JP2020503242A - Saicarの蓄積を減少させる化合物及び使用 - Google Patents
Saicarの蓄積を減少させる化合物及び使用 Download PDFInfo
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- JP2020503242A JP2020503242A JP2019516529A JP2019516529A JP2020503242A JP 2020503242 A JP2020503242 A JP 2020503242A JP 2019516529 A JP2019516529 A JP 2019516529A JP 2019516529 A JP2019516529 A JP 2019516529A JP 2020503242 A JP2020503242 A JP 2020503242A
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- Prior art keywords
- acid
- compound
- derivative
- pharmaceutically acceptable
- saicar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 DB03433 Chemical compound 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 16
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- 238000000034 method Methods 0.000 claims description 8
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Abstract
Description
Claims (15)
- DrugBank IDがDB03639、DB01821、DB04700、DB02927、DB02267、DB04633、DB04207、DB03433、DB03003、DB01910、DB01813、DB02011、DB03327、DB02075、DB02077、DB01815、DB01974、DB04323、DB03927、DB03582、DB02537、DB01634、DB04153、DB04649、DB04778、DB02824、DB04701、DB01657、DB02941、DB04684、DB02492、DB03427、DB03686、DB04762、DB03602、DB03566、DB04808、DB04341、DB01895、DB03624、DB04434、DB04602である化合物又はその薬学上許容される誘導体の、SAICAR合成酵素妨害剤又は抑制剤の製造における使用。
- SAICAR合成酵素はPAICSであることを特徴とする請求項1に記載の使用。
- 化合物の薬学上許容される誘導体は、その簡単な誘導体であることを特徴とする請求項1に記載の使用。
- 簡単な誘導体は、その低級エステル、低級エーテル、低級アルキル置換体、薬用塩、低級アミドのうちの1種であることを特徴とする請求項3に記載の使用。
- DrugBank IDがDB03639、DB01821、DB04700、DB02927、DB02267、DB04633、DB04207、DB03433、DB03003、DB01910、DB01813、DB02011、DB03327、DB02075、DB02077、DB01815、DB01974、DB04323、DB03927、DB03582、DB02537、DB01634、DB04153、DB04649、DB04778、DB02824、DB04701、DB01657、DB02941、DB04684、DB02492、DB03427、DB03686、DB04762、DB03602、DB03566、DB04808、DB04341、DB01895、DB03624、DB04434、DB04602である化合物又はその薬学上許容される誘導体の、ADSL欠損症治療又は緩和用薬物又は保健物の製造における使用。
- 化合物の薬学上許容される誘導体は、その簡単な誘導体であることを特徴とする請求項5に記載の使用。
- 簡単な誘導体は、その低級エステル、低級エーテル、低級アルキル置換体、薬用塩、低級アミドのうちの1種であることを特徴とする請求項6に記載の使用。
- ADSL欠損症治療又は緩和用組成物であって、活性成分は、DrugBank IDがDB03639、DB01821、DB04700、DB02927、DB02267、DB04633、DB04207、DB03433、DB03003、DB01910、DB01813、DB02011、DB03327、DB02075、DB02077、DB01815、DB01974、DB04323、DB03927、DB03582、DB02537、DB01634、DB04153、DB04649、DB04778、DB02824、DB04701、DB01657、DB02941、DB04684、DB02492、DB03427、DB03686、DB04762、DB03602、DB03566、DB04808、DB04341、DB01895、DB03624、DB04434、DB04602である化合物、又はその薬学上許容される誘導体から選択される少なくとも1種であることを特徴とする組成物。
- 活性成分は、DrugBank IDがDB03639、DB01821、DB04700、DB02927、DB02267、DB04633、DB04207、DB03433、DB03003、DB01910、DB01813、DB02011、DB03327、DB02075、DB02077、DB01815、DB01974、DB04323、DB03927、DB03582、DB02537、DB01634、DB04153、DB04649、DB04778、DB02824、DB04701、DB01657、DB02941、DB04684、DB02492、DB03427、DB03686、DB04762、DB03602、DB03566、DB04808、DB04341、DB01895、DB03624、DB04434、DB04602である化合物、又はその薬学上許容される誘導体から選択される少なくとも2種であることを特徴とする請求項8に記載の組成物。
- 化合物の薬学上許容される誘導体は、その簡単な誘導体であることを特徴とする請求項8又は9に記載の組成物。
- 簡単な誘導体は、その低級エステル、低級エーテル、低級アルキル置換体、薬用塩、低級アミドのうちの1種であることを特徴とする請求項10に記載の組成物。
- 組成物は、さらに薬学上又は食品上許容される補助材料を含むことを特徴とする請求項8〜11のいずれか一項に記載の組成物。
- ADSL欠損症の治療又は緩和方法であって、DrugBank IDがDB03639、DB01821、DB04700、DB02927、DB02267、DB04633、DB04207、DB03433、DB03003、DB01910、DB01813、DB02011、DB03327、DB02075、DB02077、DB01815、DB01974、DB04323、DB03927、DB03582、DB02537、DB01634、DB04153、DB04649、DB04778、DB02824、DB04701、DB01657、DB02941、DB04684、DB02492、DB03427、DB03686、DB04762、DB03602、DB03566、DB04808、DB04341、DB01895、DB03624、DB04434、DB04602である化合物又はその薬学上許容される誘導体を、治療量で患者に投与することを含む方法。
- 化合物の薬学上許容される誘導体は、その簡単な誘導体であることを特徴とする請求項13に記載の方法。
- 簡単な誘導体は、その低級エステル、低級エーテル、低級アルキル置換体、薬用塩、低級アミドのうちの1種であることを特徴とする請求項13に記載の方法。
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WO2018192318A1 (zh) * | 2017-04-20 | 2018-10-25 | 广州君赫生物科技有限公司 | 干扰saicar合成酶活性化合物的应用 |
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CN110678452B (zh) * | 2017-04-20 | 2023-02-28 | 广州君赫生物科技有限公司 | 亚精胺及其衍生物的应用 |
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