JP2022034355A - Manufacturing method of ptp package body - Google Patents

Abstract

To provide a manufacturing method of a PTP package body that allows a PTP package body to increase press-through property thereof and easily prevents a package sheet from cracking.SOLUTION: In the preparation step, a container sheet 24 and a package sheet 26 are prepared, the package sheet including hard aluminum foil of 13.5 μm to 16.5 μm in thickness used as substrates and a heat seal layer provided so as to cover one face of the hard aluminum foil. In the thermal adhesion step, pressing is performed under conditions of predetermined heating temperature and pressing pressure, causing the hard aluminum foil to bite into the surface of the container sheet 24 by the unevenness provided on the surface of a heating roll 18a to adhere to each other through the heat seal layer. The press for the thermal adhesion step is set at the values of heating temperature and press pressure that do not cause crack onto the package sheet 26. The heating temperature is within the range of 170 to 200°C, and the press pressure is 0.225 to 0.275 MPa.SELECTED DRAWING: Figure 1

Description

The present invention relates to a method for manufacturing a PTP package in which the opening of a container body is closed with a lid material.

In the PTP (press through package), as in the PTP package 10 shown in FIG. 3, a solid substance 14 such as a tablet or a capsule as a drug is placed in a storage portion 12a formed in a resin container body 12. This is a packaging form in which the accommodating portion 12a is closed by attaching the lid material 16 to the flat surface portion 12b of the container body 12.

When the PTP package 10 is opened, the contained solid material 14 is strongly pressed against the inner surface of the lid material 16 from the outside of the accommodating portion 12a, penetrates the lid material 16, and is taken out. Hard aluminum foil is widely used. When the lid material 16 is attached to the container body 12, the heat seal layer provided on one surface of the lid material 16 is brought into contact with the flat surface portion 12b of the container body 12, and the heat-resistant coating provided on the other surface of the lid material 16 is provided. A method of heating from the side of the layer and welding the heat seal layer to the flat surface portion 12b is used. Further, on the surface of the lid material 16 on the heat-resistant coat layer side, for example, information displays such as the name of the solid material 14, the manufacturer name, the expiration date, and the barcode are printed.

As shown in FIG. 4, the PTP package 10 is manufactured by using the PTP package manufacturing device 22 provided with the sealing device 18 and the punching device 20. The sealing device 18 is a device for superimposing and thermally adhering a band-shaped container sheet 24 and a band-shaped packaging sheet 26. In the container sheet 24, the container body 12 is continuous in one direction, and in the packaging sheet 26, the lid material 16 is continuous in one direction.

The container sheet 24 is pulled by a transfer device (not shown), and after the solid matter 14 is put into the accommodating portion 12a by the filling device 28, the container sheet 24 is sent to the sealing device 18. The packaging sheet 26 is rolled and set in a roll shape, pulled by a transfer device (not shown), and sent to the sealing device 18.

The sealing device 18 has a heating roll 18a and a receiving roll 18b, and the container sheet 24 and the packaging sheet 26 are overlapped with each other, passed between the heating roll 18a and the receiving roll 18b, and heat-bonded to each other via the heat seal layer. Let me. At this time, the heating roll 18a heats while pressing the surface of the packaging sheet 26 on the heat-resistant coat layer side, and the receiving roll 18b is placed on the flat surface portion 12b (the surface on the side where the accommodating portion 12a protrudes) of the container sheet 24. It abuts and receives the pressing force from the heating roll 18a. As shown in FIG. 5A, the heating roll 18a is provided with irregularities (for example, grid-like streaks) on the surface, whereby the packaging sheet 26 becomes a container as shown in FIG. 5B. It can bite into the surface of the sheet 24 and be firmly heat-bonded.

After that, the container sheet 24 and the packaging sheet 26 are pulled by a transfer device (not shown) and sent to the punching device 20. Then, the punching device 20 cuts the container sheet 24 and the packaging sheet 26 that are heat-bonded to each other to a specified size to form the PTP package 10. The above is the outline of the manufacturing method.

Such a manufacturing method has been conventionally disclosed in a plurality of patent documents. For example, in Patent Document 1, a resin container and an aluminum foil having a thickness of 15 to 25 μm (preferably 16.3 to 18.7 μm) are used as a base material, and heat is applied so as to cover one side of the aluminum foil. Prepare a lid material provided with a seal layer, and place the container body and the lid material at a temperature of 260 to 280 ° C. and a pressure of 0.3 to 0 so that a mesh-patterned seal is formed on the surface of the lid material. It is described that heat bonding is performed under the condition of 5.5 MPa. In addition, the range of usable aluminum foil composition, elongation at break point, tensile strength of the laminate composed of the aluminum foil and the heat seal layer, etc. is specified, and pinhole-shaped holes are formed in the aluminum foil during thermal bonding. It suppresses the occurrence.

Japanese Unexamined Patent Publication No. 2015-178386

When manufacturing the PTP package 10 with an emphasis on press-through property (easiness of taking out the solid matter 14), a method of thinning the hard aluminum foil of the base material to about 15 μm can be considered in order to make the lid material 16 easily torn. However, in general, when the hard aluminum foil is thinner than about 20 μm, kaya (cracks and pinholes in the aluminum foil) are likely to occur in the bitten portion of the lid material 16 when the heat-bonding press is performed. Therefore, it is rarely done to make the hard aluminum foil about 15 μm. Therefore, when the thickness of the hard aluminum foil is set to about 15 μm, it is necessary to review and optimize the settings of the heating temperature and the press pressure.

Patent Document 1 describes the range of the thickness of the aluminum foil, the press temperature at the time of thermal bonding, and the range of the press pressure numerically, but the range is quite wide, and the method of optimizing each numerical value is detailed. Not listed. Therefore, it is not clear the manufacturing conditions that can improve the press-through property and suppress the generation of kaya.

The present invention has been made in view of the above background art, and a PTP package having improved press-through property can be obtained, and a PTP package capable of reliably suppressing the generation of kaya on the packaging sheet can be obtained. It is an object of the present invention to provide the manufacturing method of.

The present invention is a method for manufacturing a PTP package in which an opening of an accommodating portion of a container body is closed with a lid material, wherein the container body is a band-shaped container sheet continuous in one direction and the lid material is continuous in one direction. A strip-shaped sheet having a thickness of 13.5 μm to 16.5 μm as a base material, and a packaging sheet provided with a heat seal layer so as to cover one side of the hard aluminum foil is prepared. Predetermined heating temperature and press pressure conditions by stacking the packaging sheet and the container sheet so that the heat seal layer is in contact with the container sheet and passing the packaging sheet and the container sheet between the heating roll and the receiving roll. Pressed underneath, the hard aluminum foil is made to bite into the surface of the container sheet by the unevenness provided on the surface of the heating roll, and is mutually bonded to the heat bonding step of bonding to each other via the heat seal layer. It is provided with a cutting step of cutting the packaging sheet and the container sheet to the size of the PTP package, and the heating temperature is provided so that the packaging sheet does not generate haze when the pressing is performed in the heat bonding step. A method for manufacturing a PTP package, wherein the value of the press pressure is set, the heating temperature is in the range of 170 to 200 ° C., and the press pressure is in the range of 0.225 to 0.275 MPa. In the heat bonding step, the heating temperature is more preferably in the range of 180 to 190 ° C.

Further, the unevenness of the surface of the heating roll used in the heat bonding step may be formed so that the hard aluminum foil bites into the surface of the container sheet to a depth of at least 6 μm, preferably 6 to 13 μm.

According to the method for manufacturing a PTP package of the present invention, the thickness of the hard aluminum foil, which is the base material of the packaging sheet (cover material), is set to about 15 μm, which is thinner than the conventional one, and is pressed onto the container sheet in the heat bonding step. The heating temperature and press pressure are optimized at lower values than before, and while ensuring the peeling strength of the lid material, it is possible to reliably suppress the generation of haze on the packaging sheet when heat bonding is performed. Further, since the bonding is performed at a lower bonding temperature than before, the effect of the bonding temperature on the packaged chemicals is small, which is preferable in terms of equipment maintenance and running cost. In addition, since the press pressure is low, the burden on the press device is reduced, which leads to energy saving during manufacturing. Since the base material of the lid material is a hard aluminum foil with a thickness of about 15 μm, the press-through property of the PTP package can be improved as compared with the conventional case, and the cover material can be carried when the PTP package is carried in a bag or the like. It is unlikely that the problem of sudden tearing will occur.

It is the actual measurement data when the prototype was manufactured using the manufacturing method of the PTP package of this invention, and is the graph which shows the change of the peel strength when the heating temperature and the press pressure in a heat bonding process were changed [. Hard aluminum foil thickness = 15 μm]. It is the measured data when the prototype is manufactured by using the conventional manufacturing method of the PTP package, and is a graph showing the change in the peeling strength when the heating temperature and the pressing pressure in the heat bonding process are changed []. Hard aluminum foil thickness = 20 μm]. It is a figure (a) which looked at the PTP package from the container body side, the figure (b) which looked at from the lid material side, and CC sectional drawing (c). It is a figure which shows the general PTP package manufacturing apparatus. 4 is a plan view (a) showing a detailed configuration of the sealing device of FIG. 4, and is an enlarged cross-sectional view (b) of a heat-bonded portion of the PTP package.

Hereinafter, an embodiment of the method for manufacturing a PTP packaging sheet of the present invention will be described with reference to the drawings. The method for manufacturing the PTP package according to this embodiment is the method for manufacturing the PTP package 10, and the preparation step, the heat bonding step, and the cutting step are performed in order. The heat bonding step and the cutting step are performed by the sealing device 18 and the punching device 20 of the PTP package manufacturing device 22 shown in FIG.

In the preparation step, the container sheet 24 and the packaging sheet 30 are prepared. The container sheet 24 is a strip-shaped sheet material in which the container body 12 is continuous in one direction, and is, for example, a resin such as a polyvinyl chloride resin (PVC resin), a polypropylene resin (PP resin), or a polyethylene terephthalate resin (PET resin). The container sheet 24 is manufactured by embossing the inside of a flat resin sheet formed to a thickness of about 150 to 350 μm.

The packaging sheet 30 is a strip-shaped sheet in which the lid material 16 is continuous in one direction. The base material is a hard aluminum foil having a thickness of 15 μm, and a thin heat seal layer is provided so as to cover one side of the hard aluminum foil. .. As the hard aluminum foil, a general material such as 8021 material or 8079 material specified in JIS standard can be selected. Further, a printing layer for display, a heat-resistant coat layer for protecting the surface of the hard aluminum foil, and the like may be provided on the opposite surface of the hard aluminum foil.

The flow of the heat bonding process and the cutting process is as described above, but in this embodiment, the heating temperature and the pressing pressure in the heat bonding process are optimized at lower values than before. Specifically, the heating temperature is set in the range of 170 to 200 ° C., more preferably 180 to 190 ° C., and the press pressure is set in the range of 0.225 to 0.275 MPa.

Hereinafter, the trial production and the experimental results performed for optimizing the values of the heating temperature and the press pressure in the heat bonding step will be described with reference to FIGS. 1 and 2.

The inventor prepared a conventional packaging sheet 26 having a hard aluminum foil thickness of 20 μm (tolerance ± 10%) and a packaging sheet 26 having a hard aluminum foil thickness of 15 μm (tolerance ± 10%). First, the press pressure of the sealing device 18 was set to 0.35 MPa (variation ± 10%), which is a conventional general value, and the heating temperature was changed to perform thermal bonding. Then, the change in the peel strength of the lid material 16 after the heat bonding was measured. The measurement result is a solid line graph in FIGS. 1 and 2.

The vertical axis of the graphs of FIGS. 1 and 2 is the peel strength data (mean value of n = 5 to 10) actually measured by performing a so-called 180-degree peeling test, and the numerical values on the vertical axis are constant for easy comparison. It is standardized under the conditions of. The plot of "□" is the peel strength of the region A located between the two accommodating portions 12a adjacent to the transfer direction, and the plot of "○" is the two accommodating portions adjacent to each other in the direction perpendicular to the transfer direction. It is the peel strength of the region B located between 12a. It can be said that the peel strength is sufficient if the value on the vertical axis is 450 or more. When a general sealing device 18 is used, the peel strength of the region A tends to be weaker than the peel strength of the region B. Therefore, if the peel strength of the region A is 450 or more, the heat is good as a whole. It can be said that it is glued.

When the press pressure was 0.35 MPa, the peel strength characteristics did not differ significantly between when the thickness of the hard aluminum foil was 20 μm and when the thickness was 15 μm. As for the state of kaya generation after heat bonding, the thickness was 20 μm and 15 μm, and no kaya was generated when the heating temperature was around 200 ° C.

Next, the press pressure of the sealing device 18 was changed to 0.25 MPa (variation ± 10%), and the heating temperature was changed to perform thermal bonding. Then, in the same manner as described above, the change in the peel strength of the lid material 16 after heat bonding was measured. The measurement results are graphs of broken lines in FIGS. 1 and 2. The plot of "■" is the peel strength of the region A, and the plot of "●" is the peel strength of the region B.

When the press pressure was 0.25 MPa and the thickness of the hard aluminum foil was 20 μm, the necessary and sufficient peel strength could not be obtained unless the heating temperature was set to 190 ° C. or higher, but the thickness was set to 15 μm. At times, the necessary and sufficient peel strength was obtained even at a low heating temperature of 170 ° C to 200 ° C. That is, as shown in FIGS. 1 and 2, when the thickness of the hard aluminum foil is 15 μm, even if the press pressure is reduced to 0.25 MPa, the decrease in peel strength is small, and the necessary and sufficient peel strength can be obtained at a lower temperature. Be done. Looking at the state of kaya generation after heat bonding, no kaya was generated even at a low temperature of 170 ° C. to 200 ° C. with a thickness of 15 μm.

In the case of a hard aluminum foil having a thickness of 15 μm, it is necessary to bite into a depth of at least 6 μm in order to obtain the necessary and sufficient peel strength, and in this embodiment, the bite depth h is in the range of 6 to 13 μm. there were. This range is not a depth of 20 μm or more, which is conventionally preferable, but it has been confirmed that if the bite depth is in the range of 6 to 13 μm, it is preferable from the viewpoint of peel strength and press workability. It is considered that this is because, in the case of the relatively thin 15 μm hard aluminum foil, the unevenness on the surface of the heating roll 18a easily and surely bites into the container sheet 24 together with the packaging sheet 26 of the hard aluminum foil.

In this way, when the packaging sheet 26 using a hard aluminum foil with a thickness of 15 μm (tolerance ± 10%) as a base material is heat-bonded, the heating temperature is in the range of 170 to 200 ° C. and the press pressure is 0.25 MPa (variation ±). By setting it in the range of 10%), it was found that the biting depth h was about 6 to 13 μm, the necessary and sufficient peeling strength was obtained, and the packaging sheet 16 did not generate haze.

As described above, according to the method for manufacturing a PTP package of this embodiment, the thickness of the hard aluminum foil as the base material of the packaging sheet 26 (cover material 16) is set to about 15 μm, which is thinner than the conventional one, and heat bonding is performed. Since the heating temperature and press pressure when pressing the container sheet in the process are optimized at lower values than before, packaging is performed when heat bonding is performed while ensuring the same peeling strength of the lid material as before. It is possible to reliably suppress the generation of kaya on the sheet 26. Further, since the bonding is performed at a lower bonding temperature than before, the effect of the bonding temperature on the packaged chemicals is small, which is preferable in terms of equipment maintenance and running cost. In addition, since the press pressure is low, the burden on the press device is reduced, which leads to energy saving during manufacturing. Since the base material of the lid material 16 is a hard aluminum foil having a thickness of about 15 μm, the press-through property of the PTP package 10 can be improved as compared with the conventional case, and the PTP package 10 can be carried in a bag or the like. Occasionally, the problem that the lid material 16 is unexpectedly torn is unlikely to occur.

10 PTP package 12 Container 12a Storage 12b Flat surface 14 Solid 16 Lid 18 Sealing device 18a Heating roll 18b Receiving roll 20 Punching device 22 PTP packaging manufacturing device 24 Container sheet 26 Packaging sheet 28 Filling device

Claims (3)

In the method for manufacturing a PTP package in which the opening of the container body is closed with a lid material.
A strip-shaped container sheet in which the container body is continuous in one direction,
The lid material is a strip-shaped sheet continuous in one direction, and a hard aluminum foil having a thickness of 13.5 μm to 16.5 μm is used as a base material, and a heat seal layer is provided so as to cover one surface of the hard aluminum foil. The preparatory process to prepare the prepared packaging sheet and
The packaging sheet and the container sheet are laminated so that the heat seal layer is in contact with the container sheet, and the heat seal layer is passed between the heating roll and the receiving roll to press the product under predetermined heating temperature and pressing pressure conditions. The heat bonding step of causing the hard aluminum foil to bite into the surface of the container sheet by the unevenness provided on the surface of the heating roll and adhering them to each other via the heat seal layer.
The packaging sheet and the container sheet that are bonded to each other are provided with a cutting step of cutting the size of the PTP package.
In the heat bonding step, the values of the heating temperature and the pressing pressure are set so that the packaging sheet does not generate haze when the pressing is performed, and the heating temperature is in the range of 170 to 200 ° C. A method for producing a PTP package, wherein the press pressure is in the range of 0.225 to 0.275 MPa. The method for manufacturing a PTP package according to claim 1, wherein the heating temperature is in the range of 180 to 190 ° C. The method for manufacturing a PTP package according to claim 1, wherein the hard aluminum foil bites into the surface of the container sheet to a depth of 6 to 13 μm due to the unevenness of the surface of the heating roll used in the heat bonding step.

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