JP2506478B2 - ３―置換―２―オキシインド―ル誘導体 - Google Patents

３―置換―２―オキシインド―ル誘導体

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Publication number
JP2506478B2
JP2506478B2 JP2102775A JP10277590A JP2506478B2 JP 2506478 B2 JP2506478 B2 JP 2506478B2 JP 2102775 A JP2102775 A JP 2102775A JP 10277590 A JP10277590 A JP 10277590A JP 2506478 B2 JP2506478 B2 JP 2506478B2
Authority
JP
Japan
Prior art keywords
mmol
alkyl
cor
oxindole
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2102775A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02292258A (ja
Inventor
フレデリック・ジェイコブ・エーゴット
カール・ジョセフ・ゴッダード
ゲイリー・リチャード・シュルテ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Publication of JPH02292258A publication Critical patent/JPH02292258A/ja
Application granted granted Critical
Publication of JP2506478B2 publication Critical patent/JP2506478B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
JP2102775A 1989-04-18 1990-04-18 ３―置換―２―オキシインド―ル誘導体 Expired - Fee Related JP2506478B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34011389A 1989-04-18 1989-04-18
US340113 1989-04-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP6186078A Division JP2581525B2 (ja) 1989-04-18 1994-08-08 新規中間体化合物

Publications (2)

Publication Number Publication Date
JPH02292258A JPH02292258A (ja) 1990-12-03
JP2506478B2 true JP2506478B2 (ja) 1996-06-12

Family

ID=23331948

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2102775A Expired - Fee Related JP2506478B2 (ja) 1989-04-18 1990-04-18 ３―置換―２―オキシインド―ル誘導体
JP6186078A Expired - Fee Related JP2581525B2 (ja) 1989-04-18 1994-08-08 新規中間体化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP6186078A Expired - Fee Related JP2581525B2 (ja) 1989-04-18 1994-08-08 新規中間体化合物

Country Status (33)

Country Link
US (4) US5047554A (cs)
EP (1) EP0393936B1 (cs)
JP (2) JP2506478B2 (cs)
KR (1) KR920006394B1 (cs)
CN (1) CN1022832C (cs)
AP (1) AP142A (cs)
AT (1) ATE118767T1 (cs)
AU (1) AU633767B2 (cs)
BG (1) BG60646B1 (cs)
CA (1) CA2014467C (cs)
CZ (1) CZ284340B6 (cs)
DD (1) DD293822A5 (cs)
DE (1) DE69017066T2 (cs)
DK (1) DK0393936T3 (cs)
EG (1) EG19122A (cs)
ES (1) ES2068334T3 (cs)
FI (1) FI106378B (cs)
GR (1) GR3015811T3 (cs)
HU (2) HUT58314A (cs)
IE (1) IE65091B1 (cs)
IL (3) IL94047A (cs)
IS (1) IS1636B (cs)
MA (1) MA21808A1 (cs)
MX (1) MX20359A (cs)
NO (1) NO176759C (cs)
NZ (1) NZ233320A (cs)
OA (1) OA09205A (cs)
PL (2) PL163941B1 (cs)
PT (1) PT93785B (cs)
RO (1) RO106402B1 (cs)
RU (2) RU2039042C1 (cs)
YU (1) YU47588B (cs)
ZA (1) ZA902871B (cs)

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JP4292742B2 (ja) * 2000-03-09 2009-07-08 小野薬品工業株式会社 インドール誘導体、その製造方法および用途
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AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
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US6642232B2 (en) 2001-10-10 2003-11-04 Sugen, Inc. 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors
JP2005535576A (ja) * 2002-04-22 2005-11-24 ファイザー・プロダクツ・インク シクロオキシゲナーゼ−２の選択的阻害薬としてのインドール−２−オン類
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AR060403A1 (es) * 2006-04-12 2008-06-11 Sanofi Aventis Compuestos de amino- pirimidina 2,6- sustituidos -4- monosustituidos como antagonistas del receptor de prostaglandina d2
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UA121116C2 (uk) 2014-06-06 2020-04-10 Басф Се Застосування заміщених оксадіазолів для боротьби з фітопатогенними грибами
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AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
US10492494B2 (en) 2015-11-13 2019-12-03 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
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CN115403566B (zh) * 2022-09-21 2024-01-30 山东大学 3-取代吲哚-2-酮化合物及其制备方法和应用

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Also Published As

Publication number Publication date
ES2068334T3 (es) 1995-04-16
MX20359A (es) 1994-02-28
BG91773A (bg) 1993-12-24
HU211150A9 (en) 1995-10-30
CZ184890A3 (cs) 1998-07-15
KR900016189A (ko) 1990-11-12
GR3015811T3 (en) 1995-07-31
JP2581525B2 (ja) 1997-02-12
IL110173A0 (en) 1994-10-07
RU2073671C1 (ru) 1997-02-20
KR920006394B1 (ko) 1992-08-06
CA2014467A1 (en) 1990-10-18
PL163941B1 (pl) 1994-05-31
OA09205A (en) 1992-06-30
YU47588B (sh) 1995-10-24
PT93785B (pt) 1996-09-30
EG19122A (en) 1994-07-30
PL284817A1 (en) 1991-03-25
NZ233320A (en) 1991-09-25
US5047554A (en) 1991-09-10
IE901360L (en) 1990-10-18
AP142A (en) 1991-09-26
CN1022832C (zh) 1993-11-24
AU633767B2 (en) 1993-02-04
NO176759B (no) 1995-02-13
IS3570A7 (is) 1990-10-19
NO176759C (no) 1995-05-24
PT93785A (pt) 1990-11-20
IE65091B1 (en) 1995-10-04
ZA902871B (en) 1991-11-27
EP0393936A1 (en) 1990-10-24
PL163951B1 (pl) 1994-05-31
US5290802A (en) 1994-03-01
US5919809A (en) 1999-07-06
HUT58314A (en) 1992-02-28
DD293822A5 (de) 1991-09-12
IL94047A (en) 1995-10-31
FI901915A0 (fi) 1990-04-17
US6174883B1 (en) 2001-01-16
DE69017066D1 (de) 1995-03-30
FI106378B (fi) 2001-01-31
EP0393936B1 (en) 1995-02-22
CZ284340B6 (cs) 1998-10-14
ATE118767T1 (de) 1995-03-15
CN1046525A (zh) 1990-10-31
IS1636B (is) 1996-09-20
IL94047A0 (en) 1991-01-31
MA21808A1 (fr) 1990-12-31
YU75590A (sh) 1992-07-20
JPH07118261A (ja) 1995-05-09
AP9000175A0 (en) 1990-04-30
DE69017066T2 (de) 1995-06-14
AU1051092A (en) 1992-04-09
AU5362690A (en) 1990-11-22
DK0393936T3 (da) 1995-06-26
BG60646B1 (bg) 1995-11-30
HU902462D0 (en) 1990-08-28
CA2014467C (en) 2000-02-08
NO901684D0 (no) 1990-04-17
NO901684L (no) 1990-10-19
RU2039042C1 (ru) 1995-07-09
PL287812A1 (en) 1991-07-15
RO106402B1 (ro) 1993-04-30
IL110173A (en) 1997-06-10
JPH02292258A (ja) 1990-12-03
AU621477B2 (en) 1992-03-12

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