JP2023526032A - セルフリーｄｎａサイズ検出 - Google Patents

セルフリーｄｎａサイズ検出 Download PDF

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Publication number
JP2023526032A
JP2023526032A JP2022568686A JP2022568686A JP2023526032A JP 2023526032 A JP2023526032 A JP 2023526032A JP 2022568686 A JP2022568686 A JP 2022568686A JP 2022568686 A JP2022568686 A JP 2022568686A JP 2023526032 A JP2023526032 A JP 2023526032A
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Japan
Prior art keywords
nucleic acid
acid molecules
cancer
sequencing
stranded dna
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Pending
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JP2022568686A
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English (en)
Japanese (ja)
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JP2023526032A5 (https=
JPWO2021231455A5 (https=
Inventor
ウェン，リ
ファハム，マレック
ウィットコップ，トビアス
ウー，ジョニー
Original Assignee
アキュラーゲン ホールディングス リミテッド
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Publication of JP2023526032A publication Critical patent/JP2023526032A/ja
Publication of JP2023526032A5 publication Critical patent/JP2023526032A5/ja
Publication of JPWO2021231455A5 publication Critical patent/JPWO2021231455A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022568686A 2020-05-13 2021-05-11 セルフリーｄｎａサイズ検出 Pending JP2023526032A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063024489P 2020-05-13 2020-05-13
US63/024,489 2020-05-13
US202063054617P 2020-07-21 2020-07-21
US63/054,617 2020-07-21
US202063065375P 2020-08-13 2020-08-13
US63/065,375 2020-08-13
US202063106741P 2020-10-28 2020-10-28
US63/106,741 2020-10-28
PCT/US2021/031815 WO2021231455A1 (en) 2020-05-13 2021-05-11 Cell-free dna size detection

Publications (3)

Publication Number Publication Date
JP2023526032A true JP2023526032A (ja) 2023-06-20
JP2023526032A5 JP2023526032A5 (https=) 2024-05-21
JPWO2021231455A5 JPWO2021231455A5 (https=) 2024-05-21

Family

ID=78524932

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022568686A Pending JP2023526032A (ja) 2020-05-13 2021-05-11 セルフリーｄｎａサイズ検出

Country Status (5)

Country Link
US (1) US20230167508A1 (https=)
EP (1) EP4150124A4 (https=)
JP (1) JP2023526032A (https=)
CN (1) CN116234930A (https=)
WO (1) WO2021231455A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019110750A1 (en) * 2017-12-07 2019-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for screening a subject for a cancer
JP2020504606A (ja) * 2016-12-22 2020-02-13 ガーダント ヘルス， インコーポレイテッド 核酸分子を解析するための方法およびシステム
JP2020511983A (ja) * 2017-03-29 2020-04-23 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ ヌクレアーゼ反応、リガーゼ反応、ポリメラーゼ反応、及びシーケンシング反応を組み合わせて使用し、核酸の配列、発現、コピー数、またはメチル化変化を決定するためのデバイス、プロセス、及びシステム

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3191628B1 (en) * 2014-09-12 2022-05-25 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acids
US20210327535A1 (en) * 2018-08-22 2021-10-21 The Regents Of The University Of California Sensitively detecting copy number variations (cnvs) from circulating cell-free nucleic acid
WO2020172566A1 (en) * 2019-02-22 2020-08-27 Accuragen Holdings Limited Methods and compositions for early cancer detection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020504606A (ja) * 2016-12-22 2020-02-13 ガーダント ヘルス， インコーポレイテッド 核酸分子を解析するための方法およびシステム
JP2020511983A (ja) * 2017-03-29 2020-04-23 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ ヌクレアーゼ反応、リガーゼ反応、ポリメラーゼ反応、及びシーケンシング反応を組み合わせて使用し、核酸の配列、発現、コピー数、またはメチル化変化を決定するためのデバイス、プロセス、及びシステム
WO2019110750A1 (en) * 2017-12-07 2019-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for screening a subject for a cancer

Also Published As

Publication number Publication date
EP4150124A4 (en) 2024-07-03
CN116234930A (zh) 2023-06-06
WO2021231455A1 (en) 2021-11-18
US20230167508A1 (en) 2023-06-01
EP4150124A1 (en) 2023-03-22

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