JP2720932B2 - 経口投与用アセトアミノフエン錠剤の製造法及びアセトアミノフエン二層錠剤 - Google Patents
経口投与用アセトアミノフエン錠剤の製造法及びアセトアミノフエン二層錠剤Info
- Publication number
- JP2720932B2 JP2720932B2 JP63184787A JP18478788A JP2720932B2 JP 2720932 B2 JP2720932 B2 JP 2720932B2 JP 63184787 A JP63184787 A JP 63184787A JP 18478788 A JP18478788 A JP 18478788A JP 2720932 B2 JP2720932 B2 JP 2720932B2
- Authority
- JP
- Japan
- Prior art keywords
- acetaminophen
- tablet
- release layer
- delayed release
- tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims description 185
- 229960005489 paracetamol Drugs 0.000 title claims description 92
- 238000004519 manufacturing process Methods 0.000 title description 6
- 239000003826 tablet Substances 0.000 claims description 107
- 230000003111 delayed effect Effects 0.000 claims description 65
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 46
- 239000011159 matrix material Substances 0.000 claims description 33
- 239000003979 granulating agent Substances 0.000 claims description 30
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 30
- 239000008187 granular material Substances 0.000 claims description 29
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 27
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 25
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 25
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 25
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 24
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000004615 ingredient Substances 0.000 claims description 22
- 229940069328 povidone Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 20
- 230000002745 absorbent Effects 0.000 claims description 16
- 239000002250 absorbent Substances 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 12
- 230000003628 erosive effect Effects 0.000 claims description 11
- 238000005469 granulation Methods 0.000 claims description 11
- 230000003179 granulation Effects 0.000 claims description 11
- 239000000314 lubricant Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 239000007891 compressed tablet Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 238000013329 compounding Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- 238000004898 kneading Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000010410 layer Substances 0.000 description 52
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 24
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 23
- 238000000034 method Methods 0.000 description 19
- 239000002775 capsule Substances 0.000 description 16
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 13
- 239000008108 microcrystalline cellulose Substances 0.000 description 13
- 229940016286 microcrystalline cellulose Drugs 0.000 description 13
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 13
- 229920000881 Modified starch Polymers 0.000 description 12
- 235000019359 magnesium stearate Nutrition 0.000 description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 9
- 229920002472 Starch Polymers 0.000 description 8
- 239000001913 cellulose Substances 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 229940032147 starch Drugs 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 239000007950 delayed release tablet Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 230000009102 absorption Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 229920003124 powdered cellulose Polymers 0.000 description 4
- 235000019814 powdered cellulose Nutrition 0.000 description 4
- -1 More specifically Chemical compound 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 244000147568 Laurus nobilis Species 0.000 description 3
- 235000017858 Laurus nobilis Nutrition 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000013081 microcrystal Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- 229920003072 Plasdone™ povidone Polymers 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000208140 Acer Species 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 229920003075 Plasdone™ K-29/32 polymer Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229940086245 acetaminophen 650 mg Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 208000029618 autoimmune pulmonary alveolar proteinosis Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- 239000013563 matrix tablet Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US078138 | 1987-07-27 | ||
| US07/078,138 US4820522A (en) | 1987-07-27 | 1987-07-27 | Oral sustained release acetaminophen formulation and process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6440424A JPS6440424A (en) | 1989-02-10 |
| JP2720932B2 true JP2720932B2 (ja) | 1998-03-04 |
Family
ID=22142148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63184787A Expired - Lifetime JP2720932B2 (ja) | 1987-07-27 | 1988-07-26 | 経口投与用アセトアミノフエン錠剤の製造法及びアセトアミノフエン二層錠剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4820522A (forum.php) |
| EP (1) | EP0305051B1 (forum.php) |
| JP (1) | JP2720932B2 (forum.php) |
| KR (1) | KR960005706B1 (forum.php) |
| AU (1) | AU611704B2 (forum.php) |
| CA (1) | CA1315202C (forum.php) |
| DE (1) | DE3880762T2 (forum.php) |
| ES (1) | ES2054813T3 (forum.php) |
| GR (1) | GR1000254B (forum.php) |
| HK (1) | HK87893A (forum.php) |
| IE (1) | IE62831B1 (forum.php) |
| IN (1) | IN166560B (forum.php) |
| NZ (1) | NZ225402A (forum.php) |
| PH (1) | PH25376A (forum.php) |
| PT (1) | PT88099B (forum.php) |
| ZA (1) | ZA885460B (forum.php) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968509A (en) * | 1987-07-27 | 1990-11-06 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
| US5004613A (en) * | 1987-07-27 | 1991-04-02 | Mcneil-Ppc, Inc. | Oral sustained release pharmaceutical formulation and process |
| US5073380A (en) * | 1987-07-27 | 1991-12-17 | Mcneil-Ppc, Inc. | Oral sustained release pharmaceutical formulation and process |
| US5085865A (en) * | 1989-04-12 | 1992-02-04 | Warner-Lambert Company | Sustained release pharmaceutical preparations containing an analgesic and a decongestant |
| NZ233403A (en) | 1989-04-28 | 1992-09-25 | Mcneil Ppc Inc | Simulated capsule-like medicament |
| US5198228A (en) * | 1989-09-14 | 1993-03-30 | Hoechst-Roussel Pharmaceuticals Inc. | Direct dry compressible acetaminophen tablet |
| US5037658A (en) * | 1989-09-14 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Direct dry compressible acetaminophen composition |
| US5130140A (en) * | 1989-09-14 | 1992-07-14 | Hoeschst-Roussel Pharmaceuticals Inc. | Method of making direct dry compressible acetaminophen composition |
| JPH0714872B2 (ja) * | 1990-02-06 | 1995-02-22 | 昭和薬品化工株式会社 | シロップ剤組成物 |
| US5643591A (en) * | 1991-01-16 | 1997-07-01 | Fmc Corporation | Solid dosage forms |
| FR2677886B1 (fr) * | 1991-06-18 | 1995-03-31 | Adir | Comprime matriciel permettant la liberation prolongee d'indapamide apres administration par voie orale. |
| US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
| US5225201A (en) * | 1991-08-23 | 1993-07-06 | Minnesota Mining And Manufacturing Company | Salsalate tablet |
| US5431916A (en) * | 1993-04-29 | 1995-07-11 | The Procter & Gamble Company | Pharmaceutical compositions and process of manufacture thereof |
| US5370878A (en) * | 1993-09-30 | 1994-12-06 | Hallmark Pharmaceuticals, Inc. | Method for preparing a direct compression granulated acetaminophen composition |
| US6210714B1 (en) * | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
| GB9325445D0 (en) | 1993-12-13 | 1994-02-16 | Cortecs Ltd | Pharmaceutical formulations |
| US6471994B1 (en) | 1995-01-09 | 2002-10-29 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US6936277B2 (en) | 1995-01-09 | 2005-08-30 | J. Rettenmaier & Soehne Gmbh & Co. Kg | Pharmaceutical excipient having improved compressibility |
| US6395303B1 (en) | 1996-06-10 | 2002-05-28 | Edward Mendell Co., Inc. | Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose |
| US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| US5948438A (en) * | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
| CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
| US6391337B2 (en) | 1995-11-15 | 2002-05-21 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US6852336B2 (en) | 1995-11-15 | 2005-02-08 | J. Rettenmaier & Soehne Gmbh + Co. Kg | Directly compressible high load acetaminophen formulations |
| US5733578A (en) | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| US5766623A (en) * | 1996-03-25 | 1998-06-16 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Compactable self-sealing drug delivery agents |
| CZ98899A3 (cs) * | 1996-09-24 | 1999-12-15 | Eli Lilly And Company | Složení potahovaných částic |
| JP4010585B2 (ja) * | 1996-10-15 | 2007-11-21 | 久光製薬株式会社 | 陰イオン交換樹脂を含有する錠剤 |
| US7179486B1 (en) | 1997-04-01 | 2007-02-20 | Nostrum Pharmaceuticals, Inc. | Process for preparing sustained release tablets |
| US8524277B2 (en) * | 1998-03-06 | 2013-09-03 | Alza Corporation | Extended release dosage form |
| US6254891B1 (en) | 1998-09-03 | 2001-07-03 | Ascent Pediatrics, Inc. | Extended release acetaminophen |
| US6126967A (en) * | 1998-09-03 | 2000-10-03 | Ascent Pediatrics | Extended release acetaminophen particles |
| US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
| US6264983B1 (en) | 1999-09-16 | 2001-07-24 | Rhodia, Inc. | Directly compressible, ultra fine acetaminophen compositions and process for producing same |
| US6500462B1 (en) | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
| GB0009522D0 (en) * | 2000-04-19 | 2000-06-07 | Smithkline Beecham Plc | Composition |
| US6358526B1 (en) | 2000-08-16 | 2002-03-19 | Rexall Sundown | Method of making tablets and tablet compositions produced therefrom |
| SE0003125D0 (sv) * | 2000-09-05 | 2000-09-05 | Astrazeneca Ab | Modified polymers |
| BR0115585A (pt) | 2000-11-28 | 2005-12-13 | Fmc Corp | Composições de revestimento de pronta liberação, endurecìvel, comestìvel, seca e, úmida, forma de dosagem sólida, e, método para revestir uma forma de dosagem sólida farmacêutica ou veterinária, confeito, semente, ração animal, fertilizante, comprimido de pesticida ou alimento |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| KR100392430B1 (ko) * | 2001-02-01 | 2003-07-23 | 부광약품 주식회사 | 속효성과 지속성을 동시에 갖는 발포성 아세트아미노펜제제 |
| US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| ES2399880T3 (es) * | 2002-03-15 | 2013-04-04 | Cypress Bioscience, Inc. | Milnaciprán para el tratamiento del síndrome del intestino irritable |
| KR100522239B1 (ko) * | 2002-07-16 | 2005-10-18 | 주식회사 서울제약 | 아세트아미노펜을 함유하는 제어방출성의 경구용 제제 |
| ATE386509T1 (de) * | 2002-09-21 | 2008-03-15 | Shuyi Zhang | Formulierung von acetaminophen und tramadol mit verzögerter freisetzung |
| US20090162431A1 (en) * | 2002-09-21 | 2009-06-25 | Shuyi Zhang | Sustained release formulations containing acetaminophen and tramadol |
| US20060003004A1 (en) * | 2002-10-25 | 2006-01-05 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
| TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
| US20040132826A1 (en) * | 2002-10-25 | 2004-07-08 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
| US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
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- 1988-07-13 NZ NZ225402A patent/NZ225402A/xx unknown
- 1988-07-25 KR KR1019880009313A patent/KR960005706B1/ko not_active Expired - Fee Related
- 1988-07-25 AU AU20012/88A patent/AU611704B2/en not_active Ceased
- 1988-07-25 CA CA000572939A patent/CA1315202C/en not_active Expired - Lifetime
- 1988-07-26 IE IE228688A patent/IE62831B1/en not_active IP Right Cessation
- 1988-07-26 JP JP63184787A patent/JP2720932B2/ja not_active Expired - Lifetime
- 1988-07-26 EP EP88306879A patent/EP0305051B1/en not_active Expired - Lifetime
- 1988-07-26 GR GR880100491A patent/GR1000254B/el unknown
- 1988-07-26 ZA ZA885460A patent/ZA885460B/xx unknown
- 1988-07-26 ES ES88306879T patent/ES2054813T3/es not_active Expired - Lifetime
- 1988-07-26 DE DE8888306879T patent/DE3880762T2/de not_active Expired - Fee Related
- 1988-07-26 PT PT88099A patent/PT88099B/pt not_active IP Right Cessation
-
1989
- 1989-07-25 PH PH37269A patent/PH25376A/en unknown
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1993
- 1993-08-26 HK HK878/93A patent/HK87893A/en not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097606A (en) | 1975-10-08 | 1978-06-27 | Bristol-Myers Company | APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same |
Also Published As
| Publication number | Publication date |
|---|---|
| IE882286L (en) | 1989-01-27 |
| ZA885460B (en) | 1990-03-28 |
| GR1000254B (el) | 1992-05-12 |
| DE3880762T2 (de) | 1993-09-23 |
| US4820522A (en) | 1989-04-11 |
| PT88099B (pt) | 1995-03-01 |
| EP0305051A1 (en) | 1989-03-01 |
| ES2054813T3 (es) | 1994-08-16 |
| DE3880762D1 (de) | 1993-06-09 |
| AU611704B2 (en) | 1991-06-20 |
| NZ225402A (en) | 1990-06-26 |
| KR960005706B1 (ko) | 1996-05-01 |
| PH25376A (en) | 1991-06-03 |
| AU2001288A (en) | 1989-04-20 |
| HK87893A (en) | 1993-09-03 |
| CA1315202C (en) | 1993-03-30 |
| GR880100491A (en) | 1989-04-12 |
| PT88099A (pt) | 1989-06-30 |
| KR890001526A (ko) | 1989-03-27 |
| IE62831B1 (en) | 1995-03-08 |
| EP0305051B1 (en) | 1993-05-05 |
| JPS6440424A (en) | 1989-02-10 |
| IN166560B (forum.php) | 1990-06-09 |
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