JP2022508511A5 - - Google Patents
Info
- Publication number
- JP2022508511A5 JP2022508511A5 JP2021542068A JP2021542068A JP2022508511A5 JP 2022508511 A5 JP2022508511 A5 JP 2022508511A5 JP 2021542068 A JP2021542068 A JP 2021542068A JP 2021542068 A JP2021542068 A JP 2021542068A JP 2022508511 A5 JP2022508511 A5 JP 2022508511A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- lipid
- alkyl
- group
- alkenyl
- Prior art date
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023193747A JP7747712B2 (ja) | 2018-10-01 | 2023-11-14 | 活性物質の送達のための生分解性脂質 |
| JP2025155219A JP2026009116A (ja) | 2018-10-01 | 2025-09-18 | 活性物質の送達のための生分解性脂質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862739548P | 2018-10-01 | 2018-10-01 | |
| US62/739,548 | 2018-10-01 | ||
| PCT/US2019/053617 WO2020072324A1 (en) | 2018-10-01 | 2019-09-27 | Biodegradable lipids for the delivery of active agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023193747A Division JP7747712B2 (ja) | 2018-10-01 | 2023-11-14 | 活性物質の送達のための生分解性脂質 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022508511A JP2022508511A (ja) | 2022-01-19 |
| JP2022508511A5 true JP2022508511A5 (https=) | 2022-08-01 |
| JPWO2020072324A5 JPWO2020072324A5 (https=) | 2022-08-01 |
| JP7387745B2 JP7387745B2 (ja) | 2023-11-28 |
Family
ID=68281954
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542068A Active JP7387745B2 (ja) | 2018-10-01 | 2019-09-27 | 活性物質の送達のための生分解性脂質 |
| JP2023193747A Active JP7747712B2 (ja) | 2018-10-01 | 2023-11-14 | 活性物質の送達のための生分解性脂質 |
| JP2025155219A Pending JP2026009116A (ja) | 2018-10-01 | 2025-09-18 | 活性物質の送達のための生分解性脂質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023193747A Active JP7747712B2 (ja) | 2018-10-01 | 2023-11-14 | 活性物質の送達のための生分解性脂質 |
| JP2025155219A Pending JP2026009116A (ja) | 2018-10-01 | 2025-09-18 | 活性物質の送達のための生分解性脂質 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220370356A1 (https=) |
| EP (3) | EP4635481A3 (https=) |
| JP (3) | JP7387745B2 (https=) |
| KR (2) | KR20260003834A (https=) |
| CN (2) | CN113164379B (https=) |
| AU (2) | AU2019351809C1 (https=) |
| CA (1) | CA3114435A1 (https=) |
| DK (2) | DK3860561T3 (https=) |
| ES (2) | ES3046484T3 (https=) |
| WO (1) | WO2020072324A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6997862B2 (ja) | 2018-08-21 | 2022-02-10 | 株式会社東芝 | 生分解性化合物、脂質粒子、脂質粒子を含む組成物、およびキット |
| ES3046484T3 (en) * | 2018-10-01 | 2025-12-02 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| WO2020219876A1 (en) * | 2019-04-25 | 2020-10-29 | Intellia Therapeutics, Inc. | Ionizable amine lipids and lipid nanoparticles |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| US20240050378A1 (en) * | 2020-12-02 | 2024-02-15 | Merck Sharp & Dohme Llc | Lipid nanoparticle compositions containing monoester cationic lipids |
| WO2022155728A1 (en) * | 2021-01-19 | 2022-07-28 | The University Of British Columbia | Sulfur-containing lipids |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| CN115010681A (zh) * | 2021-09-07 | 2022-09-06 | 安徽荣灿生物科技有限公司 | 一类阳离子脂质体分子及其制备和应用 |
| CN115894281B (zh) * | 2021-09-22 | 2025-07-01 | 广州谷森制药有限公司 | 阳离子脂质化合物、其制备方法、组合物及应用 |
| AR127312A1 (es) | 2021-10-08 | 2024-01-10 | Suzhou Abogen Biosciences Co Ltd | Compuestos lipídicos ycomposiciones de nanopartículas lipídicas |
| CN114409554A (zh) * | 2022-01-27 | 2022-04-29 | 英维沃生物科技(苏州)有限公司 | 一种新型阳离子脂质化合物及其组合物和用途 |
| CN119654166A (zh) | 2022-04-01 | 2025-03-18 | 内诺维什疗法股份有限公司 | mRNA递送方法及其组合物 |
| CN117003808A (zh) * | 2022-04-28 | 2023-11-07 | 北京科兴中维生物技术有限公司 | 一种阳离子脂质化合物及其制备方法和用途 |
| CN116969851A (zh) | 2022-04-29 | 2023-10-31 | 北京剂泰医药科技有限公司 | 可电离脂质化合物 |
| CN115887674B (zh) * | 2022-04-29 | 2023-08-25 | 北京剂泰医药科技有限公司 | 脂质纳米颗粒 |
| CN117263818A (zh) * | 2022-06-14 | 2023-12-22 | 杭州高田生物医药有限公司 | 阳离子脂质化合物及其制备方法和应用 |
| KR20250094676A (ko) * | 2022-10-25 | 2025-06-25 | 나노베이션 테라퓨틱스 인크. | 안티-센스 올리고뉴클레오티드 전달을 위한 지질 나노입자 제형 |
| AU2024206116A1 (en) * | 2023-01-06 | 2025-07-10 | Arrowhead Pharmaceuticals, Inc. | Lipid conjugates for the delivery of therapeutic agents to adipose tissue |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| WO2000003683A2 (en) | 1998-07-20 | 2000-01-27 | Inex Pharmaceuticals Corporation | Liposomal encapsulated nucleic acid-complexes |
| US7901708B2 (en) | 2002-06-28 | 2011-03-08 | Protiva Biotherapeutics, Inc. | Liposomal apparatus and manufacturing methods |
| CN1981044B (zh) * | 2004-06-07 | 2010-05-05 | 普洛体维生物治疗公司 | 包封干扰rna的脂质 |
| WO2006007712A1 (en) | 2004-07-19 | 2006-01-26 | Protiva Biotherapeutics, Inc. | Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents |
| US9005654B2 (en) | 2005-07-27 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
| EP3192788A1 (en) | 2006-10-03 | 2017-07-19 | Arbutus Biopharma Corporation | Lipid containing formulations |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| AU2009238175C1 (en) * | 2008-04-15 | 2023-11-30 | Arbutus Biopharma Corporation | Novel lipid formulations for nucleic acid delivery |
| CN104119242B (zh) | 2008-10-09 | 2017-07-07 | 泰米拉制药公司 | 改善的氨基脂质和递送核酸的方法 |
| WO2010054384A1 (en) | 2008-11-10 | 2010-05-14 | Alnylam Pharmaceuticals, Inc. | Lipids and compositions for the delivery of therapeutics |
| HUE037082T2 (hu) * | 2008-11-10 | 2018-08-28 | Arbutus Biopharma Corp | Új lipidek és készítmények terápiás hatóanyagok szállítására |
| EP3243504A1 (en) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
| KR20180094137A (ko) | 2009-05-05 | 2018-08-22 | 알닐람 파마슈티칼스 인코포레이티드 | 지질 조성물 |
| MX342785B (es) * | 2009-06-10 | 2016-10-12 | Alnylam Pharmaceuticals Inc | Formulacion mejorada de lipido. |
| EP2506879A4 (en) | 2009-12-01 | 2014-03-19 | Protiva Biotherapeutics Inc | PREPARATIONS OF SNALP CONTAINING ANTIOXIDANTS |
| US20110313017A1 (en) * | 2010-01-13 | 2011-12-22 | Protiva Biotherapeutics, Inc. | Snalp formulations containing polyoxazoline-dialkyloxypropyl conjugates |
| SG186085A1 (en) | 2010-06-03 | 2013-01-30 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| EP2788006B1 (en) * | 2011-12-07 | 2026-01-07 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| US20140308304A1 (en) | 2011-12-07 | 2014-10-16 | Alnylam Pharmaceuticals, Inc. | Lipids for the delivery of active agents |
| EP2788316B1 (en) | 2011-12-07 | 2019-04-24 | Alnylam Pharmaceuticals, Inc. | Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents |
| WO2013116126A1 (en) * | 2012-02-01 | 2013-08-08 | Merck Sharp & Dohme Corp. | Novel low molecular weight, biodegradable cationic lipids for oligonucleotide delivery |
| AU2013249548A1 (en) * | 2012-04-19 | 2014-11-06 | Sirna Therapeutics, Inc. | Novel diester and triester based low molecular weight, biodegradable cationic lipids for oligonucleotide delivery |
| US9687448B2 (en) * | 2012-12-07 | 2017-06-27 | Alnylam Pharmaceuticals, Inc. | Nucleic acid lipid particle formulations |
| WO2015011633A1 (en) * | 2013-07-23 | 2015-01-29 | Protiva Biotherapeutics, Inc. | Compositions and methods for delivering messenger rna |
| EP4019506A1 (en) * | 2013-12-19 | 2022-06-29 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| EP4286012A3 (en) * | 2015-09-17 | 2024-05-29 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| ES3046484T3 (en) * | 2018-10-01 | 2025-12-02 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
-
2019
- 2019-09-27 ES ES23157471T patent/ES3046484T3/es active Active
- 2019-09-27 CN CN201980077559.5A patent/CN113164379B/zh active Active
- 2019-09-27 DK DK19789841.4T patent/DK3860561T3/da active
- 2019-09-27 EP EP25196729.5A patent/EP4635481A3/en active Pending
- 2019-09-27 JP JP2021542068A patent/JP7387745B2/ja active Active
- 2019-09-27 CN CN202410415224.2A patent/CN118307422A/zh active Pending
- 2019-09-27 DK DK23157471.6T patent/DK4218722T3/da active
- 2019-09-27 US US17/250,952 patent/US20220370356A1/en active Pending
- 2019-09-27 CA CA3114435A patent/CA3114435A1/en active Pending
- 2019-09-27 AU AU2019351809A patent/AU2019351809C1/en active Active
- 2019-09-27 KR KR1020257040845A patent/KR20260003834A/ko active Pending
- 2019-09-27 KR KR1020217013284A patent/KR102900877B1/ko active Active
- 2019-09-27 EP EP23157471.6A patent/EP4218722B1/en active Active
- 2019-09-27 ES ES19789841T patent/ES2951836T3/es active Active
- 2019-09-27 WO PCT/US2019/053617 patent/WO2020072324A1/en not_active Ceased
- 2019-09-27 EP EP19789841.4A patent/EP3860561B1/en active Active
-
2023
- 2023-11-14 JP JP2023193747A patent/JP7747712B2/ja active Active
-
2025
- 2025-07-24 AU AU2025208491A patent/AU2025208491A1/en active Pending
- 2025-09-18 JP JP2025155219A patent/JP2026009116A/ja active Pending
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