JP2024536413A - 二環式ペプチドリガンド薬物コンジュゲート - Google Patents
二環式ペプチドリガンド薬物コンジュゲート Download PDFInfo
- Publication number
- JP2024536413A JP2024536413A JP2024521039A JP2024521039A JP2024536413A JP 2024536413 A JP2024536413 A JP 2024536413A JP 2024521039 A JP2024521039 A JP 2024521039A JP 2024521039 A JP2024521039 A JP 2024521039A JP 2024536413 A JP2024536413 A JP 2024536413A
- Authority
- JP
- Japan
- Prior art keywords
- drug conjugate
- acid
- peptide
- peptide ligand
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2114279.9A GB202114279D0 (en) | 2021-10-06 | 2021-10-06 | Bicyclic peptide ligand drug conjugates |
| GB2114279.9 | 2021-10-06 | ||
| PCT/GB2022/052524 WO2023057758A1 (en) | 2021-10-06 | 2022-10-06 | Bicyclic peptide ligand drug conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024536413A true JP2024536413A (ja) | 2024-10-04 |
| JPWO2023057758A5 JPWO2023057758A5 (https=) | 2025-10-15 |
| JP2024536413A5 JP2024536413A5 (https=) | 2025-10-15 |
Family
ID=78497713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024521039A Pending JP2024536413A (ja) | 2021-10-06 | 2022-10-06 | 二環式ペプチドリガンド薬物コンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240398965A1 (https=) |
| EP (1) | EP4412657A1 (https=) |
| JP (1) | JP2024536413A (https=) |
| CN (1) | CN118215505A (https=) |
| GB (1) | GB202114279D0 (https=) |
| WO (1) | WO2023057758A1 (https=) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| DK1844337T3 (da) | 2005-01-24 | 2013-09-30 | Pepscan Systems Bv | Bindingsforbindelser, immunogene forbindelser og peptidmimetika |
| AU2009211253B2 (en) | 2008-02-05 | 2014-11-06 | Bicyclerd Limited | Methods and compositions |
| JP6882978B2 (ja) | 2014-10-29 | 2021-06-02 | バイスクルアールディー・リミテッド | Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド |
| IL279489B2 (en) * | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201914872D0 (en) * | 2019-10-15 | 2019-11-27 | Bicycletx Ltd | Bicyclic peptide ligand drug conjugates |
-
2021
- 2021-10-06 GB GBGB2114279.9A patent/GB202114279D0/en not_active Ceased
-
2022
- 2022-10-06 WO PCT/GB2022/052524 patent/WO2023057758A1/en not_active Ceased
- 2022-10-06 JP JP2024521039A patent/JP2024536413A/ja active Pending
- 2022-10-06 EP EP22789999.4A patent/EP4412657A1/en active Pending
- 2022-10-06 CN CN202280074636.3A patent/CN118215505A/zh active Pending
- 2022-10-06 US US18/698,562 patent/US20240398965A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240398965A1 (en) | 2024-12-05 |
| EP4412657A1 (en) | 2024-08-14 |
| CN118215505A (zh) | 2024-06-18 |
| GB202114279D0 (en) | 2021-11-17 |
| WO2023057758A1 (en) | 2023-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20251003 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20251003 |