JP2024507361A - レバウジオシドｄを製造するための組成物及び方法 - Google Patents

レバウジオシドｄを製造するための組成物及び方法 Download PDF

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JP2024507361A
JP2024507361A JP2023549555A JP2023549555A JP2024507361A JP 2024507361 A JP2024507361 A JP 2024507361A JP 2023549555 A JP2023549555 A JP 2023549555A JP 2023549555 A JP2023549555 A JP 2023549555A JP 2024507361 A JP2024507361 A JP 2024507361A
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rebaudioside
polypeptide
amino acid
b12gt
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JPWO2022178145A5 (https=
JP2024507361A5 (https=
Inventor
イウジン ロバーツ，カイル
ザンヘリーニ，アレクサンドル
グラブス，ダニエラ
ダルガス クリスチャンセン，ニクラス
ジェイ． ハヴラーネク，ジェームズ
アンドリュー バン，イー－エン
デブコタ，アスウィニ
ナンス，マーク
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アルゼダ コーポレーション
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Publication of JP2024507361A publication Critical patent/JP2024507361A/ja
Publication of JPWO2022178145A5 publication Critical patent/JPWO2022178145A5/ja
Publication of JP2024507361A5 publication Critical patent/JP2024507361A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2023549555A 2021-02-17 2022-02-17 レバウジオシドｄを製造するための組成物及び方法 Pending JP2024507361A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163150515P 2021-02-17 2021-02-17
US63/150,515 2021-02-17
PCT/US2022/016820 WO2022178145A1 (en) 2021-02-17 2022-02-17 Compositions and methods for producing rebaudioside d

Publications (3)

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JP2024507361A true JP2024507361A (ja) 2024-02-19
JPWO2022178145A5 JPWO2022178145A5 (https=) 2025-02-20
JP2024507361A5 JP2024507361A5 (https=) 2025-02-20

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JP2023549555A Pending JP2024507361A (ja) 2021-02-17 2022-02-17 レバウジオシドｄを製造するための組成物及び方法

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US (1) US20240368661A1 (https=)
EP (1) EP4294934A4 (https=)
JP (1) JP2024507361A (https=)
KR (1) KR20240010448A (https=)
CN (1) CN117616129A (https=)
BR (1) BR112023016512A2 (https=)
CA (1) CA3208720A1 (https=)
CO (1) CO2023010756A2 (https=)
MX (1) MX2023009628A (https=)
PE (1) PE20240694A1 (https=)
WO (1) WO2022178145A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3266431A1 (en) * 2022-09-02 2024-03-07 Arzeda Corp. Compositions and methods for producing rebaudioside m
CN115947788B (zh) * 2022-10-12 2023-08-29 东北农业大学 色氨酸和亮氨酸跨链交互作用β-发卡抗菌肽WLF及制备方法和应用
EP4608984A2 (en) * 2022-10-26 2025-09-03 Arzeda Corp. Enzymatically mediated reactive crystallization of steviol glycosides
EP4724575A1 (en) * 2023-06-06 2026-04-15 Arzeda Corp. Compositions and methods for producing rebaudioside d and rebaudioside m
WO2026006475A1 (en) * 2024-06-25 2026-01-02 Arzeda Corp. Compositions and methods for glycosylation of steviol glycosides
CN119799672B (zh) * 2025-01-15 2025-07-25 皖西学院 一种糖基转移酶突变体及其在合成红景天苷中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200032227A1 (en) * 2018-07-30 2020-01-30 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
PE20200291A1 (es) * 2017-05-15 2020-02-05 Purecircle Usa Inc Glicosidos de esteviol de alta pureza
EP3973069A4 (en) * 2019-05-23 2023-09-13 Arzeda Corp. COMPOSITIONS AND METHODS FOR PRODUCING STEVIOL GLYCOSIDES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200032227A1 (en) * 2018-07-30 2020-01-30 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
WO2020028039A1 (en) * 2018-07-30 2020-02-06 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICALENGINEERING JOURNAL, vol. 159, JPN6026000630, 2020, ISSN: 0005769426 *

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PE20240694A1 (es) 2024-04-10
EP4294934A4 (en) 2025-05-21
CN117616129A (zh) 2024-02-27
BR112023016512A2 (pt) 2023-10-24
CA3208720A1 (en) 2022-08-25
EP4294934A1 (en) 2023-12-27
MX2023009628A (es) 2024-01-25
KR20240010448A (ko) 2024-01-23
US20240368661A1 (en) 2024-11-07
CO2023010756A2 (es) 2024-01-15
WO2022178145A1 (en) 2022-08-25

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