JP2024514708A - フォンウィルブランド因子(vwf)阻害剤 - Google Patents
フォンウィルブランド因子(vwf)阻害剤 Download PDFInfo
- Publication number
- JP2024514708A JP2024514708A JP2023565152A JP2023565152A JP2024514708A JP 2024514708 A JP2024514708 A JP 2024514708A JP 2023565152 A JP2023565152 A JP 2023565152A JP 2023565152 A JP2023565152 A JP 2023565152A JP 2024514708 A JP2024514708 A JP 2024514708A
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- antibody
- antigen
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2105625.4A GB202105625D0 (en) | 2021-04-20 | 2021-04-20 | Von willebrand factor (VWF) inhibitors |
| GB2105625.4 | 2021-04-20 | ||
| PCT/GB2022/050989 WO2022223966A1 (en) | 2021-04-20 | 2022-04-20 | Von willebrand factor (vwf) inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024514708A true JP2024514708A (ja) | 2024-04-02 |
| JPWO2022223966A5 JPWO2022223966A5 (https=) | 2025-03-26 |
| JP2024514708A5 JP2024514708A5 (https=) | 2025-03-26 |
Family
ID=76377797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023565152A Pending JP2024514708A (ja) | 2021-04-20 | 2022-04-20 | フォンウィルブランド因子(vwf)阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240228660A1 (https=) |
| EP (1) | EP4326778A1 (https=) |
| JP (1) | JP2024514708A (https=) |
| KR (1) | KR20240004332A (https=) |
| CN (1) | CN117597367A (https=) |
| AU (1) | AU2022262695A1 (https=) |
| BR (1) | BR112023021631A2 (https=) |
| CA (1) | CA3214716A1 (https=) |
| GB (1) | GB202105625D0 (https=) |
| IL (1) | IL307441A (https=) |
| MX (1) | MX2023012391A (https=) |
| WO (1) | WO2022223966A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202215432D0 (en) * | 2022-10-19 | 2022-11-30 | Ip2Ipo Innovations Ltd | Von Willebrand factor (VWF) antibody |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011510622A (ja) * | 2008-01-23 | 2011-04-07 | グレンマーク ファーマシューティカルズ エスアー | フォンウィレブランド因子に特異的なヒト化抗体 |
| EP2543678A1 (en) * | 2011-07-08 | 2013-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies for the treatment and prevention of thrombosis |
-
2021
- 2021-04-20 GB GBGB2105625.4A patent/GB202105625D0/en not_active Ceased
-
2022
- 2022-04-20 JP JP2023565152A patent/JP2024514708A/ja active Pending
- 2022-04-20 EP EP22720748.7A patent/EP4326778A1/en active Pending
- 2022-04-20 CA CA3214716A patent/CA3214716A1/en active Pending
- 2022-04-20 CN CN202280030093.5A patent/CN117597367A/zh active Pending
- 2022-04-20 AU AU2022262695A patent/AU2022262695A1/en active Pending
- 2022-04-20 BR BR112023021631A patent/BR112023021631A2/pt unknown
- 2022-04-20 US US18/556,638 patent/US20240228660A1/en active Pending
- 2022-04-20 IL IL307441A patent/IL307441A/en unknown
- 2022-04-20 KR KR1020237036079A patent/KR20240004332A/ko active Pending
- 2022-04-20 WO PCT/GB2022/050989 patent/WO2022223966A1/en not_active Ceased
- 2022-04-20 MX MX2023012391A patent/MX2023012391A/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011510622A (ja) * | 2008-01-23 | 2011-04-07 | グレンマーク ファーマシューティカルズ エスアー | フォンウィレブランド因子に特異的なヒト化抗体 |
| EP2543678A1 (en) * | 2011-07-08 | 2013-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies for the treatment and prevention of thrombosis |
Non-Patent Citations (1)
| Title |
|---|
| 宮田 茂樹: "GPIb結合ドメインならびにC末端部分を認識する抗von Willebrand因子(vWF)モノクローナル抗体を用い", 奈良医学雑誌, vol. 42, no. 5, JPN6026011347, 1991, pages 437 - 448, ISSN: 0005821260 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240228660A1 (en) | 2024-07-11 |
| MX2023012391A (es) | 2024-02-02 |
| CN117597367A (zh) | 2024-02-23 |
| KR20240004332A (ko) | 2024-01-11 |
| IL307441A (en) | 2023-12-01 |
| EP4326778A1 (en) | 2024-02-28 |
| WO2022223966A1 (en) | 2022-10-27 |
| CA3214716A1 (en) | 2022-10-27 |
| GB202105625D0 (en) | 2021-06-02 |
| AU2022262695A1 (en) | 2023-10-05 |
| BR112023021631A2 (pt) | 2024-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250317 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250317 |
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