JP2020528874A - 皮膚及び/又は粘膜を水和させるためのネフェリウム・ラパセウム(nephelium lappaceum)の果皮の抽出物の使用 - Google Patents
皮膚及び/又は粘膜を水和させるためのネフェリウム・ラパセウム(nephelium lappaceum)の果皮の抽出物の使用 Download PDFInfo
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- JP2020528874A JP2020528874A JP2019565201A JP2019565201A JP2020528874A JP 2020528874 A JP2020528874 A JP 2020528874A JP 2019565201 A JP2019565201 A JP 2019565201A JP 2019565201 A JP2019565201 A JP 2019565201A JP 2020528874 A JP2020528874 A JP 2020528874A
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- skin
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- cosmetic
- mucous membranes
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
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Abstract
Description
実施例1a)果皮及び唯一の溶媒としての水の全重量に対して10重量%の量のN.ラパセウム(N.lappaceum)の乾燥果皮を、20℃の温度で1時間にわたって浸軟により抽出した。得られた抽出物をデカントし、遠心分離し、そして上清をろ過した。抽出物は液体形態である。
実施例2a)インボルクリン合成の増大
プロトコル:2%のウシ胎仔血清を含有するMCDB153培地(Dutscher France)中で、正常、すなわち非病的なヒトケラチノサイトを培養した。37℃で3日間の培養の後、種々の最終濃度のN.ラパセウム(N.lappaceum)の抽出物(培地の全体積に対する重量による)を含有するか、又は抽出物を含まない(対照)、MCDB153培地で成長培地を置き換えた(表1)。培養培地を置き換え、次に抽出緩衝液中に可溶化した。インボルクリンの量をELISAアッセイによって定量化した。得られた結果は、対照に対する%で表される(n=3)(MEAN:平均;SD:標準偏差)。
葉抽出物:葉及び抽出した水の全重量に対して10重量%の量のN.ラパセウム(N.lappaceum)の乾燥葉を、周囲温度、すなわち20℃で1時間にわたって唯一の溶媒としての水の中で浸軟により抽出した。次に抽出物をデンカントし、遠心分離し、そして上清をろ過する。抽出物は液体形態である。
プロトコル:2%のウシ胎仔血清を含有するMCDB153培地(Dutscher France)中で、正常なヒトケラチノサイトを培養した。37℃で3日間の培養の後、所与の濃度(培地の全体積に対する重量による最終濃度)のN.ラパセウム(N.lappaceum)の抽出物を含有する(表2)か、又は抽出物を含まない(対照)、MCDB153培地で成長培地を置き換えた。
プロトコル:2%のウシ胎仔血清を含有するMCDB153培地(Dutscher France)中で、正常、すなわち非病的なヒトケラチノサイトを培養した。37℃で3日間の培養の後、2つの最終濃度のエラグ酸又はゲラニン(w/v最終培地)を含有するか、又はエラグ酸もゲラニンも含まない(対照)、MCDB153培地で成長培地を置き換えた(表3)。培養培地を置き換えた。インボルクリンの量をELISAアッセイにより定量化した。得られた結果は、対照に対する%で表される(n=3)。
プロトコル:27人の女性集団の皮膚の水和のインビボ測定は、実施例4に記載される2%(w/v)の活性成分を含む化粧品製剤を一方の頬に適用してからT14(2週)及びT28(4週)の時点で、MoistureMap MM100(登録商標)機器(Courage & Khazaka)を用いる静電容量の測定によって実行した。実施例4の化粧品成分を含まないプラセボクリームを適用した後、同じ集団の他方の頬において同じ測定を行った。
実施例3a)ATP合成
プロトコル:DMEM(ダルベッコ変法イーグル培地)及び10%のウシ胎仔血清を含む成長培地において、37℃(CO2=5%、95%相対湿度)で3日間、正常、すなわち非病的なヒト線維芽細胞をインキュベートした。培地の全体積に対して、2つの最終体積濃度で、実施例1c)に従って調製された果皮抽出物を含有するHanks生理食塩水(H8264,Sigma France)で培地を置き換えた。24時間のインキュベーション期間の後、細胞をUVA下で照射し、次に37℃で24時間にわたって培養に戻した。
プロトコル:2%のウシ胎仔血清を含有するMCDB153培地(Dutscher France)中で、正常なヒトケラチノサイトをコンフルエンスまで培養した。培地の全体積に対して0.2体積%の培地中の最終濃度の、実施例1c)に従って調製された果皮抽出物の存在下、又は抽出物を用いずに(対照)、細胞を24時間にわたってインキュベートした。
果皮抽出物 実施例1a) 0.5%
グリセリン 80%
水 19.5%
実施例5a):身体及び顔用セラムの形態の本発明に従う組成物:
特に種々の相を混ぜ合わせることに関して当業者に知られている方法に従って、以下の組成物が調製される。示される量は、組成物の全重量に対する重量百分率である。
キサンタンガム 0.50
EDTA 0.05
ステアレス−2 2.00
ステアレス−21 2.50
セテアリルアルコール 1.00
カプリル酸プロピルヘプチル 15.00
水酸化ナトリウム(30%溶液) 0.10
フェノキシエタノール、クロルフェネシン、安息香酸、ブチレングリコール、ソルビン酸の混合物(Germazide(商標)PBS) 1.25
ポリアクリレート−X、イソヘキサデカン及びポリソルベート60の混合物(Sepigel(商標)SMS60) 4.00
水 100になるまでの量
Claims (16)
- 健康な皮膚及び/又は健康な粘膜、有利には、健康な乾燥皮膚及び/又は健康な乾燥粘膜の水和及び/又はバリア効果を維持及び/又は増大させるための、ネフェリウム・ラパセウム(Nephelium lappaceum)の果皮抽出物の美容的使用。
- 前記果皮抽出物が、前記皮膚及び/又は前記粘膜においてインボルクリン合成及び/又はヒアルロン酸含有量を増大させることを特徴とする、請求項1に記載の美容的使用。
- 前記抽出物が、溶媒又は溶媒混合物、例えば、水、アルコール、グリコール、ポリオール、99/1〜1/99(w/w)の水/アルコール、水/グリコール、又は水/ポリオール混合物(例えば、水と、エタノール、グリセロール及び/又はブチレングリコール、及び/又は他のグリコール、例えば、キシリトール及び/又はプロパンジオールとの混合物)の中での抽出によって得られる、請求項1又は2に記載の使用。
- 前記抽出物が、唯一の溶媒としての水の中での抽出によって得られる、請求項1〜3のいずれか一項に記載の使用。
- 局所的又は経口的、優先的には、局所的である、請求項1〜4のいずれか一項に記載の美容的使用。
- 前記抽出物が健康な乾燥皮膚及び/又は健康な乾燥粘膜に適用されることを特徴とする、請求項1〜5のいずれか一項に記載の美容的使用。
- 前記抽出物が皮膚の色つやの輝きを増大させることを特徴とする、請求項1〜6のいずれか一項に記載の美容的使用。
- 前記抽出物が、ATP及び/又はタウリントランスポーターTAUTの合成を増大させる、請求項7に記載の美容的使用。
- 前記抽出物が、グリセリンを含有する水溶液中に可溶化され、有利には、前記抽出物を含む水溶液の全重量に対して、60重量%〜90重量%の濃度、より有利には70重量%〜85重量%の濃度、非常に有利には80重量%の濃度で存在することを特徴とする、請求項1〜8のいずれか一項に記載の美容的使用。
- 少なくとも1つの許容可能な化粧品賦形剤を含む化粧品組成物において、前記抽出物が、前記組成物の全重量に対して、1x10−4重量%〜10重量%、優先的には1x10−4重量%〜5重量%、より優先的には1x10−3重量%〜3重量%の濃度で前記組成物中に存在することを特徴とする、請求項1〜9のいずれか一項に記載の美容的使用。
- 健康な皮膚及び/又は健康な粘膜、有利には、健康な乾燥皮膚及び/又は健康な乾燥粘膜の水和及び/又はバリア効果を維持及び/又は増大させるため、且つ/或いは皮膚の色つやの輝きを増大させるために、請求項1〜6のいずれか一項に記載の抽出物、又はそれを含む化粧品組成物を投与すること、優先的には、局所的に投与することを含む、美容ケア方法。
- 皮膚及び/又は粘膜においてインボルクリン合成及び/又はヒアルロン酸含有量を増大させるため、且つ/或いは皮膚においてATP及び/又はタウリントランスポーターTAUTの合成を増大させるための、請求項11に記載の美容ケア方法。
- 有利には、脚、足、脇の下、手、大腿、胃、胸、首、腕、胴、背中、口唇粘膜、顔及び/又は頭皮、より有利には、胸及び/又は顔、さらにより有利には、顔から選択される、身体及び/又は顔及び/又は粘膜の全て又は一部に、請求項1〜6のいずれか一項に記載の抽出物又はそれを含む化粧品組成物を局所適用することにある、請求項11又は12に記載の美容ケア方法。
- 皮膚及び/又は粘膜の異常乾燥状態に起因する病態、例えば、アトピー性皮膚炎、ひび割れ、湿疹及び/又は魚鱗癬などの予防及び/又は処置において使用するため、優先的には、皮膚科学的に使用するための、ネフェリウム・ラパセウム(Nephelium lappaceum)の果皮抽出物、又はそれを含む医薬組成物、優先的には、皮膚用組成物。
- 前記組成物の全重量に対して1x10−4重量%〜10重量%の濃度、有利には、1x10−3重量%〜3重量%の濃度、より有利には、前記組成物の全重量に対して0.01重量%〜3重量%の濃度で前記組成物中に存在することを特徴とする、請求項14に記載の抽出物。
- 請求項3又は4において定義される、請求項14又は15に記載の抽出物。
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FR1757404A FR3069779A1 (fr) | 2017-08-02 | 2017-08-02 | Utilisation d'un extrait de pericarpe de nephelium lappaceum pour hydrater la peau et/ou les muqueuses |
PCT/FR2018/051973 WO2019025725A1 (fr) | 2017-08-02 | 2018-08-01 | Utilisation d'un extrait de péricarpe de nephelium lappaceum pour hydrater la peau et/ou les muqueuses |
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CN111067915A (zh) * | 2020-01-09 | 2020-04-28 | 昆明医科大学 | 老鹳草素在制备用于治疗维生素d不足和/或缺乏疾病的药物中的用途 |
CN111084780A (zh) * | 2020-01-09 | 2020-05-01 | 昆明医科大学 | 老鹳草素在制备治疗骨质疏松合并骨折的药物中的用途 |
CN112137939A (zh) * | 2020-11-10 | 2020-12-29 | 上海辉文生物技术股份有限公司 | 具有减少细纹和增加皮肤弹性的组合物、制备方法及其应用 |
CN113980069B (zh) * | 2021-10-26 | 2023-04-25 | 湖南绿蔓生物科技股份有限公司 | 一种从红毛丹果皮中提取老鹳草素的方法及其应用 |
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JP2020529420A (ja) | 2020-10-08 |
BR112019025318A2 (pt) | 2020-06-23 |
WO2019025725A1 (fr) | 2019-02-07 |
FR3069779A1 (fr) | 2019-02-08 |
JP7309620B2 (ja) | 2023-07-18 |
KR102625374B1 (ko) | 2024-01-15 |
KR20200035040A (ko) | 2020-04-01 |
BR112020000997B1 (pt) | 2023-05-16 |
BR112020000997A2 (pt) | 2020-07-14 |
EP3661604A1 (fr) | 2020-06-10 |
US20200237643A1 (en) | 2020-07-30 |
FR3069780A1 (fr) | 2019-02-08 |
JP7275103B2 (ja) | 2023-05-17 |
CN110944720A (zh) | 2020-03-31 |
US20200163870A1 (en) | 2020-05-28 |
US11364193B2 (en) | 2022-06-21 |
US11547655B2 (en) | 2023-01-10 |
CN110691630A (zh) | 2020-01-14 |
KR20200034954A (ko) | 2020-04-01 |
EP3612276A1 (fr) | 2020-02-26 |
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