JP2023508616A - 治療部位での免疫系応答性を刺激し維持するためのナノ粒子システム - Google Patents

治療部位での免疫系応答性を刺激し維持するためのナノ粒子システム Download PDF

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JP2023508616A
JP2023508616A JP2022565737A JP2022565737A JP2023508616A JP 2023508616 A JP2023508616 A JP 2023508616A JP 2022565737 A JP2022565737 A JP 2022565737A JP 2022565737 A JP2022565737 A JP 2022565737A JP 2023508616 A JP2023508616 A JP 2023508616A
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nanoparticles
cells
nanoparticle
binding domain
encoding
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JP2023508616A5 (https=
JPWO2021138600A5 (https=
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シュテファン，マティアス
ニールセン，ウルリク
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Fred Hutchinson Cancer Center
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Fred Hutchinson Cancer Center
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JP2022565737A 2019-12-31 2020-12-31 治療部位での免疫系応答性を刺激し維持するためのナノ粒子システム Pending JP2023508616A (ja)

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US201962956033P 2019-12-31 2019-12-31
US62/956,033 2019-12-31
PCT/US2020/067729 WO2021138600A1 (en) 2019-12-31 2020-12-31 Nanoparticle systems to stimulate and maintain immune system responsiveness at treatment sites

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JP2023508616A true JP2023508616A (ja) 2023-03-02
JP2023508616A5 JP2023508616A5 (https=) 2024-01-12
JPWO2021138600A5 JPWO2021138600A5 (https=) 2024-01-12

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US (1) US20230331804A1 (https=)
EP (1) EP4085137A4 (https=)
JP (1) JP2023508616A (https=)
KR (1) KR20220130712A (https=)
CN (1) CN115135764A (https=)
AU (1) AU2020417305A1 (https=)
BR (1) BR112022013068A2 (https=)
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Families Citing this family (11)

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CN111629715A (zh) 2018-01-18 2020-09-04 弗莱德哈钦森癌症研究中心 通过调节细胞活化状态改变体内免疫细胞的炎症状态
CN113166783B (zh) 2018-10-09 2024-10-11 不列颠哥伦比亚大学 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
US12565529B2 (en) 2021-05-24 2026-03-03 Provention Bio, Inc. Methods for treating type 1 diabetes
WO2023081644A1 (en) * 2021-11-02 2023-05-11 Engage Biologics Inc. Materials and methods for treatment with mrna encoding multispecific binding molecules
EP4561537A2 (en) * 2022-07-27 2025-06-04 Trustees Of Tufts College Lipid nanoparticles for immunotherapy
CN116003627B (zh) * 2022-09-16 2025-05-13 四川大学华西医院 NKG2D-NKp46细胞接合器分子及其用途
CN116874600B (zh) * 2023-07-13 2024-07-05 浙江大学 来自纳米抗体可靶向cd163受体的短肽的制备方法及其应用
WO2025026553A1 (en) * 2023-08-02 2025-02-06 BioNTech SE Agents and methods for targeted delivery to cells
WO2025128615A1 (en) * 2023-12-12 2025-06-19 Seagen Inc. Multispecific egfr antibodies and use in the treatment of cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019213308A1 (en) * 2018-05-01 2019-11-07 Fred Hutchinson Cancer Research Center Nanoparticles for gene expression and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2294579C (en) * 1997-06-23 2007-10-09 Sequus Pharmaceuticals, Inc. Liposome-entrapped polynucleotide composition and method
WO1999064074A1 (en) * 1998-06-11 1999-12-16 The Trustees Of The University Of Pennsylvania Methods and compositions for delivering proteins to macrophage cells and cells of macrophage derived lineage
WO2016004043A1 (en) * 2014-06-30 2016-01-07 Blend Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
CN119564879A (zh) * 2015-08-18 2025-03-07 乐天医药生技股份有限公司 用于光免疫疗法的组合物、联用及相关方法
AU2016308286B2 (en) * 2015-08-18 2022-04-07 Rakuten Medical, Inc. Phthalocyanine dye conjugates and their storage
EP3353309A4 (en) * 2015-09-25 2019-04-10 Tarveda Therapeutics, Inc. COMPOSITIONS AND METHOD FOR GENERIC EDITING
AU2017313806B2 (en) * 2016-08-17 2023-07-20 Orbis Health Solutions Llc Tumor-targeting bead vectors and methods of using the same
CN111629715A (zh) * 2018-01-18 2020-09-04 弗莱德哈钦森癌症研究中心 通过调节细胞活化状态改变体内免疫细胞的炎症状态
CR20200459A (es) * 2018-04-13 2020-11-11 Hoffmann La Roche Moléculas de unión a antígeno dirigidas a her2 que comprendan 4-1bbl

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019213308A1 (en) * 2018-05-01 2019-11-07 Fred Hutchinson Cancer Research Center Nanoparticles for gene expression and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MOLECULAR THERAPY, vol. 27, no. 4, JPN6025008833, April 2019 (2019-04-01), pages 773 - 784, ISSN: 0005765095 *
PLOS ONE, vol. 10, no. 10, JPN6025008834, 2015, pages 0141669, ISSN: 0005765096 *

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