JP2021116245A - パップ剤 - Google Patents
パップ剤 Download PDFInfo
- Publication number
- JP2021116245A JP2021116245A JP2020009507A JP2020009507A JP2021116245A JP 2021116245 A JP2021116245 A JP 2021116245A JP 2020009507 A JP2020009507 A JP 2020009507A JP 2020009507 A JP2020009507 A JP 2020009507A JP 2021116245 A JP2021116245 A JP 2021116245A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- plaster layer
- poultice
- mass
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
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Abstract
Description
[1] 支持体上に膏体層を備えるパップ剤であって、
上記膏体層に対して支持体と反対側の面に剥離ライナーを更に備え、
膏体層が生理活性物質と、水と、ポリ(アクリル酸メチル/アクリル酸2−エチルヘキシル)及びポリ(メタクリル酸/アクリル酸n−ブチル)の少なくとも1つと、脂肪酸アルキルエステル及びアルキレンジカルボン酸エステルの少なくとも1つと、を含有し、
剥離ライナーを剥がしてから、温度25℃、相対湿度55%の環境下で24時間静置した後の、膏体層の損失弾性率が周波数15Hz、測定温度32℃の条件において、3000〜7000Paである、パップ剤。
[2] 生理活性物質が、ケトプロフェン又はその薬学的に許容可能な塩である、[1]に記載のパップ剤。
[3] 脂肪酸アルキルエステルが、ラウリン酸ヘキシル、ミリスチン酸イソプロピル及びパルミチン酸イソプロピルからなる群より選択される少なくとも1種を含む、[1]又は[2]に記載のパップ剤。
[4] アルキレンジカルボン酸エステルが、アジピン酸ジイソプロピルを含む、[1]〜[3]のいずれかに記載のパップ剤。
各パップ剤から剥離ライナーを除去し、以下の試験条件でプローブタックを評価した。また、皮膚に貼付してから24時間後の付着力を想定して、製造したパップ剤を、剥離ライナーを除去した状態で温度25℃、相対湿度55%の条件で24時間静置した後、同様にプローブタック試験を実施した。
[試験条件]
装置:プローブタックテスター(テスター産業株式会社製)
プローブ:ベークライトプローブ
接触速度:1cm/秒
接触時間:1秒
保持リング:真鍮製20g
各パップ剤(大きさ:50mm×100mm)から剥離ライナーを除去し、JIS Z0237:2009に記載の方法に準拠してボールタック試験を実施した。パップ剤の膏体面(皮膚へ貼付する面)が上面になるようにパップ剤を球転装置の傾斜板に配置した。傾斜板の傾斜角は30°である。膏体層の上端(上側の辺)から100mm(助走路)の位置(スタート位置)に、所定の直径を有するボールを配置した場合、ボールが傾斜板上を転がり、膏体層上に5秒間以上留まるかどうかを評価した。配置するボールのサイズは、直径1/32インチのボールから1/32インチずつ大きくなる32種類であり、最も大きいボールの直径は1インチ(32/32インチ)である。膏体層上を通過せずに停止したボールのうち、直径が最も大きいボールの直径を記録した。
製造したパップ剤を幅2.5cmとなるように矩形に切断し、試験板に貼付した。パップ剤をローラーで圧着した後、以下の試験条件で定速剥離した。パップ剤の剥離に要する荷重(ピール強度)を測定した。
また、皮膚に貼付してから24時間後に剥離する場合の痛みの強弱を推測するために、製造したパップ剤から剥離ライナーを除去して、試験板にローラーで圧着した状態で温度25℃、相対湿度55%の条件で24時間静置した後、同様に180°ピール強度試験を実施した。
[試験条件]
装置:テンシロン型引張試験機(商品名:RTA−100、株式会社エー・アンド・デイ社製)
試験板:PTFE板
剥離速度:300mm/分
皮膚に貼付してから24時間後の付着力を想定して、製造したパップ剤を、剥離ライナーを除去した状態で温度25℃、相対湿度55%の条件で24時間静置した後、以下の測定条件で損失弾性率を測定した。得られた損失弾性率のうち、周波数15Hzにおける損失弾性率を記録した。
[測定条件]
装置:レオメーターHAAKE MARS−III(サーモフィッシャー・サイエンティフィック株式会社製)
試料部:直径20mmの平行平板
ギャップ間隔:1mm
試料量:0.7g
温度:32℃
周波数:0.01〜100Hz
歪:1%
Claims (4)
- 支持体上に膏体層を備えるパップ剤であって、
前記膏体層に対して支持体と反対側の面に剥離ライナーを更に備え、
前記膏体層が生理活性物質と、水と、ポリ(アクリル酸メチル/アクリル酸2−エチルヘキシル)及びポリ(メタクリル酸/アクリル酸n−ブチル)の少なくとも1つと、脂肪酸アルキルエステル及びアルキレンジカルボン酸エステルの少なくとも1つと、を含有し、
剥離ライナーを剥がしてから、温度25℃、相対湿度55%の環境下で24時間静置した後の、前記膏体層の損失弾性率が周波数15Hz、測定温度32℃の条件において、3000〜7000Paである、パップ剤。 - 前記生理活性物質が、ケトプロフェン又はその薬学的に許容可能な塩である、請求項1に記載のパップ剤。
- 前記脂肪酸アルキルエステルが、ラウリン酸ヘキシル、ミリスチン酸イソプロピル及びパルミチン酸イソプロピルからなる群より選択される少なくとも1種を含む、請求項1又は2に記載のパップ剤。
- 前記アルキレンジカルボン酸エステルが、アジピン酸ジイソプロピルを含む、請求項1〜3のいずれか一項に記載のパップ剤。
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JP2020009507A JP7282701B2 (ja) | 2020-01-23 | 2020-01-23 | パップ剤 |
PCT/JP2020/005599 WO2020166665A1 (ja) | 2019-02-14 | 2020-02-13 | パップ剤 |
KR1020217025033A KR102664518B1 (ko) | 2019-02-14 | 2020-02-13 | 파프제 |
TW109104562A TW202045151A (zh) | 2019-02-14 | 2020-02-13 | 泥敷劑 |
CN202080013897.5A CN113423394A (zh) | 2019-02-14 | 2020-02-13 | 泥罨剂 |
EP20755936.0A EP3925604A4 (en) | 2019-02-14 | 2020-02-13 | POULTICE |
US17/429,683 US11903915B2 (en) | 2019-02-14 | 2020-02-13 | Poultice |
BR112021015884-7A BR112021015884A2 (pt) | 2019-02-14 | 2020-02-13 | Cataplasma |
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03223212A (ja) * | 1989-12-28 | 1991-10-02 | Nitto Denko Corp | 経皮吸収ゲル製剤 |
JPH04346922A (ja) * | 1991-05-24 | 1992-12-02 | Doujin Iyaku Kako Kk | 貼付剤 |
JPH0565224A (ja) * | 1991-09-09 | 1993-03-19 | Nitto Denko Corp | ゲル材およびこれを用いた治療用ゲル製剤 |
JPH06199701A (ja) * | 1992-12-29 | 1994-07-19 | Lion Corp | 外用消炎鎮痛剤 |
JPH09315976A (ja) * | 1996-05-29 | 1997-12-09 | Nitto Denko Corp | 経皮投与用製剤 |
JP2006008593A (ja) * | 2004-06-25 | 2006-01-12 | Nichiban Co Ltd | 鼻用貼付剤 |
JP2007326844A (ja) * | 2006-05-11 | 2007-12-20 | Sekisui Chem Co Ltd | 貼付剤 |
WO2015129808A1 (ja) * | 2014-02-27 | 2015-09-03 | 久光製薬株式会社 | ケトプロフェン含有パップ剤 |
JP2019081755A (ja) * | 2017-10-30 | 2019-05-30 | 興和株式会社 | 組成物 |
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Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03223212A (ja) * | 1989-12-28 | 1991-10-02 | Nitto Denko Corp | 経皮吸収ゲル製剤 |
JPH04346922A (ja) * | 1991-05-24 | 1992-12-02 | Doujin Iyaku Kako Kk | 貼付剤 |
JPH0565224A (ja) * | 1991-09-09 | 1993-03-19 | Nitto Denko Corp | ゲル材およびこれを用いた治療用ゲル製剤 |
JPH06199701A (ja) * | 1992-12-29 | 1994-07-19 | Lion Corp | 外用消炎鎮痛剤 |
JPH09315976A (ja) * | 1996-05-29 | 1997-12-09 | Nitto Denko Corp | 経皮投与用製剤 |
JP2006008593A (ja) * | 2004-06-25 | 2006-01-12 | Nichiban Co Ltd | 鼻用貼付剤 |
JP2007326844A (ja) * | 2006-05-11 | 2007-12-20 | Sekisui Chem Co Ltd | 貼付剤 |
WO2015129808A1 (ja) * | 2014-02-27 | 2015-09-03 | 久光製薬株式会社 | ケトプロフェン含有パップ剤 |
JP2019081755A (ja) * | 2017-10-30 | 2019-05-30 | 興和株式会社 | 組成物 |
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