JP2022523226A - 増強された生理活性を有する多量体オリゴヌクレオチド - Google Patents

増強された生理活性を有する多量体オリゴヌクレオチド Download PDF

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JP2022523226A
JP2022523226A JP2021552130A JP2021552130A JP2022523226A JP 2022523226 A JP2022523226 A JP 2022523226A JP 2021552130 A JP2021552130 A JP 2021552130A JP 2021552130 A JP2021552130 A JP 2021552130A JP 2022523226 A JP2022523226 A JP 2022523226A
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oligonucleotide
subunits
multimer
stranded
subunit
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JPWO2020180897A5 (https=
JP2022523226A5 (https=
Inventor
ジョナサン マイルズ ブラウン
クリスティン ケイ．エイチ． ニューマン
ハンス‐ピーター ヴォルンロシェル
フィリップ ハドヴィガー
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エムペグ エルエイ リミテッド ライアビリティ カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/3519—Fusion with another nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers

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  • Wood Science & Technology (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2021552130A 2019-03-04 2020-03-03 増強された生理活性を有する多量体オリゴヌクレオチド Pending JP2022523226A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962813599P 2019-03-04 2019-03-04
US62/813,599 2019-03-04
US201962824771P 2019-03-27 2019-03-27
US62/824,771 2019-03-27
PCT/US2020/020845 WO2020180897A1 (en) 2019-03-04 2020-03-03 Multimeric oligonucleotides with enhanced bioactivity

Publications (3)

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JP2022523226A true JP2022523226A (ja) 2022-04-21
JPWO2020180897A5 JPWO2020180897A5 (https=) 2023-02-15
JP2022523226A5 JP2022523226A5 (https=) 2023-02-15

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US (1) US20230287406A1 (https=)
EP (1) EP3935168A4 (https=)
JP (1) JP2022523226A (https=)
CN (1) CN113994004A (https=)
AU (1) AU2020233375A1 (https=)
CA (1) CA3132505A1 (https=)
IL (1) IL286070A (https=)
WO (1) WO2020180897A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3576752A4 (en) 2017-02-06 2020-12-16 Mpeg La, LLC MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE
AU2021263932B2 (en) * 2020-04-30 2025-07-03 Mpeg La, L.L.C. Multimeric oligonucleotides with divided strands
US20240318174A1 (en) * 2021-02-08 2024-09-26 Ractigen Therapeutics Multi-Valent Oligonucleotide Agent and Methods of Use Thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018030338A1 (ja) * 2016-08-08 2018-02-15 浩文 山本 アジュバント組成物
JP2018518186A (ja) * 2015-06-15 2018-07-12 エムペグ エルエイ リミテッド ライアビリティ カンパニー 定義されたマルチコンジュゲートオリゴヌクレオチド

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ATE356630T1 (de) * 1998-04-03 2007-04-15 Univ Iowa Res Found Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine
US8748405B2 (en) * 2007-01-26 2014-06-10 City Of Hope Methods and compositions for the treatment of cancer or other diseases
US20080311040A1 (en) * 2007-03-06 2008-12-18 Flagship Ventures METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA
KR101141544B1 (ko) * 2009-03-13 2012-05-03 한국과학기술원 에스아이알엔에이 다중 접합체 및 이의 제조방법
HK1200484A1 (zh) * 2011-09-14 2015-08-07 Translate Bio Ma, Inc. 多聚寡核苷酸化合物
US9956294B2 (en) * 2013-01-18 2018-05-01 H. Lee Moffitt Cancer Center And Research Institute, Inc. Targeted sensitization of non-del(5q) malignant cells
JP7073109B2 (ja) * 2015-07-02 2022-05-23 シティ・オブ・ホープ ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法
EP3368671A1 (en) * 2015-10-26 2018-09-05 Translate Bio Ma, Inc. Methods and compositions for increasing smn expression
EP3576752A4 (en) * 2017-02-06 2020-12-16 Mpeg La, LLC MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE
JP2020522265A (ja) * 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018518186A (ja) * 2015-06-15 2018-07-12 エムペグ エルエイ リミテッド ライアビリティ カンパニー 定義されたマルチコンジュゲートオリゴヌクレオチド
WO2018030338A1 (ja) * 2016-08-08 2018-02-15 浩文 山本 アジュバント組成物

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Publication number Publication date
WO2020180897A1 (en) 2020-09-10
IL286070A (en) 2021-10-31
AU2020233375A1 (en) 2021-09-30
CA3132505A1 (en) 2020-09-10
EP3935168A4 (en) 2024-04-10
CN113994004A (zh) 2022-01-28
US20230287406A1 (en) 2023-09-14
EP3935168A1 (en) 2022-01-12

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