JP2024505887A - 抗cd19キメラ抗原受容体を発現する細胞を生成するためのレンチウイルス - Google Patents

抗cd19キメラ抗原受容体を発現する細胞を生成するためのレンチウイルス Download PDF

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JP2024505887A
JP2024505887A JP2023545274A JP2023545274A JP2024505887A JP 2024505887 A JP2024505887 A JP 2024505887A JP 2023545274 A JP2023545274 A JP 2023545274A JP 2023545274 A JP2023545274 A JP 2023545274A JP 2024505887 A JP2024505887 A JP 2024505887A
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JPWO2022164935A5 (https=
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アンドリュー シャーレンバーグ,
クリストファー ニコライ,
ライアン クリスマン,
アレッサンドラ サリバン,
キャスリン ミケルス,
ビョン リュウ,
ション グリーン,
ローリー バイツ,
ロペス, スサナ ヘルナンデス
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ウモジャ バイオファーマ, インコーポレイテッド
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JP2023545274A 2021-01-27 2022-01-26 抗cd19キメラ抗原受容体を発現する細胞を生成するためのレンチウイルス Pending JP2024505887A (ja)

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US202163142347P 2021-01-27 2021-01-27
US63/142,347 2021-01-27
US202163185765P 2021-05-07 2021-05-07
US63/185,765 2021-05-07
PCT/US2022/013947 WO2022164935A1 (en) 2021-01-27 2022-01-26 Lentivirus for generating cells expressing anti-cd19 chimeric antigen receptor

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JP2024505887A true JP2024505887A (ja) 2024-02-08
JPWO2022164935A5 JPWO2022164935A5 (https=) 2025-01-22
JP2024505887A5 JP2024505887A5 (https=) 2025-01-22

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US (1) US20240141375A1 (https=)
EP (1) EP4284821A1 (https=)
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KR (1) KR20230143150A (https=)
AU (1) AU2022212952A1 (https=)
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Car t細胞療法のための組成物および方法
JP7549303B2 (ja) 2018-01-22 2024-09-11 エンドサイト・インコーポレイテッド Car t細胞の使用方法
CN112105382A (zh) 2018-02-23 2020-12-18 恩多塞特公司 用于car t细胞疗法的顺序方法
CN112262214A (zh) 2018-04-12 2021-01-22 优莫佳生物制药股份有限公司 病毒载体及包装细胞系
US12419913B2 (en) 2019-02-08 2025-09-23 Dna Twopointo, Inc. Modification of CAR-T cells
US20240122978A1 (en) * 2019-10-16 2024-04-18 Umoja Biopharma, Inc. Retroviral vector for univeral receptor therapy
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
US12565529B2 (en) 2021-05-24 2026-03-03 Provention Bio, Inc. Methods for treating type 1 diabetes
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2024081820A1 (en) 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells
JP2026500897A (ja) * 2022-11-04 2026-01-09 ウモジャ バイオファーマ インコーポレイテッド 融合分子を呈示するレンチウイルス粒子およびその使用
TW202434621A (zh) * 2022-11-04 2024-09-01 美商優莫佳生物製藥有限公司 多核苷酸構築體及相關病毒載體及方法
WO2024216227A1 (en) * 2023-04-12 2024-10-17 Vyriad Cd3-redirected vectors, components thereof, and uses of the vectors and components thereof
EP4694916A1 (en) 2023-04-14 2026-02-18 SOTIO Biotech Inc. Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists
WO2024215987A1 (en) 2023-04-14 2024-10-17 Sotio Biotech Inc. IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES
WO2024220598A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Lentiviral vectors with two or more genomes
KR20260005358A (ko) 2023-04-27 2026-01-09 밀테니 비오텍 비.브이. & 씨오. 케이지 항-cd3 디스플레이를 갖는 슈도타이핑된 레트로바이러스 벡터 입자
WO2024238153A1 (en) * 2023-05-15 2024-11-21 Umoja Biopharma, Inc. Lentiviral delivery of anti-cd20 chimeric antigen receptors
KR20260016952A (ko) 2023-05-23 2026-02-04 사나 바이오테크놀로지, 인크. 탠덤 퓨소젠 및 관련 지질 입자
WO2025078492A1 (en) 2023-10-13 2025-04-17 Miltenyi Biotec B.V. & Co. KG Cd3-targeted nipah-pseudotyped lentiviral vector particles
WO2025102013A1 (en) * 2023-11-10 2025-05-15 Vyriad Rhabdovirus g proteins having one or more cysteine-rich regions and uses thereof
WO2025176853A1 (en) 2024-02-22 2025-08-28 Miltenyi Biotec B.V. & Co. KG Cd4- or cd8-targeted retroviral vector particles for generation of cells expressing a bispecific chimeric antigen receptor
WO2025212519A1 (en) 2024-04-01 2025-10-09 Moonlight Bio, Inc. Dll3 binding proteins and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188693A1 (en) * 2012-06-15 2013-12-19 Imaginab, Inc. Antigen binding constructs to cd3
JP2016531567A (ja) * 2013-07-29 2016-10-13 ブルーバード バイオ, インコーポレイテッド 多部分シグナル伝達タンパク質およびその使用
JP2017502690A (ja) * 2013-12-20 2017-01-26 ノバルティス アーゲー 調節可能キメラ抗原受容体
JP2019509063A (ja) * 2016-03-19 2019-04-04 エフ1 オンコロジー,インコーポレイティド リンパ球に形質導入を行うための方法及び組成物、並びにその制御された増加
WO2019118885A1 (en) * 2017-12-14 2019-06-20 Bluebird Bio, Inc. Nkg2d daric receptors
WO2019210057A1 (en) * 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Rapamycin resistant cells
WO2020106992A1 (en) * 2018-11-21 2020-05-28 Umoja Biopharma, Inc. Multicistronic vector for surface engineering lentiviral particles

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US5278056A (en) 1988-02-05 1994-01-11 The Trustees Of Columbia University In The City Of New York Retroviral packaging cell lines and process of using same
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5670488A (en) 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
DE69434860T2 (de) 1993-02-22 2007-03-15 The Rockefeller University Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
FR2712812B1 (fr) 1993-11-23 1996-02-09 Centre Nat Rech Scient Composition pour la production de produits thérapeutiques in vivo.
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5948893A (en) 1996-01-17 1999-09-07 The United States Of America As Represented By The Secretary Of The Navy Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
NZ532635A (en) 2001-11-13 2007-05-31 Univ Pennsylvania A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method
US9434928B2 (en) 2011-11-23 2016-09-06 Nationwide Children's Hospital, Inc. Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
WO2013148327A1 (en) 2012-03-26 2013-10-03 The Regents Of The University Of California Nipah virus envelope psuedotyped lentiviruses and methods of their use
GB201503500D0 (en) 2015-03-02 2015-04-15 Ucl Business Plc Cell
JP7206214B2 (ja) 2016-12-13 2023-01-17 シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) インビトロ及びインビボで操作された細胞において発現された化学誘導シグナル伝達複合体の外因性薬物活性化の方法
CN111479921B (zh) * 2017-09-18 2024-08-02 埃克苏马生物技术公司 用于以基因方式修饰且扩增淋巴细胞以及调节其活性的方法及组合物
AU2018337142B2 (en) 2017-09-22 2025-07-03 Wuxi Biologics Ireland Limited. Novel bispecific CD3/CD19 polypeptide complexes
ES2991089T3 (es) 2017-09-22 2024-12-02 Centre Nat Rech Scient Glicoproteína mutada del virus de la estomatitis vesicular
CN112262214A (zh) 2018-04-12 2021-01-22 优莫佳生物制药股份有限公司 病毒载体及包装细胞系

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188693A1 (en) * 2012-06-15 2013-12-19 Imaginab, Inc. Antigen binding constructs to cd3
JP2016531567A (ja) * 2013-07-29 2016-10-13 ブルーバード バイオ, インコーポレイテッド 多部分シグナル伝達タンパク質およびその使用
JP2017502690A (ja) * 2013-12-20 2017-01-26 ノバルティス アーゲー 調節可能キメラ抗原受容体
JP2019509063A (ja) * 2016-03-19 2019-04-04 エフ1 オンコロジー,インコーポレイティド リンパ球に形質導入を行うための方法及び組成物、並びにその制御された増加
WO2019118885A1 (en) * 2017-12-14 2019-06-20 Bluebird Bio, Inc. Nkg2d daric receptors
WO2019210057A1 (en) * 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Rapamycin resistant cells
WO2020106992A1 (en) * 2018-11-21 2020-05-28 Umoja Biopharma, Inc. Multicistronic vector for surface engineering lentiviral particles

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANETT PFEIFFER ET AL.: "In vivo generation of human CD19-CAR T cells results in B-cell depletion and signs of cytokine relea", EMBO MOLECULAR MEDICINE, vol. 10: e9158, JPN7025005499, 17 September 2018 (2018-09-17), pages 1 - 11, ISSN: 0005758792 *
ANNIKA M. FRANK ET AL.: "Combining T-cell?specific activation and in vivo gene delivery through CD3-targeted lentiviral vecto", BLOOD ADVANCES, vol. VOLUME 4, NUMBER 22, JPN7025005500, 20 November 2020 (2020-11-20), pages 5702 - 5715, ISSN: 0005758791 *
SHIWANI AGARWAL ET AL.: "In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes", MOLECULAR THERAPY, vol. 28, no. 8, JPN7025005498, 5 August 2020 (2020-08-05), pages 1783 - 1794, ISSN: 0005758793 *
WAI-HANG LEUNG ET AL.: "Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimeri", JCI INSIGHT., vol. 4(11):e124430, JPN7025005497, 6 June 2019 (2019-06-06), pages 1 - 18, ISSN: 0005758794 *

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