JP2020525253A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020525253A5 JP2020525253A5 JP2020520437A JP2020520437A JP2020525253A5 JP 2020525253 A5 JP2020525253 A5 JP 2020525253A5 JP 2020520437 A JP2020520437 A JP 2020520437A JP 2020520437 A JP2020520437 A JP 2020520437A JP 2020525253 A5 JP2020525253 A5 JP 2020525253A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue filler
- spf
- filler according
- cross
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000945 filler Substances 0.000 claims 41
- 229920001223 polyethylene glycol Polymers 0.000 claims 16
- 125000005647 linker group Chemical group 0.000 claims 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 12
- 239000002202 Polyethylene glycol Substances 0.000 claims 12
- 108010022355 Fibroins Proteins 0.000 claims 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 8
- 238000004132 cross linking Methods 0.000 claims 8
- 229920002674 hyaluronan Polymers 0.000 claims 8
- 229960003160 hyaluronic acid Drugs 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims 6
- 230000001815 facial effect Effects 0.000 claims 6
- AOBIOSPNXBMOAT-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane Chemical compound C1OC1COCCOCC1CO1 AOBIOSPNXBMOAT-UHFFFAOYSA-N 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- -1 (2,3-epoxy) Propoxy Chemical group 0.000 claims 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 4
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims 4
- 229960004194 lidocaine Drugs 0.000 claims 4
- UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- PLDLPVSQYMQDBL-UHFFFAOYSA-N 2-[[3-(oxiran-2-ylmethoxy)-2,2-bis(oxiran-2-ylmethoxymethyl)propoxy]methyl]oxirane Chemical compound C1OC1COCC(COCC1OC1)(COCC1OC1)COCC1CO1 PLDLPVSQYMQDBL-UHFFFAOYSA-N 0.000 claims 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 2
- 125000001033 ether group Chemical group 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 150000003333 secondary alcohols Chemical class 0.000 claims 2
- LFKLPJRVSHJZPL-UHFFFAOYSA-N 1,2:7,8-diepoxyoctane Chemical compound C1OC1CCCCC1CO1 LFKLPJRVSHJZPL-UHFFFAOYSA-N 0.000 claims 1
- WTYYGFLRBWMFRY-UHFFFAOYSA-N 2-[6-(oxiran-2-ylmethoxy)hexoxymethyl]oxirane Chemical compound C1OC1COCCCCCCOCC1CO1 WTYYGFLRBWMFRY-UHFFFAOYSA-N 0.000 claims 1
- KUAUJXBLDYVELT-UHFFFAOYSA-N 2-[[2,2-dimethyl-3-(oxiran-2-ylmethoxy)propoxy]methyl]oxirane Chemical compound C1OC1COCC(C)(C)COCC1CO1 KUAUJXBLDYVELT-UHFFFAOYSA-N 0.000 claims 1
- XOBTWQWSFMZPNQ-UHFFFAOYSA-N 5-(oxiran-2-ylmethyl)-7-oxabicyclo[4.1.0]heptane Chemical compound C1CCC2OC2C1CC1CO1 XOBTWQWSFMZPNQ-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 108010013296 Sericins Proteins 0.000 claims 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims 1
- 238000002835 absorbance Methods 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 230000003416 augmentation Effects 0.000 claims 1
- 238000006065 biodegradation reaction Methods 0.000 claims 1
- 239000001273 butane Substances 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000036425 denaturation Effects 0.000 claims 1
- 238000004925 denaturation Methods 0.000 claims 1
- 125000004386 diacrylate group Chemical group 0.000 claims 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims 1
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920000223 polyglycerol Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 238000002834 transmittance Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023122912A JP7660619B2 (ja) | 2017-06-26 | 2023-07-28 | 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
| JP2024192754A JP2025020289A (ja) | 2017-06-26 | 2024-11-01 | 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762525131P | 2017-06-26 | 2017-06-26 | |
| US62/525,131 | 2017-06-26 | ||
| US201862641095P | 2018-03-09 | 2018-03-09 | |
| US62/641,095 | 2018-03-09 | ||
| PCT/US2018/039574 WO2019005848A1 (en) | 2017-06-26 | 2018-06-26 | HYALURONIC SILK ACID TISSUE FILLING AGENTS AND METHODS OF USE THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023122912A Division JP7660619B2 (ja) | 2017-06-26 | 2023-07-28 | 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020525253A JP2020525253A (ja) | 2020-08-27 |
| JP2020525253A5 true JP2020525253A5 (https=) | 2021-08-12 |
Family
ID=64742709
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520437A Pending JP2020525253A (ja) | 2017-06-26 | 2018-06-26 | 絹−ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
| JP2023122912A Active JP7660619B2 (ja) | 2017-06-26 | 2023-07-28 | 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
| JP2024192754A Pending JP2025020289A (ja) | 2017-06-26 | 2024-11-01 | 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023122912A Active JP7660619B2 (ja) | 2017-06-26 | 2023-07-28 | 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
| JP2024192754A Pending JP2025020289A (ja) | 2017-06-26 | 2024-11-01 | 絹－ヒアルロン酸系組織フィラー、及びそれを用いる方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP4169539B1 (https=) |
| JP (3) | JP2020525253A (https=) |
| KR (1) | KR20200032103A (https=) |
| CN (1) | CN111263646A (https=) |
| AU (2) | AU2018290810C1 (https=) |
| CA (1) | CA3068296A1 (https=) |
| CO (1) | CO2020000774A2 (https=) |
| ES (2) | ES2935887T3 (https=) |
| IL (2) | IL299584A (https=) |
| MA (1) | MA49520A (https=) |
| SG (1) | SG11201913229PA (https=) |
| UA (1) | UA127350C2 (https=) |
| WO (1) | WO2019005848A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230190997A1 (en) | 2017-06-26 | 2023-06-22 | Evolved By Nature, Inc. | Silk-hyaluronic acid based tissue filers and methods of using the same |
| JP6508431B1 (ja) | 2017-09-21 | 2019-05-08 | 住友電気工業株式会社 | 半絶縁性ヒ化ガリウム結晶基板 |
| AU2019405953B2 (en) * | 2018-12-19 | 2025-09-18 | Evolved By Nature, Inc. | Silk-hyaluronic acid tissue fillers and methods of making and using the same |
| US20220193305A1 (en) * | 2019-03-29 | 2022-06-23 | Trustees Of Tufts College | Crosslinked silk fibroin-based compositions, and methods of making and using the same |
| AU2020289479A1 (en) * | 2019-06-06 | 2022-02-03 | Evolved By Nature, Inc. | Silk stimulated collagen production and methods of use thereof |
| WO2020262596A1 (en) * | 2019-06-26 | 2020-12-30 | Compagnie Generale Des Etablissements Michelin | A noise improving tread |
| CN110339398A (zh) * | 2019-07-18 | 2019-10-18 | 王月玲 | 一种含氨基酸透明质酸钠注射剂及其制备方法 |
| EP4017537A4 (en) * | 2019-08-20 | 2023-08-16 | Evolved by Nature, Inc. | SILK PERSONAL CARE PRODUCTS |
| EP3995530B1 (en) * | 2019-09-27 | 2025-05-28 | LG Chem, Ltd. | A method of preparing polymer microparticles, polymer microparticles, medical composition, cosmetic composition, medical articles, and cosmetic articles using the same |
| PL4077402T3 (pl) * | 2019-12-19 | 2024-07-29 | Croma-Pharma Gmbh | Kwas hialuronowy modyfikowany tiolem i hydrożel zawierający usieciowany kwas hialuronowy |
| CN116507315A (zh) * | 2020-06-19 | 2023-07-28 | 自然进化公司 | 用于组织填充、组织间隔和组织膨胀的丝-透明质酸组合物 |
| US20250295691A1 (en) * | 2020-06-19 | 2025-09-25 | Evolved By Nature, Inc. | Silk-Hyaluronic Acid Compositions For Tissue Filling, Tissue Spacing, and Tissue Bulking |
| JP2024519426A (ja) * | 2020-09-29 | 2024-05-14 | ジロパ・インコーポレイテッド | 疼痛の緩和及び麻痺のための組成物及び方法 |
| TR202101065A1 (tr) * | 2021-01-25 | 2022-08-22 | Hacettepe Ueniversitesi | Hyaluroni̇k asi̇t jel i̇çeren bi̇r doku dolgu malzemesi̇ ve üreti̇m yöntemi̇ |
| CN114213517B (zh) * | 2021-02-08 | 2024-07-09 | 复向丝泰医疗科技(苏州)有限公司 | 利用切向流超滤技术制备可控高浓度丝素蛋白溶液的方法 |
| JP7695344B2 (ja) | 2021-05-21 | 2025-06-18 | ケンブリッジ クロップス インコーポレイテッド． ドゥーイングビジネスアズ モリ | 絹フィブロイン溶液及び絹フィブロインを含む粉末を製造するためのシステム及び方法 |
| WO2023275278A1 (en) * | 2021-06-30 | 2023-01-05 | Merz Pharma Gmbh & Co. Kgaa | Hyaluronic acid dermal fillers crosslinked with polyethylene glycol diglycidyl ether, method for making same and uses thereof |
| CN113368220A (zh) * | 2021-07-05 | 2021-09-10 | 云南维他源生物科技有限公司 | 一种ahco组合物及其制剂与应用 |
| KR20230013682A (ko) | 2021-07-16 | 2023-01-27 | 주식회사 휴메딕스 | Pegde로 가교된 히알루론산 필러 및 이의 제조방법 |
| US11864569B2 (en) | 2021-08-16 | 2024-01-09 | Cambridge Crops, Inc. | Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin |
| CN114028610B (zh) * | 2021-10-26 | 2022-10-25 | 北京诺康达医药科技股份有限公司 | 一种亲水性注射型皮肤填充组合物及其制备方法与应用 |
| KR102766244B1 (ko) * | 2024-02-16 | 2025-02-10 | 충남대학교 산학협력단 | Lc-ms/ms 기반의 히알루론산, bdde 및 bdde 가교된 히알루론산의 정량방법 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH453269A4 (https=) | 1968-03-29 | 1973-01-31 | ||
| FR2334107A1 (fr) | 1975-12-05 | 1977-07-01 | Pasteur Institut | Procede de couplage de substances biologiques par des liaisons covalentes |
| US4355023A (en) | 1980-09-30 | 1982-10-19 | The Massachusetts General Hospital | Antibody fragment compositions and process |
| US4657853A (en) | 1984-09-14 | 1987-04-14 | E. I. Du Pont De Nemours And Company | Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US20060105022A1 (en) | 2004-11-15 | 2006-05-18 | Shiseido Co., Ltd. | Process for preparing crosslinked hyaluronic acid gel |
| US8357795B2 (en) * | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| US20110189292A1 (en) | 2009-04-20 | 2011-08-04 | Allergan, Inc. | Dermal fillers comprising silk fibroin hydrogels and uses thereof |
| WO2011059325A2 (en) * | 2009-11-11 | 2011-05-19 | University Of Twente, Institute For Biomedical Technology And Technical Medicine (Mira) | Dextran-hyaluronic acid based hydrogels |
| KR102238406B1 (ko) * | 2011-06-03 | 2021-04-08 | 알러간 인더스트리 에스에이에스 | 항산화제를 포함하는 피부 충전제 조성물 |
| CN108379112A (zh) * | 2011-09-14 | 2018-08-10 | 阿勒根公司 | 用于细纹治疗的真皮填充剂组合物 |
| CN102836465B (zh) * | 2012-08-30 | 2014-06-04 | 浙江星月生物科技股份有限公司 | 一种注射用丝素蛋白透明质酸复合凝胶及其制备与应用 |
| WO2014055895A1 (en) * | 2012-10-05 | 2014-04-10 | Allergan, Inc. | Injectable device and method for sculpting, augmenting or correcting facial features such as the chin |
| US20140315828A1 (en) * | 2013-04-22 | 2014-10-23 | Allergan, Inc. | Cross-linked silk-hyaluronic acid compositions |
| HK1224315A1 (zh) | 2013-06-28 | 2017-08-18 | Galderma S.A. | 用於制备交联的透明质酸产物的方法 |
| CA2925820C (en) * | 2013-09-30 | 2021-11-30 | Silk Therapeutics, Inc. | Silk protein fragment compositions and articles manufactured therefrom |
| EA035551B1 (ru) | 2014-12-02 | 2020-07-06 | Силк Терапьютикс, Инк. | Изделие |
| MX2017013949A (es) * | 2015-04-29 | 2018-11-09 | Silk Therapeutics Inc | Composiciones mectantes a base de seda y sus metodos. |
| US10175996B2 (en) | 2016-05-02 | 2019-01-08 | Norman R. Byrne | Information display and control for work areas |
| EP3503841A4 (en) * | 2016-08-24 | 2020-04-22 | Allergan, Inc. | CO-CROSSLINKED HYALURONIC ACID-FIBROIN HYDROGELS FOR IMPROVING THE SUSTAINABILITY OF TISSUE GRAFTS AND FOR INCREASING SOFT TISSUES |
-
2018
- 2018-06-26 AU AU2018290810A patent/AU2018290810C1/en active Active
- 2018-06-26 EP EP22197284.7A patent/EP4169539B1/en active Active
- 2018-06-26 SG SG11201913229PA patent/SG11201913229PA/en unknown
- 2018-06-26 CA CA3068296A patent/CA3068296A1/en active Pending
- 2018-06-26 JP JP2020520437A patent/JP2020525253A/ja active Pending
- 2018-06-26 IL IL299584A patent/IL299584A/en unknown
- 2018-06-26 WO PCT/US2018/039574 patent/WO2019005848A1/en not_active Ceased
- 2018-06-26 EP EP18823073.4A patent/EP3645063B1/en active Active
- 2018-06-26 CN CN201880055268.1A patent/CN111263646A/zh active Pending
- 2018-06-26 ES ES18823073T patent/ES2935887T3/es active Active
- 2018-06-26 ES ES22197284T patent/ES3018883T3/es active Active
- 2018-06-26 UA UAA202000401A patent/UA127350C2/uk unknown
- 2018-06-26 KR KR1020207002371A patent/KR20200032103A/ko not_active Ceased
- 2018-06-26 MA MA049520A patent/MA49520A/fr unknown
-
2019
- 2019-12-24 IL IL271692A patent/IL271692B2/en unknown
-
2020
- 2020-01-23 CO CONC2020/0000774A patent/CO2020000774A2/es unknown
-
2023
- 2023-07-28 JP JP2023122912A patent/JP7660619B2/ja active Active
-
2024
- 2024-09-10 AU AU2024219582A patent/AU2024219582A1/en active Pending
- 2024-11-01 JP JP2024192754A patent/JP2025020289A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020525253A5 (https=) | ||
| Geanaliu-Nicolae et al. | Blended natural support materials—collagen based hydrogels used in biomedicine | |
| Li et al. | Bifunctional reinforcement of green biopolymer packaging nanocomposites with natural cellulose nanocrystal–rosin hybrids | |
| Sayed et al. | Enhancing mechanical and biodegradation properties of polyvinyl alcohol/silk fibroin nanofibers composite patches for Cardiac Tissue Engineering | |
| KR102071029B1 (ko) | 생체안정성과 기계적 물성이 향상된 생분해성 고분자 하이드로겔 복합체 및 이의 제조방법 | |
| RU2011107878A (ru) | Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты | |
| US7226972B2 (en) | Process for cross-linking hyaluronic acid to polymers | |
| TWI251596B (en) | Method for producing a double-crosslinked hyaluronate material | |
| AU2004261752B2 (en) | Complex matrix for biomedical use | |
| KR101918452B1 (ko) | 카복시메틸키토산과 가교된 히알루론산 및 콜라겐을 포함하는 조성물 및, 그 제조방법 | |
| Wang et al. | IPN hydrogel nanocomposites based on agarose and ZnO with antifouling and bactericidal properties | |
| AU2005219595A1 (en) | Biocompatible crosslinked gel | |
| IL261574B2 (en) | Modified hyaluronic acid, method for making same and uses thereof | |
| CN102399295A (zh) | 低巯基化改性度生物相容高分子巯基化衍生物及其交联材料和用途 | |
| CN1342171A (zh) | 多重交联的透明质酸衍生物的生产方法 | |
| CN103739862A (zh) | 明胶/羧甲基壳聚糖/poss光交联水凝胶及制备方法 | |
| RU2020112214A (ru) | Композиции и способы для улучшения внешнего вида кожи | |
| Emre Oz et al. | A review of functionalised bacterial cellulose for targeted biomedical fields | |
| Shahriari et al. | Advances in self-healing hydrogels to repair tissue defects | |
| França et al. | Oxi-HA/ADH hydrogels: a novel approach in tissue engineering and regenerative medicine | |
| Ishikawa et al. | An interpenetrating polymer network hydrogel with biodegradability through controlling self-assembling peptide behavior with hydrolyzable cross-linking networks | |
| John et al. | Nanocellulose-based hydrogels for biomedical applications | |
| Mojahedi et al. | Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity | |
| KR20180034170A (ko) | 히알루론산 및 실크 단백질을 함유하는 투명 하이드로겔 막 및 이의 제조 방법 | |
| CN111790003A (zh) | 一种促进皮肤损伤快速修复的液体伤口敷料及其制备方法 |