|
US4880635B1
(en)
|
1984-08-08 |
1996-07-02 |
Liposome Company |
Dehydrated liposomes
|
|
US4921757A
(en)
|
1985-04-26 |
1990-05-01 |
Massachusetts Institute Of Technology |
System for delayed and pulsed release of biologically active substances
|
|
US5109113A
(en)
|
1986-05-02 |
1992-04-28 |
Genentech, Inc. |
Membrane anchor fusion polypeptides
|
|
US4920016A
(en)
|
1986-12-24 |
1990-04-24 |
Linear Technology, Inc. |
Liposomes with enhanced circulation time
|
|
JPH0825869B2
(ja)
|
1987-02-09 |
1996-03-13 |
株式会社ビタミン研究所 |
抗腫瘍剤包埋リポソ−ム製剤
|
|
US4911928A
(en)
|
1987-03-13 |
1990-03-27 |
Micro-Pak, Inc. |
Paucilamellar lipid vesicles
|
|
US4917951A
(en)
|
1987-07-28 |
1990-04-17 |
Micro-Pak, Inc. |
Lipid vesicles formed of surfactants and steroids
|
|
US5244797B1
(en)
|
1988-01-13 |
1998-08-25 |
Life Technologies Inc |
Cloned genes encoding reverse transcriptase lacking rnase h activity
|
|
US5223394A
(en)
|
1989-04-10 |
1993-06-29 |
Biogen, Inc. |
Recombinant dna molecule comprising lymphocyte function-associated antigen 3 phosphatidylinositol linkage signal sequence
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
WO1994013806A1
(en)
|
1992-12-11 |
1994-06-23 |
The Dow Chemical Company |
Multivalent single chain antibodies
|
|
GB9304239D0
(en)
*
|
1993-03-01 |
1993-04-21 |
British Bio Technology |
Viral particles
|
|
BR9400600A
(pt)
|
1994-02-17 |
1995-10-24 |
Finep Financiadora De Estudos |
Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos
|
|
AU2589095A
(en)
|
1994-05-16 |
1995-12-05 |
Washington University |
Cell membrane fusion composition and method
|
|
ATE388720T1
(de)
|
1997-04-10 |
2008-03-15 |
Univ Southern California |
Sich an extrazelluläre matrixbestandteile anbindende modifizierte proteine
|
|
US6136598A
(en)
*
|
1997-05-09 |
2000-10-24 |
Fred Hutchinson Cancer Research Center |
Mus dunni endogenous retroviral packaging cell lines
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
WO1999013905A1
(en)
|
1997-09-18 |
1999-03-25 |
The Trustees Of The University Of Pennsylvania |
Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery
|
|
US7994295B2
(en)
|
1997-12-22 |
2011-08-09 |
The University Of Tennessee Research Corporation |
Recombinant viruses comprising the membrane-proximal domain of VSV G protein
|
|
DE69942334D1
(de)
|
1998-03-02 |
2010-06-17 |
Massachusetts Inst Technology |
Poly-zinkfinger-proteine mit verbesserten linkern
|
|
FR2780069B1
(fr)
|
1998-06-23 |
2002-06-28 |
Inst Nat Sante Rech Med |
Famille de sequences nucleiques et de sequences proteiques deduites presentant des motifs retroviraux endogenes humains et leurs applications
|
|
ES2323744T3
(es)
|
1998-10-01 |
2009-07-23 |
University Of Southern California |
Sistema retroviral de suministro de genes y metodos de uso.
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US7030215B2
(en)
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US20030104526A1
(en)
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
GB9918680D0
(en)
|
1999-08-09 |
1999-10-13 |
Medical Res Council |
Polypeptide
|
|
ATE351916T1
(de)
|
1999-10-12 |
2007-02-15 |
Pasteur Institut |
Lentivirale triplex-dns, und vektoren und rekombinante zellen, die lentivirale triplex-dns enthalten
|
|
CA2392490A1
(en)
|
1999-11-24 |
2001-05-31 |
Mcs Micro Carrier Systems Gmbh |
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
|
|
AU2001262684A1
(en)
|
2000-06-01 |
2001-12-11 |
Dnavec Research Inc. |
Pseudo-type retrovirus vector containing membrane protein having hemagglutinin activity
|
|
JP5008244B2
(ja)
|
2000-06-23 |
2012-08-22 |
ワイス・ホールディングズ・コーポレイション |
野性型およびキメラのインフルエンザウイルス様粒子（ｖｌｐ）のアセンブリー
|
|
EP1201750A1
(en)
|
2000-10-26 |
2002-05-02 |
Genopoietic |
Synthetic viruses and uses thereof
|
|
US6395523B1
(en)
|
2001-06-01 |
2002-05-28 |
New England Biolabs, Inc. |
Engineering nicking endonucleases from type IIs restriction endonucleases
|
|
US7008669B2
(en)
|
2001-06-13 |
2006-03-07 |
Seiko Epson Corporation |
Ceramic and method of manufacturing the same, dielectric capacitor, semiconductor device, and element
|
|
US20040028687A1
(en)
|
2002-01-15 |
2004-02-12 |
Waelti Ernst Rudolf |
Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
|
|
EP1476547B1
(en)
|
2002-01-23 |
2006-12-06 |
The University of Utah Research Foundation |
Targeted chromosomal mutagenesis using zinc finger nucleases
|
|
US20030232410A1
(en)
|
2002-03-21 |
2003-12-18 |
Monika Liljedahl |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
|
AU2003258060B2
(en)
|
2002-03-27 |
2007-07-12 |
Baylor College Of Medicine |
Potent oncolytic herpes simplex virus for cancer therapy
|
|
US9045727B2
(en)
|
2002-05-17 |
2015-06-02 |
Emory University |
Virus-like particles, methods of preparation, and immunogenic compositions
|
|
EP2806025B1
(en)
|
2002-09-05 |
2019-04-03 |
California Institute of Technology |
Use of zinc finger nucleases to stimulate gene targeting
|
|
PL377161A1
(pl)
|
2002-11-21 |
2006-01-23 |
Pevion Biotech Ltd. |
Wysoce efektywne pęcherzyki fuzogenne, sposób ich wytwarzania oraz kompozycje farmaceutyczne zawierające te pęcherzyki
|
|
US20060153826A1
(en)
|
2003-01-28 |
2006-07-13 |
Sylvain Arnould |
Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
|
|
EP1651667B1
(en)
|
2003-04-04 |
2012-03-28 |
Centre National De La Recherche Scientifique |
Protein with fusogenic activity, nucleic acid sequences encoding said protein and pharmaceutical compositions comprising the same
|
|
US7011966B2
(en)
|
2003-04-16 |
2006-03-14 |
New England Biolabs, Inc. |
Method for cloning and expression of AcuI restriction endonuclease and AcuI methylase in E. coli
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US7842673B2
(en)
|
2003-12-17 |
2010-11-30 |
The Trustees Of Columbia University In The City Of New York |
Delivery of DNA or RNA via gap junctions from host cells to target cells and a cell-based delivery system for antisense or siRNA
|
|
WO2006033679A2
(en)
|
2004-05-25 |
2006-03-30 |
Chimeracore, Inc. |
Self-assembling nanoparticle drug delivery system
|
|
WO2006027202A1
(en)
|
2004-09-06 |
2006-03-16 |
Unite De Recherche En Biotherapie Et Oncologie (Rubio) |
Generation of multiparent cell hybrids
|
|
KR20070060115A
(ko)
|
2004-09-16 |
2007-06-12 |
상가모 바이오사이언스 인코포레이티드 |
단백질 생산을 위한 조성물 및 방법
|
|
US7998733B2
(en)
|
2004-10-05 |
2011-08-16 |
Merial Limited |
Chimeric vectors
|
|
GB0426641D0
(en)
*
|
2004-12-03 |
2005-01-05 |
Bioactive Protein Delivery The |
Protein delivery system
|
|
US9034650B2
(en)
|
2005-02-02 |
2015-05-19 |
Intrexon Corporation |
Site-specific serine recombinases and methods of their use
|
|
US8178291B2
(en)
|
2005-02-18 |
2012-05-15 |
Monogram Biosciences, Inc. |
Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
|
|
EP2327771A1
(en)
|
2005-03-15 |
2011-06-01 |
Cellectis |
I-crel meganuclease variants with modified specificity, method of preparation and uses thereof
|
|
CA2501301A1
(en)
*
|
2005-03-18 |
2006-09-18 |
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health |
Human endogenous foamy retrovirus and uses thereof
|
|
AU2006252406B2
(en)
|
2005-06-01 |
2012-05-17 |
California Institute Of Technology |
Method of targeted gene delivery using viral vectors
|
|
AU2006272634B2
(en)
|
2005-07-26 |
2013-01-24 |
Sangamo Therapeutics, Inc. |
Targeted integration and expression of exogenous nucleic acid sequences
|
|
US9783791B2
(en)
|
2005-08-10 |
2017-10-10 |
Agilent Technologies, Inc. |
Mutant reverse transcriptase and methods of use
|
|
JP4938263B2
(ja)
|
2005-08-19 |
2012-05-23 |
独立行政法人農業生物資源研究所 |
一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用
|
|
CA2891996A1
(en)
|
2005-10-18 |
2007-04-26 |
Duke University |
Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity
|
|
GB0526210D0
(en)
|
2005-12-22 |
2006-02-01 |
Oxford Biomedica Ltd |
Vectors
|
|
GB0526211D0
(en)
|
2005-12-22 |
2006-02-01 |
Oxford Biomedica Ltd |
Viral vectors
|
|
WO2007099387A1
(en)
|
2006-03-03 |
2007-09-07 |
Mymetics Corporation |
Virosome-like vesicles comprising gp41-derived antigens
|
|
WO2007107156A2
(en)
|
2006-03-17 |
2007-09-27 |
Aarhus Universitet |
Chimeric viral envelopes
|
|
US9085778B2
(en)
|
2006-05-03 |
2015-07-21 |
VL27, Inc. |
Exosome transfer of nucleic acids to cells
|
|
ZA200900379B
(en)
|
2006-07-21 |
2010-08-25 |
Univ California |
Human endogenous retrovirus polypeptide compositions and methods of use thereof
|
|
AU2007291936B2
(en)
|
2006-08-30 |
2012-09-27 |
Artes Biotechnology Gmbh |
Recombinant proteins and virus like particles comprising L and S polypeptides of avian hepadnaviridae and methods, nucleic acid constructs, vectors and host cells for producing same
|
|
WO2008110914A2
(en)
|
2007-03-15 |
2008-09-18 |
Inserm |
Methods for producing active scfv antibodies and libraries therefor
|
|
EP2136788B1
(en)
|
2007-03-30 |
2011-10-26 |
Bind Biosciences, Inc. |
Cancer cell targeting using nanoparticles
|
|
CA2683063A1
(en)
|
2007-04-09 |
2008-10-16 |
Chimeros, Inc. |
Self-assembling nanoparticle drug delivery system
|
|
EP2137300B1
(en)
|
2007-04-26 |
2011-10-26 |
Ramot at Tel-Aviv University Ltd. |
Pluripotent autologous stem cells from oral or gastrointestinal mucosa
|
|
US8703469B2
(en)
|
2007-07-06 |
2014-04-22 |
Boyce Thompson Institute For Plant Research |
Baculoviruses with enhanced virion production and a method for the production of baculoviruses
|
|
ES2708856T3
(es)
|
2007-08-03 |
2019-04-11 |
Pasteur Institut |
Vectores de transferencia de gen lentivírico y sus aplicaciones medicinales
|
|
EP2036980A1
(de)
|
2007-09-14 |
2009-03-18 |
Gruber, Jens |
Herabregulation der Genexpression mittels Nukleinsäure-beladener virusähnlicher Partikel
|
|
US20090203140A1
(en)
|
2007-09-27 |
2009-08-13 |
Sangamo Biosciences, Inc. |
Genomic editing in zebrafish using zinc finger nucleases
|
|
EP2297303A4
(en)
|
2008-04-29 |
2012-06-20 |
Brigham & Womens Hospital |
CELL MEMBRANE MANIPULATION
|
|
US9394531B2
(en)
|
2008-05-28 |
2016-07-19 |
Sangamo Biosciences, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
|
US9296790B2
(en)
|
2008-10-03 |
2016-03-29 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods and compositions for protein delivery
|
|
DE102008050860A1
(de)
|
2008-10-08 |
2010-04-15 |
Dorothee Von Laer |
LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virenproduzentenzellen zur Therapie von Tumoren
|
|
US8536121B2
(en)
|
2008-12-03 |
2013-09-17 |
Shanghai Institutes For Biological Sciences, Cas |
Methods and reagents for the diagnosis, prevention and treatment of insulin resistance using beta-arrestin2 and its up-regulators
|
|
US9791435B2
(en)
|
2009-01-09 |
2017-10-17 |
Centre National De La Recherche Scientifique |
Receptor binding ligands, their use in the detection of cells with biological interest
|
|
CA2753082A1
(en)
|
2009-02-20 |
2010-08-26 |
International Aids Vaccine Initiative |
Recombinant viral vectors
|
|
BRPI1009221A2
(pt)
|
2009-03-04 |
2016-03-15 |
Univ Texas |
proteínas de fusão transcriptase reversa estabilizadas.
|
|
JP2012520084A
(ja)
|
2009-03-13 |
2012-09-06 |
レンチゲン コーポレイション |
非組み込み型レトロウイルスベクターワクチン
|
|
EP3569254B1
(en)
|
2009-04-17 |
2022-07-20 |
Oxford University Innovation Limited |
Composition for delivery of genetic material
|
|
JP5667180B2
(ja)
|
2009-07-01 |
2015-02-12 |
イオン メディックス インコーポレイテッド |
哺乳類の有核細胞に由来するマイクロベシクル及びその用途
|
|
US8889394B2
(en)
|
2009-09-07 |
2014-11-18 |
Empire Technology Development Llc |
Multiple domain proteins
|
|
ES2693167T3
(es)
|
2009-11-13 |
2018-12-07 |
Inserm - Institut National De La Santé Et De La Recherche Médicale |
Administración directa de proteínas con microvesículas modificadas por ingeniería
|
|
EP2325322A1
(en)
|
2009-11-23 |
2011-05-25 |
4-Antibody AG |
Retroviral vector particles and methods for their generation and use
|
|
HUE041436T2
(hu)
|
2009-12-10 |
2019-05-28 |
Univ Minnesota |
Tal-effektor-közvetített DNS-módosítás
|
|
WO2011106376A2
(en)
|
2010-02-23 |
2011-09-01 |
The General Hospital Corporation |
Use of microvesicles in the treatment of medical conditions
|
|
US20130017210A1
(en)
|
2010-03-17 |
2013-01-17 |
Stc.Unm |
Display of antibody fragments on virus-like particles of rna bacteriophages
|
|
US20110311587A1
(en)
|
2010-06-04 |
2011-12-22 |
Pramila Walpita |
Fusogenic virus-like particles and uses thereof
|
|
WO2011159951A2
(en)
|
2010-06-17 |
2011-12-22 |
Sanford-Burnham Medical Research Institute |
Targeting tumor associated macrophages using bisphosphonate-loaded particles
|
|
US9458484B2
(en)
|
2010-10-22 |
2016-10-04 |
Bio-Rad Laboratories, Inc. |
Reverse transcriptase mixtures with improved storage stability
|
|
EP2691114A1
(en)
|
2011-03-29 |
2014-02-05 |
Principium Europe S.r.l. |
Delivery of large molecular weight biologically active substances
|
|
EP3617330B1
(en)
*
|
2011-04-01 |
2023-12-27 |
Genentech, Inc. |
Biomarkers for predicting sensitivity to cancer treatments
|
|
WO2012168307A2
(en)
|
2011-06-07 |
2012-12-13 |
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Improved recombination efficiency by inhibition of nhej dna repair
|
|
US10081684B2
(en)
|
2011-06-28 |
2018-09-25 |
Whitehead Institute For Biomedical Research |
Using sortases to install click chemistry handles for protein ligation
|
|
HK1199285A1
(en)
|
2011-08-12 |
2015-06-26 |
Virxsys Corporation |
Compositions and methods for inducing apoptosis
|
|
EP2761006B1
(en)
|
2011-09-28 |
2016-12-14 |
Zera Intein Protein Solutions, S.L. |
Split inteins and uses thereof
|
|
CN104080917B
(zh)
|
2011-09-29 |
2016-11-02 |
国家健康与医学研究院 |
用突变体BaEV糖蛋白假型化的慢病毒载体
|
|
EP2583974B1
(en)
|
2011-10-21 |
2017-04-26 |
Technische Universität Dresden |
Pseudotyping of foamy viruses
|
|
ES2874233T3
(es)
|
2011-11-11 |
2021-11-04 |
Variation Biotechnologies Inc |
Composiciones y métodos para el tratamiento de citomegalovirus
|
|
AU2012340213B2
(en)
|
2011-11-16 |
2017-12-07 |
Sangamo Therapeutics, Inc. |
Modified DNA-binding proteins and uses thereof
|
|
GB201121070D0
(en)
|
2011-12-07 |
2012-01-18 |
Isis Innovation |
composition for delivery of biotherapeutics
|
|
JP2015509085A
(ja)
|
2012-01-01 |
2015-03-26 |
キュービーアイ エンタープライゼズ リミテッドＱｂｉ Ｅｎｔｅｒｐｒｉｓｅｓ Ｌｔｄ． |
治療剤および診断剤の選択的送達のためのｅｎｄｏ１８０を標的とする粒子
|
|
US9528107B2
(en)
|
2012-01-31 |
2016-12-27 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for selection of nucleic acids
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
EP2636746A1
(en)
|
2012-03-06 |
2013-09-11 |
Life Science Inkubator |
A novel drug delivery system based on JCV-VLP
|
|
US9610346B2
(en)
|
2012-03-23 |
2017-04-04 |
International Aids Vaccine Initiative |
Recombinant viral vectors
|
|
EP3663395B1
(en)
|
2012-03-26 |
2024-07-31 |
The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology, Transfer, |
Delivery of packaged rna to mammalian cells
|
|
WO2013148327A1
(en)
|
2012-03-26 |
2013-10-03 |
The Regents Of The University Of California |
Nipah virus envelope psuedotyped lentiviruses and methods of their use
|
|
US9347065B2
(en)
|
2012-03-29 |
2016-05-24 |
International Aids Vaccine Initiative |
Methods to improve vector expression and genetic stability
|
|
AU2013243948A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins associated with human disease
|
|
DK3431497T3
(da)
|
2012-06-27 |
2022-10-10 |
Univ Princeton |
Spaltede inteiner, konjugater og anvendelser deraf
|
|
CA2877384C
(en)
|
2012-07-02 |
2023-05-09 |
Iprogen Biotech Inc. |
Intracellular protein delivery
|
|
US9181535B2
(en)
|
2012-09-24 |
2015-11-10 |
The Chinese University Of Hong Kong |
Transcription activator-like effector nucleases (TALENs)
|
|
WO2014055778A2
(en)
|
2012-10-03 |
2014-04-10 |
Agrivida, Inc. |
Multiprotein expression cassettes
|
|
JO3470B1
(ar)
|
2012-10-08 |
2020-07-05 |
Merck Sharp & Dohme |
مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
|
|
MX2015005505A
(es)
|
2012-10-30 |
2016-01-08 |
Redvax Gmbh |
Vacunas basadas en particular recombinantes contra la infeccion de citomegalovirus humano.
|
|
US8835149B2
(en)
*
|
2012-12-06 |
2014-09-16 |
Exxonmobil Research And Engineering Company |
DGAT genes comprising pleckstrin homology domains and methods of use for triglyceride production in recombinant microorganisms
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
DK2931898T3
(en)
*
|
2012-12-12 |
2016-06-20 |
Massachusetts Inst Technology |
CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
|
|
WO2014093718A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
WO2014134412A1
(en)
|
2013-03-01 |
2014-09-04 |
Regents Of The University Of Minnesota |
Talen-based gene correction
|
|
EP3608308B1
(en)
|
2013-03-08 |
2021-07-21 |
Novartis AG |
Lipids and lipid compositions for the delivery of active agents
|
|
US9504747B2
(en)
|
2013-03-08 |
2016-11-29 |
Novartis Ag |
Lipids and lipid compositions for the delivery of active agents
|
|
AU2014251388B2
(en)
|
2013-04-12 |
2017-03-30 |
Evox Therapeutics Limited |
Therapeutic delivery vesicles
|
|
US20140348754A1
(en)
|
2013-05-14 |
2014-11-27 |
California Institute Of Technology |
Method of Delivering Therapeutics and Imaging Agents to the Brain by Nanoparticles that Cross the Blood Brain Barrier
|
|
US9593356B2
(en)
|
2013-06-11 |
2017-03-14 |
Takara Bio Usa, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
MX2015017312A
(es)
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
WO2015038915A2
(en)
|
2013-09-12 |
2015-03-19 |
Apse, Llc |
Compositions and methods using capsids resistant to hydrolases
|
|
WO2015048566A1
(en)
|
2013-09-26 |
2015-04-02 |
The General Hospital Corporation |
Methods of isolating extracellular vesicles
|
|
US10538570B2
(en)
|
2013-09-30 |
2020-01-21 |
Northwestern University |
Targeted and modular exosome loading system
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
AU2014361781B2
(en)
|
2013-12-12 |
2021-04-01 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
|
|
ES2895651T3
(es)
|
2013-12-19 |
2022-02-22 |
Novartis Ag |
Lípidos y composiciones lipídicas para la administración de agentes activos
|
|
US10072273B2
(en)
|
2014-01-10 |
2018-09-11 |
Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Pseudotyped lentiviral vectors
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US20170173113A1
(en)
|
2014-03-13 |
2017-06-22 |
Research Institute At Nationwide Children's Hospital |
Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes
|
|
US20160051697A1
(en)
|
2014-04-07 |
2016-02-25 |
The Board Of Regents For Oklahoma State University |
Nanodelivery device for therapeutic loading of circulating erythrocytes
|
|
TWI686475B
(zh)
|
2014-04-29 |
2020-03-01 |
財團法人國家衛生研究院 |
對抗腸病毒感染之基於腺病毒載體之疫苗
|
|
WO2015171543A1
(en)
|
2014-05-05 |
2015-11-12 |
California Institute Of Technology |
Mutant akt-specific capture agents, compositions, and methods of using and making
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
WO2015191911A2
(en)
*
|
2014-06-12 |
2015-12-17 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US10583104B2
(en)
|
2014-08-06 |
2020-03-10 |
Indiana University Research And Technology Corporation |
Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis
|
|
WO2016037985A1
(en)
|
2014-09-08 |
2016-03-17 |
Ruprecht-Karls-Universität Heidelberg |
Construct for the delivery of a molecule into the cytoplasm of a cell
|
|
US10010607B2
(en)
|
2014-09-16 |
2018-07-03 |
Institut Curie |
Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune response
|
|
WO2016054326A1
(en)
|
2014-10-01 |
2016-04-07 |
The General Hospital Corporation |
Methods for increasing efficiency of nuclease-induced homology-directed repair
|
|
WO2016069774A1
(en)
|
2014-10-28 |
2016-05-06 |
Agrivida, Inc. |
Methods and compositions for stabilizing trans-splicing intein modified proteases
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
US10900034B2
(en)
|
2014-12-03 |
2021-01-26 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
|
KR102376244B1
(ko)
|
2014-12-24 |
2022-03-21 |
오토러스 리미티드 |
세포
|
|
WO2016131009A1
(en)
|
2015-02-13 |
2016-08-18 |
University Of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
US10501733B2
(en)
|
2015-02-27 |
2019-12-10 |
University Of Washington |
Polypeptide assemblies and methods for the production thereof
|
|
US12060391B2
(en)
|
2015-03-16 |
2024-08-13 |
The Broad Institute, Inc. |
Constructs for continuous monitoring of live cells
|
|
US10314906B2
(en)
|
2015-03-18 |
2019-06-11 |
University Of Massachusetts |
Virus-like particle compositions and vaccines against Epstein-Barr virus infection and disease
|
|
CN107624131B
(zh)
|
2015-05-15 |
2022-05-17 |
韦克塔里斯公司 |
包含至少两种衣壳化的非病毒rna的逆转录病毒颗粒
|
|
US20180177727A1
(en)
|
2015-06-10 |
2018-06-28 |
Board Of Regents, The University Of Texas System |
Use of exosomes for the treatment of disease
|
|
EP3929286A1
(en)
|
2015-06-17 |
2021-12-29 |
Poseida Therapeutics, Inc. |
Compositions and methods for directing proteins to specific loci in the genome
|
|
US10624849B2
(en)
|
2015-09-28 |
2020-04-21 |
Northwestern University |
Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites
|
|
EP3356520B1
(en)
|
2015-10-02 |
2022-03-23 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Lentiviral protein delivery system for rna-guided genome editing
|
|
EP3365437B1
(en)
|
2015-10-20 |
2025-06-04 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods and products for genetic engineering
|
|
WO2017068077A1
(en)
|
2015-10-20 |
2017-04-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
|
US20170112773A1
(en)
|
2015-10-23 |
2017-04-27 |
Board Of Regents, The University Of Texas System |
Plasma membrane vesicles comprising functional transmembrane proteins
|
|
JP7109784B2
(ja)
|
2015-10-23 |
2022-08-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
遺伝子編集のための進化したＣａｓ９蛋白質
|
|
US10316295B2
(en)
*
|
2015-12-17 |
2019-06-11 |
The Penn State Research Foundation |
Paramyxovirus virus-like particles as protein delivery vehicles
|
|
MX2018009904A
(es)
|
2016-02-15 |
2019-07-08 |
Univ Temple |
Escision de secuencias de acido nucleico retrovirales.
|
|
PL3265263T3
(pl)
|
2016-02-23 |
2019-06-28 |
Fronius International Gmbh |
Urządzenie spawalnicze z laserowym urządzeniem do wstępnego podgrzewania drutu dodatkowego
|
|
RU2018136151A
(ru)
|
2016-03-15 |
2020-04-15 |
Кодиак Байосайнсиз, Инк. |
Терапевтические мембранные везикулы
|
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
TWI773666B
(zh)
|
2016-03-30 |
2022-08-11 |
美商英特利亞醫療公司 |
Crispr/cas 組分之脂質奈米粒子調配物
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
EP3235828A1
(en)
|
2016-04-21 |
2017-10-25 |
Genethon |
Stable pseudotyped lentiviral particles and uses thereof
|
|
EP3235908A1
(en)
|
2016-04-21 |
2017-10-25 |
Ecole Normale Superieure De Lyon |
Methods for selectively modulating the activity of distinct subtypes of cells
|
|
AU2017263138B2
(en)
|
2016-05-13 |
2022-08-25 |
Flash Therapeutics |
Viral particle for RNA transfer, especially into cells involved in immune response
|
|
DK3455239T3
(da)
|
2016-05-13 |
2021-07-05 |
Flash Therapeutics |
Partikel til indkapsling af et genomteknisk system
|
|
GB201609216D0
(en)
|
2016-05-25 |
2016-07-06 |
Evox Therapeutics And Isis Innovation Ltd |
Exosomes comprising therapeutic polypeptides
|
|
GB201610041D0
(en)
|
2016-06-08 |
2016-07-20 |
Oxford Genetics Ltd |
Methods
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US10337051B2
(en)
|
2016-06-16 |
2019-07-02 |
The Regents Of The University Of California |
Methods and compositions for detecting a target RNA
|
|
GB2552460A
(en)
|
2016-07-11 |
2018-01-31 |
Evox Therapeutics Ltd |
CPP-Mediated EV Loading
|
|
GB2552301A
(en)
|
2016-07-11 |
2018-01-24 |
Evox Therapeutics Ltd |
Metabolic drug loading of EVs
|
|
GB2552473A
(en)
*
|
2016-07-21 |
2018-01-31 |
Evox Therapeutics Ltd |
Surface decoration of extracellular vesicles
|
|
EP3275462A1
(en)
|
2016-07-27 |
2018-01-31 |
Fundació Privada Institut de Recerca de la SIDA-Caixa |
Virus-like particles with high-density coating for the production of neutralizing antibodies
|
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
CN110312799A
(zh)
|
2016-08-17 |
2019-10-08 |
博德研究所 |
新型crispr酶和系统
|
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US10576167B2
(en)
|
2016-08-17 |
2020-03-03 |
Factor Bioscience Inc. |
Nucleic acid products and methods of administration thereof
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US9580698B1
(en)
|
2016-09-23 |
2017-02-28 |
New England Biolabs, Inc. |
Mutant reverse transcriptase
|
|
US11730823B2
(en)
|
2016-10-03 |
2023-08-22 |
President And Fellows Of Harvard College |
Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles
|
|
US20180245065A1
(en)
|
2016-11-01 |
2018-08-30 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
|
JP7231226B2
(ja)
*
|
2016-11-07 |
2023-03-01 |
ユニバーシティ オブ マサチューセッツ |
顔面肩甲上腕型筋ジストロフィーのための治療標的
|
|
EP3540056A4
(en)
|
2016-11-10 |
2020-06-03 |
Kaneka Corporation |
METHOD FOR PRODUCING TRANSGENIC CELLS
|
|
AU2017374044B2
(en)
|
2016-12-08 |
2023-11-30 |
Intellia Therapeutics, Inc. |
Modified guide RNAs
|
|
US11192929B2
(en)
|
2016-12-08 |
2021-12-07 |
Regents Of The University Of Minnesota |
Site-specific DNA base editing using modified APOBEC enzymes
|
|
US11666603B2
(en)
|
2016-12-23 |
2023-06-06 |
Exopharm Limited |
Methods and compositions for purification or isolation of microvesicles and exosomes
|
|
GB201702863D0
(en)
|
2017-02-22 |
2017-04-05 |
Evox Therapeutics Ltd |
Improved loading of EVs with therapeutic proteins
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
US12350368B2
(en)
|
2017-04-14 |
2025-07-08 |
The Broad Institute, Inc. |
Delivery of large payloads
|
|
AU2018266111B2
(en)
|
2017-05-08 |
2024-11-07 |
Flagship Pioneering Innovations V, Inc. |
Compositions for facilitating membrane fusion and uses thereof
|
|
CA3062614A1
(en)
|
2017-05-10 |
2018-11-15 |
University Of Utah Research Foundation |
Compositions and methods of use of arc capsids
|
|
US20200172895A1
(en)
|
2017-05-25 |
2020-06-04 |
The General Hospital Corporation |
Using split deaminases to limit unwanted off-target base editor deamination
|
|
CA3065946A1
(en)
|
2017-06-05 |
2018-12-13 |
Research Institute At Nationwide Children's Hospital |
Enhanced modified viral capsid proteins
|
|
IL271275B1
(en)
|
2017-06-13 |
2026-04-01 |
Flagship Pioneering Innovations V Inc |
Preparations containing croons and their uses
|
|
WO2018234576A1
(en)
|
2017-06-22 |
2018-12-27 |
Institut Gustave Roussy |
HUMAN ENDOGENOUS RETROVIRAL PROTEIN
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
US20200206360A1
(en)
|
2017-08-17 |
2020-07-02 |
Ilias Biologics Inc. |
Exosomes for target specific delivery and methods for preparing and delivering the same
|
|
AU2018322831B2
(en)
|
2017-09-01 |
2023-04-27 |
Inprother Aps |
A vaccine for use in the prophylaxis and/or treatment of a disease
|
|
PT3688162T
(pt)
|
2017-09-29 |
2024-04-23 |
Intellia Therapeutics Inc |
Formulações
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
JP7208231B2
(ja)
*
|
2017-10-20 |
2023-01-18 |
ジェネトン |
肺組織への標的化薬物及び遺伝子送達のためのシンシチンの使用
|
|
CA3079215A1
(en)
|
2017-10-24 |
2019-05-02 |
Magenta Therapeutics, Inc. |
Compositions and methods for the depletion of cd117+ cells
|
|
GB201717446D0
(en)
|
2017-10-24 |
2017-12-06 |
Evox Therapeutics Ltd |
Affinity purification of engineering extracellular vesicles
|
|
FR3072973B1
(fr)
|
2017-10-26 |
2022-02-11 |
Univ Pierre Et Marie Curie Paris 6 |
Particules pseudo-virales utiles pour traiter des dysfonctionnements immunitaires
|
|
JP2021503278A
(ja)
|
2017-11-01 |
2021-02-12 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
ＣａｓＺ組成物及び使用方法
|
|
WO2019089808A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Class 2 crispr/cas compositions and methods of use
|
|
US20210187018A1
(en)
|
2017-12-07 |
2021-06-24 |
Flagship Pioneering Innovations V, Inc. |
Cytobiologics and therapeutic uses thereof
|
|
US20210163933A1
(en)
|
2017-12-11 |
2021-06-03 |
University Of Massachusetts |
Arc protein extracellular vesicle nucleic acid delivery platform
|
|
US11660355B2
(en)
|
2017-12-20 |
2023-05-30 |
Cedars-Sinai Medical Center |
Engineered extracellular vesicles for enhanced tissue delivery
|
|
WO2019126774A1
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
GB201802163D0
(en)
|
2018-02-09 |
2018-03-28 |
Evox Therapeutics Ltd |
Compositions for EV storage and formulation
|
|
CA3091478A1
(en)
|
2018-02-17 |
2019-08-22 |
Flagship Pioneering Innovations V, Inc. |
Compositions and methods for membrane protein delivery
|
|
GB201804291D0
(en)
|
2018-03-16 |
2018-05-02 |
Evox Therapeutics Ltd |
Cell-mediated exosome delivery
|
|
CN112218621A
(zh)
|
2018-04-10 |
2021-01-12 |
西北大学 |
包含基于靶向亲和域的膜蛋白的胞外囊泡
|
|
WO2019213257A1
(en)
|
2018-05-01 |
2019-11-07 |
Wake Forest University Health Sciences |
Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
|
|
AU2019266327B2
(en)
|
2018-05-11 |
2025-11-06 |
Beam Therapeutics Inc. |
Methods of editing single nucleotide polymorphism using programmable base editor systems
|
|
JP7558929B2
(ja)
|
2018-05-11 |
2024-10-01 |
ビーム セラピューティクス インク． |
プログラム可能塩基エディターシステムを用いて病原性変異を抑制する方法
|
|
AU2019269593A1
(en)
|
2018-05-15 |
2020-11-26 |
Flagship Pioneering Innovations V, Inc. |
Fusosome compositions and uses thereof
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
EP3820509A1
(en)
|
2018-07-09 |
2021-05-19 |
Flagship Pioneering Innovations V, Inc. |
Fusosome compositions and uses thereof
|
|
WO2020012335A1
(en)
|
2018-07-10 |
2020-01-16 |
Alia Therapeutics S.R.L. |
Vesicles for traceless delivery of guide rna molecules and/or guide rna molecule/rna-guided nuclease complex(es) and a production method thereof
|
|
WO2020013317A1
(ja)
|
2018-07-13 |
2020-01-16 |
国立大学法人京都大学 |
ウイルス様粒子及びその使用
|
|
AU2019314208A1
(en)
|
2018-08-02 |
2021-02-18 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
AU2019316094B2
(en)
|
2018-08-03 |
2026-02-19 |
Beam Therapeutics Inc. |
Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
|
|
EP3841203A4
(en)
|
2018-08-23 |
2022-11-02 |
The Broad Institute Inc. |
CAS9 VARIANTS WITH NON-CANONICAL PAM SPECIFICITIES AND THEIR USES
|
|
CN113286880A
(zh)
|
2018-08-28 |
2021-08-20 |
旗舰先锋创新Vi有限责任公司 |
调控基因组的方法和组合物
|
|
US20240173430A1
(en)
|
2018-09-05 |
2024-05-30 |
The Broad Institute, Inc. |
Base editing for treating hutchinson-gilford progeria syndrome
|
|
KR20210055733A
(ko)
|
2018-09-07 |
2021-05-17 |
빔 테라퓨틱스, 인크. |
핵염기 편집 시스템을 전달하기 위한 조성물 및 방법
|
|
EP3850088A4
(en)
|
2018-09-07 |
2023-07-19 |
Beam Therapeutics, Inc. |
Compositions and methods for improving base editing
|
|
JP7344300B2
(ja)
|
2018-09-18 |
2023-09-13 |
ブイエヌブイ ニューコ インク． |
Ａｒｃベースのカプシドおよびその使用
|
|
US20210403907A1
(en)
|
2018-09-18 |
2021-12-30 |
Vnv Newco Inc. |
Arc-based capsids and uses thereof
|
|
WO2020069463A1
(en)
|
2018-09-28 |
2020-04-02 |
The Regents Of The University Of California |
Ligand-directed targeting vectors
|
|
SG11202103317XA
(en)
|
2018-10-17 |
2021-05-28 |
Senti Biosciences Inc |
Combinatorial cancer immunotherapy
|
|
AU2019362064A1
(en)
|
2018-10-19 |
2021-05-20 |
Ohio State Innovation Foundation |
Extracellular vesicles for targeted therapies against myeloid-derived suppressor cells
|
|
AU2019365100B2
(en)
|
2018-10-22 |
2025-10-09 |
University Of Rochester |
Genome editing by directed non-homologous DNA insertion using a retroviral integrase-Cas9 fusion protein
|
|
WO2020086908A1
(en)
|
2018-10-24 |
2020-04-30 |
The Broad Institute, Inc. |
Constructs for improved hdr-dependent genomic editing
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
SG11202105079QA
(en)
|
2018-11-14 |
2021-06-29 |
Flagship Pioneering Innovations V Inc |
Fusosome compositions for cns delivery
|
|
WO2020102503A2
(en)
|
2018-11-14 |
2020-05-22 |
Flagship Pioneering Innovations V, Inc. |
Fusosome compositions for t cell delivery
|
|
EP3880832A1
(en)
|
2018-11-14 |
2021-09-22 |
Flagship Pioneering Innovations V, Inc. |
Fusosome compositions for hematopoietic stem cell delivery
|
|
US12496274B2
(en)
|
2018-11-14 |
2025-12-16 |
Flagship Pioneering Innovations V, Inc. |
Compositions and methods for compartment-specific cargo delivery
|
|
US20220282275A1
(en)
|
2018-11-15 |
2022-09-08 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
|
WO2020102709A1
(en)
|
2018-11-16 |
2020-05-22 |
The Regents Of The University Of California |
Compositions and methods for delivering crispr/cas effector polypeptides
|
|
SG11202106931PA
(en)
|
2018-12-27 |
2021-07-29 |
Verimmune Llc |
Conjugated virus-like particles and uses thereof as anti-tumor immune redirectors
|
|
US20220194990A1
(en)
|
2019-01-31 |
2022-06-23 |
Board Of Regents Of The University Of Nebraska |
Virus-like particles and methods of use thereof
|
|
WO2020160481A1
(en)
|
2019-02-01 |
2020-08-06 |
The General Hospital Corporation |
Targetable 3'-overhang nuclease fusion proteins
|
|
MX2021009337A
(es)
|
2019-02-04 |
2021-10-13 |
Codiak Biosciences Inc |
Cadenas principales de proteínas de la membrana para la modificación genética de exosomas.
|
|
WO2020180975A1
(en)
|
2019-03-04 |
2020-09-10 |
President And Fellows Of Harvard College |
Highly multiplexed base editing
|
|
CA3130789A1
(en)
|
2019-03-07 |
2020-09-10 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
US20200347100A1
(en)
|
2019-03-15 |
2020-11-05 |
The Broad Institute, Inc. |
Non-naturally occurring capsids for delivery of nucleic acids and/or proteins
|
|
JP7657726B2
(ja)
|
2019-03-19 |
2025-04-07 |
ザ ブロード インスティテュート，インコーポレーテッド |
編集ヌクレオチド配列を編集するための方法および組成物
|
|
EP3715453A1
(en)
|
2019-03-26 |
2020-09-30 |
Johann Wolfgang Goethe-Universität Frankfurt |
Methods and products for a safe and efficient transduction of gene editing components
|
|
US20220195514A1
(en)
|
2019-03-29 |
2022-06-23 |
The Broad Institute, Inc. |
Construct for continuous monitoring of live cells
|
|
US20220204975A1
(en)
|
2019-04-12 |
2022-06-30 |
President And Fellows Of Harvard College |
System for genome editing
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US20220184225A1
(en)
|
2019-04-23 |
2022-06-16 |
Case Western Reserve University |
Fusogenic particles and related methods for delivering therapeutic agents to cells
|
|
WO2020225287A1
(en)
|
2019-05-06 |
2020-11-12 |
Veterinärmedizinische Universität Wien |
Lentiviral nanoparticles
|
|
WO2020252455A1
(en)
|
2019-06-13 |
2020-12-17 |
The General Hospital Corporation |
Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
|
|
GB201910651D0
(en)
|
2019-07-25 |
2019-09-11 |
Autolus Ltd |
Virus-like particle
|
|
US11401530B2
(en)
|
2019-08-19 |
2022-08-02 |
The Catholic University Of America |
Bacteriophage-based artificial viruses for human genome remodeling
|
|
CA3152861A1
(en)
|
2019-08-29 |
2021-03-04 |
Beam Therapeutics Inc. |
Compositions and methods for editing a mutation to permit transcription or expression
|
|
AU2020341454A1
(en)
|
2019-09-03 |
2022-03-10 |
Sana Biotechnology, Inc. |
CD24-associated particles and related methods and uses thereof
|
|
CA3153700A1
(en)
|
2019-09-09 |
2021-03-18 |
Scribe Therapeutics Inc. |
Compositions and methods for use in immunotherapy
|
|
EP4028514A1
(en)
|
2019-09-09 |
2022-07-20 |
Beam Therapeutics Inc. |
Novel crispr enzymes, methods, systems and uses thereof
|
|
CN115175996A
(zh)
|
2019-09-20 |
2022-10-11 |
博德研究所 |
新颖vi型crispr酶和系统
|
|
CN114616336B
(zh)
|
2019-09-20 |
2025-11-14 |
博德研究所 |
用于将货物递送至靶细胞的组合物和方法
|
|
KR20220108036A
(ko)
|
2019-09-26 |
2022-08-02 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
최소 아레스틴 도메인 함유 단백질 1 (arrdc1) 구축물
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
GB201915855D0
(en)
|
2019-10-31 |
2019-12-18 |
Univ Oxford Innovation Ltd |
An extracellular vesicle
|
|
US20240125764A1
(en)
|
2019-11-08 |
2024-04-18 |
The Regents Of The University Of California |
Compositions and methods for temporal control of cell modulation
|
|
US20230040216A1
(en)
|
2019-11-19 |
2023-02-09 |
The Broad Institute, Inc. |
Retrotransposons and use thereof
|
|
US20230086199A1
(en)
|
2019-11-26 |
2023-03-23 |
The Broad Institute, Inc. |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
|
EP4069838A1
(en)
|
2019-12-03 |
2022-10-12 |
Beam Therapeutics Inc. |
Synthetic guide rna, compositions, methods, and uses thereof
|
|
AU2020398658A1
(en)
|
2019-12-06 |
2022-07-07 |
Scribe Therapeutics Inc. |
Particle delivery systems
|
|
CA3171066A1
(en)
|
2020-03-11 |
2021-09-16 |
Saar GILL |
Methods and composition for gene delivery using an engineered viral particle
|
|
AU2021236391A1
(en)
|
2020-03-13 |
2022-09-29 |
Capricor, Inc. |
Exosomal nucleic acid vaccine modularly configured to harness multiple antigen presentation mechanisms
|
|
CA3171143A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Targeted delivery of extracellular vesicles
|
|
US20230174598A1
(en)
|
2020-03-18 |
2023-06-08 |
University Of Florida Research Foundation, Incorporated |
Modified arrestin-1 to enhance photoreceptor survival in retinal disease
|
|
AU2021236683A1
(en)
|
2020-03-19 |
2022-11-17 |
Intellia Therapeutics, Inc. |
Methods and compositions for directed genome editing
|
|
WO2021188996A1
(en)
|
2020-03-20 |
2021-09-23 |
The Broad Institute, Inc. |
Compositions and methods for enhanced lentiviral production
|
|
JP2023521663A
(ja)
|
2020-03-31 |
2023-05-25 |
サナ バイオテクノロジー，インコーポレイテッド |
標的化脂質粒子及び組成物ならびにその使用
|
|
CA3176495A1
(en)
|
2020-04-27 |
2021-11-04 |
Aruna Bio, Inc. |
Binding agents and uses thereof for central nervous system delivery
|
|
WO2021222318A1
(en)
|
2020-04-28 |
2021-11-04 |
The Broad Institute, Inc. |
Targeted base editing of the ush2a gene
|
|
CA3176046A1
(en)
|
2020-05-04 |
2021-11-11 |
Michael C. BASSIK |
Compositions, systems, and methods for the generation, identification, and characterization of effector domains for activating and silencing gene expression
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
US11129892B1
(en)
|
2020-05-18 |
2021-09-28 |
Vnv Newco Inc. |
Vaccine compositions comprising endogenous Gag polypeptides
|
|
EP4164694A4
(en)
|
2020-06-12 |
2025-01-22 |
President and Fellows of Harvard College |
ARRDC1-MEDIATED MICROVESICLE-BASED DELIVERY TO THE NERVOUS SYSTEM
|
|
JP2023531506A
(ja)
|
2020-06-23 |
2023-07-24 |
ザ ジェネラル ホスピタル コーポレイション |
トンネルナノチューブ細胞および生体分子の送達のためのその使用方法
|
|
IL299658A
(en)
|
2020-07-06 |
2023-03-01 |
Flagship Pioneering Innovations V Inc |
Methods and compositions for the production of viral phosomes
|
|
EP4185600A4
(en)
|
2020-07-24 |
2024-12-04 |
The General Hospital Corporation |
Enhanced virus-like particles and methods of use thereof for delivery to cells
|
|
MX2023001164A
(es)
|
2020-07-29 |
2023-09-15 |
Univ America Catholic |
Diseño de virus artificiales a base de bacteriofagos para la remodelación del genoma humano.
|
|
EP4217490A2
(en)
|
2020-09-24 |
2023-08-02 |
The Broad Institute Inc. |
Prime editing guide rnas, compositions thereof, and methods of using the same
|
|
CA3094859A1
(en)
|
2020-10-01 |
2022-04-01 |
Entos Pharmaceuticals Inc. |
Proteolipid vesicles formulated with fusion associated small transmembrane proteins
|
|
WO2022081987A1
(en)
|
2020-10-16 |
2022-04-21 |
President And Fellows Of Harvard College |
Ww-domain-activated extracellular vesicles
|
|
CA3195463A1
(en)
|
2020-10-16 |
2022-04-21 |
President And Fellows Of Harvard College |
Ww-domain-activated extracellular vesicles targeting coronaviruses
|
|
JP2023546156A
(ja)
|
2020-10-16 |
2023-11-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
Ｈｉｖを標的にするｗｗドメイン活性化細胞外ベシクル
|
|
EP4232583A1
(en)
|
2020-10-21 |
2023-08-30 |
Massachusetts Institute of Technology |
Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
|
|
IL302568A
(en)
|
2020-11-04 |
2023-07-01 |
Senti Biosciences Inc |
Protein payload release
|
|
CA3196996A1
(en)
|
2020-11-19 |
2022-05-27 |
Baisong Lu |
Vectors, systems and methods for eukaryotic gene editing
|
|
WO2022119957A1
(en)
|
2020-12-02 |
2022-06-09 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
US20240052331A1
(en)
|
2020-12-18 |
2024-02-15 |
The Board Institute, Inc. |
Evolution of botulinum neurotoxin proteases
|
|
EP4274901A1
(en)
|
2021-01-11 |
2023-11-15 |
Sana Biotechnology, Inc. |
Use of cd8-targeted viral vectors
|
|
US20240102052A1
(en)
|
2021-01-27 |
2024-03-28 |
Vnv Newco Inc. |
Pnma2-based capsids and uses thereof
|
|
US20240084330A1
(en)
|
2021-01-28 |
2024-03-14 |
The Broad Institute, Inc. |
Compositions and methods for delivering cargo to a target cell
|
|
US20240132916A1
(en)
|
2021-02-09 |
2024-04-25 |
The Broad Institute, Inc. |
Nuclease-guided non-ltr retrotransposons and uses thereof
|
|
US20220287968A1
(en)
|
2021-03-09 |
2022-09-15 |
Florida State University Research Foundation, Inc. |
Lipid vesicle-mediated delivery to cells
|
|
IL307544A
(en)
|
2021-04-08 |
2023-12-01 |
Sana Biotechnology Inc |
Cd8-specific antibody constructs and compositions thereof
|
|
JP2024515886A
(ja)
|
2021-04-30 |
2024-04-10 |
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア |
幹細胞に対して脂質ナノ粒子治療薬を標的化するための組成物及び方法
|
|
AU2022280957A1
(en)
|
2021-05-28 |
2023-11-30 |
Sana Biotechnology, Inc. |
Lipid particles containing a truncated baboon endogenous retrovirus (baev) envelope glycoprotein and related methods and uses
|
|
US12565647B2
(en)
|
2021-05-28 |
2026-03-03 |
The Regents Of The University Of California |
Compositions and methods for targeted delivery of CRISPR-Cas effector polypeptides and transgenes
|
|
WO2022261150A2
(en)
|
2021-06-09 |
2022-12-15 |
Scribe Therapeutics Inc. |
Particle delivery systems
|
|
WO2022261148A1
(en)
|
2021-06-09 |
2022-12-15 |
Scribe Therapeutics Inc. |
Compositions of glycoprotein particles
|
|
WO2023015217A1
(en)
|
2021-08-04 |
2023-02-09 |
Sana Biotechnology, Inc. |
Use of cd4-targeted viral vectors
|
|
WO2023023055A1
(en)
|
2021-08-16 |
2023-02-23 |
Renagade Therapeutics Management Inc. |
Compositions and methods for optimizing tropism of delivery systems for rna
|
|
WO2023076898A1
(en)
|
2021-10-25 |
2023-05-04 |
The Broad Institute, Inc. |
Methods and compositions for editing a genome with prime editing and a recombinase
|
|
US20250230511A1
(en)
|
2021-10-29 |
2025-07-17 |
Sana Biotechnology, Inc. |
Methods and reagents for amplifying viral vector nucleic acid products
|
|
KR20240099393A
(ko)
|
2021-11-01 |
2024-06-28 |
톰 바이오사이언시스, 인코포레이티드 |
유전자 편집 기구와 핵산 카고의 동시 전달을 위한 단일 작제물 플랫폼
|
|
EP4441073A2
(en)
|
2021-12-03 |
2024-10-09 |
The Broad Institute, Inc. |
Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same
|
|
WO2023102538A1
(en)
|
2021-12-03 |
2023-06-08 |
The Broad Institute, Inc. |
Self-assembling virus-like particles for delivery of prime editors and methods of making and using same
|
|
US20250223584A2
(en)
|
2021-12-03 |
2025-07-10 |
The Broad Institute, Inc. |
Compositions and methods for efficient in vivo delivery
|
|
AU2022407531A1
(en)
|
2021-12-09 |
2024-06-20 |
Vesigen, Inc. |
Arrdc1-mediated microvesicles (armms) degrading system and uses thereof
|
|
US20250059560A1
(en)
|
2021-12-16 |
2025-02-20 |
Sana Biotechnology, Inc. |
Methods and systems of particle production
|
|
EP4448775A1
(en)
|
2021-12-17 |
2024-10-23 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
WO2023122764A1
(en)
|
2021-12-22 |
2023-06-29 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
GB202118946D0
(en)
|
2021-12-23 |
2022-02-09 |
Evox Therapeutics Ltd |
Engineered extracellular vesicles with improved cargo delivery
|
|
WO2023129993A2
(en)
|
2021-12-29 |
2023-07-06 |
Intima Bioscience, Inc. |
Antigen delivery platform and methods of use
|
|
WO2023133425A1
(en)
|
2022-01-04 |
2023-07-13 |
The Broad Institute, Inc. |
Compositions and methods for delivering cargo to a target cell
|
|
EP4460574A4
(en)
|
2022-01-04 |
2026-01-14 |
Broad Inst Inc |
COMPOSITIONS AND METHODS OF CARGO ADMINISTRATION TO A TARGET CELL
|
|
WO2023173028A2
(en)
|
2022-03-09 |
2023-09-14 |
The Regents Of The University Of Colorado A Body Corporate |
Tissue and cell-type specific delivery of therapeutic molecules incorporating viral and human fusiogenic proteins
|
|
WO2023173140A2
(en)
|
2022-03-11 |
2023-09-14 |
President And Fellows Of Harvard College |
Targeted delivery of armms
|
|
EP4511486A1
(en)
|
2022-04-20 |
2025-02-26 |
Massachusetts Institute Of Technology |
Site specific genetic engineering utilizing trans-template rnas
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
EP4511487A1
(en)
|
2022-04-20 |
2025-02-26 |
Massachusetts Institute Of Technology |
Programmable gene editing using guide rna pair
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
CN120303407A
(zh)
|
2022-05-17 |
2025-07-11 |
恩维洛普治疗有限责任公司 |
用于有效体内递送的组合物和方法
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
WO2023230498A1
(en)
|
2022-05-25 |
2023-11-30 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for rna-guided rna-targeting crispr effectors with cas7-11 variants
|
|
EP4532713A1
(en)
|
2022-05-27 |
2025-04-09 |
Beam Therapeutics Inc. |
Identification of nanoparticles for preferential tissue or cell targeting
|
|
WO2023240027A1
(en)
|
2022-06-07 |
2023-12-14 |
Scribe Therapeutics Inc. |
Particle delivery systems
|
|
WO2023240124A1
(en)
|
2022-06-07 |
2023-12-14 |
Regeneron Pharmaceuticals, Inc. |
Pseudotyped viral particles for targeting tcr-expressing cells
|
|
WO2023245134A2
(en)
|
2022-06-15 |
2023-12-21 |
Vesigen, Inc. |
Arrdc1-mediated micro vesicle-based delivery of therapeutic agents to cells of the peripheral nervous system
|
|
WO2024006988A2
(en)
|
2022-06-30 |
2024-01-04 |
The Broad Institute, Inc. |
Engineered delivery vesicles and uses thereof
|
|
EP4558128A1
(en)
|
2022-07-21 |
2025-05-28 |
Institut National de la Santé et de la Recherche Médicale |
Extracellular vesicles functionalized with an erv syncitin and uses thereof for cargo delivery
|
|
GB202210861D0
(en)
|
2022-07-25 |
2022-09-07 |
Univ Oxford Innovation Ltd |
Loaded extracellular vesicle
|
|
WO2024026295A1
(en)
|
2022-07-27 |
2024-02-01 |
Aera Therapeutics, Inc. |
Endogenous gag-based and pnma family capsids and uses thereof
|
|
US20260055146A1
(en)
|
2022-08-24 |
2026-02-26 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
EP4580647A1
(en)
|
2022-08-31 |
2025-07-09 |
The Broad Institute, Inc. |
Gtp cyclohydrolase-cleaving proteases
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
WO2024107959A1
(en)
|
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|
|
US20240191256A1
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|
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|
|
US20240189247A1
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|
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|
|
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|
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|