JP2024504592A - 遺伝子転写フレームワーク、ベクターシステム、ゲノム配列編集方法および応用 - Google Patents
遺伝子転写フレームワーク、ベクターシステム、ゲノム配列編集方法および応用 Download PDFInfo
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- JP2024504592A JP2024504592A JP2023541700A JP2023541700A JP2024504592A JP 2024504592 A JP2024504592 A JP 2024504592A JP 2023541700 A JP2023541700 A JP 2023541700A JP 2023541700 A JP2023541700 A JP 2023541700A JP 2024504592 A JP2024504592 A JP 2024504592A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Management Or Editing Of Information On Record Carriers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110089068.1A CN112708636A (zh) | 2021-01-22 | 2021-01-22 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
| CN202110089068.1 | 2021-01-22 | ||
| PCT/CN2021/134710 WO2022156378A1 (zh) | 2021-01-22 | 2021-12-01 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024504592A true JP2024504592A (ja) | 2024-02-01 |
| JPWO2022156378A5 JPWO2022156378A5 (https=) | 2024-12-10 |
| JP2024504592A5 JP2024504592A5 (https=) | 2024-12-10 |
Family
ID=75550451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023541700A Pending JP2024504592A (ja) | 2021-01-22 | 2021-12-01 | 遺伝子転写フレームワーク、ベクターシステム、ゲノム配列編集方法および応用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250263737A1 (https=) |
| EP (1) | EP4282968A4 (https=) |
| JP (1) | JP2024504592A (https=) |
| KR (1) | KR20230135630A (https=) |
| CN (1) | CN112708636A (https=) |
| AU (1) | AU2021422067A1 (https=) |
| BR (1) | BR112023014382A2 (https=) |
| CA (1) | CA3206081A1 (https=) |
| MX (1) | MX2023008635A (https=) |
| WO (1) | WO2022156378A1 (https=) |
| ZA (1) | ZA202308025B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112481259B (zh) * | 2020-11-24 | 2022-09-16 | 南昌大学 | 两种甘薯U6基因启动子IbU6的克隆与应用 |
| CN115044583A (zh) * | 2022-03-21 | 2022-09-13 | 隋云鹏 | 用于基因编辑的rna框架和基因编辑方法 |
| CN115312121B (zh) * | 2022-09-29 | 2023-03-24 | 北京齐碳科技有限公司 | 靶基因位点检测方法、装置、设备及计算机存储介质 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011518555A (ja) * | 2008-04-14 | 2011-06-30 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 標的組込みのための線形ドナーコンストラクト |
| WO2020047124A1 (en) * | 2018-08-28 | 2020-03-05 | Flagship Pioneering, Inc. | Methods and compositions for modulating a genome |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102080101B (zh) * | 2010-11-25 | 2013-01-09 | 北京济福霖生物技术有限公司 | 一种定点整合外源基因的方法 |
| WO2016030501A1 (en) * | 2014-08-28 | 2016-03-03 | Centre National De La Recherche Scientifique - Cnrs - | Synthetic alu-retrotransposon vectors for gene therapy |
| US11339427B2 (en) * | 2016-02-12 | 2022-05-24 | Jumpcode Genomics, Inc. | Method for target specific RNA transcription of DNA sequences |
| US20210340562A1 (en) * | 2018-10-19 | 2021-11-04 | Board Of Regents, The University Of Texas System | Engineered long interspersed element (line) transposons and methods of use |
| JP7831937B2 (ja) * | 2019-09-03 | 2026-03-17 | クリエイト・メディシンズ,インコーポレーテッド | ゲノム組込みのための方法および組成物 |
| CN112210573B (zh) * | 2020-10-14 | 2024-02-06 | 浙江大学 | 一种用基因编辑改造原代细胞的dna模板及定点插入方法 |
-
2021
- 2021-01-22 CN CN202110089068.1A patent/CN112708636A/zh active Pending
- 2021-12-01 JP JP2023541700A patent/JP2024504592A/ja active Pending
- 2021-12-01 US US18/266,592 patent/US20250263737A1/en active Pending
- 2021-12-01 AU AU2021422067A patent/AU2021422067A1/en active Pending
- 2021-12-01 BR BR112023014382A patent/BR112023014382A2/pt unknown
- 2021-12-01 EP EP21920753.7A patent/EP4282968A4/en active Pending
- 2021-12-01 CA CA3206081A patent/CA3206081A1/en active Pending
- 2021-12-01 WO PCT/CN2021/134710 patent/WO2022156378A1/zh not_active Ceased
- 2021-12-01 MX MX2023008635A patent/MX2023008635A/es unknown
- 2021-12-01 KR KR1020237028513A patent/KR20230135630A/ko active Pending
-
2023
- 2023-08-18 ZA ZA2023/08025A patent/ZA202308025B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011518555A (ja) * | 2008-04-14 | 2011-06-30 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 標的組込みのための線形ドナーコンストラクト |
| WO2020047124A1 (en) * | 2018-08-28 | 2020-03-05 | Flagship Pioneering, Inc. | Methods and compositions for modulating a genome |
Non-Patent Citations (1)
| Title |
|---|
| SANDRA R. RICHARDSON ET AL.: ""The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes"", MICROBIOLOGY SPECTRUM, vol. 3, no. 2, JPN6025043308, 2015, ISSN: 0005831042 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4282968A4 (en) | 2024-12-04 |
| BR112023014382A2 (pt) | 2023-10-31 |
| CN112708636A (zh) | 2021-04-27 |
| US20250263737A1 (en) | 2025-08-21 |
| ZA202308025B (en) | 2024-03-27 |
| CA3206081A1 (en) | 2022-07-28 |
| AU2021422067A1 (en) | 2023-09-07 |
| KR20230135630A (ko) | 2023-09-25 |
| MX2023008635A (es) | 2023-10-17 |
| EP4282968A1 (en) | 2023-11-29 |
| WO2022156378A1 (zh) | 2022-07-28 |
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