JP2022514349A - 絹－ヒアルロン酸組織フィラー、及びそれを製造及び使用する方法 - Google Patents

絹－ヒアルロン酸組織フィラー、及びそれを製造及び使用する方法 Download PDF

Info

Publication number
JP2022514349A
JP2022514349A JP2021535549A JP2021535549A JP2022514349A JP 2022514349 A JP2022514349 A JP 2022514349A JP 2021535549 A JP2021535549 A JP 2021535549A JP 2021535549 A JP2021535549 A JP 2021535549A JP 2022514349 A JP2022514349 A JP 2022514349A
Authority
JP
Japan
Prior art keywords
tissue filler
silk
spf
kda
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021535549A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020132331A5 (https=
JP2022514349A5 (https=
Inventor
グレゴリー・エイチ・アルトマン
レベッカ・エル・ラクチュール
ペン・シュー
エルレイ・ジン
カルロス・ジェイ・ボスケス
パトリック・ヤコノ
パトリック・ヨハンソン
Original Assignee
エボルブド バイ ネイチャー， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エボルブド バイ ネイチャー， インコーポレイテッド filed Critical エボルブド バイ ネイチャー， インコーポレイテッド
Publication of JP2022514349A publication Critical patent/JP2022514349A/ja
Publication of JPWO2020132331A5 publication Critical patent/JPWO2020132331A5/ja
Publication of JP2022514349A5 publication Critical patent/JP2022514349A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0059—Cosmetic or alloplastic implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021535549A 2018-12-19 2019-12-19 絹－ヒアルロン酸組織フィラー、及びそれを製造及び使用する方法 Pending JP2022514349A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862781952P 2018-12-19 2018-12-19
US62/781,952 2018-12-19
US201962865633P 2019-06-24 2019-06-24
US62/865,633 2019-06-24
PCT/US2019/067617 WO2020132331A1 (en) 2018-12-19 2019-12-19 Silk-hyaluronic acid tissue fillers and methods of making and using the same

Publications (3)

Publication Number Publication Date
JP2022514349A true JP2022514349A (ja) 2022-02-10
JPWO2020132331A5 JPWO2020132331A5 (https=) 2022-12-26
JP2022514349A5 JP2022514349A5 (https=) 2022-12-26

Family

ID=71100930

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021535549A Pending JP2022514349A (ja) 2018-12-19 2019-12-19 絹－ヒアルロン酸組織フィラー、及びそれを製造及び使用する方法

Country Status (12)

Country Link
US (2) US12296067B2 (https=)
EP (1) EP3897564A4 (https=)
JP (1) JP2022514349A (https=)
KR (1) KR20210144660A (https=)
CN (1) CN113677320A (https=)
AU (1) AU2019405953B2 (https=)
BR (1) BR112021012141A2 (https=)
CA (1) CA3124196A1 (https=)
IL (1) IL284082B2 (https=)
MA (1) MA54563A (https=)
SG (1) SG11202106411QA (https=)
WO (1) WO2020132331A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102684409B1 (ko) 2023-05-02 2024-07-11 (재)씨젠의료재단 석신산-가교 히알루론산을 포함하는 피부 필러 조성물 및 그 제조방법
KR102684411B1 (ko) 2023-05-02 2024-07-11 (재)씨젠의료재단 설포석신산-가교 히알루론산 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230190997A1 (en) 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
AU2019405953B2 (en) 2018-12-19 2025-09-18 Evolved By Nature, Inc. Silk-hyaluronic acid tissue fillers and methods of making and using the same
EP4099978A1 (en) * 2020-02-06 2022-12-14 Merz Pharma GmbH & Co. KGaA Injectable composition for skin and soft tissue augmentation
WO2022155682A1 (en) * 2021-01-15 2022-07-21 Trustees Of Tufts College Tunable silk-based biomaterials with saccharide substitutions, and methods of producing the same
TWI880094B (zh) 2021-06-23 2025-04-11 德商莫茲製藥有限兩合公司 以絲蛋白交聯多醣及所得材料之用途
KR102509832B1 (ko) * 2022-02-23 2023-03-14 주식회사 지씨에스 상이한 구조를 이루는 다분산 펩타이드 기반의 최소 침습 임플란트가 가능한 하이드로겔 조성물 및 그의 용도
AU2023392523A1 (en) 2022-12-15 2025-04-10 Merz Pharma Gmbh & Co. Kgaa Injectable gel comprising botulinum toxin and uses thereof
KR20250079371A (ko) * 2023-11-27 2025-06-04 조은애 친환경 용매를 사용한 생분해성 고분자 마이크로그래뉼이 융합된 히알루론산 겔을 포함하는 조직 수복용 주사제 조성물 및 그 제조 방법
CN121197526B (zh) * 2025-10-15 2026-04-14 苏州苏豪生物材料科技有限公司 一种注射用含生长因子的丝素蛋白基生物材料及制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110189292A1 (en) * 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
CN102836465A (zh) * 2012-08-30 2012-12-26 浙江星月生物科技股份有限公司 一种注射用丝素蛋白透明质酸复合凝胶及其制备与应用
WO2014176158A1 (en) * 2013-04-22 2014-10-30 Allergan, Inc. Cross linked silk-hyaluronic acid composition
JP2015527391A (ja) * 2012-09-06 2015-09-17 ナンヤン テクノロジカル ユニヴァーシティー ヒアルロン酸をベースとする薬物送達システム
JP2016531943A (ja) * 2013-09-30 2016-10-13 シルク セラピューティクス， インコーポレイテッド 絹タンパク質断片組成物及びそれから製造された物品
WO2018039496A1 (en) * 2016-08-24 2018-03-01 Allergan, Inc. Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation
WO2019005848A1 (en) * 2017-06-26 2019-01-03 Silk, Inc. HYALURONIC SILK ACID TISSUE FILLING AGENTS AND METHODS OF USE THEREOF

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
JP4669662B2 (ja) 2001-10-25 2011-04-13 ユニヴァーシティー オブ コネティカット 生物活性材料、生物活性材料の製法およびその使用方法
EP1459728A4 (en) 2001-11-29 2005-04-20 Nat Inst Of Agrobio Sciences EMULSIFIER AND METHOD FOR ITS MANUFACTURE
US7632873B2 (en) 2002-12-13 2009-12-15 L'oreal S.A. Cosmetic dermatological composition comprising at least one gradient copolymer, makeup comprising the cosmetic or dermatological composition and cosmetic method using the composition
WO2004067575A1 (en) 2003-01-31 2004-08-12 Biosphere S.P.A. Water soluble and biocompatible gels of hyaluronic acid cross-linked with bi-functional l-aminoacids or l-aminoesters
US7060260B2 (en) 2003-02-20 2006-06-13 E.I. Du Pont De Nemours And Company Water-soluble silk proteins in compositions for skin care, hair care or hair coloring
US7115388B2 (en) 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
EP1660013A4 (en) 2003-08-26 2011-07-20 Gel Del Technologies Inc BIOMATERIAL AND PROTEIN BIOCOACERVATES, METHODS OF MAKING AND USING THEM
US20070196421A1 (en) 2005-10-03 2007-08-23 Hunter William L Soft tissue implants and drug combination compositions, and use thereof
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
JP5123873B2 (ja) 2009-02-20 2013-01-23 出光テクノファイン株式会社 繊維架橋体および繊維架橋体の製造方法
JP2010213984A (ja) 2009-03-18 2010-09-30 Naisemu:Kk 柔軟剤及び／又は保湿剤含有生体埋込用医療材料、該医療材料中の柔軟剤及び／又は保湿剤の含有量を調整する方法及び、該生体内埋込用医療材料の製造方法
WO2011059325A2 (en) 2009-11-11 2011-05-19 University Of Twente, Institute For Biomedical Technology And Technical Medicine (Mira) Dextran-hyaluronic acid based hydrogels
AU2015275313A1 (en) 2010-11-08 2016-01-21 Allergan Industrie, Sas Hyaluronic acid based formulations
KR102238406B1 (ko) 2011-06-03 2021-04-08 알러간 인더스트리 에스에이에스 항산화제를 포함하는 피부 충전제 조성물
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
CN108379112A (zh) 2011-09-14 2018-08-10 阿勒根公司 用于细纹治疗的真皮填充剂组合物
ES2791769T3 (es) 2011-11-09 2020-11-05 Tufts College Espumas de fibroína de seda inyectables y usos de la misma
US20150079012A1 (en) 2012-04-20 2015-03-19 Trustees Of Tufts College Silk fibroin-based personal care compositions
US20140023688A1 (en) 2012-07-13 2014-01-23 Firmenich Sa Encapsulated oils
WO2014055895A1 (en) 2012-10-05 2014-04-10 Allergan, Inc. Injectable device and method for sculpting, augmenting or correcting facial features such as the chin
LT2903589T (lt) 2012-10-08 2018-06-11 Anteis Sa Injekcinė sterili vandeninė kompozicija, pagaminta iš tinklinės struktūros hialurono rūgšties ir hidroksiapatito, estetiniam naudojimui
WO2014127007A1 (en) 2013-02-12 2014-08-21 Seryx Biomedical, Inc. Ophthalmic formulation derived from silk protein
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
WO2014189780A2 (en) 2013-05-20 2014-11-27 Tufts University Apparatus and method for forming a nanofiber hydrogel composite
EP3033117A4 (en) 2013-08-20 2017-04-19 Wake Forest University Health Sciences Tissue repair devices utilizing self-assembled materials
JP6369783B2 (ja) 2014-06-12 2018-08-08 株式会社アーダン 加水分解フィブロインを含む軟膏及びその製造方法
US11260012B2 (en) 2015-01-12 2022-03-01 Evolved By Nature, Inc. Preserved silk protein fragment compositions and articles manufactured therefrom
MX2017013949A (es) 2015-04-29 2018-11-09 Silk Therapeutics Inc Composiciones mectantes a base de seda y sus metodos.
FR3036035B1 (fr) 2015-05-11 2018-10-05 Laboratoires Vivacy Compositions comprenant au moins un polyol et au moins un anesthesique
CN104998302B (zh) 2015-08-31 2017-11-24 中原工学院 一种以取向纳米纤维毡为骨架的纳米软骨修复材料及其制备方法
TWI727014B (zh) 2016-03-24 2021-05-11 德商梅茲製藥有限兩合公司 修飾透明質酸與其製造方法及其用途
US10857262B2 (en) * 2016-10-31 2020-12-08 Sofregen Medical, Inc. Compositions comprising low molecular weight silk fibroin fragments and plasticizers
CN106492279A (zh) 2016-11-04 2017-03-15 武汉纺织大学 一种丝素蛋白‑透明质酸复合凝胶的快速制备方法
CN107880282B (zh) 2016-12-29 2020-09-29 北京键凯科技股份有限公司 一种注射用多元甘醇环氧衍生物交联的透明质酸钠凝胶及其制备方法
US20230190997A1 (en) 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
CN107619481B (zh) 2017-08-09 2020-08-14 浙江理工大学 一种利用桑蚕丝制备粘性丝素蛋白水凝胶的方法
CN108392680B (zh) 2018-02-09 2020-12-18 珠海睿展生物材料有限公司 一种可塑形全降解硬组织填充生物材料
AU2019405953B2 (en) 2018-12-19 2025-09-18 Evolved By Nature, Inc. Silk-hyaluronic acid tissue fillers and methods of making and using the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110189292A1 (en) * 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
CN102836465A (zh) * 2012-08-30 2012-12-26 浙江星月生物科技股份有限公司 一种注射用丝素蛋白透明质酸复合凝胶及其制备与应用
JP2015527391A (ja) * 2012-09-06 2015-09-17 ナンヤン テクノロジカル ユニヴァーシティー ヒアルロン酸をベースとする薬物送達システム
WO2014176158A1 (en) * 2013-04-22 2014-10-30 Allergan, Inc. Cross linked silk-hyaluronic acid composition
JP2016531943A (ja) * 2013-09-30 2016-10-13 シルク セラピューティクス， インコーポレイテッド 絹タンパク質断片組成物及びそれから製造された物品
WO2018039496A1 (en) * 2016-08-24 2018-03-01 Allergan, Inc. Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation
WO2019005848A1 (en) * 2017-06-26 2019-01-03 Silk, Inc. HYALURONIC SILK ACID TISSUE FILLING AGENTS AND METHODS OF USE THEREOF

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102684409B1 (ko) 2023-05-02 2024-07-11 (재)씨젠의료재단 석신산-가교 히알루론산을 포함하는 피부 필러 조성물 및 그 제조방법
KR102684411B1 (ko) 2023-05-02 2024-07-11 (재)씨젠의료재단 설포석신산-가교 히알루론산 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법

Also Published As

Publication number Publication date
EP3897564A4 (en) 2022-10-19
AU2019405953B2 (en) 2025-09-18
AU2019405953A1 (en) 2021-08-05
US20230114250A1 (en) 2023-04-13
BR112021012141A2 (pt) 2021-08-31
IL284082B1 (en) 2025-03-01
EP3897564A1 (en) 2021-10-27
IL284082B2 (en) 2025-07-01
SG11202106411QA (en) 2021-07-29
IL284082A (en) 2021-08-31
US12296067B2 (en) 2025-05-13
CN113677320A (zh) 2021-11-19
US20250332322A1 (en) 2025-10-30
CA3124196A1 (en) 2020-06-25
WO2020132331A1 (en) 2020-06-25
MA54563A (fr) 2022-03-30
KR20210144660A (ko) 2021-11-30

Similar Documents

Publication Publication Date Title
JP7660619B2 (ja) 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法
JP2022514349A (ja) 絹－ヒアルロン酸組織フィラー、及びそれを製造及び使用する方法
US11660372B2 (en) Silk-hyaluronic acid based tissue fillers and methods of using the same
US20250295691A1 (en) Silk-Hyaluronic Acid Compositions For Tissue Filling, Tissue Spacing, and Tissue Bulking
US12611484B2 (en) Silk-hyaluronic acid based tissue filers and methods of using the same
HK40064387A (en) Silk-hyaluronic acid tissue fillers and methods of making and using the same
HK40031640A (en) Silk-hyaluronic acid based tissue fillers and methods of using the same
HK40091189A (en) Silk-hyaluronic acid based tissue fillers and methods of using the same
HK40091189B (en) Silk-hyaluronic acid based tissue fillers and methods of using the same
CN116507315A (zh) 用于组织填充、组织间隔和组织膨胀的丝-透明质酸组合物
EA045185B1 (ru) Тканевые филлеры на основе шелка и гиалуроновой кислоты и способы их применения
HK40030280A (en) Silk-hyaluronic acid based tissue fillers and methods of using the same
HK40030280B (en) Silk-hyaluronic acid based tissue fillers and methods of using the same

Legal Events

Date Code Title Description
RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20220527

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221216

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221216

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230905

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230912

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231205

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240312

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240702

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20241001

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20241121

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241127

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20241129

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250226

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250523

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250718

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250826

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20251104