JP2588039B2 - 段階的な活性物質放出を呈する皮膚経由医療薬として使用されるプラスタ及びその製造方法 - Google Patents
段階的な活性物質放出を呈する皮膚経由医療薬として使用されるプラスタ及びその製造方法Info
- Publication number
- JP2588039B2 JP2588039B2 JP2058242A JP5824290A JP2588039B2 JP 2588039 B2 JP2588039 B2 JP 2588039B2 JP 2058242 A JP2058242 A JP 2058242A JP 5824290 A JP5824290 A JP 5824290A JP 2588039 B2 JP2588039 B2 JP 2588039B2
- Authority
- JP
- Japan
- Prior art keywords
- active substance
- plaster
- matrix
- depot
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000013543 active substance Substances 0.000 title claims description 110
- 239000011505 plaster Substances 0.000 title claims description 65
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 230000001747 exhibiting effect Effects 0.000 title claims 6
- 239000011159 matrix material Substances 0.000 claims abstract description 84
- 239000010410 layer Substances 0.000 claims abstract description 46
- 229940079593 drug Drugs 0.000 claims abstract description 19
- 238000009792 diffusion process Methods 0.000 claims abstract description 13
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 9
- 239000011241 protective layer Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000012071 phase Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 238000010410 dusting Methods 0.000 claims 1
- 238000003475 lamination Methods 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 238000003825 pressing Methods 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 239000012790 adhesive layer Substances 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 description 9
- 238000012423 maintenance Methods 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 230000035515 penetration Effects 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 4
- 230000004907 flux Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 230000000147 hypnotic effect Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- GLVVKKSPKXTQRB-UHFFFAOYSA-N ethenyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC=C GLVVKKSPKXTQRB-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229960002715 nicotine Drugs 0.000 description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 2
- 229920000193 polymethacrylate Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 229940125683 antiemetic agent Drugs 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3908432A DE3908432A1 (de) | 1989-03-14 | 1989-03-14 | Pflaster als therapeutisches system zur verabreichung von wirkstoffen an die haut mit einer abgestuften wirkstoffabgabe, verfahren zu seiner herstellung sowie verwendung |
| DE3908432.9 | 1989-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0314515A JPH0314515A (ja) | 1991-01-23 |
| JP2588039B2 true JP2588039B2 (ja) | 1997-03-05 |
Family
ID=6376397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2058242A Expired - Lifetime JP2588039B2 (ja) | 1989-03-14 | 1990-03-12 | 段階的な活性物質放出を呈する皮膚経由医療薬として使用されるプラスタ及びその製造方法 |
Country Status (28)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4110027C2 (de) * | 1991-03-27 | 1996-08-29 | Lohmann Therapie Syst Lts | Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster |
| JP3212340B2 (ja) * | 1992-01-27 | 2001-09-25 | アルケア株式会社 | 皮膚保護用ペースト状組成物 |
| DK170792B1 (da) * | 1992-08-27 | 1996-01-22 | Coloplast As | Hudpladeprodukt til dosering af et eller flere medikamenter |
| US5523095A (en) * | 1993-12-15 | 1996-06-04 | Eastman Chemical Company | Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends |
| US5536505A (en) * | 1993-12-15 | 1996-07-16 | Eastman Chemical Company | Controlled release matrix system using cellulose acetate/poly-2-ethyl-2-oxazoline blends |
| US5547681A (en) * | 1994-07-14 | 1996-08-20 | Union Carbide Chemicals & Plastics Technology Corporation | Dermal patch |
| DE19802050A1 (de) * | 1998-01-21 | 1999-07-22 | Labtec Gmbh | Zubereitung zur Freisetzung von Coenzym Q 10 in die Mundhöhle |
| US5939477A (en) * | 1998-02-02 | 1999-08-17 | Dow Corning Corporation | Silicone pressure sensitive adhesive composition containing functionalized polyisobutylene |
| FR2784581B1 (fr) * | 1998-10-20 | 2002-12-13 | Oreal | Patch, ensemble constitue d'un patch et d'un recipient, et procede |
| WO2000033812A2 (en) * | 1998-12-07 | 2000-06-15 | Elan Corporation, Plc | Transdermal patch for delivering volatile liquid drugs |
| DE29913844U1 (de) | 1999-08-07 | 1999-10-07 | Klocke Verpackungs-Service GmbH, 76356 Weingarten | Applikations-Packung |
| US6974588B1 (en) | 1999-12-07 | 2005-12-13 | Elan Pharma International Limited | Transdermal patch for delivering volatile liquid drugs |
| US20020004065A1 (en) | 2000-01-20 | 2002-01-10 | David Kanios | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| FR2804870B1 (fr) * | 2000-02-16 | 2002-08-16 | Oreal | Structure composite a matrice adhesive contenant un ou plusieurs actifs |
| DE10110391A1 (de) * | 2001-03-03 | 2002-09-26 | Lohmann Therapie Syst Lts | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
| FR2822711B1 (fr) * | 2001-03-28 | 2003-06-13 | Oreal | Dispositif de traitement comportant une enveloppe definissant une cavite dans laquelle peut-etre engagee une partie du corps |
| AR033748A1 (es) * | 2002-05-15 | 2004-01-07 | Thalas Group Inc | Un dispositivo para la administracion transdermica de sustancias farmacologicamente activas que comprende dos capas adhesivas superpuestas y un procedimiento para prepararlo |
| US20050202073A1 (en) * | 2004-03-09 | 2005-09-15 | Mylan Technologies, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
| US9205062B2 (en) | 2004-03-09 | 2015-12-08 | Mylan Pharmaceuticals, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
| US7888422B2 (en) | 2005-11-09 | 2011-02-15 | Mylan Technologies Inc. | Long-wearing removable pressure sensitive adhesive |
| DE102007006244B4 (de) * | 2007-02-08 | 2012-03-15 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System zur Verabreichung wasserlöslicher Wirkstoffe |
| US9017301B2 (en) * | 2007-09-04 | 2015-04-28 | Mylan Technologies, Inc. | Transdermal drug delivery systems comprising a coated release liner |
| WO2012138727A1 (en) | 2011-04-04 | 2012-10-11 | The Procter & Gamble Company | Home care article |
| BR112014003460B1 (pt) | 2011-08-15 | 2019-05-21 | The Procter & Gamble Company | Artigos conformáveis para cuidados pessoais |
| WO2013025744A2 (en) | 2011-08-15 | 2013-02-21 | The Procter & Gamble Company | Personal care methods |
| CN105324157B (zh) | 2013-06-27 | 2019-01-29 | 宝洁公司 | 个人护理组合物和制品 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3731683A (en) * | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
| US4262003A (en) * | 1975-12-08 | 1981-04-14 | Alza Corporation | Method and therapeutic system for administering scopolamine transdermally |
| JPS57179437U (enrdf_load_stackoverflow) * | 1981-05-06 | 1982-11-13 | ||
| JPS5984819U (ja) * | 1982-11-29 | 1984-06-08 | 松下電器産業株式会社 | 油入静止機器巻線 |
| US4597961A (en) * | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| JPS6216414A (ja) * | 1985-07-11 | 1987-01-24 | Nitto Electric Ind Co Ltd | 複合製剤 |
| US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
| US4666441A (en) * | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
| EP0249475A3 (en) * | 1986-06-13 | 1989-10-11 | Alza Corporation | Delayed percutaneous delivery |
| DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
| DE3809978A1 (de) * | 1988-03-24 | 1989-10-05 | Lohmann Gmbh & Co Kg | Reservoir fuer gesteuerte wirkstoffabgabe, dieses enthaltende vorrichtung, sowie verfahren zu deren herstellung und verwendung der vorrichtung |
-
1989
- 1989-03-14 DE DE3908432A patent/DE3908432A1/de active Granted
-
1990
- 1990-03-07 MY MYPI90000357A patent/MY107088A/en unknown
- 1990-03-07 AU AU50766/90A patent/AU622775B2/en not_active Expired
- 1990-03-07 PH PH40156A patent/PH26277A/en unknown
- 1990-03-08 DK DK90104407.3T patent/DK0387694T3/da active
- 1990-03-08 CZ CS19901137A patent/CZ286264B6/cs not_active IP Right Cessation
- 1990-03-08 DE DE59010095T patent/DE59010095D1/de not_active Expired - Lifetime
- 1990-03-08 EP EP90104407A patent/EP0387694B1/de not_active Expired - Lifetime
- 1990-03-08 AT AT90104407T patent/ATE133569T1/de not_active IP Right Cessation
- 1990-03-08 SK SK1137-90A patent/SK280996B6/sk not_active IP Right Cessation
- 1990-03-08 ES ES90104407T patent/ES2085293T3/es not_active Expired - Lifetime
- 1990-03-08 IL IL9367990A patent/IL93679A/en not_active IP Right Cessation
- 1990-03-09 NO NO90901127A patent/NO901127L/no unknown
- 1990-03-12 JP JP2058242A patent/JP2588039B2/ja not_active Expired - Lifetime
- 1990-03-13 NZ NZ232896A patent/NZ232896A/en unknown
- 1990-03-13 DD DD90338651A patent/DD296844A5/de not_active IP Right Cessation
- 1990-03-13 HU HU901423A patent/HU206992B/hu unknown
- 1990-03-14 KR KR90003381A patent/KR950013462B1/ko not_active Expired - Lifetime
- 1990-03-14 IE IE91490A patent/IE74681B1/en not_active IP Right Cessation
- 1990-03-14 ZA ZA901940A patent/ZA901940B/xx unknown
- 1990-03-14 CA CA002012124A patent/CA2012124A1/en not_active Abandoned
- 1990-03-14 PT PT93431A patent/PT93431B/pt not_active IP Right Cessation
- 1990-03-14 PL PL28430090A patent/PL162638B1/pl unknown
- 1990-03-14 YU YU49490A patent/YU48229B/sh unknown
- 1990-03-14 SI SI9010494A patent/SI9010494B/sl unknown
- 1990-03-15 FI FI901291A patent/FI107371B/fi active IP Right Grant
-
1991
- 1991-06-20 US US07/721,903 patent/US5176915A/en not_active Expired - Lifetime
-
1993
- 1993-04-01 HR HRP-494/90A patent/HRP930666B1/xx not_active IP Right Cessation
-
1996
- 1996-04-29 GR GR960401166T patent/GR3019786T3/el unknown
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