JP2023061279A - Virus inspection system, virus inspection method, and virus sample collecting method - Google Patents

Abstract

To provide a virus inspection system for easily performing virus inspection.SOLUTION: The virus inspection system is provided with a measuring apparatus 3 for measuring an amount of virus in a sample, a server 1 for collecting a measured value of the amount of virus measured by the measuring apparatus 3, and a user terminal 2 for displaying information of the amount of virus based on information transmitted by the server 1. The measuring apparatus 3 comprises a main unit, which can be separated from each other, and a sensor stick, which includes a sensor capable of measuring the amount of virus. The virus amount measured by the sensor stick is transmitted to the server 1 through the main unit.SELECTED DRAWING: Figure 1

Description

TECHNICAL FIELD The present invention relates to technology of a virus inspection system, a virus inspection method, and a virus specimen collection method.

Antigen tests include antigen quantitative tests and antigen qualitative tests. An antigen quantitative test is a test for examining how much antigen is present in a specimen. Antigen qualitative calculation is a test to determine whether or not the sample contains an antigen. Although the antigen qualitative test is less sensitive than the former, it can be tested with a simple test kit, takes about 15 minutes, and gives the results on the spot. On the other hand, the antigen quantitative test takes about 30 minutes and is more sensitive than the antigen quantitative test. However, the antigen quantitative test requires a dedicated test device. Therefore, if a quarantine station does not have a dedicated device for antigen quantitative testing, it is necessary to transport the specimen to a testing institution.

Currently, both the PCR test and the antigen test are judged positive or negative based on the results of one test, and no follow-up observations are made for each individual during the 14-day waiting period. At present, quarantine stations such as airports often use antigen quantitative tests instead of PCR tests from the viewpoint of convenience and throughput.

In the antigen qualitative test, an immunochromatographic measuring device as disclosed in Patent Document 1 and Non-Patent Document 1 is used to visually determine the lines generated by the antigen-antibody reaction. In such tests, the property (capillary phenomenon) of the subject slowly flowing while dissolving the reagent on the cellulose membrane is applied. The antigen in the sample moves on the cellulose membrane while forming an immune complex with an antibody (labeled antibody) labeled with a metal colloid or the like prepared in advance in the sample dropping portion. After that, the immune complex is trapped on the capture antibody prepared in advance on the cellulose membrane and colored. The test result is determined by visually observing the color reaction. As described above, the total test time for the antigen qualitative test is about 15 minutes. Therefore, inspection can be performed on the spot.

On the other hand, as shown in Non-Patent Document 1, the antigen quantitative test uses a dedicated measuring instrument, so as described above, the sensitivity is higher than the antigen qualitative test, and the antigen can be quantitatively measured. A chemiluminescent enzyme immunoassay method is used for the antigen quantitative test. In the chemiluminescent enzyme immunoassay method, an antigen is allowed to react with an immobilized antibody, then the enzyme-labeled antibody is subjected to a secondary reaction with the antigen, and a chemiluminescent substrate is added to measure the luminescence intensity.

In addition, in Patent Documents 2 and 3, as an electrochemical detection method for proteins, pathogens, etc., influenza viruses are electrochemically enhanced by chemically modifying a diamond electrode with a peptide that has an affinity for influenza viruses. A sensitive detection method is presented. That is, in Patent Documents 2 and 3, by combining functional molecules such as peptides, enzymes, and antibodies with the wide potential window and low noise, which are the characteristics of diamond electrodes, many problems occur in sensor applications. It has been shown that it is possible to achieve the desired selectivity and to measure various substances, including viruses, with high accuracy. At this time, the virus binds to the functional molecule chemically modified on the diamond electrode, and the degree of inhibition of the oxidation-reduction reaction of the reagent contained in the solution is measured. That is, when the amount of virus increases, a large number of virus-trapping sites are generated on the diamond electrode, which inhibits the oxidation-reduction reaction of the reagent on the diamond electrode surface, resulting in a lower signal. By using such a measurement principle, it is possible to perform a quantitative test of the amount of virus.

Furthermore, Patent Document 4 shows an electrochemical sensor unit using an electrochemical detection method. A feature of this method is that the stick holding the electrochemical sensor and the transmitter are detachable. As a result, the stick part can be easily replaced, so that repeated measurements can be easily performed. It is also possible to analyze the signals measured from the transmitter on the cloud and save the time-series data.

In addition, Non-Patent Document 2 shows an inspection flow at a Japanese quarantine station.

Japanese Patent Application Laid-Open No. 2021-4810 WO2019/139009 WO2016/175049 Japanese Patent Application Laid-Open No. 2021-18230

Tadaki Suzuki, “About COVID-19 antigen/antibody test”, [online], December 22, 2020, National Institute of Infectious Diseases, [searched October 15, 2021], Internet <URL: https://www.niid.go.jp/niid/images/plan/kisyo/2_suzuki.pdf＞ “Ministry of Health, Labor and Welfare/Regarding new measures related to border measures”, [online], Ministry of Health, Labor and Welfare, [searched on October 15, 2021], Internet <URL: https://www.mhlw.go.jp/stf /seisakunitsuite/bunya/0000121431_00209.html＞

In the materials announced by the National Institute of Infectious Diseases at the 2020 Rare Infectious Disease Diagnosis Technology Workshop (December 22, 2020), the new coronavirus shown in (A1) to (A3) below Pharmacokinetics were shown. The new coronavirus refers to SARS-CoV-2.
(A1) Viral multiplication occurs transiently early in the disease.
(A2) The virus does not continue to multiply during the period when symptoms are present.
(A3) Depending on when the test is taken, the virus may disappear from the sample collection site and may not be detected (the performance of the test is not necessarily bad).

At present, diagnosis is made only based on test results at a certain point in time for each individual, including measures at the border. In other words, the inspection is not performed frequently due to the problems of the inspection method (size of the measuring device, inspection time, etc.). Therefore, with the current test methods, it is not possible to determine the situation and timing from infection to the onset of the new coronavirus, and the situation and timing of the spread of the new coronavirus after the onset. During this time, the behavior of the affected person creates the possibility of infecting others. In addition, there are an increasing number of cases in which symptoms suddenly change after being forced to wait at home based on the results of measuring heat and oxygen saturation at a certain point.

Also, when returning to society after receiving treatment for the new coronavirus infection, it is possible to wait at a medical institution or at home for a certain period of time after symptoms disappear, and at a certain stage conduct a PCR test before returning to society. A decision is made whether or not Although the degree of morbidity and recovery varies from person to person, testing is not possible due to testing methods, so almost all affected individuals receive the same treatment.

On the other hand, current PCR tests and antigen tests for the new coronavirus cannot be performed frequently, so there is a limit to cell medicine (protecting one's own health).

The present invention has been made in view of such a background, and an object of the present invention is to easily perform a virus test.

In order to solve the above-described problems, the present invention provides a virus measuring device that measures the amount of virus in a sample, a server that collects the amount of virus measured by the virus measuring device, and information transmitted from the server. a terminal device that displays information about the measured viral load, the virus measuring device comprising a body that can be separated from each other; and a sensor unit that includes an electrochemical sensor capable of measuring the viral load. wherein the amount of virus measured by the sensor unit is transmitted to the server via the main unit.
Other solutions will be described as appropriate in the embodiments.

According to the present invention, virus inspection can be easily performed.

1 is a diagram showing a schematic configuration example of a virus inspection system according to this embodiment; FIG. It is a figure which shows the structural example of the server which concerns on this embodiment. It is a figure which shows the hardware constitutions of a server. It is a figure which shows the structural example of the user terminal in this embodiment. It is a figure (1) which shows the external appearance of a measuring device. It is a figure (part 2) which shows the external appearance of a measuring device. It is a figure which shows the internal structure of a sensor stick. It is a figure which shows another example of a measuring device. It is a figure which shows the example of the measurement data used by this embodiment. It is a figure which shows the example of the subject data used by this embodiment. It is a figure which shows the example of the signal level data used by this embodiment. FIG. 10 is a diagram showing an example of a virus check start screen; It is a diagram showing an example of the inspection result display screen, FIG. 11 is a diagram showing an example of an infection status progress screen displayed on the user terminal; 7 is a flowchart showing the procedure of measurement value acquisition processing; 4 is a flow chart showing the procedure of inspection result display processing. FIG. 10 is a flowchart showing the procedure of infection status progress display processing; FIG. It is a figure which shows the sample extraction method in this embodiment.

Next, modes for carrying out the present invention (referred to as "embodiments") will be described in detail with reference to the drawings as appropriate. In this embodiment, the novel coronavirus refers to SARS-CoV-2. That is, in this embodiment, the virus to be measured for viral load is SARS-CoV-2. Also, in the present embodiment, the novel coronavirus is simply referred to as a virus as appropriate. Furthermore, in the present embodiment, the specimen is assumed to be a virus specimen (virus specimen).

This embodiment provides a virus inspection system Z that measures the amount of virus over time and presents information about the amount of virus to the user. In this embodiment, a person who uses the virus inspection system Z, for example, a person who uses the virus inspection system Z is called a user. Among users, a person who performs a virus test (a person who collects a sample and measures the amount of virus) is appropriately referred to as a subject.

[system]
FIG. 1 is a diagram showing a schematic configuration example of a virus inspection system Z according to this embodiment.
The virus inspection system Z has a measuring device (virus measuring device) 3 , a user terminal (terminal device) 2 and a server 1 .
As shown in FIG. 1, a measuring device 3 and a user terminal 2 are connected via communication such as wireless communication, and the user terminal 2 and server 1 are connected via a WAN (Wide Area Network) or the like.
The user terminal 2 is a smart phone, a tablet computer, or other mobile terminal, and is a terminal possessed by a user. Alternatively, the user terminal 2 may be a personal computer (PC) owned by an individual. In this embodiment, it is assumed that a smart phone is used as the user terminal 2 . The user terminal 2 transmits to the server 1 the information output from the measuring device 3 for measuring the amount of virus, and displays the information transmitted from the server 1 and, if necessary, logs and the like. In this manner, the user terminal 2 (terminal device) displays information on the measured virus load based on the information transmitted from the server 1 . Note that the user terminal 2 will be described later.

The measuring device 3 measures the amount of virus and transmits information about the measurement result including the measured value to the user terminal 2 . That is, the measuring device 3 measures the amount of virus in the sample. The measuring device 3 will be described later. The user terminal 2 runs an application for transmitting the measured values according to the present embodiment to the server 1 and for viewing information about the measured values. The user terminal 2 then transmits the measured value transmitted from the measuring device 3 to the server 1 . The measured value is the amount of virus measured by the measuring device 3 (unit: pg/ml).

The server 1 collects and accumulates information about measurement results transmitted from the user terminal 2 and transmits the accumulated information to the user terminal 2 in response to a request from the user terminal 2 . In this way, the server 1 collects the amount of virus measured by the measuring device (virus measuring device) 3 . Server 1 will be described later.

Note that the server 1 may be installed in the form of a cloud, or may be installed in an operating company (not shown).

[Server 1]
FIG. 2 is a diagram showing a configuration example of the server 1 according to this embodiment.
The server 1 includes a storage processing unit 101, a transmission processing unit 102, an update processing unit 103, a user registration unit 104, a user interface 105, and the like. The server 1 also includes measurement data 111, user data 112, signal level data 113, sensor profile 114, and the like.

A service providing terminal 4 is also connected to the server 1 . The service providing terminal 4 is a terminal installed in an operating company (not shown). Also, the service providing terminal 4 can access measurement data 111 , user data 112 and signal level data 113 .

The storage processing unit 101 stores the virus amount measurement value and the like transmitted from the user terminal 2 in the measurement data 111 . The storage processing unit 101 also refers to the sensor profile 114 to obtain information about the sensor 322 (see FIG. 5C) provided in the measuring device 3 and stores the obtained information about the sensor 322 in the measurement data 111 . In addition, the storage processing unit 101 refers to the user data 112 and stores only user information registered in the user data 112 in the measurement data 111 . Furthermore, when storing the measured value in the measurement data 111, the storage processing unit 101 refers to the signal level (threshold value) stored in the signal level data 113, determines the alarm level corresponding to the stored measured value, The alarm level is stored in the measurement data 111 together with the measurement value.

Upon receiving a request from the user terminal 2 , the transmission processing unit 102 acquires information corresponding to the request from the measurement data 111 and transmits the acquired information to the user terminal 2 .

The update processing unit 103 updates the signal level data 113 based on the measurement data 111 .
The user registration unit 104 stores user registration information by the user in the user data 112 .
The user interface 105 mediates between the user terminal 2 , the service providing terminal 4 , measurement data 111 , user data 112 and signal level data 113 . The user terminal 2 can be connected to the service providing terminal 4 via the user interface 105 . This allows the user to send questions and the like to the operating company and receive answers and the like. Also, the user terminal 2 can access measurement data 111 , user data 112 and signal level data 113 via the user interface 105 .

The measurement data 111 stores information about the measurement result of the virus amount.
The user data 112 stores information about users.
The signal level data 113 stores information about signal levels (described later).
Measurement data 111, user data 112, and signal level data 113 will be described later.

The sensor profile 114 stores information (sensor type, lot, etc.) relating to the sensor 322 (see FIG. 5C). Specifically, the manufacturing number of the sensor stick 32 (see FIGS. 5A and 5B) and the sensor type, sensor lot, etc. of the sensor 322 (see FIG. 5C) provided in the sensor stick 32 are stored in association with each other. It is The sensor type stores information indicating which viral infectious disease the sensor 322 (see FIG. 5C) corresponds to. Incidentally, the sensor profile 114 is created in advance by the operating company.

The virus inspection system Z shown in this embodiment is characterized by having measurement data 111 and signal level data 113 .

In actual measurement, waveform data obtained by the sensor 322 (see FIG. 5C) is first sent to the server 1 and converted into actual quantitative values by the storage processing unit 101 . This quantitative value is saved in the measurement data 111 together with other data (measurement date, measurement time, location, etc.). In this embodiment, waveform data and quantitative values converted from the waveform data are collectively referred to as measured values. In addition, by accumulating basic data on the amount of virus, it is possible to determine whether the amount of virus is small, medium, or large (judgment of the alarm level).
The user visually recognizes the determination result (alert level) and, if necessary, takes action such as visiting a medical institution 5 (see FIG. 15).

[Hardware Configuration of Server 1]
FIG. 3 is a diagram showing the hardware configuration of the server 1. As shown in FIG.
The server 1 includes a memory 11, a CPU (Central Processing Unit) 12, an HDD (Hard Disk Drive), a SSD (Solid State Drive), and a storage device (storage unit) 13. FIG. Further, the server 1 has an input device 14, an output device 15, a transmitting/receiving device 16 for transmitting/receiving information to/from the user terminal 2 and the service providing terminal 4 (see FIG. 2).

A program stored in the storage device 13 is loaded into the memory 11, and the loaded program is executed by the CPU 12, thereby realizing the units 101 to 104 shown in FIG.
Further, the storage device 13 stores measurement data 111, user data 112, signal level data 113, and sensor profile 114 shown in FIG.

[User terminal 2]
FIG. 4 is a diagram showing a configuration example of the user terminal 2 in this embodiment.
The user terminal 2 includes a memory 200 such as a RAM (Random Access Memory), a CPU 21, and a storage device 22 such as a ROM (Read Only Memory). Further, the server 1 has an input/output device (display unit) 23 having a tall touch panel or the like, a measuring device 3 (see FIG. 1), and a transmitting/receiving device 24 for transmitting/receiving information to/from the server 1 (see FIG. 1). ing. A transmission/reception processing unit (position information processing unit) 201, a display processing unit 202, and a location information acquisition unit 203 are realized by executing a program stored in the memory 200 by the CPU 21. FIG.

The transmission/reception processing unit 201 controls transmission/reception of information between the measuring device 3 (see FIG. 1) and the server 1 (see FIG. 1). In addition, the transmission/reception processing unit 201 generates second measurement data by adding information such as a user ID and current location information (position information) to information including measurement values sent from the measuring device 3 (first measurement data). do. That is, the transmission processing unit 201 adds the location information of the user terminal (terminal device) 2 to the virus load, and then transmits the virus load to which the location information is added to the server 1 .
The display processing unit 202 displays information on the input/output device 23 .
The location information acquisition unit 203 is a GPS (Global Positioning System) device or the like, and acquires information about the current location of the user terminal 2 .

[Measuring device 3]
5A and 5B are diagrams showing the appearance of the measuring device 3. FIG. 5C is a diagram showing the internal configuration of the sensor stick 32. As shown in FIG.
As shown in FIGS. 5A and 5B, the measuring device 3 is composed of a sensor stick (sensor section) 32 and a body section 31 . As shown in FIG. 5A, the sensor stick 32 and the main body 31 are separable.
Further, the body portion 31 is provided with an LED (Light Emission Diode) light emitting portion 311 and an insertion portion 312 into which the sensor stick 32 is inserted.
The sensor stick 32 has a stick-like shape and has a sensor 322 for measuring the amount of virus as shown in FIG. 5C. However, the shape of the sensor stick 32 need not be stick-like as shown in FIGS. 5A to 5C. Further, as shown in FIG. 5A, the sensor stick 32 is provided with an opening 321 . The opening 321 will be described later.
The main body 31 shown in FIGS. 5A and 5B incorporates an electronic circuit for driving the sensor stick 32 and obtaining measurement values of the sensor 322 and a short-range wireless communication device.

As shown in FIG. 5C, the sensor stick 32 has a cover portion 32A and a base portion 32B. The substrate portion 32B is provided with a sensor (electrochemical sensor) 322 and a signal/voltage supply line 323 connected to the sensor 322 . The sensor 322 is the electrochemical sensor of Patent Document 3 adapted to the novel coronavirus. The sensor stick 32 is configured by joining the cover portion 32A and the base portion 32B. As shown in the example of FIG. 5C, an opening 321 is provided in the cover portion 32A. The opening 321 and the sensor 322 are arranged so that the sample can be introduced into the sensor 322 through the opening 321 when the cover 32A and the base material 32B are joined together.
With such a configuration, the sensor 322 comes into contact with the sample (virus) when the subject introduces the sample into the opening 321 .

As described above, the measuring device 3 has a body portion 31 separable from each other and a sensor stick (sensor portion) 32 having a sensor (electrochemical sensor) 322 capable of measuring the amount of virus.

The subject inserts the sensor stick 32 into the insertion portion 312 of the main body 31 as shown by the white arrow in FIG. 5A and FIG. 5B. After that, the subject introduces the sample into the opening 321 of the sensor stick 32 . When the subject inserts the sensor stick 32 into the insertion portion 312 of the main body 31 and the signal/voltage supply line 323 shown in FIG. 5C is connected to the signal/voltage line (not shown) of the main body 31, FIG. The LED light emitting portion 311 shown in 5B lights up. This allows the subject to confirm the connection between the sensor stick 32 and the body portion 31 .

By inserting the sensor stick 32 into the insertion portion 312 of the body portion 31, drive power is supplied from the body portion 31 to the sensor 322 via the signal/voltage supply line 323 shown in FIG. 5C. Thereby, the amount of virus contacting the sensor 322 is measured by the sensor 322 . The measured value is transmitted to the main unit 31 via the signal/voltage supply line 323 . Then, a transmission unit (not shown) provided in the main unit 31 generates first measurement data in which the measurement date, measurement time, manufacturing number of the sensor stick 32, etc. are added to the measurement value, and the generated first measurement Data (measurement results) are transmitted to the user terminal 2 . Thereafter, the user terminal 2 generates second measurement data by adding the user ID and current location information to the received first measurement data, and transmits the second measurement data to the server 1 . Note that the measured values may be temporarily stored in the main unit 31 .

As described above, the measuring device 3 has a structure in which the sensor stick 32 containing the sensor 322 which is an electrochemical sensor and the main body 31 are separated, and when the two are combined, a state in which measurement can be performed is achieved. Become. With such a structure, multiple measurements can be easily made by exchanging the sensor stick 32 .

The measured values obtained by collecting the sample as described above are sent to the user terminal 2 such as a smart phone through the main unit 31 and stored in the server 1 . Also, the measured values are displayed on the input/output device 23 of the user terminal 2 in response to a request from the user terminal 2 . Moreover, if necessary, the measurement data 111 of the server 1 is linked with the medical institution 5 (see FIG. 15).

(Another example of measuring device 3)
FIG. 6 is a diagram showing another example of the measuring device 3. As shown in FIG.
In FIG. 6, the same reference numerals are assigned to the same configurations as in FIGS. 5A and 5B, and the description thereof is omitted.
In the measuring device 3a shown in FIG. 6, the main body 31 is provided with a display 313 for displaying the measured value by the sensor 322 (see FIG. 5C). A display device 313 is composed of a liquid crystal display or the like. With such a configuration, the subject can immediately confirm the measured value when the virus amount is measured.

[Various data]
(Measurement data 111)
FIG. 7 is a diagram showing an example of measurement data 111 used in this embodiment.
The measurement data 111 stores the result of the virus inspection using the measurement device 3 .
Specifically, as shown in FIG. 7, the measurement data 111 includes, for each user ID, the date of measurement (date), the time of measurement (time), the place of measurement (location), Information on the type of sensor used, sensor lot, measured value, and alarm level is stored for each measurement.
A user ID is an identifier uniquely assigned to a user.
The location is the location where the measurement was performed, and information (latitude and longitude information, etc.) related to the current location of the user terminal 2 acquired by the location information acquisition unit 203 of the user terminal 2 is stored. By storing such location information, it is possible to manage where the virus amount was measured.

As described above, the sensor type stores information indicating which viral infectious disease (virus) the sensor 322 corresponds to. The example shown in FIG. 7 indicates that a sensor 322 corresponding to "Covid 19", that is, a novel coronavirus infection (novel coronavirus) is used.

The sensor lot is the lot number of the sensor 322 during the manufacturing process. Although the sensor lot does not have to be stored in the measurement data 111, if there is an abnormality in a certain sensor 322 by having information on the sensor lot, the information on the sensor 322 having the same sensor lot can be invalidated. The accuracy of data 111 can be maintained.
The measured value stores the amount of virus measured by the measuring device 3 .
The alarm level indicates the level of the measured value. The alarm level is information stored by referring to the measured value and the signal level data 113 shown in FIG. Alarm levels will be described later in FIG.

(User data 112)
FIG. 8 is a diagram showing an example of user data 112 used in this embodiment.
The user data 112 stores information about users.
Specifically, the user data 112 stores the user's name, sex, age, address, contact information, membership number, etc. in association with the user ID.
7 and 8, the measurement data 111 and the user data 112 are separated and stored in the storage device 13 (see FIG. 3). linked by. The operating company has authority to link the measurement data 111 and the user data 112 . As a matter of course, the user side does not have the authority to link the measurement data 111 and the user data 112 . Note that the measurement data 111 and the user data 112 may be combined into one.

(Signal level data 113)
FIG. 9 is a diagram showing an example of signal level data 113 used in this embodiment.
The signal level has a "minimum detectable level", a "low viral load" level, a "medium viral load" level, and a "high viral load" level. However, the signal levels are not limited to these four.
The signal level data 113 stores each signal level in association with the number of measurements, average, standard deviation, and data acquisition period.

Each signal level is calculated based on the average value of the measured values. That is, the number of measurements, average, standard deviation, and data acquisition period stored in the signal level data 113 were used when each signal level was calculated.

The minimum detection level is the signal level above which the determination unit determines that the novel coronavirus has been detected. In other words, if the measured value does not exceed the minimum detection level, it is determined that the new coronavirus is not infected.

The minimum detection level is determined by the mean and standard deviation of the measured values (background measured values) obtained by measuring samples that are known not to contain the novel coronavirus. For example, a value obtained by adding three times the standard deviation to the average value of the background measurement values is set as the minimum detection level threshold. However, it is not limited to three times the standard deviation.

The “low viral load” level, “medium viral load” level, and “high viral load” level are calculated based on measurements from actual affected individuals. That is, the "low viral load" level, the "medium viral load" level, and the "high viral load" level are thresholds based on the viral load collected in the past. In the example shown in FIG. 9, the average and the standard deviation are calculated for the signal levels of the "low viral load" level, the "medium viral load" level, and the "high viral load" level. only the average is used. That is, the average associated with the "low viral load" level is the threshold for the "low viral load" level. The same is true for the "medium viral load" level and the "high viral load" level. In this way, the signal level data 113 stores the “low viral load” level, the “medium viral load” level, and the “high viral load” level, which are thresholds based on the virus load collected in the past.

In this embodiment, based on the minimum detection level, the "low viral load" level, the "medium viral load" level, and the "high viral load" level, an alarm is issued when the measured value rises. There are five alarm levels as follows.
"0th alarm level": When the measured value is less than the minimum detection level.
"First alarm level": When the measured value is above the minimum detection level and below the "low virus amount" level.
"Second alarm level": When the measured value is above the "low virus" level and below the "medium virus amount" level.
"Third alarm level": When the measured value is above the "medium viral amount" level and below the "large viral amount" level.
"Fourth alarm level": When the measured value is at the "high viral load" level or higher.

Minimum detection levels are based on measurements performed in the laboratory. On the other hand, the ranges of "low viral load" level, "medium viral load" level, and "high viral load" level will be determined by accumulating information on various actual cases. Therefore, the "low viral load" level, "medium viral load" level, and "high viral load" level change depending on the number of measurements. That is, the threshold value (average) of the signal level of the virus load is sequentially updated (updated) by the update processing unit 103 shown in FIG.

In this way, the signal level data 113 used in this embodiment accumulates statistical data (number of measurements, average, standard deviation) regarding the signal level of each virus load. The newly measured measurement value is compared with the signal level. Then, the user terminal 2 displays the warning level extracted as a result of the comparison on the screen. This makes it possible to issue a warning to the subject. By confirming such an alarm level by the subject, the subject can take measures such as consultation with the medical institution 5 (see FIG. 15).

This point is a major feature of the virus test system Z in this embodiment, which is different from conventional antigen quantitative tests and antigen qualitative tests.

[Screen example]
Next, screen examples of the user terminal 2 are shown with reference to FIGS. 10A, 10B, and 11. FIG.
(Virus check start screen 210)
FIG. 10A is a diagram showing an example of the virus inspection start screen 210. FIG.
Virus inspection start screen 210 has user ID input window 211 , inspection content input window 212 , and inspection enable button 213 .
In the example shown in FIG. 10A, the subject enters a user ID into the user ID entry window 211. In the example shown in FIG. It should be noted that the password may be input after the user ID is input.
Then, the subject inputs the examination contents in the examination contents input window 212 . The inspection content is the type of virus to be inspected (new coronavirus, etc.). Note that the inspection content input window 212 may be capable of handling a plurality of inspection contents (viruses). Information may be directly input to the examination content input window 212, or may be selectable from a pull-down menu.

If the information entered in the user ID input window 211 and the inspection content input window 212 is correct, the inspection possible button 213 changes from red, which means that inspection is impossible, to green, which means that inspection is possible. By pressing (tapping) the testable button 213 that has changed to green, the subject becomes ready for testing. The testable state is a state in which the measuring device 3 can measure the amount of virus. As described above, in the example shown in the present embodiment, information is input to each input window on the virus test start screen 210 before the virus amount is measured by the measuring device 3. good too. Further, in this embodiment, if the information input in the user ID input window 211 and the inspection content input window 212 is correct, the inspection possible button 213 changes from red indicating that the inspection is impossible to green indicating that the inspection is possible. Yes, but not limited to this. For example, the checkable button 213 may transition from being grayed out to being selectable.

(Inspection result display screen 220)
FIG. 10B is a diagram showing an example of the inspection result display screen 220.
The inspection result display screen 220 has an inspection content display area 221 , a measured value display area 222 and an alarm type display area 223 .
The inspection content display area 221 displays the current inspection content (type of virus to be inspected). In other words, the information displayed in the examination content display area 221 is the information itself input to the examination content input window 212 in FIG. 7A.
The measured value display area 222 displays the measured value (currently measured value) transmitted from the measuring device 3 .

The warning type display area 223 displays the warning level (warning) output as a result of matching the measured value with the signal level data 113 shown in FIG. The displayed alarm levels are "0th alarm level" to "4th alarm level" as described in FIG. In addition, in the case of the “0th alarm level”, a sentence such as “No virus detected” may be displayed in the alarm type display area 223 . Thus, the warning type display area 223 displays a warning based on the signal level (threshold).

(Infection status progress screen 230)
FIG. 11 is a diagram showing an example of an infection status progress screen 230 displayed on the user terminal 2. As shown in FIG.
Note that the infection status progress screen 230 shown in FIG. 11 is displayed by being activated by the user terminal 2 .
In the infection state progress screen 230 shown in FIG. 11, the history of a certain subject from non-infected to infected state is shown, with the number of examinations on the horizontal axis and the measured value (unit: pg/mL) on the vertical axis. It is shown.
Graph G1 shown in FIG. 11 is a graph showing time-series changes in measured values (viral load). In other words, the graph G1 shows the time series of the viral load measured multiple times by one subject.
The dashed line L1 indicates the lowest detection level, the dashed line L2 indicates the "low viral amount" level, the dashed line L3 indicates the "medium viral amount" level, and the dashed line L4 indicates the "large viral" level. Further, the range R0 indicates "0th alarm level", the range R1 indicates "1st alarm level", the range R2 indicates "2nd alarm level", and the range R3 indicates "1st alarm level". 3 alarm level”, and the range R4 indicates the “fourth alarm level”. If the viral load is within the "0th alarm level" (range R0), the subject is determined not to be infected with the virus.

By displaying an infection status progress screen 230 as shown in FIG. 11 on the user terminal 2, the subject can easily check his or her own infection status.

The complication of the new coronavirus is that it can already be infectious to humans in an asymptomatic state. In addition, it is said that the new coronavirus has the highest viral load immediately after the onset and is most likely to infect others. With the virus inspection system Z shown in this embodiment, even if there is a risk of infection or if there are no symptoms, the subject himself/herself can perform a simple inspection, and furthermore, the change in the viral load over time can be confirmed. can be done. This makes it possible not only to manage the health of the examinee himself but also to grasp the risk of infection to others.

In addition, in the example shown in FIG. 11, the subject himself/herself can determine the severity by confirming in which range of the ranges R1 to R4 the current viral load falls. can. Further, by determining the slope of the graph G1 by the display processing unit 202 (see FIG. 4), it is possible to determine whether or not the number of viruses is rapidly increasing. Then, if the slope of the graph G1 is greater than or equal to a predetermined value, the display processing unit 202 may display a warning on the input/output device 23 (see FIG. 4).

[flowchart]
Next, referring to FIGS. 12 to 14, there are flow charts showing processing procedures performed by the virus inspection system Z according to this embodiment.

(Measured value acquisition process)
FIG. 12 is a flow chart showing the procedure of the measurement value acquisition process.
First, a subject collects a specimen (S101). Sample collection is performed by the method described later with reference to FIG.
Subsequently, the subject inputs information in each input window displayed on the virus test start screen 210 shown in FIG. 10A. After that, the subject inserts the sensor stick 32 into the measuring device 3 and attaches the sample to the sensor 322 (S102).
Then, the measuring device 3 measures the amount of virus and transmits the first measurement data to the user terminal 2 (S103). That is, a measurement step is performed in which the sensor stick (sensor unit) 32 measures the amount of virus. The first measurement data transmitted to the user terminal 2 includes information such as the measurement value, the date of measurement, the time of measurement, and the manufacturing number of the sensor stick 32 .

Upon receiving the measurement data 111 from the measurement device 3, the transmission/reception processing unit 201 of the user terminal 2 generates second measurement data by adding the user ID, current location information, etc. to the first measurement data. Then, the transmission/reception processing unit 201 transmits the generated second measurement data (information about the measurement result) to the server 1 (S111). The current location information is information acquired by the location information acquisition unit 203 of the user terminal 2 . In this way, the amount of virus measured by the sensor stick 32 (sensor section) is transmitted from the sensor stick 32 to the server 1 via the main body section 31 .

In this way, in steps S103 and S104, the sensor stick (sensor unit) 32 measures the amount of virus, and the measured amount of virus is sent from the sensor stick 32 to the server 1 via the main unit 31. and a sending step is performed. That is, the virus load measured by the sensor stick (sensor unit) 32 is transmitted from the main unit 31 to the server 1 via the user terminal (terminal device) 2 .

The storage processing unit 101 of the server 1 that has received the second measurement data stores each piece of information of the second measurement data in the measurement data 111 using the user ID included in the second measurement data as a key (S121). In step S121, the storage processing unit 101 refers to the sensor profile 114 based on the manufacturing number of the sensor stick 32 included in the second measurement data, and determines the sensor type corresponding to the sensor stick 32 and the sensor lot (sensor 322 information). Then, the storage processing unit 101 stores the sensor type and sensor lot in the measurement data 111 together with the measurement value, measurement date, measurement time, and location information included in the second measurement data. The storage processing unit 101 also refers to the user data 112 and stores information in the measurement data 111 only when the subject is registered as a user. Thus, in step S121, the server 1 performs a storage step of storing the received virus load in the storage device (storage unit) 13. FIG.

Then, the storage processing unit 101 of the server 1 determines the alarm level by referring to the signal level stored in the signal level data 113 based on the measured value included in the received second measurement data, and determines the determined alarm level. is stored in the alarm level column of the measurement data 111 (S122).

(Inspection result display processing)
FIG. 13 is a flow chart showing the procedure of inspection result display processing.
First, when the subject activates the test result display screen 220 on the user terminal 2, the transmission/reception processing unit 201 of the user terminal 2 transmits a test result request to the server 1 (S201). A user ID is included in the inspection result request.

The transmission processing unit 102 of the server 1 that has received the inspection result request searches for the measurement data 111 using the user ID included in the inspection result request as a key. Then, the transmission processing unit 102 acquires the latest measurement value associated with the retrieved user ID. After that, the transmission processing unit 102 transmits alarm information including the acquired measurement value, the sensor type and the alarm level associated with the acquired measurement value to the user terminal 2 that is the transmission source of the test result request ( S202).

The display processing unit 202 of the user terminal 2 that has received the warning information displays the information included in the received warning information on the inspection result display screen 220 shown in FIG. 10B (S203). Specifically, the display processing unit 202 displays the inspection content display area 221 shown in FIG. 10B based on the sensor type included in the alarm information. The display processing unit 202 also displays the measured value included in the alarm information in the measured value display area 222 shown in FIG. 10B. Furthermore, the display processing unit 202 displays the alarm level included in the alarm information in the alarm type display area 223 . In this way, in step S203, the display step of displaying information on the virus load transmitted from the server 1 on the input/output device (display unit) 23 of the user terminal (terminal device) 2 is performed.

(Infection status progress display process)
FIG. 14 is a flow chart showing the procedure of infection status progress display processing.
First, when the subject activates the infection status progress screen 230 (FIG. 11) on the user terminal 2, the transmission/reception processor 201 of the user terminal 2 sends an infection status request to the server 1 (S301). A user ID is included in the infection status request.

The transmission processing unit 102 of the server 1 that has received the infection status request acquires all measurement values from the measurement data 111 using the user ID included in the infection status request as a key (S302).
After that, the transmission processing unit 102 of the server 1 transmits to the user terminal 2 the acquired infection state information including all the measured values and the respective signal level information stored in the signal level data 113 (S303). ).

The display processing unit 202 of the user terminal 2 that has received the infection status information displays the infection status information on the infection status progress screen 230 shown in FIG. 11 (S304). Specifically, the display processing unit 202 displays a graph G1 shown in FIG. 11 based on a plurality of measured values included in the infection status information. Furthermore, the display processing unit 202 displays dashed lines L1 to L4 based on the respective signal level information included in the infection status information. In this way, in step S304, the display step of displaying information on the virus load transmitted from the server 1 on the input/output device (display unit) 23 of the user terminal (terminal device) 2 is performed.

[Specimen collection method]
FIG. 15 is a diagram showing a sample collection method according to this embodiment.
In the virus inspection system Z according to this embodiment, samples are collected by the following method.
(A1) Specimen collection method using nasopharyngeal swab (specimen collection method 601: fourth collection method).
That is, the examiner slowly inserts the sterile wipe (wipe) 61 through the subject's own nostrils and stops when resistance is felt (step of bringing the wipe into contact with the nasopharynx of the subject). As a guideline, the insertion should be stopped at about 10 cm for adults and about 5 cm for children. Then, the sterile wipe stick 61 is kept at that position for about 10 seconds so that the nasal discharge permeates the sterile wipe stick 61 . After that, the examiner slowly rotates the sterile swab 61 and withdraws it from the nostril of the examinee to collect a nasopharyngeal swab. After that, the examiner dips the tip of the sterile wipe stick 61 into about 1 to 2 mL of solution (sterilized physiological saline, etc.) stored in the container for storage and transport 62 (step of soaking the wipe stick in the solution). A specimen is taken. Then, the subject immerses the sensor 322 (see FIG. 5C) portion of the sensor stick 32 in the measuring device 3 in the specimen in the storage/transport container 62 (step of immersing the electrochemical sensor in the solution). Note that the sensor stick 32 is immersed in the sample while being inserted into the main body 31 (see FIGS. 5A and 5B) (the same applies to sample collection indicated by reference numerals 602 to 604 to be described later). This initiates viral load measurement.

In the sample collection method 601, nasal swab fluid is collected by stopping the sterile swab 61 before it reaches the nasopharynx (intranasal cavity) (fifth collection method).

In this way, according to the sample collection method 601, by immersing the electrochemical sensor in the solution mixed with the nasopharyngeal swab or nasal swab collected by the swab, the amount of virus contained in the solution Measured by a chemical sensor. In addition, by using a nasal swab instead of a nasopharyngeal swab in the specimen collection method 601, the specimen collection method 601 includes a step of contacting the nasal cavity of the subject with the swab and a step of immersing the swab in the solution. and immersing the electrochemical sensor in the solution.

According to the sample collection method shown in (A1), it is possible to easily collect a sample for measuring the amount of virus.

(A2) A specimen collection method in which the subject collects saliva on the collection paper 63 (specimen collection method 602: first collection method). As indicated by reference numeral 602, the subject drips saliva onto the collection paper 63 (step of dripping saliva onto the collection paper 63). After that, the subject soaks the collection paper 63 to which saliva is attached in about 1 to 2 mL of solution (sterilized physiological saline, etc.) stored in the storage/transport container 62, and the specimen is collected ( a step of attaching the components of saliva adhering to the sampling paper 63 to the electrochemical sensor). As a result, saliva adhering to the collection paper 63 can adhere to the electrochemical sensor. The subject then dips the sensor 322 (see FIG. 5C) portion of the sensor stick 32 into the specimen in the container 62 for storage and transportation.

Alternatively, the subject may directly press the sensor 322 portion of the sensor stick 32 against the portion of the sampling paper 63 to which saliva is attached. As a result, saliva (specimen) components adhere to the sensor stick 32 . This initiates viral load measurement. Such a sampling method greatly facilitates virus testing.

In this way, the amount of virus contained in the subject's saliva is measured by the electrochemical sensor.

The sampling paper 63 is made of a waterproof material so that the saliva (specimen) does not leak, and it is particularly desirable that the side opposite to the side that comes in contact with the saliva (specimen) is coated. If the saliva (specimen) is highly viscous, 1 to 2 mL of saliva may be collected in a waterproof collection bag instead of the collection paper 63, and a buffer solution may be dripped there. Then, the subject may attach the solution mixed with the sample to the sensor 322 of the sensor stick 32 .

(A3) A method in which a subject collects a specimen with nasal rinse 64 such as sterile physiological saline (specimen collection method 603: third collection method). The liquid collected by nasal gargling is stored in a container for storage and transport 62 (a step of collecting the nasal gargling liquid discharged from the subject as a result of nasal gargling). Then, the subject immerses the sensor 322 portion of the sensor stick 32 in the liquid stored in the storage/transport container 62 (step of immersing the electrochemical sensor in the nasal rinse liquid 64).

Thus, according to the sample collection method 603, the amount of virus contained in the nasal rinse 64 is measured by the electrochemical sensor.

(A4) A method in which the subject blows his or her nose with the collection paper 65 (the step of blowing the nose with the collection paper) and uses nasal discharge adhering to the collection paper 65 as a specimen (specimen collection method 604: second collection method). In this case, when the subject presses the sensor 322 part of the sensor stick 32 against the nasal secretion adhered to the collection paper 65, the specimen adheres to the sensor 322 (the nasal secretion adhered to the collection paper 65 is detected by the electrochemical sensor). step). In the method shown in (A4), saliva can be used instead of nasal discharge. In this way, the amount of virus contained in nasal secretions of the subject is measured by the electrochemical sensor.

Thus, in this embodiment, in addition to such nasopharyngeal swabs, saliva and nasal discharge from blowing the nose can also be used as specimens.
Collecting a specimen by saliva or blowing the nose can greatly reduce the burden on both the medical staff and the examinee compared to nasopharyngeal swabs and nasal swabs. Incidentally, it has been pointed out that saliva specimens are less sensitive to digestive enzymes, so it is desirable to collect saliva specimens before eating or drinking. Also, to avoid physical removal of the virus, do not brush your teeth, gargle, or eat or drink before collection. If it is unavoidable, it is recommended to wait at least 10 minutes, if possible, 30 minutes. Then, the subject naturally drips saliva directly into the specimen container. Furthermore, the test subject repeats the procedure several times until a sufficient sample volume (approximately 1-2 mL) is obtained.

By performing the methods shown in (A2) to (A4), a subject can easily collect a sample by himself or herself without receiving assistance from a medical professional. In addition, by exchanging the sensor stick 32, an individual can perform the inspection any number of times. The amount of virus in the specimen is uploaded as measurement data 111 from the main unit 31 to the server 1 via the user terminal 2 . This makes it possible to collect information about ongoing viral load. Information (second measurement data) on the measurement results uploaded to the server 1 is shared with the medical institution 5 . In addition, it is preferable that the server 1 notifies the medical institution 5 when the measured values are accumulated to a certain value or more.

Also, the used sensor stick 32 is placed in a collection bag 611 and incinerated (reference numeral 612). Note that the sensor stick 32 and the sampling papers 63, 65, etc. used for the measurement are disposable each time.

As described above, the virus inspection system Z of this embodiment has the following features.
(B1) Samples include nasopharyngeal swabs, nasal swabs, saliva, and nasal secretions collected by blowing the nose or the like.

Specifically, nasopharyngeal swabs, nasal swabs, saliva (currently within 9 days after onset), nasal discharge from nasal paper, etc. are used as test specimens. Then, the subject can perform measurement by a simple operation of touching the sensor 322 of the sensor stick 32 . If the saliva is highly viscous, a buffer is added to the saliva.

Note that when saliva is used as a sample, the subject may drip saliva into a dedicated collector and collect the saliva in one section.

(B2) In the measuring device 3, the sensor stick 32 including the electrochemical sensor (sensor 322) and the main body 31 are configured to be separable so that the sensor stick 32 can be easily replaced. In this embodiment, by replacing the sensor stick 32, it is possible to quantify the change in the amount of new coronavirus over time, so if the amount of virus exceeding the minimum detection level in the antigen quantitative test is detected, a warning is displayed. By doing so, it is possible to quickly detect an increasing tendency of the measured values. In addition, as shown in FIG. 11, the subject can easily check his or her infection status by displaying the time series of the measured values.

(B3) The sensor 322 of the sensor stick 32 uses an electrochemical detection method that can quantitatively test the amount of novel coronavirus. Then, analysis is performed by comparing with the signal level in the server 1, and time-series information of the amount of virus (measured value) is stored.
(B5) Display the measurement date, measurement time, and measurement position for each measurement value, and display a warning when the measurement value exceeds the minimum detection level.

By using the virus inspection system Z according to this embodiment, an individual can easily perform a quantitative inspection of the novel coronavirus. In other words, the virus inspection system Z according to this embodiment provides a business model for coronavirus inspection. In particular, a test system is provided for an antigen test that diagnoses by detecting antigens specifically produced by cells infected with the novel coronavirus.

As a specification situation of the virus inspection system Z according to this embodiment, use in the following situation is conceivable.

(E1) Strengthen quarantine at airport quarantine stations. In this case, by using the virus inspection system Z of the present embodiment to have as many people as possible take time-series information on the amount of virus, it is possible to strengthen border control measures at airports and the like. In this case, the subject waits at the airport for a predetermined period of time, during which the subject is asked to measure the amount of virus at predetermined intervals. However, the measurement may be performed at the airport only for the first time, and then continuously performed at home or the like.
(E2) Enhancement of individual self-medication. In this case, avoiding close-contact settings, diligently washing hands, disinfecting, and conducting regular inspections using the virus inspection system Z of the embodiment will allow the subject to protect their own health against the new coronavirus. can be responsible for
(E3) Continuous examination by the subject while waiting at the hotel.

Further, according to the virus inspection system Z according to the present embodiment, in addition to (E1) to (E3) described above, it can also be used for research analysis on an increase in the amount of virus in the body at a research institution.

In this embodiment, it is assumed that the viral load of the new coronavirus is tested, but the virus to be tested is not limited to the new coronavirus.

Further, the date and time of the next recommended measurement may be displayed on the test result display screen 220 shown in FIG. 10B.
The main unit 31 of the measuring device 3 and the sensor stick 32 may be able to communicate by proximity communication using RFID (Radio Frequency Identifier) or the like.
Furthermore, in the present embodiment, the sample is adhered to the sensor 322 after the sensor stick 32 is inserted into the main body 31, but the present invention is not limited to this. The sensor stick 32 may be inserted into the insertion portion 321 of the main body portion 31 after the sample is adhered to the sensor 322 .

1 server 2 user terminal (terminal device)
3, 3a measuring device (virus measuring device)
5 Medical institution 13 Storage device (storage unit)
23 input/output device (display)
31 main unit 32 sensor stick (sensor unit)
32A Cover part 32B Base material part 61 Sterile wipe stick (wipe stick)
62 container for storage and transport 63 sampling paper 64 nasal rinse 65 sampling paper 101 storage processing unit 102 transmission processing unit 103 update processing unit 104 user registration unit 105 user interface 111 measurement data 112 user data 113 signal level data (including threshold)
114 Sensor profile 210 Virus inspection start screen 211 User ID input window 212 Inspection content input window 213 Inspection enable button 220 Inspection result display screen 221 Inspection content display area 222 Measured value display area 223 Alarm type display area (warning is displayed)
230 infection status progress screen 312 insertion part 321 opening 322 sensor (electrochemical sensor)
201 Transmission/reception processing unit 202 Display processing unit 203 Location information acquisition unit 601 Specimen collection method (method for collecting nasopharyngeal swab, nasal swab, step of contacting the nasopharynx with a swab, step of contacting the swab with the nasal cavity, swab Step of immersing the rod in the solution, step of immersing the electrochemical sensor in the solution, fourth sampling method, fifth sampling method)
602 Specimen collection method (saliva collection method, saliva dripping step, saliva component adhering to electrochemical sensor, first collection method)
603 Specimen collection method (specimen collection method using nasal rinse, step of collecting nasal rinse, step of immersing electrochemical sensor in nasal rinse, third sampling method)
604 Specimen Collection Method (Method for Collecting Nasal Discharge, Step of Blowing Nose, Step of Adhering Nasal Discharge to Electrochemical Sensor, Second Collection Method)
611 collection bag 612 code G1 graph (time series of viral load)
L1 dashed line (threshold)
L2 dashed line (threshold)
L3 dashed line (threshold)
L4 dashed line (threshold)
R0 range R1 range R2 range R3 range R4 range S103 Measurement and transmission to user terminal (measurement step, transmission step)
S104 Send to server (send step)
S122 Store each information of the second measurement data (storage step)
S203 display (display step)
S304 display (display step)
Z virus inspection system

Claims (12)

a virus measuring device that measures the amount of virus in a sample;
a server that collects the amount of virus measured by the virus measurement device;
a terminal device that displays information about the measured virus load based on information transmitted from the server;
The virus measurement device is
having a body that can be separated from each other and a sensor that includes an electrochemical sensor capable of measuring the amount of virus,
A virus inspection system, wherein the amount of virus measured by the sensor unit is transmitted to the server via the main unit. The server has
A threshold based on the virus load collected in the past is stored,
2. The virus inspection system according to claim 1, wherein a warning based on said threshold is displayed on said terminal device. 2. The virus inspection system according to claim 1, wherein the terminal device displays a time series of the viral load measured multiple times by one subject. The virus inspection system according to any one of claims 1 to 3, wherein the virus whose viral load is to be measured is SARS-CoV-2. the virus load measured by the sensor unit is transmitted from the main unit to the server via the terminal device;
The terminal device
5. The method according to any one of claims 1 to 4, characterized in that after adding the location information of the terminal device to the virus load, the virus load to which the location information is added is transmitted to the server. virus inspection system. The virus inspection system according to any one of claims 1 to 5, wherein the amount of virus contained in the subject's saliva is measured by the electrochemical sensor. The virus inspection system according to any one of claims 1 to 5, wherein the amount of virus contained in nasal discharge of the subject is measured by the electrochemical sensor. The virus inspection system according to any one of claims 1 to 5, wherein the amount of virus contained in nasal rinse is measured by the electrochemical sensor. 6. The electrochemical sensor according to any one of claims 1 to 5, wherein the virus amount contained in a solution mixed with a nasopharyngeal swab sampled with a swab is measured by the electrochemical sensor. virus inspection system. 6. The electrochemical sensor according to any one of claims 1 to 5, wherein the amount of virus contained in a solution mixed with a nasal swab sampled with a swab is measured by the electrochemical sensor. virus detection system. a virus measuring device that measures the amount of virus in a sample;
a server that collects the amount of virus measured by the virus measurement device;
a terminal device that displays information about the measured virus load based on information transmitted from the server;
with
The virus measurement device is
a sensor unit comprising a main unit separable from each other and an electrochemical sensor capable of measuring the amount of virus,
a measurement step in which the sensor unit measures the amount of virus;
a sending step of sending the measured virus load from the sensor unit to the server via the main unit;
a storage step in which the server stores the received virus load in a storage unit;
a display step of displaying information about the virus load transmitted from the server on a display unit of the terminal device;
A virus inspection method characterized by executing A virus sample collection method using a measuring device having a body that can be separated from each other and a sensor that has an electrochemical sensor that can measure the amount of virus,
A first sampling method comprising the steps of: dripping saliva onto a sampling paper; and attaching components of saliva attached to the sampling paper to the electrochemical sensor;
A second sampling method comprising the steps of: blowing the nose using the sampling paper; and attaching nasal discharge adhered to the sampling paper to the electrochemical sensor;
A third collection method comprising the steps of: collecting nasal rinse fluid exhaled from the subject as a result of performing nasal rinse; and immersing the electrochemical sensor in the nasal rinse fluid;
A fourth collection method comprising the steps of: contacting the nasopharynx of the subject with a wipe; soaking the wipe in a solution; and soaking the electrochemical sensor in the solution;
A fifth collection method comprising the steps of: bringing a wipe into contact with the subject's nasal cavity; soaking the wipe in a solution; and soaking the electrochemical sensor in the solution;
A method for collecting a virus sample, characterized in that it is at least one method of collecting.

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