JP2022508705A5 - - Google Patents
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- Publication number
- JP2022508705A5 JP2022508705A5 JP2021545273A JP2021545273A JP2022508705A5 JP 2022508705 A5 JP2022508705 A5 JP 2022508705A5 JP 2021545273 A JP2021545273 A JP 2021545273A JP 2021545273 A JP2021545273 A JP 2021545273A JP 2022508705 A5 JP2022508705 A5 JP 2022508705A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024210877A JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862745786P | 2018-10-15 | 2018-10-15 | |
| US62/745,786 | 2018-10-15 | ||
| US201862767819P | 2018-11-15 | 2018-11-15 | |
| US62/767,819 | 2018-11-15 | ||
| US201962836398P | 2019-04-19 | 2019-04-19 | |
| US62/836,398 | 2019-04-19 | ||
| US201962887812P | 2019-08-16 | 2019-08-16 | |
| US62/887,812 | 2019-08-16 | ||
| US201962901984P | 2019-09-18 | 2019-09-18 | |
| US62/901,984 | 2019-09-18 | ||
| PCT/US2019/056112 WO2020081450A1 (en) | 2018-10-15 | 2019-10-14 | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024210877A Division JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022508705A JP2022508705A (ja) | 2022-01-19 |
| JPWO2020081450A5 JPWO2020081450A5 (https=) | 2022-10-21 |
| JP2022508705A5 true JP2022508705A5 (https=) | 2022-10-21 |
| JP7600123B2 JP7600123B2 (ja) | 2024-12-16 |
Family
ID=68425337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021545273A Active JP7600123B2 (ja) | 2018-10-15 | 2019-10-14 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
| JP2024210877A Active JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024210877A Active JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11479556B1 (https=) |
| EP (1) | EP3867242A1 (https=) |
| JP (2) | JP7600123B2 (https=) |
| KR (1) | KR102816424B1 (https=) |
| CN (2) | CN113412259B (https=) |
| AU (2) | AU2019360928B2 (https=) |
| BR (2) | BR112021007115A2 (https=) |
| CA (1) | CA3115526A1 (https=) |
| IL (1) | IL281904B2 (https=) |
| MX (2) | MX2021004191A (https=) |
| WO (1) | WO2020081450A1 (https=) |
Families Citing this family (52)
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| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
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| CN119751456A (zh) | 2018-04-16 | 2025-04-04 | C4医药公司 | 螺环化合物 |
| JP7600123B2 (ja) | 2018-10-15 | 2024-12-16 | ニューリックス セラピューティクス，インコーポレイテッド | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
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| KR20240035820A (ko) | 2021-07-09 | 2024-03-18 | 플렉시움 인코포레이티드 | Ikzf2를 조절하는 아릴 화합물 및 약학 조성물 |
| IL309796A (en) | 2021-07-14 | 2024-02-01 | Nurix Therapeutics Inc | Bifunctional compounds for BTK degradation with reduced IMID activity |
| WO2023004163A1 (en) | 2021-07-23 | 2023-01-26 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk with enhanced imid activity |
| WO2023009709A1 (en) * | 2021-07-29 | 2023-02-02 | Ajax Therapeutics, Inc. | Pyrazolo piperazines as jak2 inhibitors |
| WO2023059582A1 (en) * | 2021-10-04 | 2023-04-13 | Halda Therapeutics Opco, Inc. | Heterobifunctional compounds and their use in treating disease |
| AU2022379494A1 (en) * | 2021-10-26 | 2024-05-30 | Nurix Therapeutics, Inc. | Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk |
| TW202325289A (zh) | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Ｊａｋ２抑制劑之形式及組合物 |
| JP7782035B2 (ja) | 2021-11-09 | 2025-12-08 | エイジャックス セラピューティクス， インコーポレイテッド | Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール |
| CA3238118A1 (en) * | 2021-11-18 | 2023-05-25 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Fused imide derivative |
| CN116143757B (zh) * | 2021-11-22 | 2024-07-05 | 杭州和正医药有限公司 | 一种可降解btk激酶的多功能化合物、组合物及应用 |
| CN115894450B (zh) * | 2021-11-30 | 2023-09-12 | 山东如至生物医药科技有限公司 | 一种新型多环类化合物及其组合物和用途 |
| WO2023143249A1 (zh) * | 2022-01-28 | 2023-08-03 | 上海齐鲁制药研究中心有限公司 | 靶向malt1的蛋白降解化合物 |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
| WO2023227080A1 (zh) * | 2022-05-25 | 2023-11-30 | 百极弘烨(南通)医药科技有限公司 | 一种protac化合物、含其的药物组合物及其制备方法和应用 |
| JP2025523393A (ja) | 2022-06-06 | 2025-07-23 | シーフォー セラピューティクス， インコーポレイテッド | 二環式置換グルタルイミドセレブロンバインダー |
| CN119816484A (zh) * | 2022-08-26 | 2025-04-11 | 富士胶片株式会社 | 新型哌嗪衍生物或其盐及医药组合物 |
| CN120202200A (zh) * | 2023-06-01 | 2025-06-24 | 标新生物医药科技(上海)有限公司 | 基于氧代异吲哚啉基取代的四氢嘧啶二酮的化合物及其应用 |
| CN119451952A (zh) * | 2023-06-01 | 2025-02-14 | 标新生物医药科技(上海)有限公司 | 氧代异吲哚啉基取代的四氢嘧啶二酮衍生物及其应用 |
| CN121889391A (zh) | 2023-08-03 | 2026-04-17 | 海思科医药集团股份有限公司 | 一种多环并环btk降解剂及其在医药上的应用 |
| WO2025094065A1 (en) | 2023-11-01 | 2025-05-08 | Aurigene Oncology Limited | Amino-substituted pyridazine compounds as smarca2 and/or smarca4 degraders |
| CN121335894A (zh) * | 2024-02-04 | 2026-01-13 | 上海超阳药业有限公司 | 一种具备降解酪氨酸蛋白激酶btk活性的化合物及其制备方法和用途 |
| WO2025174220A1 (ko) * | 2024-02-14 | 2025-08-21 | 주식회사 유빅스테라퓨틱스 | Shp2 단백질 분해 활성을 갖는 화합물 및 이들의 의약 용도 |
| WO2025193454A1 (en) | 2024-03-01 | 2025-09-18 | Prelude Therapeutics Incorporated | Brm and brg1 targeting antibody-drug conjugates and methods of use thereof |
| TW202543650A (zh) | 2024-03-08 | 2025-11-16 | 美商海爾達醫療運營公司 | 異雙官能化合物及其在治療疾病中之用途 |
| CN119119080A (zh) * | 2024-09-06 | 2024-12-13 | 上海信诺维生物医药有限公司 | 一种irak4的蛋白降解剂 |
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| WO2023004163A1 (en) | 2021-07-23 | 2023-01-26 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk with enhanced imid activity |
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2019
- 2019-10-14 JP JP2021545273A patent/JP7600123B2/ja active Active
- 2019-10-14 WO PCT/US2019/056112 patent/WO2020081450A1/en not_active Ceased
- 2019-10-14 MX MX2021004191A patent/MX2021004191A/es unknown
- 2019-10-14 CN CN201980082722.7A patent/CN113412259B/zh active Active
- 2019-10-14 US US15/734,774 patent/US11479556B1/en active Active
- 2019-10-14 EP EP19797494.2A patent/EP3867242A1/en active Pending
- 2019-10-14 CN CN202410998099.2A patent/CN118955473A/zh active Pending
- 2019-10-14 BR BR112021007115-6A patent/BR112021007115A2/pt unknown
- 2019-10-14 AU AU2019360928A patent/AU2019360928B2/en active Active
- 2019-10-14 IL IL281904A patent/IL281904B2/en unknown
- 2019-10-14 KR KR1020217014388A patent/KR102816424B1/ko active Active
- 2019-10-14 CA CA3115526A patent/CA3115526A1/en active Pending
- 2019-10-14 BR BR122023024103-7A patent/BR122023024103A2/pt unknown
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2021
- 2021-04-09 MX MX2024008539A patent/MX2024008539A/es unknown
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2022
- 2022-07-28 US US17/876,433 patent/US11866442B2/en active Active
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2023
- 2023-09-28 US US18/374,282 patent/US12583862B2/en active Active
- 2023-11-14 AU AU2023266254A patent/AU2023266254B2/en active Active
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2024
- 2024-12-04 JP JP2024210877A patent/JP7741282B2/ja active Active
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2025
- 2025-10-08 US US19/353,387 patent/US20260035378A1/en active Pending