JP2025086912A5 - - Google Patents

Info

Publication number
JP2025086912A5
JP2025086912A5 JP2025025892A JP2025025892A JP2025086912A5 JP 2025086912 A5 JP2025086912 A5 JP 2025086912A5 JP 2025025892 A JP2025025892 A JP 2025025892A JP 2025025892 A JP2025025892 A JP 2025025892A JP 2025086912 A5 JP2025086912 A5 JP 2025086912A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025025892A
Other languages
Japanese (ja)
Other versions
JP2025086912A (ja
Filing date
Publication date
Priority claimed from PCT/US2020/045759 external-priority patent/WO2021030344A1/en
Application filed filed Critical
Publication of JP2025086912A publication Critical patent/JP2025086912A/ja
Publication of JP2025086912A5 publication Critical patent/JP2025086912A5/ja
Pending legal-status Critical Current

Links

JP2025025892A 2019-08-12 2025-02-20 Rna誘導ヌクレアーゼ及びその活性断片及び変異体ならびに使用方法 Pending JP2025086912A (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201962885483P 2019-08-12 2019-08-12
US62/885,483 2019-08-12
US201962901875P 2019-09-18 2019-09-18
US62/901,875 2019-09-18
US202063030088P 2020-05-26 2020-05-26
US63/030,088 2020-05-26
PCT/US2020/045759 WO2021030344A1 (en) 2019-08-12 2020-08-11 Rna-guided nucleases and active fragments and variants thereof and methods of use
JP2022509175A JP7640527B2 (ja) 2019-08-12 2020-08-11 Rna誘導ヌクレアーゼ及びその活性断片及び変異体ならびに使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2022509175A Division JP7640527B2 (ja) 2019-08-12 2020-08-11 Rna誘導ヌクレアーゼ及びその活性断片及び変異体ならびに使用方法

Publications (2)

Publication Number Publication Date
JP2025086912A JP2025086912A (ja) 2025-06-09
JP2025086912A5 true JP2025086912A5 (https=) 2025-10-30

Family

ID=72243198

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022509175A Active JP7640527B2 (ja) 2019-08-12 2020-08-11 Rna誘導ヌクレアーゼ及びその活性断片及び変異体ならびに使用方法
JP2025025892A Pending JP2025086912A (ja) 2019-08-12 2025-02-20 Rna誘導ヌクレアーゼ及びその活性断片及び変異体ならびに使用方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2022509175A Active JP7640527B2 (ja) 2019-08-12 2020-08-11 Rna誘導ヌクレアーゼ及びその活性断片及び変異体ならびに使用方法

Country Status (12)

Country Link
US (1) US20220364074A1 (https=)
EP (1) EP4013864A1 (https=)
JP (2) JP7640527B2 (https=)
KR (1) KR20220062289A (https=)
CN (2) CN114641568B (https=)
AU (1) AU2020329912A1 (https=)
BR (1) BR112022002695A2 (https=)
CA (1) CA3147783A1 (https=)
IL (1) IL290562A (https=)
MX (1) MX2022001849A (https=)
TW (1) TW202120688A (https=)
WO (1) WO2021030344A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
EP3204496A1 (en) 2014-10-10 2017-08-16 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
EP3797160A1 (en) 2018-05-23 2021-03-31 The Broad Institute Inc. Base editors and uses thereof
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
ES2970169T3 (es) * 2018-12-27 2024-05-27 Lifeedit Therapeutics Inc Polipéptidos útiles para edición génica y métodos de uso
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
JP7657726B2 (ja) 2019-03-19 2025-04-07 ザ ブロード インスティテュート,インコーポレーテッド 編集ヌクレオチド配列を編集するための方法および組成物
US12473543B2 (en) 2019-04-17 2025-11-18 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
TW202208626A (zh) * 2020-04-24 2022-03-01 美商生命編輯公司 Rna引導核酸酶及其活性片段與變體,以及使用方法
DE112021002672T5 (de) 2020-05-08 2023-04-13 President And Fellows Of Harvard College Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
CA3174356A1 (en) 2020-07-01 2022-01-06 Santosh NARAYAN Compositions and methods for cellular reprogramming using circular rna
JP2023534693A (ja) 2020-07-15 2023-08-10 ライフエディット セラピューティクス,インコーポレイティド ウラシル安定化タンパク質並びにその活性断片及びバリアント並びに使用方法
TWI910226B (zh) 2020-09-11 2026-01-01 美商生命編輯治療學公司 Dna修飾酶及活性片段,及其變異體與使用方法
CN117295817A (zh) 2021-03-22 2023-12-26 生命编辑制药股份有限公司 Dna修饰酶及其活性片段和变体以及使用方法
IL307855A (en) * 2021-04-22 2023-12-01 Emendobio Inc OMNI CRISPR Nucleases 117, 140, 150-158, 160-165, 167-177, 180-188, 191-198, 200, 201, 203, 205-209, 211-217, 219, 220, 222, 223, 226 , 227, 229, 231-236, 238-245, 247, 250, 254, 256, 257, 260 and 262 news
WO2024077267A1 (en) * 2022-10-07 2024-04-11 The Broad Institute, Inc. Prime editing methods and compositions for treating triplet repeat disorders
EP4612284A2 (en) 2022-11-04 2025-09-10 Life Edit Therapeutics, Inc. Evolved adenine deaminases and rna-guided nuclease fusion proteins with internal insertion sites and methods of use
CA3277009A1 (en) * 2022-12-16 2024-06-20 Life Edit Therapeutics, Inc. RNA GUIDELINES TARGETING THE TRAC GENE AND METHODS OF USE
WO2024178397A2 (en) 2023-02-24 2024-08-29 Elevatebio Technologies, Inc. Modified immune effector cells and methods of use
TW202546224A (zh) * 2024-02-12 2025-12-01 美商生命編輯治療學公司 新穎的rna引導之核酸酶及用於聚合酶編輯之蛋白質
WO2026003754A1 (en) 2024-06-25 2026-01-02 Life Edit Therapeutics, Inc. Novel reverse transcriptases and uses thereof

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217344A (en) 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4186183A (en) 1978-03-29 1980-01-29 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in chemotherapy of leishmaniasis
US4261975A (en) 1979-09-19 1981-04-14 Merck & Co., Inc. Viral liposome particle
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5049386A (en) 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5569597A (en) 1985-05-13 1996-10-29 Ciba Geigy Corp. Methods of inserting viral DNA into plant material
US4774085A (en) 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators
US4853331A (en) 1985-08-16 1989-08-01 Mycogen Corporation Cloning and expression of Bacillus thuringiensis toxin gene toxic to beetles of the order Coleoptera
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
US5608142A (en) 1986-12-03 1997-03-04 Agracetus, Inc. Insecticidal cotton plants
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5039523A (en) 1988-10-27 1991-08-13 Mycogen Corporation Novel Bacillus thuringiensis isolate denoted B.t. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin
EP0463056A1 (en) 1989-03-17 1992-01-02 E.I. Du Pont De Nemours And Company External regulation of gene expression
EP0452269B1 (en) 1990-04-12 2002-10-09 Syngenta Participations AG Tissue-preferential promoters
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1991017424A1 (en) 1990-05-03 1991-11-14 Vical, Inc. Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
US5498830A (en) 1990-06-18 1996-03-12 Monsanto Company Decreased oil content in plant seeds
CA2051562C (en) 1990-10-12 2003-12-02 Jewel M. Payne Bacillus thuringiensis isolates active against dipteran pests
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
US5399680A (en) 1991-05-22 1995-03-21 The Salk Institute For Biological Studies Rice chitinase promoter
CA2116449C (en) 1991-08-27 2005-04-05 Vaughan Alan Hilder Proteins with insecticidal properties against homopteran insects and their use in plant protection
TW261517B (https=) 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5789156A (en) 1993-06-14 1998-08-04 Basf Ag Tetracycline-regulated transcriptional inhibitors
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5608144A (en) 1994-08-12 1997-03-04 Dna Plant Technology Corp. Plant group 2 promoters and uses thereof
US5659026A (en) 1995-03-24 1997-08-19 Pioneer Hi-Bred International ALS3 promoter
US6072050A (en) 1996-06-11 2000-06-06 Pioneer Hi-Bred International, Inc. Synthetic promoters
CA2315546C (en) 1998-02-26 2008-04-29 Pioneer Hi-Bred International, Inc. Constitutive maize promoters
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
CZ20013894A3 (cs) 1999-05-04 2002-04-17 Monsanto Technology Llc Polypeptidové kompozice toxické pro hmyz z řádu Coleoptera a transgenní rostliny rezistentní proti hmyzu
AU7491600A (en) 1999-09-15 2001-04-17 Monsanto Technology Llc Lepidopteran-active bacillus thuringiensis delta-endotoxin compositions and methods of use
US20050183161A1 (en) 2003-10-14 2005-08-18 Athenix Corporation AXMI-010, a delta-endotoxin gene and methods for its use
US7629504B2 (en) 2003-12-22 2009-12-08 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry9 nucleic acids
NZ573398A (en) 2006-06-14 2011-11-25 Athenix Corp Axmi-031, axmi-039, axmi-040 and axmi-049, a family of delta-endotoxin genes and methods for their use
EP2334794B8 (en) 2008-09-15 2017-04-19 The Children's Medical Center Corporation Modulation of bcl11a for treatment of hemoglobinopathies
MX346215B (es) 2009-07-02 2017-03-10 Athenix Corp Gen plaguicida axmi-205 y metodos para su uso.
WO2011084324A2 (en) 2009-12-21 2011-07-14 Pioneer Hi-Bred International, Inc. Novel bacillus thuringiensis gene with lepidopteran activity
US10167547B2 (en) 2009-12-24 2019-01-01 Jx Nippon Mining & Metals Corporation Gadolinium sputtering target and production method of said target
WO2012024200A2 (en) 2010-08-19 2012-02-23 Pioneer Hi-Bred International, Inc. Novel bacillus thuringiensis gene with lepidopteran activity
US9405700B2 (en) 2010-11-04 2016-08-02 Sonics, Inc. Methods and apparatus for virtualization in an integrated circuit
EP3241902B1 (en) * 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
DK3444342T3 (da) 2012-07-11 2020-08-24 Sangamo Therapeutics Inc Fremgangsmåder og sammensætninger til behandlingen af lysosomale aflejringssygdomme
EP3760719A1 (en) * 2013-11-18 2021-01-06 CRISPR Therapeutics AG Crispr-cas system materials and methods
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
EP3633032A3 (en) 2014-08-28 2020-07-29 North Carolina State University Novel cas9 proteins and guiding features for dna targeting and genome editing
WO2016114972A1 (en) * 2015-01-12 2016-07-21 The Regents Of The University Of California Heterodimeric cas9 and methods of use thereof
CN107849546A (zh) * 2015-05-15 2018-03-27 先锋国际良种公司 对cas内切核酸酶系统、pam序列和指导rna元件的快速表征
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
JP7109784B2 (ja) 2015-10-23 2022-08-01 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したCas9蛋白質
CA3010628A1 (en) * 2016-03-11 2017-09-14 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
EP3699281A1 (en) * 2016-03-11 2020-08-26 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
AU2017292173B2 (en) * 2016-07-06 2022-01-13 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
KR102547316B1 (ko) 2016-08-03 2023-06-23 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
EA201990815A1 (ru) * 2016-11-14 2019-09-30 Институте Оф Генетисс Анд Девелопментал Биологй. Чинесе Асадемй Оф Ссиенсес Способ редактирования основания у растений
JP2020510439A (ja) * 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
CA3057192A1 (en) * 2017-03-23 2018-09-27 President And Fellows Of Harvard College Nucleobase editors comprising nucleic acid programmable dna binding proteins
AU2018240515B2 (en) * 2017-03-24 2024-07-25 CureVac SE Nucleic acids encoding CRISPR-associated proteins and uses thereof
AR111790A1 (es) * 2017-05-11 2019-08-21 Inst Genetics & Developmental Biology Cas Método para la producción de una planta resistente a herbicidas mediante la introducción de un sistema de edición de bases de un gen relacionado con la resistencia a herbicidas
US20200172895A1 (en) * 2017-05-25 2020-06-04 The General Hospital Corporation Using split deaminases to limit unwanted off-target base editor deamination
WO2019036185A1 (en) * 2017-08-15 2019-02-21 The Regents Of The University Of California COMPOSITIONS AND METHODS FOR IMPROVING GENOMIC SEQUENCE CORRECTION
US11649442B2 (en) * 2017-09-08 2023-05-16 The Regents Of The University Of California RNA-guided endonuclease fusion polypeptides and methods of use thereof
MA50877A (fr) * 2017-11-21 2020-09-30 Bayer Healthcare Llc Matériaux et méthodes pour le traitement de la rétinite pigmentaire autosomique dominante
KR20200093635A (ko) * 2017-12-06 2020-08-05 제너레이션 바이오 컴퍼니 변형된 폐쇄된 말단 dna (cedna)를 사용한 유전자 편집
BR112020024863A2 (pt) 2018-06-05 2022-02-01 Lifeedit Inc Nucleases guiadas por rna, fragmentos ativos e variantes das mesmas e métodos de uso
US12540352B2 (en) * 2018-09-20 2026-02-03 Institute Of Zoology, Chinese Academy Of Sciences Method for detecting nucleic acid

Similar Documents

Publication Publication Date Title
CN308417828S (https=)
CN308418412S (https=)
CN308404099S (https=)
CN308404266S (https=)
CN308404388S (https=)
CN308404395S (https=)
CN308404568S (https=)
CN308404616S (https=)
CN308404703S (https=)
CN308405326S (https=)
CN308407366S (https=)
CN308407893S (https=)
CN308407969S (https=)
CN308408305S (https=)
CN308408333S (https=)
CN308408496S (https=)
CN308408652S (https=)
CN308408706S (https=)
CN308403377S (https=)
CN308408769S (https=)
CN308408888S (https=)
CN308408964S (https=)
CN308412184S (https=)
CN308412524S (https=)
CN308412827S (https=)