JP2020132625A - 肝臓癌に対するサフラナールとソラフェニブの併用療法 - Google Patents
肝臓癌に対するサフラナールとソラフェニブの併用療法 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
Description
Claims (20)
- サフラナールまたはその薬学的に許容されるプロドラッグ、およびソラフェニブを含む、肝臓癌治療の薬物の治療的組み合わせ。
- 前記プロドラッグが、前記サフラナールの塩、水和物、ヘミアセタール、アセタール、チオアセタール、シリルエーテル、互変異性体、異性体、およびそれらの組み合わせからなる群から選択される、請求項1に記載の薬物の治療的組み合わせ。
- 前記サフラナールおよびソラフェニブが、同じ単一の医薬組成物に配合される、請求項1に記載の薬物の治療的組み合わせ。
- 前記サフラナールおよびソラフェニブが、別々の医薬組成物である、請求項1に記載の薬物の治療的組み合わせ。
- 対象における肝臓癌の重症度を治療、抑制、または軽減する方法であって、請求項1に記載の薬物の治療的組み合わせを対象に投与することを含む方法。
- 前記肝臓癌が、肝細胞癌(HCC)、線維層板状HCC、胆管癌、血管肉腫、転移性肝臓癌、およびそれらの組み合わせからなる群から選択される、請求項5に記載の方法。
- 前記肝臓癌が肝細胞癌である、請求項5に記載の方法。
- 対象に投与する、サフラナール:ソラフェニブの質量比が約50:1〜約1:1の範囲である、請求項5に記載の方法。
- 対象に投与する、サフラナール:ソラフェニブの質量比が約25:1〜約1:1の範囲である、請求項5に記載の方法。
- サフラナール:ソラフェニブの質量比が、対象に1日、1週間、14日、21日、または28日投与する前記サフラナールおよびソラフェニブの量に基づく、請求項5に記載の方法。
- 前記サフラナールまたはそのプロドラッグの投与量が、対象の体重1kgあたり約10mg/日〜約1000mg/日である、請求項5記載の方法。
- 前記サフラナールまたはそのプロドラッグの投与量が、対象の体重1kgあたり約200mg/日〜約750mg/日である、請求項5記載の方法。
- 前記サフラナールまたはそのプロドラッグの投与量が、対象の体重1kgあたり約250mg/日〜約500mg/日である、請求項5に記載の方法。
- 前記サフラナールが、ソラフェニブの前、ソラフェニブと同時に、またはソラフェニブの後に対象に投与される、請求項5に記載の方法。
- 前記ソラフェニブの対象への投与量が約800、600、400、または200mg/日である、請求項5に記載の方法。
- 前記ソラフェニブが、サフラナール非投与下で必要な用量の50%以上90%以下の有効投与量で投与される、請求項5に記載の方法。
- 肝臓癌がソラフェニブに対して一次または二次耐性を有する、請求項5記載の方法。
- 前記サフラナールの薬学的に許容される第1の組成物、ソラフェニブの第2の医薬組成物、および肝臓癌の治療のための第1の組成物および第2の組成物の投与に関する指示書を含む、肝臓癌の治療用キット。
- 前記肝臓癌が、肝細胞癌(HCC)、線維層板状HCC、胆管癌、血管肉腫、転移性肝臓癌、およびそれらの組み合わせからなる群から選択される、請求項18に記載のキット。
- 肝臓癌が肝細胞癌である、請求項18に記載のキット。
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US16/275,878 US10568873B1 (en) | 2019-02-14 | 2019-02-14 | Safranal-sorafenib combination therapy for liver cancer |
US16/275,878 | 2019-02-14 |
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US20090215835A1 (en) * | 2005-10-31 | 2009-08-27 | Scott Wilhelm | Treatment of cancer with sorafenib |
JP2017507955A (ja) * | 2014-02-28 | 2017-03-23 | ミルナ セラピューティクス,インク. | 肝臓癌のためのソラフェニブとマイクロrnaの併用療法 |
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US20090215835A1 (en) * | 2005-10-31 | 2009-08-27 | Scott Wilhelm | Treatment of cancer with sorafenib |
JP2017507955A (ja) * | 2014-02-28 | 2017-03-23 | ミルナ セラピューティクス,インク. | 肝臓癌のためのソラフェニブとマイクロrnaの併用療法 |
Non-Patent Citations (2)
Title |
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JOURNAL OF CLINICAL ONCOLOGY, vol. 31, no. 15, JPN6022034751, 2013, pages 15171, ISSN: 0005000212 * |
JOURNAL OF NUTRITION & INTERMEDIARY METABOLISM, vol. 3, JPN6022034752, 2016, pages 23 - 32, ISSN: 0005000213 * |
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AU2019264661A1 (en) | 2020-09-03 |
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