JP2023024968A5 - - Google Patents
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- JP2023024968A5 JP2023024968A5 JP2022161723A JP2022161723A JP2023024968A5 JP 2023024968 A5 JP2023024968 A5 JP 2023024968A5 JP 2022161723 A JP2022161723 A JP 2022161723A JP 2022161723 A JP2022161723 A JP 2022161723A JP 2023024968 A5 JP2023024968 A5 JP 2023024968A5
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- JP
- Japan
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024037011A JP2024102041A (ja) | 2016-07-05 | 2024-03-11 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16177973 | 2016-07-05 | ||
| EP16177973.1 | 2016-07-05 | ||
| PCT/EP2017/066845 WO2018007475A1 (en) | 2016-07-05 | 2017-07-05 | Pre-mrna splice switching or modulating oligonucleotides comprising bicyclic scaffold moieties, with improved characteristics for the treatment of genetic disorders |
| JP2018566905A JP7817791B2 (ja) | 2016-07-05 | 2017-07-05 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566905A Division JP7817791B2 (ja) | 2016-07-05 | 2017-07-05 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024037011A Division JP2024102041A (ja) | 2016-07-05 | 2024-03-11 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023024968A JP2023024968A (ja) | 2023-02-21 |
| JP2023024968A5 true JP2023024968A5 (https=) | 2023-03-02 |
Family
ID=56360269
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566905A Active JP7817791B2 (ja) | 2016-07-05 | 2017-07-05 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
| JP2022161723A Pending JP2023024968A (ja) | 2016-07-05 | 2022-10-06 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
| JP2024037011A Pending JP2024102041A (ja) | 2016-07-05 | 2024-03-11 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566905A Active JP7817791B2 (ja) | 2016-07-05 | 2017-07-05 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024037011A Pending JP2024102041A (ja) | 2016-07-05 | 2024-03-11 | 遺伝性障害の治療のための改善された特徴を有する二環式スキャフォールド部分を含むプレｍＲＮＡスプライススイッチング又は調節オリゴヌクレオチド |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20180028554A1 (https=) |
| EP (2) | EP4252845A3 (https=) |
| JP (3) | JP7817791B2 (https=) |
| KR (3) | KR102824513B1 (https=) |
| CN (2) | CN121271865A (https=) |
| AU (2) | AU2017291960B2 (https=) |
| BR (1) | BR112019000061A2 (https=) |
| CA (2) | CA3029772A1 (https=) |
| IL (3) | IL301091A (https=) |
| MX (2) | MX2018016253A (https=) |
| NZ (2) | NZ789904A (https=) |
| RU (2) | RU2022107926A (https=) |
| WO (1) | WO2018007475A1 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017004056A2 (pt) | 2014-09-12 | 2017-12-05 | Biogen Ma Inc | composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo |
| JP7511326B2 (ja) | 2015-10-09 | 2024-07-05 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物およびその方法 |
| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| US10941402B2 (en) | 2016-09-01 | 2021-03-09 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded RNA-editing oligonucleotides |
| EP3694530A4 (en) * | 2017-10-12 | 2021-06-30 | Wave Life Sciences Ltd. | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
| WO2019190927A2 (en) * | 2018-03-26 | 2019-10-03 | Duke University | Splice-switching oligonucleotides and methods of use |
| IL277889B2 (en) | 2018-04-12 | 2025-01-01 | Wave Life Sciences Ltd | Oligonucleotide preparations and methods of using them |
| EP3790596A4 (en) * | 2018-05-11 | 2022-04-06 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| US20220193250A1 (en) | 2018-08-02 | 2022-06-23 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| EP3829595A4 (en) | 2018-08-02 | 2022-08-24 | Dyne Therapeutics, Inc. | MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES |
| IL282818B1 (en) * | 2018-11-02 | 2026-04-01 | Biomarin Tech Bv | Bispecific antisense oligonucleotides for dystrophin exon skipping |
| SG11202105626TA (en) * | 2018-12-06 | 2021-06-29 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof |
| US12497615B2 (en) | 2019-04-25 | 2025-12-16 | Avidity Biosciences, Inc. | Nucleic acid compositions and methods of multi-exon skipping |
| WO2020252376A1 (en) * | 2019-06-13 | 2020-12-17 | Proqr Therapeutics Ii B.V. | Antisense rna editing oligonucleotides comprising cytidine analogs |
| US20220348917A1 (en) * | 2019-09-04 | 2022-11-03 | Exicure Operating Company | Liposomal spherical nucleic acid (sna) constructs for splice modulation |
| RU2738093C9 (ru) * | 2019-12-23 | 2020-12-29 | Общество с ограниченной ответственностью "Гелеспон" | Способ синтеза 2'-о-(2-метоксиэтил) тиофосфатного олигонуклеотида |
| CA3158528A1 (en) | 2019-12-23 | 2021-07-01 | Jim SWILDENS | Antisense oligonucleotides for nucleotide deamination in the treatment of stargardt disease |
| CR20220485A (es) | 2020-02-28 | 2022-11-10 | Ionis Pharmaceuticals Inc | Compuestos y métodos para modular smn2 |
| EP4222262A1 (en) * | 2020-09-30 | 2023-08-09 | BioMarin Technologies B.V. | Antisense oligonucleotides targeting the exon 51 of dystrophin gene |
| MX2023012559A (es) | 2021-04-30 | 2023-12-15 | Sarepta Therapeutics Inc | Métodos de tratamiento para la distrofia muscular. |
| IL309936A (en) | 2021-07-09 | 2024-03-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of dystrophinopathy |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| US20250154504A1 (en) | 2022-02-14 | 2025-05-15 | Proqr Therapeutics Ii B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
| JP2025509438A (ja) | 2022-03-17 | 2025-04-11 | サレプタ セラピューティクス， インコーポレイテッド | ホスホロジアミデートモルホリノオリゴマーコンジュゲート |
| US12071621B2 (en) | 2022-04-05 | 2024-08-27 | Avidity Biosciences, Inc. | Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping |
| CN115806984B (zh) * | 2022-10-18 | 2023-10-10 | 昆明理工大学 | 环状rna及载体和载体的应用 |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| AR131145A1 (es) | 2022-11-24 | 2025-02-19 | Proqr Therapeutics Ii Bv | Oligonucleótidos antisentido para el tratamiento de hemocromatosis hfe hereditaria |
| GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
| CA3276262A1 (en) | 2022-12-09 | 2024-06-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of cardiovascular disease |
| GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
| EP4669753A1 (en) | 2023-02-20 | 2025-12-31 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
| WO2024206175A1 (en) | 2023-03-24 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| AU2024246572A1 (en) | 2023-03-27 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2024256620A1 (en) | 2023-06-16 | 2024-12-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurodegenerative disease |
| WO2025051946A1 (en) | 2023-09-07 | 2025-03-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2025056035A1 (en) * | 2023-09-13 | 2025-03-20 | Edigene Therapeutics (Beijing) Inc. | Compositions and methods for treating duchenne muscular dystrophy |
| WO2025104239A1 (en) | 2023-11-16 | 2025-05-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of classic galactosemia |
| WO2025132708A1 (en) | 2023-12-20 | 2025-06-26 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of huntington's disease |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| GB202405143D0 (en) | 2024-04-11 | 2024-05-29 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of poly-q disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| GB202410081D0 (en) | 2024-07-11 | 2024-08-28 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of cardiovascular disease |
| WO2026022136A1 (en) | 2024-07-23 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2026060374A2 (en) | 2024-09-16 | 2026-03-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| WO2026068781A1 (en) | 2024-09-30 | 2026-04-02 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2026080897A1 (en) | 2024-10-11 | 2026-04-16 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of chronic pain |
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| US6683173B2 (en) | 1998-04-03 | 2004-01-27 | Epoch Biosciences, Inc. | Tm leveling methods |
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| CA2524255C (en) * | 2003-03-21 | 2014-02-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| ATE498685T1 (de) * | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
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| CN112251436A (zh) * | 2012-01-27 | 2021-01-22 | 比奥马林技术公司 | 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸 |
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-
2017
- 2017-07-05 CA CA3029772A patent/CA3029772A1/en active Pending
- 2017-07-05 IL IL301091A patent/IL301091A/en unknown
- 2017-07-05 EP EP23175111.6A patent/EP4252845A3/en active Pending
- 2017-07-05 JP JP2018566905A patent/JP7817791B2/ja active Active
- 2017-07-05 CA CA3273798A patent/CA3273798A1/en active Pending
- 2017-07-05 US US15/642,270 patent/US20180028554A1/en not_active Abandoned
- 2017-07-05 NZ NZ789904A patent/NZ789904A/en unknown
- 2017-07-05 RU RU2022107926A patent/RU2022107926A/ru unknown
- 2017-07-05 CN CN202511348833.1A patent/CN121271865A/zh active Pending
- 2017-07-05 RU RU2018144875A patent/RU2769249C2/ru active
- 2017-07-05 WO PCT/EP2017/066845 patent/WO2018007475A1/en not_active Ceased
- 2017-07-05 BR BR112019000061-5A patent/BR112019000061A2/pt active IP Right Grant
- 2017-07-05 NZ NZ749383A patent/NZ749383A/en unknown
- 2017-07-05 KR KR1020237041259A patent/KR102824513B1/ko active Active
- 2017-07-05 EP EP17739231.3A patent/EP3481955A1/en active Pending
- 2017-07-05 MX MX2018016253A patent/MX2018016253A/es unknown
- 2017-07-05 CN CN201780042013.7A patent/CN109757108A/zh active Pending
- 2017-07-05 KR KR1020197002990A patent/KR20190027373A/ko not_active Ceased
- 2017-07-05 KR KR1020237041258A patent/KR20230175312A/ko not_active Ceased
- 2017-07-05 AU AU2017291960A patent/AU2017291960B2/en active Active
-
2018
- 2018-12-19 MX MX2023006467A patent/MX2023006467A/es unknown
-
2019
- 2019-01-03 IL IL264084A patent/IL264084B2/en unknown
-
2022
- 2022-10-06 JP JP2022161723A patent/JP2023024968A/ja active Pending
-
2023
- 2023-03-06 US US18/179,064 patent/US20230330128A1/en active Pending
- 2023-06-27 AU AU2023204080A patent/AU2023204080B2/en active Active
-
2024
- 2024-03-11 JP JP2024037011A patent/JP2024102041A/ja active Pending
-
2025
- 2025-10-12 IL IL323882A patent/IL323882A/en unknown
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