JP2024541089A - ナトリウム電位依存性チャネルαサブユニット１１（ＳＣＮ１１Ａ）阻害剤による頭痛及び片頭痛の治療方法 - Google Patents

ナトリウム電位依存性チャネルαサブユニット１１（ＳＣＮ１１Ａ）阻害剤による頭痛及び片頭痛の治療方法 Download PDF

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JP2024541089A
JP2024541089A JP2024529509A JP2024529509A JP2024541089A JP 2024541089 A JP2024541089 A JP 2024541089A JP 2024529509 A JP2024529509 A JP 2024529509A JP 2024529509 A JP2024529509 A JP 2024529509A JP 2024541089 A JP2024541089 A JP 2024541089A
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scn11a
nucleic acid
subject
acid molecule
headache
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JP2024541089A5 (https=
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プラビーン、カビタ
コッポラ、ジョバンニ
バラス、アリス
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2024529509A 2021-11-20 2022-11-21 ナトリウム電位依存性チャネルαサブユニット１１（ＳＣＮ１１Ａ）阻害剤による頭痛及び片頭痛の治療方法 Pending JP2024541089A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163281640P 2021-11-20 2021-11-20
US63/281,640 2021-11-20
PCT/US2022/080208 WO2023092112A1 (en) 2021-11-20 2022-11-21 Methods of treating headaches and migraines with sodium voltage-gated channel alpha subunit 11 (scn11a) inhibitors

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JP2024541089A true JP2024541089A (ja) 2024-11-06
JP2024541089A5 JP2024541089A5 (https=) 2025-11-20

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JP2024529509A Pending JP2024541089A (ja) 2021-11-20 2022-11-21 ナトリウム電位依存性チャネルαサブユニット１１（ＳＣＮ１１Ａ）阻害剤による頭痛及び片頭痛の治療方法

Country Status (10)

Country Link
US (1) US20230279400A1 (https=)
EP (1) EP4433090A1 (https=)
JP (1) JP2024541089A (https=)
KR (1) KR20240109247A (https=)
CN (1) CN118234513A (https=)
AU (1) AU2022393586A1 (https=)
CA (1) CA3237033A1 (https=)
IL (1) IL312312A (https=)
MX (1) MX2024006042A (https=)
WO (1) WO2023092112A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025037925A1 (ko) 2023-08-16 2025-02-20 주식회사 엘지에너지솔루션 이차전지용 양극 및 이를 포함하는 이차전지

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US96183A (en) * 1869-10-26 Improved ciiothes-mne supporter
EP2769724A1 (en) * 2013-02-22 2014-08-27 Université d'Aix-Marseille Inhibitors of Na(v) 1.9 channel activity and uses thereof for treating pain
US9139648B1 (en) * 2014-07-15 2015-09-22 Kymab Limited Precision medicine by targeting human NAV1.9 variants for treatment of pain
JP6782412B2 (ja) * 2014-11-25 2020-11-11 国立大学法人京都大学 疼痛遺伝子及びその用途
CN108530534B (zh) * 2017-03-03 2021-06-18 易森荟(武汉)生物医药有限公司 Nav1.9的靶点多肽、与其结合的抗体及抗体片段和相关药物组合物

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CN118234513A (zh) 2024-06-21
IL312312A (en) 2024-06-01
WO2023092112A1 (en) 2023-05-25
MX2024006042A (es) 2024-06-04
US20230279400A1 (en) 2023-09-07
CA3237033A1 (en) 2023-05-25
AU2022393586A1 (en) 2024-05-09
KR20240109247A (ko) 2024-07-10
EP4433090A1 (en) 2024-09-25

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