oxygen scavenging and removing agent
JP3793593B2 (en) * 1995-07-31 2006-07-05 三井農林株式会社 Method of manufacturing the anti-viral agents
US7731678B2 (en) 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
EP2053050B1 (en) * 2007-10-23 2011-08-31 Kneipp-Werke Kneipp-Mittel-Zentrale GmbH & Co. KG Dihydrochalcone similar to aspalathin and method for its manufacture
JP6236304B2 (en) * 2013-12-04 2017-11-22 ライオン株式会社 Tear secretion promoter

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271063A (en) * 1991-12-27 1993-10-19 Kunihiko Kato Agent for eliminating and removing active oxygen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271063A (en) * 1991-12-27 1993-10-19 Kunihiko Kato Agent for eliminating and removing active oxygen

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