JP2710711B2 - Cellulose diacetate hollow fiber - Google Patents
Cellulose diacetate hollow fiberInfo
- Publication number
- JP2710711B2 JP2710711B2 JP3202283A JP20228391A JP2710711B2 JP 2710711 B2 JP2710711 B2 JP 2710711B2 JP 3202283 A JP3202283 A JP 3202283A JP 20228391 A JP20228391 A JP 20228391A JP 2710711 B2 JP2710711 B2 JP 2710711B2
- Authority
- JP
- Japan
- Prior art keywords
- hollow fiber
- cellulose diacetate
- present
- fin
- polymerization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- Separation Using Semi-Permeable Membranes (AREA)
- Artificial Filaments (AREA)
Description
【0001】[0001]
【産業上の利用分野】本発明は、特定の重合体からなる
選択透過性中空糸に関する。更に詳細には本発明は、こ
れまでのものとは異なった高い平均重合度を有したセル
ロースジアセテート重合体を主成分とした選択透過性の
セルロース系中空糸を提供するものである。The present invention relates to a selectively permeable hollow fiber comprising a specific polymer. More specifically, the present invention provides a permselective cellulose-based hollow fiber mainly composed of a cellulose diacetate polymer having a high average polymerization degree different from that of the prior art.
【0002】[0002]
【従来の技術】選択透過性中空糸は逆浸透や血液透析等
において従来より実用的に使用されて来ている。特に腎
不全患者の血液を浄化するために、現在では中空糸型血
液透析器がよく使用されている。これは筐体の中に透析
膜、例えば、中空糸の膜を多数本、収納し、その中空内
部に患者の血液を流し、外部、即ち、中空糸間に透析液
を流して、中空糸を介して透析によって、血液中の老廃
物を除去し電解質濃度を是正するとともに、中空糸内外
に圧力差を与えて限外濾過によって血液中の余剰水分を
除去するものである。更に、血液中から血漿のみを分離
し、或いは、その血漿の中から特定成分を除去して自己
免疫疾患などを治療するために、中空糸が使用されてい
る。このように血液処理用の中空糸は目的に応じて特定
の物質を選択的に透過せしめなければならない。その性
能は、中空糸の素材、ポロシティ(孔の大きさ、数な
ど)、膜厚などによって決定される。2. Description of the Related Art Selectively permeable hollow fibers have been practically used in reverse osmosis and hemodialysis. In particular, hollow fiber hemodialyzers are often used at present for purifying blood of patients with renal failure. In this method, a large number of dialysis membranes, for example, hollow fiber membranes, are housed in a housing, a patient's blood is allowed to flow inside the hollow, and a dialysate is allowed to flow between the outsides, that is, between the hollow fibers. Through the dialysis, waste substances in the blood are removed to correct the electrolyte concentration, and a pressure difference is applied between the inside and outside of the hollow fiber to remove excess water in the blood by ultrafiltration. Furthermore, hollow fibers are used to separate plasma alone from blood or to remove specific components from the plasma to treat autoimmune diseases and the like. As described above, the hollow fiber for blood treatment must selectively allow a specific substance to permeate according to the purpose. The performance is determined by the material of the hollow fiber, the porosity (the size and number of pores, etc.), the film thickness and the like.
【0003】血液透析器のための中空糸の素材として
は、セルロースやセルロースアセテートが一般によく用
いられる。特にセルロースアセテートは、可塑化溶融紡
糸や湿式紡糸なる通常用いられる紡糸方法によって比較
的容易に製造でき、得られた中空糸が血液透析治療に用
いた際に例えばセルロースの中空糸の場合に比して補体
活性をある程度抑制し得る等の利点がある。[0003] As a material of a hollow fiber for a hemodialyzer, cellulose or cellulose acetate is generally often used. In particular, cellulose acetate can be produced relatively easily by commonly used spinning methods such as plasticizing melt spinning and wet spinning, and when the obtained hollow fiber is used for hemodialysis treatment, for example, compared to the case of a cellulose hollow fiber. Thus, there is an advantage that complement activity can be suppressed to some extent.
【0004】しかしながら、従来のセルロースジアセテ
ート中空糸はセルロースを酢化する段階でセルロース自
体の重合度が低下しやすく、高い重合度のものでせいぜ
い170〜200程度のものしか得られなかった。However, in the conventional cellulose diacetate hollow fiber, the degree of polymerization of the cellulose itself tends to decrease at the stage of acetylating the cellulose, and a high degree of polymerization of only about 170 to 200 was obtained at most.
【0005】[0005]
【発明が解決しようとする課題】本発明者は、従来の高
々200の重合度のセルロースジアセテートを用いたの
では、物質透過性を高めるためにポリマー濃度を下げる
と紡糸原液の粘度が充分に高くならない場合があり、そ
のような場合には、膜厚を薄くすることが困難となりや
すく、特に軸方向に延びたフィンの形状がシャープにな
りにくく、結果として所望の選択透過性中空糸が得られ
にくかった点を改善することを目的として、鋭意研究を
行なった。逆にいえば同じフィンの形状でポリマー濃度
をあげ膜内の空隙率を上げて物質の透過性を増大せしめ
ることができる。SUMMARY OF THE INVENTION The present inventor has found that using conventional cellulose diacetate having a degree of polymerization of at most 200, if the concentration of the polymer is lowered to increase the material permeability, the viscosity of the spinning dope will be insufficient. In such a case, it is difficult to reduce the film thickness, and in particular, the shape of the fin extending in the axial direction is difficult to be sharp, and as a result, a desired selectively permeable hollow fiber is obtained. We worked diligently to improve the difficulties. Conversely, with the same fin shape, the polymer concentration can be increased and the porosity in the membrane can be increased to increase the permeability of the substance.
【0006】[0006]
【課題を解決するための手段】本発明者は、従来のセル
ロースジアセテート中空糸におけるセルロースジアセテ
ートよりも高い重合度のセルロースジアセテートを得
て、かかる重合度の高いセルロースジアセテートを用い
ることによって、より優れた特性を有した選択透過性中
空糸が得られることを見い出し、本発明に到達したもの
である。The present inventors have obtained cellulose diacetate having a higher polymerization degree than that of the conventional cellulose diacetate hollow fiber, and have used the cellulose diacetate having a high polymerization degree. The present inventors have found that a selectively permeable hollow fiber having more excellent properties can be obtained, and have reached the present invention.
【0007】すなわち本発明は、実質上セルロースジア
セテートからなる選択透過性壁膜を有した中空糸であっ
て、該実質上のセルロースジアセテートの平均重合度が
230〜400の範囲にあり、該壁膜の外面側に軸方向
に沿って延びた少なくとも1条のフィンを有し、前記壁
膜のフィンのない部分の厚さが20μm以下であり、か
つ前記中空糸の平均切断強度が0.4g/de以上であ
ることを特徴とするセルロースジアセテート中空糸であ
る。本発明の中空糸の選択透過性壁膜は、体液処理のた
めの物質選択透過性膜に好適なものである。That is, the present invention relates to a hollow fiber having a permselective wall membrane consisting essentially of cellulose diacetate, wherein the average degree of polymerization of the cellulose diacetate is substantially in the range of 230 to 400. At least one fin extending in the axial direction is provided on the outer surface side of the wall membrane, the thickness of the fin-free portion of the wall membrane is 20 μm or less, and the average cutting strength of the hollow fiber is 0. It is a cellulose diacetate hollow fiber characterized by being at least 4 g / de. The selectively permeable wall membrane of the hollow fiber of the present invention is suitable for a substance selectively permeable membrane for treating body fluids.
【0008】以下に本発明についてさらに詳細に説明す
る。まず本発明の選択透過性のセルロースジアセテート
中空糸は実質上のセルロースジアセテート重合体を主た
る構成成分とするものである。かかる実質上のセルロー
スジアセテート重合体としては、通常セルロースジアセ
テートとして取り扱われる範囲内にあるものをいい、具
体的には平均酢化度が50〜57%の範囲内にあるもの
があげられる。Hereinafter, the present invention will be described in more detail. First, the selectively permeable cellulose diacetate hollow fiber of the present invention contains a substantial component of a substantially cellulose diacetate polymer. As such a substantial cellulose diacetate polymer, those which are usually within the range handled as cellulose diacetate, specifically, those having an average acetylation degree within the range of 50 to 57% can be mentioned.
【0009】本発明におけるセルロースジアセテート重
合体は、平均重合度が230〜400であることを特徴
としている。尚ここで言う平均重合度は重量平均分子量
をその重合体の繰返し単位の分子量で割った値を意味す
る。その重量平均分子量の測定法として例えばゲル濾過
クロマトグラフィー、粘度率の測定、沈降平衡の測定、
光散乱法なる方法が挙げられる。[0009] The cellulose diacetate polymer of the present invention is characterized by having an average degree of polymerization of 230 to 400. Here, the average degree of polymerization means a value obtained by dividing the weight average molecular weight by the molecular weight of the repeating unit of the polymer. As a method for measuring the weight average molecular weight, for example, gel filtration chromatography, measurement of viscosity, measurement of sedimentation equilibrium,
Light scattering method may be used.
【0010】セルロースジアセテート重合体の平均重合
度が230未満の場合には、高さの高いフィンを具備し
且つ選択透過性の高いセルロースジアセテート中空糸が
得にくい。また再湿伸長率の低い中空糸が得られにく
い。又、中空糸による物質の透過性を増大せしめる為
に、紡糸時のポリマー濃度を低めた場合、ポリマー粘度
が低すぎ、紡糸性が非常に悪くなる。平均重合度として
は、240〜350が更に好ましく、特に250〜30
0が好ましい。When the average degree of polymerization of the cellulose diacetate polymer is less than 230, it is difficult to obtain a cellulose diacetate hollow fiber having high fins and high permselectivity. Further, it is difficult to obtain a hollow fiber having a low rewetting elongation rate. In addition, when the polymer concentration during spinning is reduced in order to increase the permeability of the substance by the hollow fiber, the polymer viscosity is too low, and the spinnability becomes very poor. The average degree of polymerization is more preferably from 240 to 350, and particularly preferably from 250 to 30.
0 is preferred.
【0011】尚セルロースジアセテート重合体の平均重
合度が400以上の場合は、重合体自体が製造しにく
く、また中空糸を溶融紡糸する場合、温度が非常に高く
なり、セルロースジアセテートの分解がしやすくなる。When the average degree of polymerization of the cellulose diacetate polymer is 400 or more, it is difficult to produce the polymer itself, and when the hollow fiber is melt-spun, the temperature becomes extremely high, and the decomposition of the cellulose diacetate is difficult. Easier to do.
【0012】本発明のセルロースジアセテート中空糸
は、かかるセルロースジアセテート重合体を主要成分と
するものであり、その具体的な含有率としては50%以
上、更には70%以上が好ましい。尚それ以外に含まれ
る成分は特に限定されるものではなく、例えばポリメチ
ルメタアクリレート、ポリエチレン、ポリプロピレン、
ポリアクリロニトリル、ポリビニルアルコール、ニトロ
セルロース等の有機高分子が挙げられる。The cellulose diacetate hollow fiber of the present invention contains such a cellulose diacetate polymer as a main component, and its specific content is preferably 50% or more, more preferably 70% or more. In addition, the components contained other than that are not particularly limited, for example, polymethyl methacrylate, polyethylene, polypropylene,
Organic polymers such as polyacrylonitrile, polyvinyl alcohol, and nitrocellulose are exemplified.
【0013】更に本発明の中空糸の外径(d)として
は、例えば血液透析等の体液処理用の場合には、100
〜400μが好ましく、更には200〜300μが好ま
しい。膜厚(h)としては20μ以下、更には5〜20
μ、特に10〜15μが好ましい。Further, the outer diameter (d) of the hollow fiber of the present invention is, for example, 100% in the case of body fluid treatment such as hemodialysis.
~ 400μ, more preferably 200 ~ 300μ. The film thickness (h) is not more than 20 μm, and more preferably 5 to 20
μ, particularly preferably 10 to 15 μ.
【0014】また本発明のセルロース系中空糸として
は、外周部において長手方向に延長されたフィンを有し
たものであり、該フィンの高さHと巾Wの比H/Wが
0.5以上であることを特徴としている。該比H/Wが
0.5未満の場合には、流体分離器内に収納した場合の
中空糸どうしの密着を防止する効果が得にくく好ましく
ない。さらに好ましいH/Wとしては0.8以上であ
る。尚、フィンの巾Wとは、フィンの高さHの1/2の
位置における巾を意味するものである。The cellulosic hollow fiber of the present invention has a fin extending in the longitudinal direction at the outer periphery, and the ratio H / W of the height H to the width W of the fin is 0.5 or more. It is characterized by being. If the ratio H / W is less than 0.5, it is not preferable because the effect of preventing the hollow fibers from sticking together when housed in the fluid separator cannot be obtained. H / W is more preferably 0.8 or more. Note that the fin width W means a width at a position 1 / of the fin height H.
【0015】更に本発明における該中空糸のフィンの数
xは少なくとも1であるが、11以上になるとフィン根
元部による有効膜面積の減少が顕著になり、例えば血液
透析器における物質透析性能、水透過性能が著しく低下
し、実用的でない。即ちかかるxは一般に1〜10であ
るが、さらには2〜8が好ましく、特に有効な範囲は3
〜7である。Further, in the present invention, the number x of the fins of the hollow fiber is at least 1. However, when it is 11 or more, the effective membrane area is significantly reduced by the root of the fin. The transmission performance is remarkably reduced, which is not practical. That is, such x is generally 1 to 10, more preferably 2 to 8, and the particularly effective range is 3 to 10.
~ 7.
【0016】その場合のフィンの高さ(H)としては5
〜100μ、更には9〜60μが好ましい。尚フィン高
さと膜厚の比H/hは0.5〜3が好ましく、さらには
1〜2が好ましい。更にフィンの平均高さH(μ)とフ
ィンを除外した中空糸の平均外径d(μ)の比H/d
は、0.01〜1の範囲にあることが好ましく、更には
0.02〜0.5の範囲、特に0.03〜0.2の範囲
にあることが望ましい。またフィンの根元の巾はフィン
の上部に比して狭いのが望ましいが、通常は紡糸原液が
口金から吐出後、原液の表面張力で根元部分は広くなり
やすい。かかる根元の巾としては15〜50μ、好まし
くは20〜40μのものが適当である。この様な範囲に
ある中空糸は真円性良好であり中空糸内での血液凝固や
残血が生じにくい点でも好ましい。In this case, the height (H) of the fin is 5
-100 μm, more preferably 9-60 μm. The ratio H / h between the fin height and the film thickness is preferably 0.5-3, more preferably 1-2. Furthermore, the ratio H / d of the average height H (μ) of the fins and the average outer diameter d (μ) of the hollow fibers excluding the fins.
Is preferably in the range of 0.01 to 1, more preferably in the range of 0.02 to 0.5, and particularly preferably in the range of 0.03 to 0.2. The width of the root of the fin is desirably narrower than that of the upper part of the fin. However, usually, after the spinning dope is discharged from the spinneret, the root tends to be wider due to the surface tension of the stock solution. The width of the root is suitably 15 to 50 μm, preferably 20 to 40 μm. A hollow fiber in such a range is preferable because it has good circularity and hardly causes blood coagulation or residual blood in the hollow fiber.
【0017】更に本発明の中空糸のうちで、平均切断強
度が0.4g/de以上であるものが好ましく、特に
0.6g/de以上のものが望ましい。強度が0.4g
/de未満の場合には、形態保持性に劣り、中空糸の製
造工程や流体分離器の製造工程中で破断しやすく、特に
外径dが100〜300μで膜厚が5〜20μの範囲の
中空糸の場合にはその傾向が大きい。尚該強度の上限と
しては特に限定されるものではなく、例えば0.9g/
de以下が一般的である。Further, among the hollow fibers of the present invention, those having an average breaking strength of at least 0.4 g / de are preferred, and those having an average breaking strength of at least 0.6 g / de are more preferred. 0.4g strength
When the ratio is less than / de, the shape retention is poor, and it is easily broken during the hollow fiber manufacturing process and the fluid separator manufacturing process. In particular, when the outer diameter d is 100 to 300 µm and the film thickness is 5 to 20 µm. In the case of a hollow fiber, the tendency is large. The upper limit of the strength is not particularly limited. For example, 0.9 g /
De or less is common.
【0018】また本発明の中空糸は、その再湿伸長率が
3%以下であることを特徴としている。再湿伸長率が3
%を超える場合には、実質上乾燥状態流体分離器に収納
した後に水や水溶液等を充填し再湿潤状態にした際の該
中空糸の伸びが大きすぎて、中空糸どうしの局所的な密
着が増し、中空糸の折れ曲りなどが発生しやすくなるの
で好ましくない。かかる再湿伸長率としては、2.5%
以下が更に好ましい。また再湿伸長率の下限としては特
に限定されるものではないが、0.5%以上、更に好ま
しくは1%以上であれば、流体分離器内で再湿潤時に中
空糸が適度な伸びを呈し、流体分離器内全体に中空糸束
が広がる効果も得られる。尚該再湿伸長率αは実質上乾
燥状態にある中空糸を約0.1g/deの荷重下で測定
した長さLと該中空糸を水で湿潤状態にして約0.1g
/deの荷重下で測定した場合の長さL1 を測定し、α
={(L1 −L)/L}×100なる計算式により得ら
れるものである。ここで実質上の乾燥状態とは中空糸を
グリセリン水溶液に浸漬した後乾燥することにより得ら
れるグリセリン含有率が30〜60%、水含有率0.5
〜9%の状態を意味する。Further, the hollow fiber of the present invention is characterized in that its rewetting elongation is 3% or less. Rewetting elongation rate is 3
%, The elongation of the hollow fibers when filled with water or an aqueous solution after being stored in a fluid separator substantially in a dry state and brought into a rewet state is too large, and the local adhesion between the hollow fibers is large. And the hollow fiber is liable to be bent, which is not preferable. The rewetting elongation rate is 2.5%
The following are more preferred. The lower limit of the rewetting elongation rate is not particularly limited, but if it is 0.5% or more, more preferably 1% or more, the hollow fiber exhibits an appropriate elongation at the time of rewetting in the fluid separator. Also, the effect of spreading the hollow fiber bundle throughout the fluid separator can be obtained. The rewetting elongation α is about 0.1 g when the hollow fiber in a substantially dry state is measured with a load L of about 0.1 g / de and the hollow fiber is wetted with water.
The length L 1 when measured under a load of / de is measured, and α
= {(L 1 −L) / L} × 100. Here, the “substantially dry state” means that the glycerin content obtained by immersing the hollow fiber in an aqueous glycerin solution and then drying is 30 to 60%, and the water content is 0.5.
状態 9%.
【0019】更に本発明の膜厚が薄い中空糸のうちで、
実質上曲げ剛性が200mg/200本以上の範囲にある
ものが好ましく、また湿潤時において中空糸内に加圧し
た場合の耐圧性として破裂圧力が4kg/cm2 以上である
ことが好ましい。かかる範囲にあるものは、流体分離器
製造時等における中空糸の取扱いが容易であり、流体分
離器内での各中空糸の長さが均一になりやすく、また分
離器の使用時における加圧運転による中空糸の破損が生
じにくい利点が得られる。Further, among the thin hollow fibers of the present invention,
Preferably, the material has a bending stiffness substantially in the range of 200 mg / 200 or more, and preferably has a burst pressure of 4 kg / cm 2 or more as a pressure resistance when pressed into the hollow fiber when wet. In the range, the handling of the hollow fiber is easy at the time of manufacturing the fluid separator, etc., the length of each hollow fiber within the fluid separator tends to be uniform, and the pressure during the use of the separator is increased. An advantage is obtained that the hollow fiber is less likely to be damaged by the operation.
【0020】また本発明の薄膜のセルロースジアセテー
ト中空糸は、流体の選択透過性を有しており、さらに具
体的には例えば血液透析用中空糸の場合には、フィン部
を除いた部分での水透過性能UFRとしては、3.0〜
40.0ml/(m2 ・hr・mmHg)の範囲にあるものが好
ましく、殊に5.0〜30.0ml/(m2 ・hr・mmHg)
が良い。Further, the cellulose diacetate hollow fiber of the thin film of the present invention has a selective permeability of a fluid. More specifically, for example, in the case of a hollow fiber for hemodialysis, the portion excluding the fin portion is used. Of the water permeation performance UFR of 3.0 to 3.0
Those having a range of 40.0 ml / (m 2 · hr · mmHg) are preferable, and especially 5.0 to 30.0 ml / (m 2 · hr · mmHg).
Is good.
【0021】かかる本発明の選択透過性を有したセルロ
ース系中空糸は、流体分離に優れた分離性能を発揮する
ものである。その流体分離としては特に限定されるもの
ではなく、例えば透析、限外濾過、逆浸透等の液体分離
や、人工肺用等の気体分離などが挙げられる。特に本発
明の中空糸は、中空糸外における流体の流動状態が良好
であることを必要とする透析等の拡散速度の差による分
離や中空糸内でのスムーズな流動を必要とする血液処理
に適している。The cellulosic hollow fiber having selective permeability according to the present invention exhibits excellent separation performance in fluid separation. The fluid separation is not particularly limited, and examples thereof include liquid separation such as dialysis, ultrafiltration, and reverse osmosis, and gas separation such as for artificial lungs. In particular, the hollow fiber of the present invention is suitable for separation due to a difference in diffusion speed, such as dialysis, which requires that the fluid flow state outside the hollow fiber is good, and for blood treatment that requires smooth flow inside the hollow fiber. Are suitable.
【0022】本発明の中空糸の製造方法としては、溶融
紡糸、湿式紡糸、半乾半湿紡糸等のいずれであってもよ
い。即ち溶融紡糸法の場合には紡糸原液が加熱された溶
融液であり、溶融液を該紡糸口金から吐出し冷却するこ
とにより固化せしめてフィン付中空糸を成形した後、セ
ルロースジエステル重合体を溶解せず添加剤を溶解し得
る溶媒により例えばフィン付中空糸中の添加剤の少なく
とも一部を抽出除去することによって選択透過性を有し
たフィン付セルロースジアセテート中空糸を得るもので
ある。The method for producing the hollow fiber of the present invention may be any of melt spinning, wet spinning, semi-dry semi-wet spinning and the like. That is, in the case of the melt spinning method, the spinning stock solution is a heated melt, and the melt is discharged from the spinneret, cooled and solidified to form hollow fibers with fins, and then the cellulose diester polymer is dissolved. A finned cellulose diacetate hollow fiber having selective permeability is obtained by extracting and removing at least a part of the additive in the finned hollow fiber with a solvent capable of dissolving the additive without using the solvent.
【0023】以下に実施例をあげてさらに詳述するが、
これらの実施例により本発明が何ら限定されるものでは
ない。Hereinafter, the present invention will be described in more detail with reference to Examples.
The present invention is not limited by these examples.
【0024】[0024]
【実施例,比較例】平均重合度260と170のセルロ
ースジアセテート100部に対し、ポリエチレングリコ
ール(分子量400)とジグリセリンを4対1の割合で
混合したものを170部加え混合し、その混合物を18
0℃〜190℃で溶融し、フィン付中空糸用の二重円環
状スリットを有する口金を用いて紡糸した。次いで、熱
水によりポリエチレングリコールとジグリセリンを抽出
し捲取り後、中空糸束を有効膜面積が約1m2 の血液透
析器を組み立てた。下記の表1には得られた中空糸及び
血液透析器の特性を示す。EXAMPLES AND COMPARATIVE EXAMPLES To 100 parts of cellulose diacetate having an average degree of polymerization of 260 and 170, 170 parts of a mixture of polyethylene glycol (molecular weight: 400) and diglycerin at a ratio of 4 to 1 was added and mixed. 18
The mixture was melted at 0 ° C. to 190 ° C. and spun using a die having a double annular slit for a finned hollow fiber. Next, polyethylene glycol and diglycerin were extracted with hot water and wound up, and then a hollow fiber bundle was assembled into a hemodialyzer having an effective membrane area of about 1 m 2 . Table 1 below shows the properties of the obtained hollow fiber and hemodialyzer.
【0025】但し、尿素ダイアリザンスは37℃で中空
糸内の平均血液側速度が約1.2cm/sec の尿素水溶
液、透析液側の平均流速が約1.8cm/sec の水を用い
て測定した。又糸斑は30ホールの中での中空糸内径の
最大値−最小値を示す。The urea dialysance was measured at 37 ° C. using a urea aqueous solution having an average blood side velocity of about 1.2 cm / sec in the hollow fiber and water having an average flow rate of about 1.8 cm / sec on the dialysate side. did. In addition, yarn spots indicate the maximum value-minimum value of the inner diameter of the hollow fiber in 30 holes.
【0026】[0026]
【表1】 [Table 1]
【0027】[0027]
【発明の効果】本発明の中空糸は平均重合度が通常のも
のより高く、一定のポリマー濃度での紡糸原液の粘度が
高く、非常に紡糸性が良好になる。即ち、紡糸中での断
糸が少なく、又糸斑が小さくなる。一方紡出するポリマ
ー粘度が高いのでフィン付中空糸の場合にはフィンの形
状がシャープで血液透析器として組み立てたときの透析
効率いわゆる尿素のダイアリザンスが非常に高レベルを
示す。The hollow fiber of the present invention has an average degree of polymerization higher than that of a normal one, and the viscosity of the spinning solution at a certain polymer concentration is high, so that the spinnability is very good. That is, yarn breakage during spinning is small, and yarn spots are reduced. On the other hand, since the viscosity of the spun polymer is high, in the case of the hollow fiber with fin, the shape of the fin is sharp and the dialysis efficiency when assembled as a hemodialyzer, that is, the urea dialysance shows a very high level.
Claims (2)
選択透過性壁膜を有した中空糸であって、該実質上のセ
ルロースジアセテートの平均重合度が230〜400の
範囲にあり、該壁膜の外面側に軸方向に沿って延びた少
なくとも1条のフィンを有し、前記壁膜のフィンのない
部分の厚さが20μm以下であり、かつ前記中空糸の平
均切断強度が0.4g/de以上であることを特徴とす
るセルロースジアセテート中空糸。1. A hollow fiber having a permselective wall membrane consisting essentially of cellulose diacetate, wherein the average degree of polymerization of the substantial cellulose diacetate is in the range of 230-400. At least one fin extending in the axial direction on the outer surface side, the thickness of the fin-free portion of the wall film is 20 μm or less, and the average cutting strength of the hollow fiber is 0.4 g / de. A cellulose diacetate hollow fiber characterized by the above.
物質選択透過性である請求項1のセルロースジアセテー
ト中空糸。2. The cellulose diacetate hollow fiber according to claim 1, wherein the permselectivity of the wall membrane is a substance permselectivity for treating a body fluid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3202283A JP2710711B2 (en) | 1991-07-18 | 1991-07-18 | Cellulose diacetate hollow fiber |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3202283A JP2710711B2 (en) | 1991-07-18 | 1991-07-18 | Cellulose diacetate hollow fiber |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0523556A JPH0523556A (en) | 1993-02-02 |
JP2710711B2 true JP2710711B2 (en) | 1998-02-10 |
Family
ID=16454975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3202283A Expired - Fee Related JP2710711B2 (en) | 1991-07-18 | 1991-07-18 | Cellulose diacetate hollow fiber |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2710711B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7590159B2 (en) | 2001-02-26 | 2009-09-15 | Ricoh Company, Ltd. | Surface-emission laser diode operable in the wavelength band of 1.1-1.7 micrometers and optical telecommunication system using such a laser diode |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5361576A (en) * | 1976-11-16 | 1978-06-02 | Teijin Ltd | Preparation of sterilized dialyzer |
EP0330106A1 (en) * | 1988-02-25 | 1989-08-30 | Akzo Nobel N.V. | Modified cellulose for biocompatible dialysis membranes II, and method for its preparation |
-
1991
- 1991-07-18 JP JP3202283A patent/JP2710711B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0523556A (en) | 1993-02-02 |
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